Detailed information for compound 1399074

Basic information

Technical information
  • TDR Targets ID: 1399074
  • Name: [(5S,10S,13S,14S)-3-(5-acetyloxy-3-hydroxy-4- methoxy-6-methyloxan-2-yl)oxy-10-formyl-5,14- dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)- 2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-c yclopenta[a]phenanthren-11-yl] acetate
  • MW: 664.737 | Formula: C34H48O13
  • H donors: 3 H acceptors: 7 LogP: 0.54 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1C(O)C(OC2CC[C@]3([C@](C2)(O)CCC2C3C(OC(=O)C)C[C@@]3([C@]2(O)CCC3C2=CC(=O)OC2)C)C=O)OC(C1OC(=O)C)C
  • InChi: 1S/C34H48O13/c1-17-28(46-19(3)37)29(42-5)27(39)30(44-17)47-21-6-9-32(16-35)26-23(7-10-33(32,40)13-21)34(41)11-8-22(20-12-25(38)43-15-20)31(34,4)14-24(26)45-18(2)36/h12,16-17,21-24,26-30,39-41H,6-11,13-15H2,1-5H3/t17?,21?,22?,23?,24?,26?,27?,28?,29?,30?,31-,32-,33-,34-/m0/s1
  • InChiKey: JJSVXWKQLGHFES-WXDXCBMFSA-N  


