Detailed information for compound 1399183

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 525.554 | Formula: C26H31N5O7
  • H donors: 3 H acceptors: 5 LogP: 2.45 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)c1c(C)[nH]c(c1C)C(=O)OCC(=O)N(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)CC(C)C
  • InChi: 1S/C26H31N5O7/c1-14(2)11-30(18(32)13-38-25(35)20-15(3)19(16(4)28-20)24(34)37-5)21-22(27)31(26(36)29-23(21)33)12-17-9-7-6-8-10-17/h6-10,14,28H,11-13,27H2,1-5H3,(H,29,33,36)
  • InChiKey: UFYLRQWPOSPIBZ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1702 0.4732
Leishmania major protein kinase, putative 0.0015 0.0192 0.009
Echinococcus granulosus lamin dm0 0.0027 0.058 0.0846
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0913 0.0871
Loa Loa (eye worm) methionine aminopeptidase type I 0.0043 0.1107 0.1288
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0164 0.0045
Leishmania major beta tubulin 0.008 0.2309 0.2228
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Loa Loa (eye worm) hypothetical protein 0.0036 0.087 0.0987
Trypanosoma brucei beta tubulin 0.008 0.2309 0.2158
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0043 0.1107 0.1613
Echinococcus multilocularis tubulin alpha 3 chain 0.0098 0.2903 0.4233
Loa Loa (eye worm) tubulin beta chain 0.0032 0.0723 0.0801
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.087 0.1269
Loa Loa (eye worm) beta-tubulin 0.008 0.2309 0.2817
Brugia malayi Tyrosine-protein kinase abl-1 0.0096 0.2842 0.3466
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.1189 0.1734
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0878 0.128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0128 0.0044
Leishmania major beta tubulin 0.008 0.2309 0.2228
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0014 0.0128 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0564 0.0598
Toxoplasma gondii alpha tubulin TUBA1 0.0098 0.2903 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0755 0.0151
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0043 0.1107 0.0932
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0032 0.0723 0.0689
Echinococcus granulosus twitchin 0.0012 0.0082 0.012
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0553 0.0584
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.087 0.1269
Schistosoma mansoni hypothetical protein 0.0019 0.031 0.0468
Loa Loa (eye worm) tubulin alpha chain 0.0098 0.2903 0.3573
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1702 0.4732
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0913 0.0818
Echinococcus granulosus tubulin delta chain 0.0032 0.0723 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0723 0.0689
Leishmania major beta tubulin 0.008 0.2309 0.2228
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.022 0.032
Leishmania major beta tubulin 0.008 0.2309 0.2228
Entamoeba histolytica tubulin family protein 0.008 0.2309 0.7807
Echinococcus granulosus NCK adaptor protein 0.0014 0.0128 0.0187
Schistosoma mansoni tyrosine kinase 0.0046 0.1189 0.1793
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0913 0.1376
Giardia lamblia Alpha-tubulin 0.0098 0.2903 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.3757 0.4658
Trypanosoma brucei alpha tubulin 0.0098 0.2903 0.2764
Brugia malayi SRC-1 0.0046 0.1189 0.1355
Trypanosoma brucei methionine aminopeptidase, putative 0.0043 0.1107 0.0932
Echinococcus multilocularis GPCR, family 2 0.0019 0.031 0.0453
Echinococcus granulosus tyrosine kinase 0.0039 0.097 0.1414
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1665 0.1999
Brugia malayi Tubulin alpha-2 chain 0.0098 0.2903 0.3544
Schistosoma mansoni tyrosine kinase 0.0016 0.022 0.0331
Giardia lamblia Beta tubulin 0.008 0.2309 0.7273
Schistosoma mansoni protein kinase 0.0015 0.0192 0.029
Brugia malayi Tubulin alpha chain 0.0032 0.0723 0.076
Leishmania major beta tubulin 0.008 0.2309 0.2228
Trypanosoma brucei tubulin gamma chain 0.0092 0.2706 0.2563
Echinococcus granulosus tubulin beta 4A class IVa 0.008 0.2309 0.3366
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.2476 0.361
Brugia malayi Cytochrome P450 family protein 0.0026 0.0553 0.0543
Echinococcus multilocularis tubulin alpha chain 0.0098 0.2903 0.4233
