Detailed information for compound 1398266

Basic information

Technical information
  • TDR Targets ID: 1398266
  • Name: 1-[4-(5-chloro-2-hydroxybenzoyl)pyrazol-1-yl] -2-(2-methyl-1,3-thiazol-5-yl)ethanone
  • MW: 361.803 | Formula: C16H12ClN3O3S
  • H donors: 1 H acceptors: 5 LogP: 3.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)C(=O)c1cnn(c1)C(=O)Cc1cnc(s1)C)O
  • InChi: 1S/C16H12ClN3O3S/c1-9-18-7-12(24-9)5-15(22)20-8-10(6-19-20)16(23)13-4-11(17)2-3-14(13)21/h2-4,6-8,21H,5H2,1H3
  • InChiKey: USCSGFLVXLAPQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(5-chloro-2-hydroxy-benzoyl)pyrazol-1-yl]-2-(2-methylthiazol-5-yl)ethanone
  • 1-[4-[(5-chloro-2-hydroxyphenyl)-oxomethyl]-1-pyrazolyl]-2-(2-methyl-5-thiazolyl)ethanone
  • 1-[4-(5-chloro-2-hydroxy-phenyl)carbonylpyrazol-1-yl]-2-(2-methyl-1,3-thiazol-5-yl)ethanone
  • T0515-4864
  • ZINC03299654
  • MLS000098376
  • SMR000062634

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0076 0.0076 0.0085
Brugia malayi DNA-binding protein LAG-1 0.0171 0.0261 0.0256
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus multilocularis ephrin type A receptor 4 A 0.006 0.0045 0.0047
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0076 0.0076 0.0489
Loa Loa (eye worm) SRC-1 0.006 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Brugia malayi SH2 domain containing protein 0.006 0.0045 0.0039
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus granulosus tyrosine protein kinase csk 0.006 0.0045 0.0047
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Schistosoma mansoni hypothetical protein 0.006 0.0045 0.0032
Echinococcus granulosus raf serine:threonine protein kinase 0.006 0.0045 0.0047
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Brugia malayi Protein kinase domain containing protein 0.0098 0.0118 0.0112
Brugia malayi serine/threonine-protein kinase 6 0.0083 0.009 0.0085
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Loa Loa (eye worm) RGC/RGC protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis kinesin light chain, putative 0.0076 0.0076 0.0489
Onchocerca volvulus 0.0076 0.0076 0.0188
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0076 0.0076 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0087 0.0075
Echinococcus granulosus Pleckstrin y 0.0076 0.0076 0.0085
Schistosoma mansoni axis inhibition protein axin 0.0833 0.156 0.1549
Echinococcus multilocularis Oxysterol binding protein 11 0.0076 0.0076 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0083 0.009 0.0577
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0076 0.0076 0.0489
Trypanosoma cruzi Protein kinase B 0.0098 0.0118 1
Schistosoma mansoni hypothetical protein 0.0171 0.0261 0.0249
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0098 0.0118 1
Brugia malayi Dynamin 0.0076 0.0076 0.0071
Echinococcus granulosus beta-adrenergic receptor kinase 0.3938 0.7648 0.9141
Schistosoma mansoni hypothetical protein 0.0076 0.0076 0.0064
Echinococcus multilocularis protein kinase 0.006 0.0045 0.0047
Echinococcus granulosus axis inhibition protein axin 0.0833 0.156 0.1859
Loa Loa (eye worm) serine/threonine protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0076 0.0076 0.0085
Schistosoma mansoni plexin 0.0919 0.1728 0.1718
Echinococcus granulosus oxysterol binding protein 3 0.0076 0.0076 0.0085
Entamoeba histolytica hypothetical protein 0.0076 0.0076 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Loa Loa (eye worm) RGC/RGC protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica hypothetical protein 0.0171 0.0261 0.16
Loa Loa (eye worm) AUR protein kinase 0.0083 0.009 0.0085
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.4304 0.8367 1
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Echinococcus granulosus tyrosine protein kinase Blk 0.006 0.0045 0.0047
Entamoeba histolytica hypothetical protein 0.0098 0.0118 0.0671
Echinococcus multilocularis neuroglian 0.0133 0.0187 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus granulosus G protein coupled receptor kinase 1 0.3105 0.6015 0.7187
Loa Loa (eye worm) TK/CSK protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica hypothetical protein 0.0076 0.0076 0.0403
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.006 0.0045 0.0198
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0076 0.0076 0.0085
Echinococcus granulosus regulator of G protein signaling 7 0.0833 0.156 0.1859
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0098 0.0118 1
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0076 0.0076 0.0071
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0076 0.0076 0.0085
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0171 0.0261 0.1675
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.006 0.0045 0.0047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Leishmania major protein kinase, putative 0.0098 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Echinococcus multilocularis protein tyrosine kinase 0.006 0.0045 0.0047
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Echinococcus granulosus epidermal growth factor receptor 0.006 0.0045 0.0047
Schistosoma mansoni regulator of G protein signaling 0.0833 0.156 0.1549
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.4304 0.8367 0.8366
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.006 0.0045 0.0047
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0081 0.0086 0.0466
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.039 0.0691 0.0686
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trypanosoma cruzi aurora B kinase, putative 0.0083 0.009 0.7339
Echinococcus granulosus semaphorin 5B 0.039 0.0691 0.082
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.006 0.0045 0.0286
Entamoeba histolytica hypothetical protein 0.0171 0.0261 0.16
Loa Loa (eye worm) oxysterol binding protein 0.0076 0.0076 0.0071
Echinococcus multilocularis transfer RNA-Thr 0.006 0.0045 0.0047
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0076 0.0076 0.4332
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis pdz domain containing protein 0.0076 0.0076 0.0085
Brugia malayi MAX-1A 0.0076 0.0076 0.0071
Giardia lamblia Kinase, NEK 0.006 0.0045 0.4029
Schistosoma mansoni myotubularin-related protein 0.0076 0.0076 0.0064
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Onchocerca volvulus 0.0076 0.0076 0.0188
Echinococcus granulosus retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Brugia malayi hypothetical protein 0.006 0.0045 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0014 0.0002
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0076 0.0076 0.0071