Substructure search Similarity search

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Synonyms

  • [(5S,10S,13S,14S)-3-(5-acetoxy-3-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-10-formyl-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl] acetate
  • acetic acid [(5S,10S,13S,14S)-3-[(5-acetoxy-3-hydroxy-4-methoxy-6-methyl-2-tetrahydropyranyl)oxy]-10-formyl-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl] ester
  • acetic acid [(5S,10S,13S,14S)-3-(5-acetoxy-3-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-10-formyl-5,14-dihydroxy-17-(5-keto-2H-furan-3-yl)-13-methyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl] ester
  • [(5S,10S,13S,14S)-3-(5-acetyloxy-3-hydroxy-4-methoxy-6-methyl-oxan-2-yl)oxy-5,14-dihydroxy-10-methanoyl-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl] ethanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0007 0.026 0.026
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.2835 0.2835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.4397 0.5548
Echinococcus multilocularis cathepsin L 0.001 0.0666 0.0666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Loa Loa (eye worm) ctsf protein 0.002 0.1735 0.1735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0352 0.0802
Echinococcus multilocularis cpg binding protein 0.0035 0.3361 0.3361
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.1851 0.4211
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Leishmania major cytochrome p450-like protein 0.0011 0.0712 0.0899
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0666 0.0666
Brugia malayi Cytochrome P450 family protein 0.002 0.1687 0.1687
Onchocerca volvulus Cathepsin L homolog 0.002 0.1735 0.5499
Echinococcus granulosus cathepsin l1 0.002 0.1735 0.1735
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.1687 0.8556
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.4397 0.4397
Entamoeba histolytica cysteine proteinase 2 0.001 0.0666 0.1516
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0666 0.0666
Leishmania major cathepsin L-like protease 0.002 0.1735 0.2189
Loa Loa (eye worm) hypothetical protein 0.0045 0.4397 0.4397
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.1851 1
Brugia malayi cytochrome P450 0.0011 0.0712 0.0712
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.1006 0.1006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.026 0.026
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0432 0.0432
Brugia malayi Cathepsin L-like precursor 0.002 0.1735 0.1735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0712 0.0899
Echinococcus multilocularis cysteine protease 0.002 0.1735 0.1735
Trichomonas vaginalis helicase, putative 0.0008 0.0352 0.0802
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Brugia malayi cathepsin L-like precursor 0.0014 0.1006 0.1006
Leishmania major cathepsin L-like protease 0.0077 0.7925 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.1735 0.1735
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0712 0.0899
Leishmania major cathepsin L-like protease 0.002 0.1735 0.2189
Brugia malayi Cathepsin L-like precursor 0.002 0.1735 0.1735
Plasmodium vivax unspecified product 0.001 0.0666 0.36
Schistosoma mansoni cpg binding protein 0.0033 0.3154 0.3154
Brugia malayi Cathepsin L-like precursor 0.002 0.1735 0.1735
Echinococcus granulosus cathepsin l1 0.0014 0.1006 0.1006
Brugia malayi Cathepsin L-like precursor 0.0007 0.026 0.026
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0712 0.3848
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.6395 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.1851 0.4211
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0712 0.0899
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.1851 0.4211
Trypanosoma cruzi cysteine protease, putative 0.001 0.0666 0.0841
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.1735 0.1735
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.1735 0.1735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0666 0.1516
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Brugia malayi CXXC zinc finger family protein 0.0033 0.3154 0.3154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0712 0.3848
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0666 0.0841
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.1851 0.5
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.4397 0.5548
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Brugia malayi Cathepsin L-like precursor 0.0014 0.1006 0.1006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.1851 1
Schistosoma mansoni ap endonuclease 0.0021 0.1851 0.1851
Leishmania major cathepsin L-like protease 0.002 0.1735 0.2189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.1006 0.2289
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.1687 0.1687
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0666 0.1516
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.4397 0.4397
Brugia malayi Cytochrome P450 family protein 0.0011 0.0712 0.0712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0712 0.0899
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0432 0.0432
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.4397 0.5548
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0712 0.3848
Plasmodium vivax vivapain-3 0.001 0.0666 0.36
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0352 0.0802
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.7216 0.7216
Echinococcus granulosus cathepsin L 0.001 0.0666 0.0666
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0666 0.1516
Leishmania major cathepsin L-like protease 0.0077 0.7925 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0666 0.0666
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0712 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Brugia malayi Papain family cysteine protease containing protein 0.002 0.1735 0.1735
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Onchocerca volvulus 0.002 0.1735 0.5499
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0712 0.3848
Plasmodium vivax unspecified product 0.0007 0.026 0.1404
Toxoplasma gondii cathepsin CPL 0.002 0.1735 0.2712
Loa Loa (eye worm) hypothetical protein 0.0007 0.026 0.026
Plasmodium vivax vivapain-1 0.001 0.0666 0.36
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0666 0.0841
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0712 0.3848
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.7197 0.9081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Onchocerca volvulus 0.002 0.1735 0.5499
Leishmania major cysteine peptidase A (CPA) 0.002 0.1735 0.2189
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.4397 0.4397
Brugia malayi Cathepsin L-like precursor 0.002 0.1735 0.1735
Loa Loa (eye worm) hypothetical protein 0.0014 0.1006 0.1006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0007 0.026 0.026
Loa Loa (eye worm) fibroinase 0.002 0.1735 0.1735
Echinococcus multilocularis cysteine protease 0.002 0.1735 0.1735
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0712 0.3848
Leishmania major cathepsin L-like protease 0.002 0.1735 0.2189
Brugia malayi Cytochrome P450 family protein 0.003 0.2835 0.2835
Mycobacterium leprae putative cytochrome p450 0.0011 0.0712 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0712 0.0899
Loa Loa (eye worm) hypothetical protein 0.0014 0.1006 0.1006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0712 0.3848
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.4397 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.4397 0.4397
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0638 0.0638
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.1006 0.2289
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0712 0.3848
Schistosoma mansoni ap endonuclease 0.0021 0.1851 0.1851
Onchocerca volvulus 0.0014 0.1006 0.319
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.1735 0.2189
Schistosoma mansoni hypothetical protein 0.0011 0.0712 0.0712
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7925 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.1735 0.1735
Schistosoma mansoni cytochrome P450 0.0011 0.0712 0.0712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.1006 0.2289