Giardia lamblia Alpha-tubulin 0.0098 0.2903 1
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.2903 0.3112
Echinococcus granulosus peroxisome assembly protein 26 0.0098 0.2903 0.4233
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.087 0.2499
Leishmania major beta tubulin 0.008 0.2309 0.2228
Echinococcus multilocularis roundabout 2 0.0015 0.0173 0.0252
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1665 0.1963
Echinococcus granulosus tyrosine protein kinase ABL1 0.0218 0.6859 1
Onchocerca volvulus Huntingtin homolog 0.0124 0.3757 0.4061
Echinococcus multilocularis jun protein 0.0085 0.2476 0.361
Schistosoma mansoni hypothetical protein 0.0019 0.031 0.0468
Leishmania major beta tubulin 0.008 0.2309 0.2228
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.1301 0.1961
Loa Loa (eye worm) alpha-tubulin 0.0098 0.2903 0.3573
Treponema pallidum methionine aminopeptidase (map) 0.0043 0.1107 0.1853
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0104 0.0151
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0015 0.0192 0.0126
Loa Loa (eye worm) tubulin alpha 2 0.0033 0.0779 0.0872
Trichomonas vaginalis tubulin, putative 0.0033 0.0767 0.0738
Schistosoma mansoni tubulin subunit gamma 0.0092 0.2706 0.4079
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1189 0.1734
Toxoplasma gondii alpha-tubulin I, putative 0.0098 0.2903 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.097 0.1414
Plasmodium vivax SET domain protein, putative 0.0036 0.087 0.2499
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7958 1
Schistosoma mansoni jun-related protein 0.0069 0.1953 0.2944
Mycobacterium leprae cell division protein FtsZ 0.0032 0.0723 0.2304
Loa Loa (eye worm) hypothetical protein 0.0019 0.031 0.0276
Plasmodium vivax tubulin epsilon chain, putative 0.0065 0.1807 0.5957
Entamoeba histolytica tubulin alpha-1 chain 0.0098 0.2903 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.12 0.1749
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Plasmodium vivax tubulin beta chain, putative 0.008 0.2309 0.7807
Echinococcus granulosus GPCR family 2 0.0019 0.031 0.0453
Toxoplasma gondii methionine aminopeptidase 0.0043 0.1107 0.3372
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0043 0.1107 0.1013
Brugia malayi alpha-tubulin 0.0098 0.2903 0.3544
Trypanosoma brucei alpha tubulin 0.0098 0.2903 0.2764
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1702 0.2566
Brugia malayi Probable ClpP-like protease 0.0094 0.2793 0.3403
Trichomonas vaginalis tubulin gamma chain, putative 0.0032 0.0723 0.0689
Plasmodium vivax delta tubulin, putative 0.0032 0.0723 0.1957
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1038 0.1162
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Schistosoma mansoni intermediate filament proteins 0.0027 0.058 0.0874
Schistosoma mansoni hypothetical protein 0.0052 0.1403 0.2115
Giardia lamblia Beta tubulin 0.008 0.2309 0.7273
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0192 0.029
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0043 0.1107 0.1853
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.031 0.0453
Entamoeba histolytica tubulin alpha chain, putative 0.0098 0.2903 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1189 0.1734
Leishmania major delta tubulin, putative 0.0032 0.0723 0.0626
Brugia malayi protein-tyrosine kinase 0.0039 0.097 0.1074
Echinococcus multilocularis tubulin alpha chain 0.0098 0.2903 0.4233
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1073 0.1078
Echinococcus multilocularis peroxisome assembly protein 26 0.0098 0.2903 0.4233
Brugia malayi tubulin alpha chain - mouse 0.0098 0.2903 0.3544
Loa Loa (eye worm) hypothetical protein 0.0165 0.511 0.6379
Brugia malayi hypothetical protein 0.0165 0.511 0.6363
Trichomonas vaginalis tubulin epsilon chain, putative 0.0098 0.2903 0.3112
Brugia malayi hypothetical protein 0.0124 0.3757 0.4635
Echinococcus granulosus Tubulin beta 2C chain 0.008 0.2309 0.3366
Loa Loa (eye worm) hypothetical protein 0.0037 0.0913 0.1042
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0032 0.0723 0.1957
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.031 0.0233