Echinococcus multilocularis expressed protein 0.0833 0.156 0.1859
Brugia malayi Oxysterol binding protein 0.0076 0.0076 0.0071
Trichomonas vaginalis protein kinase atn1, putative 0.006 0.0045 0.0286
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Onchocerca volvulus 0.0076 0.0076 0.0188
Schistosoma mansoni protein kinase 0.0081 0.0086 0.0074
Schistosoma mansoni hypothetical protein 0.0076 0.0076 0.0064
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0076 0.0076 0.6008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0833 0.156 0.1555
Entamoeba histolytica serine/threonine kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.006 0.0045 0.0039
Echinococcus multilocularis axis inhibition protein axin 0.0833 0.156 0.1859
Schistosoma mansoni semaphorin 5-related 0.039 0.0691 0.0679
Plasmodium falciparum calcium-dependent protein kinase 7 0.0098 0.0118 1
Giardia lamblia Kinase, CMGC MAPK 0.0082 0.0087 0.9647
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus protein kinase 0.006 0.0045 0.0047
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Echinococcus multilocularis dynamin 1 0.0076 0.0076 0.0085
Leishmania major hypothetical protein, conserved 0.006 0.0045 0.2957
Echinococcus multilocularis tyrosine protein kinase Srms 0.006 0.0045 0.0047
Brugia malayi Sema domain containing protein 0.039 0.0691 0.0686
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0098 0.0118 0.0754
Schistosoma mansoni ephrin receptor 0.006 0.0045 0.0032
Schistosoma mansoni hypothetical protein 0.039 0.0691 0.0679
Trypanosoma brucei aurora B kinase 0.0083 0.009 0.7339
Entamoeba histolytica serine/threonine kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica hypothetical protein 0.0098 0.0118 0.0671
Loa Loa (eye worm) TK/ABL protein kinase 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Schistosoma mansoni hypothetical protein 0.0076 0.0076 0.0064
Echinococcus multilocularis tyrosine protein kinase csk 0.006 0.0045 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni protein kinase 0.0081 0.0086 0.0074
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0098 0.0118 1
Onchocerca volvulus 0.0076 0.0076 0.0188
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Schistosoma mansoni hypothetical protein 0.039 0.0691 0.0679
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0083 0.009 0.6222
Entamoeba histolytica serine/threonine kinase, putative 0.006 0.0045 0.0198
Brugia malayi Cadps2 protein 0.0076 0.0076 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0138 0.0197 0.0192
Loa Loa (eye worm) rho-GTPase-activating 0.0076 0.0076 0.0071
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0098 0.0118 1
Brugia malayi Sema domain containing protein 0.039 0.0691 0.0686
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0082 0.0087 0.708
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.006 0.0045 0.0032
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Brugia malayi Plexin repeat family protein 0.0919 0.1728 0.1724
Echinococcus granulosus dynamin 1 0.0076 0.0076 0.0085
Echinococcus granulosus kinase suppressor of Ras 1 0.006 0.0045 0.0047
Echinococcus multilocularis receptor type guanylyl cyclase 0.006 0.0045 0.0047
Echinococcus multilocularis mitogen activated protein kinase 3 0.0082 0.0087 0.0098
Brugia malayi PXA domain containing protein 0.0833 0.156 0.1555
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Plasmodium falciparum oxysterol-binding protein, putative 0.0076 0.0076 0.4332
Echinococcus granulosus mitogen activated protein kinase 0.0082 0.0087 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0833 0.156 1
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Entamoeba histolytica PH domain containing protein 0.0076 0.0076 0.0403
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0833 0.156 0.1859
Loa Loa (eye worm) plexin A 0.109 0.2063 0.2059
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Schistosoma mansoni hypothetical protein 0.0529 0.0964 0.0953
Loa Loa (eye worm) TK/Met protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0082 0.0087 0.0082
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0098 0.0118 1
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Trypanosoma cruzi protein kinase, putative 0.006 0.0045 0.2957
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Trypanosoma brucei protein kinase, putative 0.0081 0.0086 0.6949
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.006 0.0045 0.0047
Entamoeba histolytica ankyrin repeat protein 0.006 0.0045 0.0198
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.006 0.0045 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0076 0.0076 0.4332
Trichomonas vaginalis protein tyrosine kinase, putative 0.006 0.0045 0.0286
Trichomonas vaginalis AGC family protein kinase 0.0083 0.009 0.0577
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus granulosus Oxysterol binding protein 11 0.0076 0.0076 0.0085
Toxoplasma gondii hypothetical protein 0.0076 0.0076 0.4332
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Trichomonas vaginalis STE family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis centaurin/arf, putative 0.0076 0.0076 0.0489
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0171 0.0261 0.1675
Echinococcus multilocularis plexin a4 0.109 0.2063 0.2461
Echinococcus granulosus Rho GTPase activating protein 24 0.0076 0.0076 0.0085
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0098 0.0118 1
Echinococcus granulosus tyrosine protein kinase csk 0.006 0.0045 0.0047
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.4304 0.8367 0.8366
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0118 0.0671
Brugia malayi Probable tyrosine-protein kinase kin-31 0.006 0.0045 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0118 0.0671
Trichomonas vaginalis protein transport protein sec7, putative 0.0076 0.0076 0.0489
Brugia malayi Plekhf2 protein 0.0076 0.0076 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Schistosoma mansoni tyrosine protein kinase 0.006 0.0045 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Schistosoma mansoni syntrophin 0.0076 0.0076 0.0064
Echinococcus granulosus c src tyrosine kinase 0.006 0.0045 0.0047
Schistosoma mansoni regulator of G protein signaling 0.0833 0.156 0.1549
Brugia malayi protein-tyrosine kinase 0.006 0.0045 0.0039
Brugia malayi hypothetical protein 0.0148 0.0217 0.0211
Loa Loa (eye worm) hypothetical protein 0.0133 0.0187 0.0182
Echinococcus multilocularis tyrosine kinase 0.006 0.0045 0.0047
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0833 0.156 0.1555
Echinococcus granulosus serine/threonine protein kinase 0.0098 0.0118 0.0134
