Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.1841 | 0.55 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.3348 | 0.3348 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.125 | 0.125 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.125 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.125 | 0.125 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.125 | 0.125 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.3348 | 0.3348 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.3348 | 0.2398 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.3348 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.3348 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.3348 | 0.2398 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.125 | 0.125 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.3348 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | unspecified product | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1841 | 0.55 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.3348 | 0.3348 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.3348 | 0.2398 |
Onchocerca volvulus | 0.0011 | 0.125 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.125 | 0.125 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.3348 | 0.2398 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.125 | 0.125 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.3348 | 0.2398 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.3348 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.3348 | 0.3348 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.3348 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.125 | 0.125 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.125 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.125 | 0.125 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1841 | 0.55 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.125 | 0.125 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3348 | 0.3348 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.125 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.3348 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.1841 | 0.55 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.3348 | 0.3348 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.125 | 0.125 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.3348 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.125 | 0.125 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.125 | 0.125 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.3348 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.3348 | 0.2398 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.125 | 0.125 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1841 | 0.55 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.125 | 0.125 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.125 | 0.125 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.125 | 0.125 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.