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0913 0.1331
Echinococcus granulosus lamin 0.0027 0.058 0.0846
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0066 0.1863 0.225
Echinococcus multilocularis tubulin gamma 1 chain 0.0092 0.2706 0.3945
Echinococcus multilocularis tubulin alpha 1C chain 0.0098 0.2903 0.4233
Echinococcus multilocularis tubulin subunit beta 0.008 0.2309 0.3366
Echinococcus granulosus tubulin alpha 0.0065 0.1807 0.2635
Schistosoma mansoni hypothetical protein 0.0171 0.5318 0.8017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0913 0.0735
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0913 0.0899
Echinococcus granulosus Tubulin beta 2C chain 0.008 0.2309 0.3366
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 0.9591
Loa Loa (eye worm) tubulin beta-4 chain 0.008 0.2309 0.2817
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1702 0.2566
Leishmania major beta tubulin 0.008 0.2309 0.2228
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1073 0.1078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.01
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.1073 0.3249
Trypanosoma cruzi tubulin delta chain 0.0032 0.0723 0.0626
Trichomonas vaginalis tubulin epsilon chain, putative 0.008 0.2309 0.2451
Trypanosoma cruzi tubulin delta chain 0.0032 0.0723 0.0626
Loa Loa (eye worm) hypothetical protein 0.0015 0.0192 0.0126
Plasmodium falciparum tubulin delta chain, putative 0.0032 0.0723 0.1957
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1702 0.4732
Brugia malayi Pre-SET motif family protein 0.0036 0.087 0.0947
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1702 0.9811
Schistosoma mansoni hypothetical protein 0.0019 0.031 0.0468
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Trypanosoma brucei alpha tubulin 0.0098 0.2903 0.2764
Schistosoma mansoni tubulin subunit beta 0.008 0.2309 0.3481
Loa Loa (eye worm) TK/ABL protein kinase 0.0218 0.6859 0.8602
Echinococcus granulosus tubulin alpha 1C chain 0.0098 0.2903 0.4233
Brugia malayi Methionine aminopeptidase protein type I 0.0043 0.1107 0.125
Echinococcus granulosus jun protein 0.0085 0.2476 0.361
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.1189 0.1734
Schistosoma mansoni hypothetical protein 0.0069 0.1953 0.2944
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.1189 0.1734
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0913 0.1331
Loa Loa (eye worm) tubulin gamma chain 0.0092 0.2706 0.3322
Toxoplasma gondii beta tubulin 0.008 0.2309 0.7807
Leishmania major basic transcription factor 3a, putative 0.0042 0.1073 0.098
Echinococcus granulosus tyrosine protein kinase Blk 0.0039 0.097 0.1414
Schistosoma mansoni tubulin subunit beta 0.0032 0.0723 0.109
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0015 0.0192 0.0281
Echinococcus granulosus c src tyrosine kinase 0.0016 0.022 0.032
Echinococcus multilocularis NCK adaptor protein 0.0014 0.0128 0.0187
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0043 0.1107 0.3372
Loa Loa (eye worm) hypothetical protein 0.0082 0.2399 0.2932
Schistosoma mansoni tubulin subunit alpha 0.0032 0.0723 0.109
Echinococcus multilocularis lamin 0.0027 0.058 0.0846
Schistosoma mansoni alpha tubulin 0.0098 0.2903 0.4377
Trichomonas vaginalis tubulin alpha chain, putative 0.008 0.2309 0.2451
Echinococcus granulosus tubulin alpha chain 0.0098 0.2903 0.4233
Echinococcus granulosus tubulin subunit TubB 0.0098 0.2903 0.4233
Echinococcus multilocularis transcription factor btf3 0.0042 0.1073 0.1565
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0218 0.6859 1
Schistosoma mansoni lamin 0.0027 0.058 0.0874
Schistosoma mansoni alpha tubulin 0.0098 0.2903 0.4377
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Schistosoma mansoni tyrosine kinase 0.0046 0.1189 0.1793
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.031 0.0453
Loa Loa (eye worm) hypothetical protein 0.0027 0.058 0.0619
Echinococcus multilocularis neuroglian 0.0012 0.0072 0.0105
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0043 0.1107 0.3372
Schistosoma mansoni tubulin subunit delta 0.0032 0.0723 0.109
Onchocerca volvulus 0.0027 0.058 0.0529
Echinococcus multilocularis Tubulin alpha 1 chain 0.0098 0.2903 0.4233