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Schistosoma mansoni ephrin receptor 0.0065 0.0054 0.0042
Plasmodium falciparum PH domain-containing protein, putative 0.0076 0.0076 0.4332
Schistosoma mansoni plexin 0.0529 0.0964 0.0953
Schistosoma mansoni dynamin 0.0076 0.0076 0.0064
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase Fps85D 0.006 0.0045 0.0047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Echinococcus granulosus Pleckstrin y 0.0076 0.0076 0.0085
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Brugia malayi hypothetical protein 0.0833 0.156 0.1555
Plasmodium falciparum protein kinase, putative 0.0081 0.0086 0.5668
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0014 0.0002
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus multilocularis Ras associated and pleckstrin y 0.0076 0.0076 0.0085
Echinococcus granulosus tyrosine protein kinase HCK 0.006 0.0045 0.0047
Brugia malayi Syntrophin-1 0.0076 0.0076 0.0071
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0014 0.0011
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Trypanosoma cruzi NIMA-related kinase, putative 0.0098 0.0118 1
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica hypothetical protein 0.0076 0.0076 0.0403
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0098 0.0118 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0133 0.0187 0.0218
Trichomonas vaginalis serine-threonine protein kinase, putative 0.006 0.0045 0.0286
Echinococcus multilocularis integrin linked protein kinase 0.006 0.0045 0.0047
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Echinococcus granulosus tyrosine protein kinase ABL1 0.006 0.0045 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.006 0.0045 0.0047
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0076 0.0076 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0833 0.156 1
Echinococcus multilocularis FL cytokine receptor 0.006 0.0045 0.0047
Echinococcus granulosus ephrin type A receptor 4 A 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0076 0.6008
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Loa Loa (eye worm) TK/FAK protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Echinococcus granulosus Regulator of G protein signaling 20 0.0833 0.156 0.1859
Loa Loa (eye worm) cytohesin 3 0.0076 0.0076 0.0071
Loa Loa (eye worm) TK/ACK protein kinase 0.006 0.0045 0.0039
Echinococcus multilocularis tyrosine protein kinase pr2 0.006 0.0045 0.0047
Entamoeba histolytica tyrosin kinase, putative 0.006 0.0045 0.0198
Echinococcus granulosus tyrosine protein kinase shark 0.006 0.0045 0.0047
Echinococcus granulosus defective proboscis extension response 0.0133 0.0187 0.0218
Trypanosoma brucei Flagellum attachment zone protein 20 0.006 0.0045 0.2957
Echinococcus multilocularis Immunoglobulin 0.0133 0.0187 0.0218
Echinococcus granulosus roundabout 2 0.0138 0.0197 0.0229
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0833 0.156 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0171 0.0261 0.1675
Schistosoma mansoni cell adhesion molecule 0.0138 0.0197 0.0185
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis protein transport protein sec7, putative 0.0076 0.0076 0.0489
Brugia malayi Guanylyl cyclase protein 23 0.006 0.0045 0.0039
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0076 0.0076 0.0071
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0076 0.6008
Echinococcus granulosus pdz domain containing protein 0.0076 0.0076 0.0085
Onchocerca volvulus Huntingtin homolog 0.0148 0.0217 0.1021
Schistosoma mansoni regulator of G protein signaling 0.0833 0.156 0.1549
Echinococcus granulosus tyrosine protein kinase pr2 0.006 0.0045 0.0047
Brugia malayi Receptor family ligand binding region containing protein 0.006 0.0045 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus granulosus calcium dependent secretion activator 1 0.0076 0.0076 0.0085
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0118 0.0671
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0118 1
Echinococcus multilocularis semaphorin 5B 0.039 0.0691 0.082
Echinococcus multilocularis protein kinase 0.006 0.0045 0.0047
Loa Loa (eye worm) TK/EGFR protein kinase 0.006 0.0045 0.0039
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0076 0.0076 0.0071
Loa Loa (eye worm) TK/KIN6 protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0087 0.056
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.006 0.0045 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis tyrosine protein kinase shark 0.006 0.0045 0.0047
Leishmania major protein kinase, putative 0.006 0.0045 0.2957
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Echinococcus multilocularis GRB2 associated binding protein 3 0.0076 0.0076 0.0085
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Loa Loa (eye worm) RGS-3 protein 0.0833 0.156 0.1555
Echinococcus granulosus cytohesin 1 0.0076 0.0076 0.0085
Schistosoma mansoni axis inhibition protein axin 0.0833 0.156 0.1549
Entamoeba histolytica tyrosin kinase, putative 0.006 0.0045 0.0198
Brugia malayi plexin A 0.109 0.2063 0.2059
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0171 0.0261 0.1675
Leishmania major serine/threonine-protein kinase a, putative 0.0098 0.0118 1
Schistosoma mansoni hypothetical protein 0.0205 0.0328 0.0316
Brugia malayi hypothetical protein 0.0833 0.156 0.1555
Onchocerca volvulus 0.0919 0.1728 1
Entamoeba histolytica PH domain containing protein 0.0076 0.0076 0.0403
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.039 0.0691 0.0686
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Schistosoma mansoni serine/threonine-protein kinase 0.0098 0.0118 0.0105
Onchocerca volvulus outspread protein homolog 0.0076 0.0076 0.0188
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Brugia malayi Fibronectin type III domain containing protein 0.0138 0.0197 0.0192
Brugia malayi Variant SH3 domain containing protein 0.0076 0.0076 0.0071
Echinococcus multilocularis rac serine:threonine kinase 0.0098 0.0118 0.0134
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Schistosoma mansoni protein kinase 0.0081 0.0086 0.0074
Echinococcus multilocularis geminin 0.0205 0.0328 0.0386
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis insulin receptor 0.006 0.0045 0.0047
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0083 0.009 0.0101
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0076 0.0076 0.4332
Schistosoma mansoni src-type protein tyrosine kinase-related 0.006 0.0045 0.0032
Echinococcus multilocularis exocyst complex component 2 0.0171 0.0261 0.0306
