Detailed information for compound 1398371

Basic information

Technical information
  • TDR Targets ID: 1398371
  • Name: 6-ethyl-3-pentylthieno[3,2-e]pyrimidin-4-one
  • MW: 250.36 | Formula: C13H18N2OS
  • H donors: 0 H acceptors: 1 LogP: 3.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCn1cnc2c(c1=O)cc(s2)CC
  • InChi: 1S/C13H18N2OS/c1-3-5-6-7-15-9-14-12-11(13(15)16)8-10(4-2)17-12/h8-9H,3-7H2,1-2H3
  • InChiKey: LRBFOASROKHCQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-ethyl-3-pentyl-thieno[3,2-e]pyrimidin-4-one
  • 6-ethyl-3-pentyl-4-thieno[3,2-e]pyrimidinone
  • 3-amyl-6-ethyl-thieno[3,2-e]pyrimidin-4-one
  • ZINC01892808
  • 6-ethyl-3-pentylthieno[2,3-d]pyrimidin-4(3H)-one
  • MLS000706593
  • SMR000230037
  • AP-906/42086842
  • ST5200972

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0049 0.0188 0.0681
Schistosoma mansoni patched 1 0.0051 0.0203 0.0734
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2079 0.2726
Echinococcus multilocularis tumor protein p63 0.0408 0.3059 0.401
Loa Loa (eye worm) hypothetical protein 0.006 0.0273 0.0985
Entamoeba histolytica hypothetical protein 0.0043 0.0143 0.1911
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0203 0.0734
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0074 0.0074
Brugia malayi Importin beta-1 subunit 0.0035 0.0074 0.0354
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1154 0.1513
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0203 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0261 0.0342
Echinococcus granulosus snurportin 1 0.0372 0.2768 0.905
Loa Loa (eye worm) hypothetical protein 0.0119 0.0746 0.2695
Entamoeba histolytica hypothetical protein 0.0043 0.0143 0.1911
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0407 0.0533
Trypanosoma cruzi Peptide deformylase 2, putative 0.0487 0.3689 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7628 1
Brugia malayi hypothetical protein 0.0286 0.2079 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0746 0.0978
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2079 0.6797
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0124 0.0597
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0143 0.0187
Entamoeba histolytica hypothetical protein 0.0043 0.0143 0.1911
Loa Loa (eye worm) hypothetical protein 0.0062 0.0295 0.1065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2768 1
Brugia malayi TAR-binding protein 0.0076 0.0407 0.1957
Echinococcus granulosus tar DNA binding protein 0.0076 0.0407 0.133
Brugia malayi hypothetical protein 0.0043 0.0143 0.0686
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0143 0.0466
Echinococcus granulosus tumor protein p63 0.0408 0.3059 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0487 0.3689 1
Brugia malayi RNA, U transporter 1 0.0099 0.0587 0.2823
Schistosoma mansoni hypothetical protein 0.0041 0.0124 0.0449
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0203 0.0664
Echinococcus multilocularis expressed conserved protein 0.0112 0.0688 0.0902
Entamoeba histolytica hypothetical protein 0.0028 0.0021 0.028
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0203 0.0266
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0746 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0407 0.1957
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1154 0.3773
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0487 0.3689 1
Onchocerca volvulus 0.006 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.2079 0.751
Loa Loa (eye worm) RNA binding protein 0.0076 0.0407 0.147
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0074 0.0096
Schistosoma mansoni importin beta-1 0.0035 0.0074 0.0266
Echinococcus granulosus importin subunit beta 1 0.0035 0.0074 0.024
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0021 0.1027
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0407 0.147
Schistosoma mansoni hypothetical protein 0.0058 0.0261 0.0942
Schistosoma mansoni hypothetical protein 0.0049 0.0188 0.0681
Loa Loa (eye worm) hypothetical protein 0.006 0.0277 0.0999
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0277 0.133
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0261 0.1255
Schistosoma mansoni hypothetical protein 0.0372 0.2768 1
Trypanosoma brucei Peptide deformylase 2 0.0487 0.3689 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0074 0.0074
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0761 0.2748
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0273 0.0985
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0074 0.0199
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0746 0.3588
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0021 0.1027
Echinococcus granulosus expressed conserved protein 0.0112 0.0688 0.225
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0203 0.0664
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0407 0.147
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0746 0.2439
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0143 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0407 0.147
Schistosoma mansoni hypothetical protein 0.0049 0.0188 0.0681
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0407 0.147
Plasmodium falciparum importin beta, putative 0.0035 0.0074 0.0074
Schistosoma mansoni survival motor neuron protein 0.0058 0.0261 0.0942
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0277 0.133
Loa Loa (eye worm) hypothetical protein 0.0041 0.0124 0.0449
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0074 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0277 0.0999
Schistosoma mansoni hypothetical protein 0.0043 0.0143 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0407 0.147
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0021 0.0057
Brugia malayi RNA binding protein 0.0076 0.0407 0.1957
Echinococcus multilocularis snurportin 1 0.0372 0.2768 0.3629
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0407 0.147
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0487 0.3689 1
Schistosoma mansoni hypothetical protein 0.0049 0.0188 0.0681
Leishmania major polypeptide deformylase-like protein, putative 0.0487 0.3689 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0266
Trypanosoma brucei Polypeptide deformylase 1 0.0487 0.3689 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0407 0.147
Loa Loa (eye worm) hypothetical protein 0.0051 0.0203 0.0734
Echinococcus multilocularis protein patched 0.0051 0.0203 0.0266
Brugia malayi CHE-14 protein 0.0051 0.0203 0.0977
Entamoeba histolytica hypothetical protein 0.0043 0.0143 0.1911
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0021 0.1027
Leishmania major importin beta-1 subunit, putative 0.0028 0.0021 0.0057

Activities

Activity type Activity value Assay description Source Reference
GI50 (ADMET) > 100 ug ml-1 Cytotoxicity against human A549 cells incubated for 1 to 11 days by MTT assay ChEMBL. No reference
MIC90 (functional) = 43.76 ug ml-1 Antitubercular activity against dormant stage of Mycobacterium tuberculosis H37Ra assessed as cell viability after 12 days by XTT reduction menadione assay ChEMBL. No reference
MIC90 (functional) = 44.13 ug ml-1 Antitubercular activity against active stage of Mycobacterium tuberculosis H37Ra assessed as cell viability after 8 days by XTT reduction menadione assay ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8356 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) 100 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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