Plasmodium falciparum tubulin gamma chain 0.0092 0.2706 0.9271
Leishmania major gamma-tubulin 0.0092 0.2706 0.2629
Plasmodium vivax tubulin alpha chain, putative 0.0098 0.2903 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.2793 0.9591
Echinococcus multilocularis growth factor receptor bound protein 2 0.0014 0.0128 0.0187
Brugia malayi Latrophilin receptor protein 2 0.0019 0.031 0.0233
Schistosoma mansoni transcription factor btf3 0.0042 0.1073 0.1618
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0767 0.0738
Toxoplasma gondii beta-1 tubulin, putative 0.008 0.2309 0.7807
Echinococcus multilocularis Tubulin alpha 1 chain 0.0098 0.2903 0.4233
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.2903 0.3112
Trypanosoma brucei beta tubulin 0.0065 0.1807 0.1647
Echinococcus multilocularis tubulin delta chain 0.0032 0.0723 0.1054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.031 0.0276
Echinococcus granulosus roundabout 2 0.0015 0.0173 0.0252
Echinococcus multilocularis Tubulin beta 2C chain 0.008 0.2309 0.3366
Echinococcus multilocularis tyrosine protein kinase Srms 0.0039 0.097 0.1414
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.1189 0.1734
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.01
Brugia malayi Tubulin beta chain 0.0032 0.0723 0.076
Echinococcus granulosus tubulin alpha chain 0.0098 0.2903 0.4233
Echinococcus multilocularis lamin dm0 0.0027 0.058 0.0846
Trichomonas vaginalis tubulin epsilon chain, putative 0.0032 0.0723 0.0689
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1073 0.1078
Echinococcus multilocularis Tubulin alpha 1 chain 0.0098 0.2903 0.4233
Brugia malayi beta-tubulin, identical 0.008 0.2309 0.2785
Leishmania major beta tubulin 0.008 0.2309 0.2228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.087 0.1312
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0104 0.0013
Loa Loa (eye worm) tubulin alpha 2 0.0066 0.1863 0.225
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0744 0.1085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0029
Echinococcus granulosus geminin 0.0171 0.5318 0.7753
Loa Loa (eye worm) hypothetical protein 0.0124 0.3757 0.4658
Loa Loa (eye worm) tubulin alpha 2 0.0066 0.1863 0.225
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.1721 1
Leishmania major epsilon tubulin, putative 0.0065 0.1807 0.1721
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0913 0.0899
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0014 0.0128 0.0193
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0913 0.1331
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.1073 0.098
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0913 0.1376
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1702 0.2482
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.2903 0.3112
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.1189 0.1734
Trypanosoma cruzi tubulin gamma chain 0.0092 0.2706 0.2629
Echinococcus granulosus neuroglian 0.0012 0.0072 0.0105
Trypanosoma cruzi beta tubulin, putative 0.008 0.2309 0.2228
Mycobacterium ulcerans methionine aminopeptidase 0.0043 0.1107 0.1853
Echinococcus multilocularis Tubulin beta 2C chain 0.008 0.2309 0.3366
Echinococcus multilocularis tubulin alpha 1C chain 0.0098 0.2903 0.4233
Toxoplasma gondii hypothetical protein 0.0033 0.0755 0.2073
Schistosoma mansoni nck2/grb4 0.0014 0.0128 0.0193
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0881 0.0961
Echinococcus granulosus tubulin epsilon chain 0.0065 0.1807 0.2635
Echinococcus granulosus Tubulin alpha 1 chain 0.0098 0.2903 0.4233
Trypanosoma brucei epsilon tubulin 0.0065 0.1807 0.1647
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0755 0.2073
Schistosoma mansoni tubulin subunit beta 0.008 0.2309 0.3481
Brugia malayi Tyrosine-protein kinase abl-1 0.0129 0.392 0.4842
Loa Loa (eye worm) tubulin alpha-2 chain 0.0098 0.2903 0.3573
Onchocerca volvulus Tyrosine kinase homolog 0.0145 0.4443 0.4823
Echinococcus granulosus Tubulin alpha 1 chain 0.0098 0.2903 0.4233
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.1189 0.1734
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0065 0.1807 0.5957
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0913 0.2658