Brugia malayi Variant SH3 domain containing protein 0.0076 0.0076 0.0071
Brugia malayi SRC-1 0.006 0.0045 0.0039
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0076 0.0076 0.6008
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0833 0.156 0.1549
Loa Loa (eye worm) hypothetical protein 0.0833 0.156 0.1555
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0014 0.0011
Echinococcus granulosus activin receptor type 0.0081 0.0086 0.0097
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.006 0.0045 0.0039
Echinococcus granulosus semaphorin 1A 0.039 0.0691 0.082
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Echinococcus multilocularis tyrosine kinase 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis activated cdc42 kinase 1 0.006 0.0045 0.0047
Leishmania major folate/biopterin transporter, putative 0.0098 0.0118 1
Brugia malayi hypothetical protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0138 0.0197 0.0192
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.006 0.0045 0.0047
Onchocerca volvulus 0.0076 0.0076 0.0188
Schistosoma mansoni zinc finger protein 0.0076 0.0076 0.0064
Echinococcus multilocularis Pleckstrin y 0.0076 0.0076 0.0085
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3938 0.7648 0.7647
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0081 0.0086 0.5668
Echinococcus granulosus oxysterol binding protein 1 0.0076 0.0076 0.0085
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0087 0.056
Loa Loa (eye worm) sema domain-containing protein 0.039 0.0691 0.0686
Echinococcus multilocularis Regulator of G protein signaling 20 0.0833 0.156 0.1859
Schistosoma mansoni oxysterol-binding protein 1 0.0076 0.0076 0.0064
Toxoplasma gondii phosphatidylinositol transfer protein 0.0076 0.0076 0.4332
Echinococcus granulosus epidermal growth factor receptor 0.006 0.0045 0.0047
Echinococcus multilocularis activin receptor type 0.0081 0.0086 0.0097
Echinococcus multilocularis natriuretic peptide receptor 1 0.006 0.0045 0.0047
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Toxoplasma gondii Oxysterol-binding protein 0.0076 0.0076 0.4332
Echinococcus multilocularis regulator of G protein signaling 0.0833 0.156 0.1859
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0076 0.0076 0.0085
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.006 0.0045 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.0086 0.6949
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4304 0.8367 0.8366
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Echinococcus multilocularis heat shock protein 70 0.006 0.0045 0.0047
Loa Loa (eye worm) sema domain-containing protein 0.039 0.0691 0.0686
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TK/DDR protein kinase 0.006 0.0045 0.0039
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0014 0.0011
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.006 0.0045 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.3938 0.7648 0.7645
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0076 0.0076 0.0188
Loa Loa (eye worm) hypothetical protein 0.0171 0.0261 0.0256
Trichomonas vaginalis centaurin alpha, putative 0.0076 0.0076 0.0489
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus multilocularis epidermal growth factor receptor 0.006 0.0045 0.0047
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus granulosus Pleckstrin y 0.0076 0.0076 0.0085
Echinococcus granulosus transcription factor collier 0.0171 0.0261 0.0306
Entamoeba histolytica hypothetical protein 0.0171 0.0261 0.16
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0833 0.156 0.1549
Schistosoma mansoni centaurin alpha 0.0076 0.0076 0.0064
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0076 0.0076 0.0403
Echinococcus granulosus tyrosine protein kinase Srms 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Giardia lamblia Protein 21.1 0.006 0.0045 0.4029
Loa Loa (eye worm) hypothetical protein 0.039 0.0691 0.0686
Giardia lamblia Kinase 0.006 0.0045 0.4029
Loa Loa (eye worm) PXA domain-containing protein 0.0833 0.156 0.1555
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) hypothetical protein 0.0133 0.0187 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Leishmania major protein kinase, putative 0.0083 0.009 0.7339
Brugia malayi ephrin receptor 1 precursor 0.006 0.0045 0.0039
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0076 0.0076 0.4332
Echinococcus multilocularis calcium dependent secretion activator 1 0.0076 0.0076 0.0085
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.0086 0.6949
Echinococcus granulosus beta 1 syntrophin 0.0076 0.0076 0.0085
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0076 0.6008
Echinococcus granulosus expressed protein 0.0833 0.156 0.1859
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni hypothetical protein 0.0076 0.0076 0.0064
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0118 0.0671
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Toxoplasma gondii aurora kinase 0.0083 0.009 0.6222
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0098 0.0118 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.006 0.0045 0.0032
Entamoeba histolytica tyrosin kinase, putative 0.006 0.0045 0.0198
Trypanosoma brucei protein kinase, putative 0.0098 0.0118 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Echinococcus granulosus retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni tyrosine-protein kinase fps85d 0.006 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TK/ROR protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis hypothetical protein 0.0076 0.0076 0.0489
Echinococcus multilocularis epidermal growth factor receptor 0.006 0.0045 0.0047
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0076 0.0076 0.0085
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Onchocerca volvulus Protein melted homolog 0.0076 0.0076 0.0188
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis oxysterol binding protein 9 0.0076 0.0076 0.0085
Brugia malayi hypothetical protein 0.0138 0.0197 0.0192
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Loa Loa (eye worm) hypothetical protein 0.0171 0.0261 0.0256
Echinococcus multilocularis DCC interacting protein 13 beta 0.0076 0.0076 0.0085
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Echinococcus multilocularis oxysterol binding protein 3 0.0076 0.0076 0.0085
Brugia malayi Dynamin 0.0076 0.0076 0.0071
Schistosoma mansoni hypothetical protein 0.0076 0.0076 0.0064
Loa Loa (eye worm) TK/INSR protein kinase 0.006 0.0045 0.0039
Echinococcus multilocularis oxysterol binding protein 1 0.0076 0.0076 0.0085
