Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | heat shock protein, putative | 0.0048 | 0.1707 | 0.119 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1911 | 0.1866 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0056 | 0.0362 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.6388 | 0.6367 |
Brugia malayi | Hsp90 protein | 0.0032 | 0.081 | 0.0425 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0032 | 0.081 | 0.0425 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0045 | 0.1543 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.5926 | 0.5903 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0048 | 0.1707 | 0.0977 |
Echinococcus granulosus | heat shock protein 90 | 0.0048 | 0.1707 | 0.0977 |
Plasmodium vivax | heat shock protein 86, putative | 0.0048 | 0.1707 | 0.1812 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0402 | 0.2327 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.1543 | 0.1015 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0402 | 0.2327 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0402 | 0.0348 |
Trichomonas vaginalis | endoplasmin, putative | 0.0035 | 0.0974 | 0.041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.6388 | 0.6069 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0402 | 0.0348 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.5926 | 0.5903 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0048 | 0.1707 | 0.1579 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Echinococcus granulosus | heat shock protein 90 | 0.0041 | 0.1321 | 0.0556 |
Echinococcus granulosus | heat shock protein | 0.0048 | 0.1707 | 0.0977 |
Trichomonas vaginalis | heat shock protein, putative | 0.0041 | 0.1321 | 0.0779 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.111 | 0.0738 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0048 | 0.1707 | 0.1074 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0028 | 0.0588 | 0.0583 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.111 | 0.0327 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0048 | 0.1707 | 0.136 |
Plasmodium vivax | heat shock protein, putative | 0.0183 | 0.9168 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.1543 | 0.1015 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0041 | 0.1321 | 0.1186 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0045 | 0.1543 | 0.1189 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.111 | 0.0327 |
Giardia lamblia | Grp94/Hsp90 | 0.0045 | 0.1543 | 0.0256 |
Echinococcus multilocularis | endoplasmin | 0.0045 | 0.1543 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1001 | 0.095 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0041 | 0.1321 | 0.0556 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0041 | 0.1321 | 0.1186 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.6388 | 0.6236 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.6388 | 0.6069 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0402 | 0.2327 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0183 | 0.9168 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0402 | 0.2605 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0048 | 0.1707 | 0.1074 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0045 | 0.1543 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0402 | 0.2327 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.111 | 0.0738 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1911 | 0.1573 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.111 | 0.0327 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0402 | 0.2327 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0056 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Echinococcus granulosus | endoplasmin | 0.0045 | 0.1543 | 0.0798 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0048 | 0.1707 | 0.1579 |
Schistosoma mansoni | heat shock protein | 0.0048 | 0.1707 | 0.0977 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0048 | 0.1707 | 0.0445 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1001 | 0.0208 |
Brugia malayi | hypothetical protein | 0.0159 | 0.7852 | 0.7762 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0402 | 0.2327 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.6388 | 0.6069 |
Treponema pallidum | heat shock protein 90 | 0.0045 | 0.1543 | 0.5 |
Schistosoma mansoni | endoplasmin | 0.0048 | 0.1707 | 0.0977 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0402 | 0.2605 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Plasmodium falciparum | heat shock protein 90 | 0.0048 | 0.1707 | 0.1812 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1001 | 0.0624 |
Echinococcus multilocularis | heat shock protein | 0.0048 | 0.1707 | 0.0977 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0048 | 0.1707 | 0.1579 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.6388 | 0.6367 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.4462 | 0.4116 |
Echinococcus multilocularis | heat shock protein 90 | 0.0048 | 0.1707 | 0.0977 |
Schistosoma mansoni | kinase | 0.0101 | 0.4607 | 0.4132 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Plasmodium falciparum | endoplasmin, putative | 0.0035 | 0.0974 | 0.1007 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0032 | 0.081 | 0.0758 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.6388 | 0.6069 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.6388 | 0.6069 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.6388 | 0.6236 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Leishmania major | heat shock protein, putative | 0.0032 | 0.081 | 0.0425 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0048 | 0.1707 | 0.1579 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1911 | 0.1573 |
Brugia malayi | heat shock protein 90 | 0.0048 | 0.1707 | 0.136 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.4462 | 0.4116 |
Brugia malayi | Endoplasmin precursor | 0.0048 | 0.1707 | 0.136 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0183 | 0.9168 | 1 |
Onchocerca volvulus | 0.0159 | 0.7852 | 0.7762 | |
Schistosoma mansoni | heat shock protein | 0.0048 | 0.1707 | 0.0977 |
Trypanosoma brucei | heat shock protein, putative | 0.0048 | 0.1707 | 0.0977 |
Trichomonas vaginalis | heat shock protein, putative | 0.0035 | 0.0974 | 0.041 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.8923 | 0.8828 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0048 | 0.1707 | 0.136 |
Schistosoma mansoni | endoplasmin | 0.0048 | 0.1707 | 0.0977 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0048 | 0.1707 | 0.1661 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0402 | 0.2327 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.5926 | 0.5756 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1911 | 0.1866 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Brugia malayi | hypothetical protein | 0.0038 | 0.111 | 0.0738 |
Plasmodium vivax | endoplasmin, putative | 0.0048 | 0.1707 | 0.1812 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.111 | 0.0738 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0048 | 0.1707 | 0.0977 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0402 | 0.2327 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.6388 | 0.6069 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.6388 | 0.6367 |
Plasmodium vivax | heat shock protein 90, putative | 0.0032 | 0.081 | 0.0827 |
Loa Loa (eye worm) | endoplasmin | 0.0048 | 0.1707 | 0.1661 |
Trypanosoma cruzi | heat shock protein, putative | 0.0032 | 0.081 | 0.0667 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0048 | 0.1707 | 0.1579 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0045 | 0.1543 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.6388 | 0.6069 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0048 | 0.1707 | 0.0977 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Echinococcus multilocularis | heat shock protein 90 | 0.0041 | 0.1321 | 0.0556 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.111 | 0.0327 |
Brugia malayi | RNA binding protein | 0.0133 | 0.6388 | 0.6236 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0402 | 0.0348 |
Entamoeba histolytica | 90 kDa heat shock protein, putative | 0.0032 | 0.081 | 0.0425 |
Leishmania major | heat shock protein 83-1 | 0.0048 | 0.1707 | 0.136 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.111 | 0.0738 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0045 | 0.1543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.7852 | 0.784 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.8923 | 0.8828 |
Echinococcus multilocularis | geminin | 0.0179 | 0.8923 | 0.8828 |
Echinococcus granulosus | geminin | 0.0179 | 0.8923 | 0.8828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.