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0094 0.0136
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0104 0.0151
Schistosoma mansoni protein kinase 0.0015 0.0192 0.029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0164 0.0089
Echinococcus granulosus beta tubulin 0.008 0.2309 0.3366
Schistosoma mansoni tubulin subunit alpha 0.0098 0.2903 0.4377
Schistosoma mansoni tubulin subunit beta 0.008 0.2309 0.3481
Trypanosoma brucei tubulin delta chain 0.0032 0.0723 0.0541
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.022 0.0331
Onchocerca volvulus 0.0067 0.1876 0.197
Loa Loa (eye worm) tubulin beta-2A chain 0.008 0.2309 0.2817
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.2793 1
Entamoeba histolytica tubulin gamma chain 0.0092 0.2706 0.9271
Plasmodium falciparum alpha tubulin 2 0.0098 0.2903 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0098 0.2903 0.4233
Echinococcus multilocularis tubulin beta 1 chain 0.008 0.2309 0.3366
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0066 0.1863 0.1956
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0723 0.0689
Plasmodium vivax tubulin gamma chain, putative 0.0092 0.2706 0.9271
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0128 0.0193
Echinococcus granulosus tubulin alpha chain 0.0098 0.2903 0.4233
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1702 0.557
Schistosoma mansoni hypothetical protein 0.0019 0.031 0.0468
Echinococcus multilocularis hypothetical protein 0.0098 0.2903 0.4233
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.1201
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0182 0.0266
Trypanosoma brucei beta tubulin 0.008 0.2309 0.2158
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0015 0.0192 0.0099
Loa Loa (eye worm) tubulin alpha chain 0.0098 0.2903 0.3573
Loa Loa (eye worm) tubulin beta chain 0.008 0.2309 0.2817
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Trichomonas vaginalis tubulin alpha chain, putative 0.0033 0.0767 0.0738
Echinococcus multilocularis tubulin alpha chain 0.0098 0.2903 0.4233
Brugia malayi Tubulin alpha chain 0.0098 0.2903 0.3544
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Echinococcus multilocularis Tubulin beta 2C chain 0.008 0.2309 0.3366
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0043 0.1107 0.1853
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0043 0.1107 0.0932
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0043 0.1107 0.1668
Echinococcus granulosus Tubulin beta 2C chain 0.008 0.2309 0.3366
Schistosoma mansoni tubulin subunit epsilon 0.0065 0.1807 0.2725
Echinococcus granulosus tubulin beta 1 chain 0.008 0.2309 0.3366
Loa Loa (eye worm) alpha-tubulin 0.0098 0.2903 0.3573
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0043 0.1107 0.373
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0043 0.1107 0.1613
Echinococcus multilocularis geminin 0.0171 0.5318 0.7753
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.0008
Giardia lamblia Gamma tubulin 0.0092 0.2706 0.9094
Loa Loa (eye worm) tubulin alpha-3 chain 0.0065 0.1819 0.2194
Leishmania major beta tubulin 0.008 0.2309 0.2228
Leishmania major beta tubulin 0.008 0.2309 0.2228
Trypanosoma cruzi epsilon tubulin, putative 0.0065 0.1807 0.1721
Echinococcus multilocularis tyrosine protein kinase Blk 0.0039 0.097 0.1414
Echinococcus granulosus tubulin alpha chain 0.0098 0.2903 0.4233
Echinococcus multilocularis tubulin subunit TubB 0.0098 0.2903 0.4233
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0043 0.1107 0.3842
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0744 0.1085
Leishmania major protein kinase, putative 0.0013 0.0114 0.001
Echinococcus granulosus tubulin alpha 3 chain 0.0098 0.2903 0.4233
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 1
Schistosoma mansoni nephrin 0.0012 0.0072 0.0108
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0155 0.4774 0.5952
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1721 0.251
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0043 0.1107 0.1668
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1721 0.251
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 1
Echinococcus granulosus tubulin subunit beta 0.008 0.2309 0.3366