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus multilocularis tyrosine protein kinase csk 0.006 0.0045 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0014 0.0009
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0076 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0045 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Brugia malayi Tyrosine-protein kinase PR2 0.006 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.006 0.0045 0.0047
Entamoeba histolytica protein kinase, putative 0.0083 0.009 0.0492
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Brugia malayi Pleckstrin Homology Domain 0.0076 0.0076 0.0071
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0076 0.0076 0.0489
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0133 0.0187 0.0218
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis tyrosine protein kinase csk 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0138 0.0197 0.0192
Echinococcus granulosus neuroglian 0.0133 0.0187 0.0218
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0833 0.156 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Onchocerca volvulus 0.0076 0.0076 0.0188
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0014 0.009
Onchocerca volvulus Huntingtin homolog 0.0148 0.0217 0.1021
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.006 0.0045 0.0047
Schistosoma mansoni zinc finger protein 0.0076 0.0076 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica tyrosin kinase, putative 0.0231 0.0379 0.2365
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.006 0.0045 0.0047
Trypanosoma brucei rac serine-threonine kinase, putative 0.0098 0.0118 1
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni protein kinase 0.0083 0.009 0.0078
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.009 0.0078
Brugia malayi Oxysterol-binding protein 0.0076 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0171 0.0261 0.0256
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Loa Loa (eye worm) RGC/RGC protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica SH2-protein kinase domain containing protein 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Echinococcus multilocularis myotubularin protein 13 0.0076 0.0076 0.0085
Schistosoma mansoni rho gtpase activating protein 0.0076 0.0076 0.0064
Brugia malayi MAP kinase sur-1 0.0082 0.0087 0.0082
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0118 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0045 0.0286
Schistosoma mansoni regulator of G protein signaling 0.0833 0.156 0.1549
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0098 0.0118 0.0754
Giardia lamblia Aurora kinase 0.0083 0.009 1
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Echinococcus granulosus integrin linked protein kinase 0.006 0.0045 0.0047
Echinococcus multilocularis fibroblast growth factor receptor 4 0.006 0.0045 0.0047
Plasmodium falciparum serine/threonine protein kinase, putative 0.0083 0.009 0.6222
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.006 0.0045 0.0047
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.006 0.0045 0.0047
Loa Loa (eye worm) syntrophin-1 0.0076 0.0076 0.0071
Brugia malayi SH2 domain containing protein 0.006 0.0045 0.0039
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.006 0.0045 0.0286
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus granulosus exocyst complex component 2 0.0171 0.0261 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0045 0.0032
Echinococcus granulosus GRB2 associated binding protein 3 0.0076 0.0076 0.0085
Loa Loa (eye worm) hypothetical protein 0.0213 0.0344 0.0339
Onchocerca volvulus Putative zinc finger protein 0.0076 0.0076 0.0188
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus granulosus DCC interacting protein 13 beta 0.0076 0.0076 0.0085
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0083 0.009 0.0492
Echinococcus multilocularis G protein coupled receptor kinase 6 0.4304 0.8367 1
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Leishmania major hypothetical protein, conserved 0.0076 0.0076 0.6008
Echinococcus multilocularis transcription factor collier 0.0171 0.0261 0.0306
Entamoeba histolytica receptor protein kinase, putative 0.006 0.0045 0.0198
Echinococcus granulosus plexin a4 0.109 0.2063 0.2461
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0148 0.0217 0.0211
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica cysteine surface protein, putative 0.006 0.0045 0.0198
Trichomonas vaginalis TK family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0076 0.0076 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0045 0.0032
Brugia malayi Regulator of G protein signaling domain containing protein 0.0833 0.156 0.1555
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0076 0.0076 0.0489
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Entamoeba histolytica serine/threonine kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus granulosus natriuretic peptide receptor 1 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Brugia malayi Uncoordinated protein 104 0.0076 0.0076 0.0071
Entamoeba histolytica receptor protein kinase, putative 0.006 0.0045 0.0198
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.006 0.0045 0.2957
Trypanosoma cruzi protein kinase, putative 0.006 0.0045 0.2957
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.006 0.0045 0.0047
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0014 0.0011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Schistosoma mansoni z-protein (S1r protein) 0.0833 0.156 0.1549
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.006 0.0045 0.0047
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0076 0.0076 0.0085
Echinococcus multilocularis protein KINase family member (kin 25) 0.006 0.0045 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Leishmania major protein kinase, putative 0.0081 0.0086 0.6949
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0133 0.0187 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.009 0.0492
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.006 0.0045 0.0198
Brugia malayi Cytohesin 3 0.0076 0.0076 0.0071
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0076 0.0076 0.0064
Brugia malayi regulator of G-protein signaling egl-10 0.0833 0.156 0.1555
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0133 0.0187 0.0182
Echinococcus multilocularis axis inhibition protein axin 0.0833 0.156 0.1859
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Echinococcus granulosus tyrosine protein kinase Src42A 0.006 0.0045 0.0047
