Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0671 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0671 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.148 | 0.0649 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.148 | 0.0649 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3537 | 0.2413 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2214 | 0.3985 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2523 | 0.2523 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2523 | 0.1985 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3537 | 0.3071 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3537 | 0.3071 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3537 | 0.3537 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0671 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3537 | 0.3071 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2214 | 0.0861 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0671 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0671 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3537 | 0.3537 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2214 | 0.0861 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.148 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.148 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3537 | 0.2413 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1338 | 0.0714 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2214 | 0.2214 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0671 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0671 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2214 | 0.3985 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0671 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0671 | 0.0671 |
Brugia malayi | hypothetical protein | 0.0043 | 0.148 | 0.148 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2523 | 0.1985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2523 | 0.2523 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2214 | 0.3985 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.148 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2214 | 0.1654 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2214 | 0.0861 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2214 | 0.0861 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1338 | 0.1338 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.6834 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6626 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.