Echinococcus multilocularis musashi 0.0027 0.058 0.0846
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0878 0.128
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0043 0.1107 0.1613
Loa Loa (eye worm) hypothetical protein 0.0082 0.2397 0.2929
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0913 0.1002
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0015 0.0192 0.0082
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1189 0.1734
Trypanosoma brucei epsilon tubulin 0.0065 0.1807 0.1647
Trichomonas vaginalis tubulin beta chain, putative 0.008 0.2309 0.2451
Onchocerca volvulus 0.0036 0.087 0.0852
Brugia malayi beta-NAC-like protein 0.0042 0.1073 0.1207
Trichomonas vaginalis tubulin alpha chain, putative 0.0033 0.0767 0.0738
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.058 0.0577
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1721 0.6016
Brugia malayi Cam kinase protein 1 0.0015 0.0192 0.0082
Toxoplasma gondii beta-tubulin, putative 0.008 0.2309 0.7807
Schistosoma mansoni tubulin subunit beta 0.008 0.2309 0.3481
Echinococcus multilocularis tubulin alpha 0.0065 0.1807 0.2635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.2476 0.361
Trypanosoma brucei epsilon tubulin 0.0065 0.1807 0.1647
Leishmania major beta tubulin 0.008 0.2309 0.2228
Leishmania major beta tubulin 0.008 0.2309 0.2228
Leishmania major beta tubulin 0.008 0.2309 0.2228
Entamoeba histolytica tubulin family protein 0.008 0.2309 0.7807
Loa Loa (eye worm) hypothetical protein 0.0098 0.2903 0.3573
Schistosoma mansoni tubulin subunit beta 0.008 0.2309 0.3481
Trichomonas vaginalis tubulin gamma chain, putative 0.008 0.2309 0.2451
Echinococcus granulosus transcription factor btf3 0.0042 0.1073 0.1565
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0032 0.0723 0.1957
Brugia malayi Tubulin beta-1 chain 0.008 0.2309 0.2785
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.4774 0.5934
Schistosoma mansoni adapter molecule crk 0.0014 0.0128 0.0193
Echinococcus granulosus beta tubulin 0.008 0.2309 0.3366
Echinococcus granulosus intermediate filament protein 0.0027 0.058 0.0846
Echinococcus granulosus Tubulin alpha 1 chain 0.0098 0.2903 0.4233
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0913 0.0899
Loa Loa (eye worm) SRC-1 0.0046 0.1189 0.1393
Brugia malayi hypothetical protein 0.0067 0.1876 0.2232
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.2903 0.3112
Onchocerca volvulus 0.0033 0.0767 0.0738
Trypanosoma brucei beta tubulin 0.008 0.2309 0.2158
Trichomonas vaginalis set domain proteins, putative 0.0286 0.9101 1
Giardia lamblia Beta tubulin 0.008 0.2309 0.7273
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0881 0.1284
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0043 0.1107 0.3372
Loa Loa (eye worm) hypothetical protein 0.0065 0.1819 0.2194
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.2793 0.4071
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Onchocerca volvulus 0.0139 0.4273 0.4634
Chlamydia trachomatis methionine aminopeptidase 0.0043 0.1107 0.373
Trypanosoma cruzi alpha tubulin, putative 0.0098 0.2903 0.2829
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.1073 0.0898
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0043 0.1107 0.1013
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.1189 0.1734
Loa Loa (eye worm) TK protein kinase 0.0039 0.097 0.1114
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2793 0.9591
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.0767 0.0738
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1189 0.1734
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.031 0.0453
Echinococcus granulosus alpha tubulin 0.0098 0.2903 0.4233
Toxoplasma gondii NAC domain-containing protein 0.0042 0.1073 0.3249
Echinococcus multilocularis tyrosine protein kinase Abl 0.0096 0.2842 0.4144
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0913 0.1331
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.058 0.0619
Trypanosoma cruzi epsilon tubulin, putative 0.0065 0.1807 0.1721
Trichomonas vaginalis tubulin, putative 0.0059 0.1622 0.1687
Trichomonas vaginalis tubulin gamma chain, putative 0.0065 0.1807 0.1893