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.006 0.0045 0.0039
Echinococcus multilocularis c src tyrosine kinase 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Schistosoma mansoni dynamin 0.0076 0.0076 0.0064
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0076 0.0076 0.0064
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus granulosus tyrosine protein kinase Src64B 0.006 0.0045 0.0047
Loa Loa (eye worm) TK/RYK protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase , putative 0.0083 0.009 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0076 0.0076 0.0085
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.156 0.186
Trypanosoma cruzi PH domain containing protein, putative 0.0076 0.0076 0.6008
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Echinococcus granulosus oxysterol binding protein 9 0.0076 0.0076 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0833 0.156 1
Echinococcus multilocularis mitogen activated protein kinase 0.0082 0.0087 0.0098
Echinococcus granulosus geminin 0.0205 0.0328 0.0386
Echinococcus granulosus mitogen activated protein kinase 3 0.0082 0.0087 0.0098
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0076 0.0076 0.0064
Trichomonas vaginalis centaurin/arf, putative 0.0076 0.0076 0.0489
Echinococcus multilocularis regulator of G protein signaling 7 0.0833 0.156 0.1859
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0081 0.0086 0.0097
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Loa Loa (eye worm) PH domain-containing protein 0.0076 0.0076 0.0071
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0076 0.0076 0.4332
Leishmania major protein kinase, putative 0.0098 0.0118 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0065 0.0054 0.0059
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0045 0.0047
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0083 0.009 0.0492
Loa Loa (eye worm) hypothetical protein 0.039 0.0691 0.0686
Loa Loa (eye worm) AUR protein kinase 0.0083 0.009 0.0085
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0118 0.0671
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0076 0.0076 0.6008
Entamoeba histolytica hypothetical protein 0.0833 0.156 1
Loa Loa (eye worm) hypothetical protein 0.039 0.0691 0.0686
Schistosoma mansoni nephrin 0.0138 0.0197 0.0185
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Brugia malayi PXA domain containing protein 0.0833 0.156 0.1555
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Echinococcus multilocularis tyrosine protein kinase Src64B 0.006 0.0045 0.0047
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0082 0.0087 0.708
Loa Loa (eye worm) hypothetical protein 0.0138 0.0197 0.0192
Echinococcus granulosus insulin receptor 0.006 0.0045 0.0047
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0098 0.0118 1
Echinococcus multilocularis Pleckstrin y 0.0076 0.0076 0.0085
Brugia malayi C-terminal src kinase protein 1 0.006 0.0045 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0014 0.009
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Echinococcus multilocularis tyrosine protein kinase ABL1 0.006 0.0045 0.0047
Entamoeba histolytica hypothetical protein 0.0833 0.156 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0118 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0133 0.0187 0.0175
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0076 0.0076 0.0071
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0076 0.0403
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0076 0.0403
Entamoeba histolytica p21-activated kinase 0.0098 0.0118 0.0671
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0171 0.0261 0.1675
Loa Loa (eye worm) TK/EPH protein kinase 0.006 0.0045 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.156 0.155
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0833 0.156 0.1549
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus granulosus tyrosine protein kinase Btk29A 0.006 0.0045 0.0047
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus multilocularis beta 1 syntrophin 0.0076 0.0076 0.0085
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Brugia malayi probable spectrin beta chain 0.0076 0.0076 0.0071
Loa Loa (eye worm) uncoordinated protein 104 0.0076 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0171 0.0261 0.0256
Echinococcus multilocularis actin binding protein anillin 0.0076 0.0076 0.0085
Loa Loa (eye worm) hypothetical protein 0.0833 0.156 0.1555
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Echinococcus multilocularis Pleckstrin y 0.0076 0.0076 0.0085
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0133 0.0187 0.0182
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0076 0.0403
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0919 0.1728 0.1724
Brugia malayi bone morphogenetic protein type 1 receptor 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni regulator of G protein signaling 0.0833 0.156 0.1549
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni tyrosine-protein kinase fps85d 0.006 0.0045 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0083 0.009 0.0577
Loa Loa (eye worm) RGC/RGC protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica hypothetical protein 0.0076 0.0076 0.0403
Loa Loa (eye worm) hypothetical protein 0.0833 0.156 0.1555
Echinococcus multilocularis regulator of G protein signaling 3 0.0833 0.156 0.1859
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.0305 0.03
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0076 0.0076 0.0403
Brugia malayi Probable tyrosine-protein kinase kin-31 0.006 0.0045 0.0039
Entamoeba histolytica serine/threonine kinase, putative 0.006 0.0045 0.0198
Giardia lamblia Kinase, NEK 0.006 0.0045 0.4029
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0076 0.0076 0.0085
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Loa Loa (eye worm) TK protein kinase 0.006 0.0045 0.0039
Schistosoma mansoni growth factor receptor-bound protein 0.0076 0.0076 0.0064
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0076 0.4332
Echinococcus granulosus axis inhibition protein axin 0.0833 0.156 0.1859
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0076 0.0076 0.0403
Trypanosoma brucei protein kinase, putative 0.0082 0.0087 0.708
Loa Loa (eye worm) hypothetical protein 0.0133 0.0187 0.0182
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0082 0.0087 0.708
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0014 0.009
Entamoeba histolytica cell surface protease gp63, putative 0.0171 0.0261 0.16
Brugia malayi integrin-linked kinase 0.006 0.0045 0.0039