Trypanosoma cruzi cruzipain precursor, putative 0.0007 0.026 0.0328
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0712 0.3848
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0712 0.3848
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.4397 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.1735 0.5499
Loa Loa (eye worm) cysteine protease 0.002 0.1735 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Onchocerca volvulus 0.002 0.1735 0.5499
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.1851 0.2336
Entamoeba histolytica cysteine proteinase, putative 0.002 0.1735 0.3945
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0352 0.0802
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.1735 0.1735
Entamoeba histolytica cysteine proteinase, putative 0.002 0.1735 0.3945
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.4397 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.4397 0.4397
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.1735 0.1735
Loa Loa (eye worm) hypothetical protein 0.002 0.1735 0.1735
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0666 0.0841
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Trypanosoma cruzi cytochrome P450, putative 0.002 0.1687 0.2129
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0712 0.3848
Trypanosoma cruzi cysteine peptidase, putative 0.0007 0.026 0.0328
Loa Loa (eye worm) cytochrome P450 0.0011 0.0712 0.0712
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0712 0.1114
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.1735 0.1735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.1687 0.2129
Plasmodium vivax vivapain-2 0.002 0.1735 0.9369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Schistosoma mansoni cpg binding protein 0.0035 0.3361 0.3361
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0352 0.0802
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0666 0.1516
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0666 0.1516
Loa Loa (eye worm) CYP4Cod1 0.002 0.1687 0.1687
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.1851 0.1851
Echinococcus granulosus cpg binding protein 0.0035 0.3361 0.3361
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.1851 0.4211
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.1851 0.2336
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0712 0.3848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Brugia malayi cathepsin F-like cysteine proteinase 0.0007 0.026 0.026
Schistosoma mansoni cathepsin s 0.0007 0.026 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.1735 0.3945
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0652 0.0652
Trypanosoma brucei cytochrome P450, putative 0.002 0.1687 0.2129
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0666 0.36
Onchocerca volvulus 0.002 0.1735 0.5499
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.1735 0.1735
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0666 0.0841
Onchocerca volvulus 0.002 0.1735 0.5499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7925 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.3154 0.3154
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.1851 0.2336
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0712 0.3848
Brugia malayi Cathepsin L-like precursor 0.002 0.1735 0.1735
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0712 0.0712
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0712 0.3848
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.1735 0.3945
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.1851 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7925 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.4397 0.4397
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.1851 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0712 0.3848
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Leishmania major cytochrome p450-like protein 0.002 0.1687 0.2129
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.6129 0.7733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Onchocerca volvulus 0.002 0.1735 0.5499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0666 0.0841
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.1735 0.9369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0432 0.0432
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0432 0.0432
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.4397 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0666 0.1516
Toxoplasma gondii exonuclease III APE 0.0021 0.1851 0.2895
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.1735 0.9369
Echinococcus granulosus cysteine protease 0.001 0.0666 0.0666
Plasmodium vivax vivapain-2 0.002 0.1735 0.9369
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0712 0.3848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Brugia malayi Cytochrome P450 family protein 0.002 0.1687 0.1687
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.1735 0.1735
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0051 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.1851 0.2336
Entamoeba histolytica cysteine protease, putative 0.002 0.1735 0.3945
Entamoeba histolytica cysteine protease, putative 0.001 0.0666 0.1516
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.4397 0.5548
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.1687 0.1687
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1735 0.3945
Onchocerca volvulus 0.0033 0.3154 1
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0666 0.0666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0352 0.0802
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0666 0.1516
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.1735 0.9369
Leishmania major cytochrome p450-like protein 0.0011 0.0712 0.0899
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.4397 0.4397
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.4397 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0712 0.3848
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0712 0.3848
Loa Loa (eye worm) hypothetical protein 0.0014 0.1006 0.1006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0352 0.0802
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0352 0.0802
Loa Loa (eye worm) hypothetical protein 0.0009 0.0506 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0666 0.0841
Loa Loa (eye worm) histone methyltransferase 0.001 0.0652 0.0652
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.1851 0.1851
Leishmania major cathepsin L-like protease 0.002 0.1735 0.2189
Onchocerca volvulus 0.002 0.1735 0.5499
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0666 0.0666
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.4397 0.4397
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0712 0.3848
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.1735 0.1735
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0666 0.0666
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.1851 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.1735 0.5499
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.1851 0.1851
Loa Loa (eye worm) hypothetical protein 0.0007 0.026 0.026
Leishmania major cathepsin L-like protease 0.0077 0.7925 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.1006 0.1006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0352 0.0802
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.4397 0.4397
Brugia malayi Cathepsin L-like precursor 0.002 0.1735 0.1735
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1735 0.3945
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0352 0.0802
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.1851 0.1851
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0652 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7925 1
Echinococcus multilocularis 0.0011 0.0712 0.0712
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.1006 0.1006
Schistosoma mansoni cpg binding protein 0.0035 0.3361 0.3361
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.7925 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0712 0.3848

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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