Echinococcus multilocularis tubulin alpha chain 0.0098 0.2903 0.4233
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0755 0.242
Schistosoma mansoni tubulin subunit beta 0.008 0.2309 0.3481
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1702 0.1615
Trichomonas vaginalis tubulin alpha chain, putative 0.0033 0.0767 0.0738
Brugia malayi Tubulin alpha-2 chain 0.0098 0.2903 0.3544
Schistosoma mansoni tyrosine kinase 0.0211 0.6634 1
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0043 0.1107 0.3372
Plasmodium vivax tubulin alpha chain, putative 0.0098 0.2903 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0104 0.0151
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Loa Loa (eye worm) BEN-1 protein 0.008 0.2309 0.2817
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Schistosoma mansoni alpha tubulin 0.0098 0.2903 0.4377
Brugia malayi tubulin alpha-2 chain 0.0098 0.2903 0.3544
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.1073 0.3249
Schistosoma mansoni tubulin subunit alpha 0.0098 0.2903 0.4377
Brugia malayi Cell division protein ftsZ 0.0032 0.0723 0.076
Echinococcus granulosus tubulin alpha 1C chain 0.0098 0.2903 0.4233
Onchocerca volvulus 0.0027 0.058 0.0529
Loa Loa (eye worm) ICD-1 protein 0.0042 0.1073 0.1246
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.2903 0.3112
Echinococcus granulosus tubulin alpha chain 0.0098 0.2903 0.4233
Echinococcus granulosus single minded 2 0.0036 0.0881 0.1284
Schistosoma mansoni hypothetical protein 0.0041 0.1038 0.1565
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.087 0.1269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.087 0.1312
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.1189 0.1734
Loa Loa (eye worm) intermediate filament protein 0.0027 0.058 0.0619
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.031 0.0453
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0039 0.097 0.1414
Echinococcus multilocularis beta tubulin 0.008 0.2309 0.3366
Leishmania major protein kinase, putative 0.0013 0.0114 0.001
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.1189 0.1734
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2793 0.9591
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Echinococcus multilocularis tubulin epsilon chain 0.0065 0.1807 0.2635
Trypanosoma brucei alpha tubulin 0.0098 0.2903 0.2764
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.087 0.1312
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0755 0.2073
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0098 0.2903 0.3112
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0128 0.0044
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0043 0.1107 0.3842
Loa Loa (eye worm) hypothetical protein 0.0066 0.1863 0.225
Brugia malayi PAS domain containing protein 0.0049 0.1301 0.1498
Brugia malayi hypoxia-induced factor 1 0.0152 0.469 0.5826
Leishmania major beta tubulin 0.008 0.2309 0.2228
Leishmania major beta tubulin 0.008 0.2309 0.2228
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.0008
Schistosoma mansoni tubulin subunit alpha 0.0098 0.2903 0.4377
Brugia malayi Pre-SET motif family protein 0.0251 0.7958 1
Schistosoma mansoni lamin 0.0027 0.058 0.0874
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.1189 0.1734
Brugia malayi Tubulin beta chain 0.0033 0.0767 0.0816
Echinococcus multilocularis tubulin, beta 4A class IVa 0.008 0.2309 0.3366
Echinococcus granulosus tubulin gamma 1 chain 0.0092 0.2706 0.3945
Onchocerca volvulus 0.0036 0.0881 0.0863
Entamoeba histolytica hypothetical protein 0.0042 0.1073 0.325
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0881 0.076
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.2793 0.4071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0116 0.0169
Brugia malayi Tubulin gamma chain 0.0092 0.2706 0.3292
Loa Loa (eye worm) BEN-1 protein 0.008 0.2309 0.2817
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0827 0.1205
Trichomonas vaginalis tubulin epsilon chain, putative 0.008 0.2309 0.2451
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.1073 0.098
Leishmania major beta tubulin 0.008 0.2309 0.2228
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0104 0.0151