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0082 0.0087 0.708
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Entamoeba histolytica hypothetical protein 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0098 0.0118 1
Brugia malayi serine/threonine kinase 12 0.0083 0.009 0.0085
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Trichomonas vaginalis alpha chimerin, putative 0.0076 0.0076 0.0489
Trypanosoma cruzi NIMA-related kinase, putative 0.0098 0.0118 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0045 0.0014 0.0009
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Trichomonas vaginalis conserved hypothetical protein 0.0833 0.156 1
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Entamoeba histolytica PH domain containing protein 0.0076 0.0076 0.0403
Plasmodium vivax PH domain containing protein 0.0076 0.0076 0.4332
Entamoeba histolytica hypothetical protein 0.0076 0.0076 0.0403
Echinococcus granulosus twitchin 0.0154 0.0228 0.0267
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Brugia malayi Raf kinase 0.006 0.0045 0.0039
Echinococcus multilocularis pleckstrin y domain containing family A 0.0076 0.0076 0.0085
Entamoeba histolytica hypothetical protein 0.0833 0.156 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0082 0.0087 0.708
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0045 0.0039
Schistosoma mansoni goodpasture antigen-binding protein 0.0076 0.0076 0.0064
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0098 0.0118 1
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus granulosus tyrosine kinase 0.006 0.0045 0.0047
Toxoplasma gondii hypothetical protein 0.0076 0.0076 0.4332
Brugia malayi IPT/TIG domain containing protein 0.0171 0.0261 0.0256
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0082 0.0087 0.708
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Brugia malayi serine/threonine protein kinase 6 0.0083 0.009 0.0085
Brugia malayi regulator of G-protein signaling rgs-7 0.0833 0.156 0.1555
Echinococcus multilocularis beta adrenergic receptor kinase 0.3938 0.7648 0.9141
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Onchocerca volvulus 0.0076 0.0076 0.0188
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0076 0.0076 0.0489
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis tyrosine protein kinase Abl 0.006 0.0045 0.0047
Loa Loa (eye worm) Plekhf2 protein 0.0076 0.0076 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica protein kinase domain containing protein 0.0231 0.0379 0.2365
Loa Loa (eye worm) protein kinase domain-containing protein 0.006 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0833 0.156 0.1555
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0076 0.0076 0.0085
Leishmania major hypothetical protein, conserved 0.0076 0.0076 0.6008
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus granulosus tyrosine kinase 0.006 0.0045 0.0047
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.006 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0148 0.0217 0.0211
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.006 0.0045 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Echinococcus multilocularis tyrosine protein kinase Fgr 0.006 0.0045 0.0047
Brugia malayi Tyrosine-protein kinase abl-1 0.006 0.0045 0.0039
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis regulator of G protein signaling 7 0.0833 0.156 0.1859
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Echinococcus granulosus regulator of G protein signaling 3 0.0833 0.156 0.1859
Loa Loa (eye worm) hypothetical protein 0.0833 0.156 0.1555
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0081 0.0086 0.0097
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0076 0.0076 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis cytohesin 1 0.0076 0.0076 0.0085
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0076 0.0076 0.0085
Onchocerca volvulus 0.039 0.0691 0.3838
Loa Loa (eye worm) hypothetical protein 0.0529 0.0964 0.0959
Echinococcus multilocularis kinase suppressor of Ras 1 0.006 0.0045 0.0047
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0833 0.156 0.1859
Loa Loa (eye worm) AUR protein kinase 0.0083 0.009 0.0085
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0014 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0833 0.156 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Loa Loa (eye worm) hypothetical protein 0.039 0.0691 0.0686
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.006 0.0045 0.0047
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Entamoeba histolytica tyrosine kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Trypanosoma brucei PH domain containing protein, putative 0.0076 0.0076 0.6008
Schistosoma mansoni serine/threonine-protein kinase 0.0098 0.0118 0.0105
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Brugia malayi Furin-like cysteine rich region family protein 0.006 0.0045 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0087 0.056
Echinococcus granulosus regulator of G protein signaling 3 0.0833 0.156 0.1859
Brugia malayi Probable exocyst complex component Sec5 0.0171 0.0261 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0045 0.0032
Schistosoma mansoni hypothetical protein 0.0171 0.0261 0.0249
Brugia malayi hypothetical protein 0.0076 0.0076 0.0071
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0076 0.0076 0.0085
Trypanosoma brucei Pseudokinase, putative 0.006 0.0045 0.2957
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis roundabout 2 0.0138 0.0197 0.0229
Echinococcus multilocularis tyrosine protein kinase 0.006 0.0045 0.0047
Brugia malayi A-kinase anchor protein 10, precursor 0.0833 0.156 0.1555
Loa Loa (eye worm) TK/ALK protein kinase 0.0302 0.0519 0.0515
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0098 0.0118 1
Echinococcus granulosus activated cdc42 kinase 1 0.006 0.0045 0.0047
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0045 0.0198
Loa Loa (eye worm) hypothetical protein 0.0133 0.0187 0.0182
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0076 0.0076 0.0085
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0082 0.0087 0.5854
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0098 0.0118 1
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus multilocularis hypothetical protein 0.039 0.0691 0.082
Echinococcus granulosus regulator of G protein signaling 7 0.0833 0.156 0.1859
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni protein kinase 0.006 0.0045 0.0032
Echinococcus granulosus tyrosine protein kinase 0.006 0.0045 0.0047
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0045 0.0198