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.1721 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0043 0.1107 0.1013
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0043 0.1107 0.373
Trichomonas vaginalis tubulin gamma chain, putative 0.0092 0.2706 0.2892
Echinococcus granulosus growth factor receptor bound protein 2 0.0014 0.0128 0.0187
Trichomonas vaginalis tubulin alpha chain, putative 0.0065 0.1807 0.1893
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Echinococcus multilocularis beta tubulin 0.008 0.2309 0.3366
Plasmodium falciparum tubulin beta chain 0.008 0.2309 0.7807
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.022 0.032
Onchocerca volvulus 0.0286 0.9101 1
Echinococcus granulosus tubulin alpha 3 chain 0.0098 0.2903 0.4233
Schistosoma mansoni hypothetical protein 0.0171 0.5318 0.8017
Loa Loa (eye worm) tubulin beta-1 chain 0.008 0.2309 0.2817
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.087 0.1312
Loa Loa (eye worm) TK protein kinase 0.0032 0.0744 0.0827
Entamoeba histolytica protein kinase, putative 0.0032 0.0744 0.2036
Trypanosoma brucei alpha tubulin, putative 0.0033 0.0767 0.0586
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0043 0.1107 0.3372
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0128 0.0193
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0182 0.0266
Echinococcus granulosus Tubulin beta 2C chain 0.008 0.2309 0.3366
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.1189 0.1734
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.2793 0.421
Echinococcus multilocularis tubulin alpha chain 0.0098 0.2903 0.4233
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0116 0.0169
Trichomonas vaginalis tubulin epsilon chain, putative 0.0098 0.2903 0.3112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1665 0.1963
Leishmania major beta tubulin 0.008 0.2309 0.2228
Brugia malayi intermediate filament protein 0.0027 0.058 0.0577
Loa Loa (eye worm) hypothetical protein 0.006 0.1665 0.1999
Schistosoma mansoni single-minded 0.0049 0.1301 0.1961
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Schistosoma mansoni tyrosine kinase 0.0016 0.022 0.0331
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Echinococcus multilocularis Tubulin beta 2C chain 0.008 0.2309 0.3366
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0913 0.1331
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.1189 0.1734
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2793 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.2793 0.3432
Echinococcus multilocularis Tubulin beta 2C chain 0.008 0.2309 0.3366
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0065 0.1819 0.1907
Schistosoma mansoni cell adhesion molecule 0.0012 0.0094 0.0141
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Plasmodium falciparum tubulin epsilon chain, putative 0.0065 0.1807 0.5957
Trichomonas vaginalis tubulin beta chain, putative 0.0098 0.2903 0.3112
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0913 0.0818
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0015 0.0192 0.0126
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.469 0.5844
Trypanosoma brucei beta tubulin 0.008 0.2309 0.2158
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.022 0.032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1702 0.2482
Trichomonas vaginalis tubulin, putative 0.008 0.2309 0.2451
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0913 0.0818
Echinococcus granulosus Tubulin beta 2C chain 0.008 0.2309 0.3366
Leishmania major alpha tubulin 0.0098 0.2903 0.2829
Toxoplasma gondii methionine aminopeptidase 0.0043 0.1107 0.3372
Schistosoma mansoni protein kinase 0.0015 0.0192 0.029
Onchocerca volvulus Huntingtin homolog 0.0124 0.3757 0.4061
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0913 0.1331
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.1073 0.325
Trichomonas vaginalis tubulin, putative 0.0033 0.0767 0.0738
Plasmodium falciparum alpha tubulin 1 0.0098 0.2903 1
Brugia malayi bZIP transcription factor family protein 0.0085 0.2476 0.2998

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 9.338 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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