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0098 0.0118 1
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0076 0.0076 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.3938 0.7648 0.7645
Echinococcus granulosus tyrosine kinase 0.006 0.0045 0.0047
Entamoeba histolytica ARF GTPase activating protein, putative 0.0076 0.0076 0.0403
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0076 0.0076 0.0085
Echinococcus multilocularis tyrosine protein kinase HCK 0.006 0.0045 0.0047
Echinococcus granulosus pleckstrin y domain containing family A 0.0076 0.0076 0.0085
Echinococcus granulosus Immunoglobulin 0.0133 0.0187 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Trichomonas vaginalis centaurin gamma, putative 0.0076 0.0076 0.0489
Loa Loa (eye worm) hypothetical protein 0.0833 0.156 0.1555
Trichomonas vaginalis AGC family protein kinase 0.0083 0.009 0.0577
Trichomonas vaginalis AGC family protein kinase 0.006 0.0045 0.0286
Schistosoma mansoni hypothetical protein 0.0205 0.0328 0.0316
Echinococcus multilocularis tyrosine protein kinase csk 0.006 0.0045 0.0047
Brugia malayi Protein kinase domain containing protein 0.0303 0.052 0.0515
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Echinococcus granulosus protein tyrosine kinase 0.006 0.0045 0.0047
Echinococcus multilocularis regulator of G protein signaling 3 0.0833 0.156 0.1859
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0045 0.0039
Brugia malayi TBC domain containing protein 0.0076 0.0076 0.0071
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0076 0.0076 0.4332
Schistosoma mansoni oxysterol-binding protein 1 0.0076 0.0076 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Entamoeba histolytica hypothetical protein 0.0171 0.0261 0.16
Loa Loa (eye worm) hypothetical protein 0.0076 0.0076 0.0071
Entamoeba histolytica serine/threonine kinase, putative 0.006 0.0045 0.0198
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Entamoeba histolytica ankyrin repeat protein 0.006 0.0045 0.0198
Schistosoma mansoni fibrocystin l 0.0171 0.0261 0.0249
Echinococcus multilocularis retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Echinococcus granulosus tyrosine protein kinase csk 0.006 0.0045 0.0047
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0076 0.0076 0.0085
Entamoeba histolytica protein kinase, putative 0.0098 0.0118 0.0671
Schistosoma mansoni vav2 0.0076 0.0076 0.0064
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.006 0.0045 0.0286
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.006 0.0045 0.0039
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Entamoeba histolytica protein kinase, putative 0.0083 0.009 0.0492
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0065 0.0054 0.0059
Entamoeba histolytica protein kinase, putative 0.006 0.0045 0.0198
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Trichomonas vaginalis centaurin beta, putative 0.0076 0.0076 0.0489
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.006 0.0045 0.0047
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Entamoeba histolytica hypothetical protein, conserved 0.0076 0.0076 0.0403
Schistosoma mansoni vesicular amine transporter 0.0136 0.0192 0.018
Schistosoma mansoni serine/threonine RGC 0.006 0.0045 0.0032
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.006 0.0045 0.0047
Brugia malayi hypothetical protein 0.039 0.0691 0.0686
Echinococcus multilocularis Rho GTPase activating protein 24 0.0076 0.0076 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0261 0.1675
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Brugia malayi hypothetical protein 0.039 0.0691 0.0686
Loa Loa (eye worm) AGC/AKT protein kinase 0.0098 0.0118 0.0112
Echinococcus multilocularis Immunoglobulin 0.0133 0.0187 0.0218
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3105 0.6015 0.7187
Echinococcus multilocularis tyrosine protein kinase Blk 0.006 0.0045 0.0047
Trypanosoma cruzi hypothetical protein 0.0076 0.0076 0.6008
Toxoplasma gondii protein kinase domain-containing protein 0.0098 0.0118 1
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0087 0.056
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0039
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0076 0.0076 0.0188
Schistosoma mansoni protein tyrosine kinase 0.006 0.0045 0.0032
Echinococcus multilocularis raf serine:threonine protein kinase 0.006 0.0045 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0076 0.0489
Echinococcus granulosus aurora kinase A 0.0083 0.009 0.0101
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0083 0.009 0.0101
Echinococcus multilocularis aurora kinase A 0.0083 0.009 0.0101
Echinococcus granulosus receptor type guanylyl cyclase 0.006 0.0045 0.0047
Echinococcus granulosus tyrosine protein kinase Lyn 0.0081 0.0086 0.0097
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0098 0.0118 1
Echinococcus granulosus myotubularin protein 13 0.0076 0.0076 0.0085
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.006 0.0045 0.0039
Echinococcus granulosus fibroblast growth factor receptor 4 0.006 0.0045 0.0047
Trichomonas vaginalis TKL family protein kinase 0.006 0.0045 0.0286
Toxoplasma gondii AtPH1 family protein 0.0076 0.0076 0.4332
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Schistosoma mansoni goodpasture antigen-binding protein 0.0076 0.0076 0.0064
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.006 0.0045 0.0198
Echinococcus multilocularis tyrosine protein kinase Src42A 0.006 0.0045 0.0047
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.006 0.0045 0.0047
Echinococcus granulosus tyrosine protein kinase Btk29A 0.006 0.0045 0.0047
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0083 0.009 0.0492
Echinococcus multilocularis retinal guanylyl cyclase 2 0.006 0.0045 0.0047
Brugia malayi PH domain containing protein 0.0076 0.0076 0.0071
Echinococcus granulosus microtubule associated protein 2 0.0833 0.156 0.186
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0193 0.0305 0.03
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Brugia malayi Protein kinase domain containing protein 0.006 0.0045 0.0039
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0081 0.0086 0.6949
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0082 0.0087 0.708
Brugia malayi hypothetical protein 0.006 0.0045 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0118 0.0754
Schistosoma mansoni tyrosine kinase 0.006 0.0045 0.0032
Echinococcus granulosus activated cdc42 kinase 1 0.006 0.0045 0.0047

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 40.152 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.