TDR Targets

Basic information

Technical information

TDR Targets ID: 1399200
Name: methyl 3-pyrimidin-2-yl-3,9-diazaspiro[5.5]un decane-9-carboxylate
MW: 290.361 | Formula: C15H22N4O2
H donors: 0 H acceptors: 3 LogP: 1.65 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)N1CCC2(CC1)CCN(CC2)c1ncccn1
InChi: 1S/C15H22N4O2/c1-21-14(20)19-11-5-15(6-12-19)3-9-18(10-4-15)13-16-7-2-8-17-13/h2,7-8H,3-6,9-12H2,1H3
InChiKey: IKTXFVMZQNCZAK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2-pyrimidinyl)-3,9-diazaspiro[5.5]undecane-9-carboxylic acid methyl ester
3-pyrimidin-2-yl-3,9-diazaspiro[5.5]undecane-9-carboxylic acid methyl ester
NCGC00012059
PCOP-708192

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Onchocerca volvulus	Neurogenic locus notch homolog	0.005	0.0447	0.1069
Onchocerca volvulus		0.0231	0.2775	1
Onchocerca volvulus		0.005	0.0447	0.1069
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Schistosoma mansoni	notch	0.005	0.0447	0.1553
Giardia lamblia	High cysteine protein	0.005	0.0447	0.5
Onchocerca volvulus	Peroxidase homolog	0.0231	0.2775	1
Brugia malayi	Calcium binding EGF domain containing protein	0.005	0.0447	0.1612
Brugia malayi	Animal haem peroxidase family protein	0.0231	0.2775	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0264	0.095
Echinococcus multilocularis	musashi	0.0028	0.0169	0.015
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Loa Loa (eye worm)	animal heme peroxidase	0.0231	0.2775	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.005	0.0447	0.0429
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0384	0.1323
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Echinococcus multilocularis	peroxidasin	0.0231	0.2775	0.2761
Brugia malayi	Animal haem peroxidase family protein	0.0231	0.2775	1
Echinococcus granulosus	neurogenic locus protein delta	0.005	0.0447	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0474	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0261	0.0877
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.005	0.0447	0.1553
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Echinococcus multilocularis	neurogenic locus protein delta	0.005	0.0447	0.0429
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Echinococcus multilocularis	lamin dm0	0.0028	0.0169	0.015
Echinococcus multilocularis	protein jagged 2	0.005	0.0447	0.0429
Schistosoma mansoni	lamin	0.0028	0.0169	0.0542
Echinococcus granulosus	slit 2 protein	0.005	0.0447	0.0718
Onchocerca volvulus		0.0231	0.2775	1
Schistosoma mansoni	notch	0.005	0.0447	0.1553
Schistosoma mansoni	laminin gamma-3 chain	0.005	0.0447	0.1553
Entamoeba histolytica	hypothetical protein	0.0035	0.0261	0.5
Brugia malayi	Peroxidasin	0.0231	0.2775	1
Brugia malayi	notch-like transmembrane receptor	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Echinococcus multilocularis	protein jagged 1	0.005	0.0447	0.0429
Onchocerca volvulus		0.005	0.0447	0.1069
Schistosoma mansoni	cell polarity protein	0.005	0.0447	0.1553
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Brugia malayi	Animal haem peroxidase family protein	0.0231	0.2775	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0261	0.5
Onchocerca volvulus	Slit protein homolog	0.005	0.0447	0.1069
Echinococcus granulosus	protein jagged 1	0.005	0.0447	0.0718
Brugia malayi	Phospholipase A2 family protein	0.0089	0.0953	0.3434
Echinococcus multilocularis	neurogenic locus protein delta	0.005	0.0447	0.0429
Entamoeba histolytica	hypothetical protein	0.0035	0.0261	0.5
Onchocerca volvulus	Phospholipase A2 homolog	0.0089	0.0953	0.3008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0384	0.0612
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0002	0.0007
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0384	0.1384
Echinococcus multilocularis	lamin	0.0028	0.0169	0.015
Onchocerca volvulus	Dual oxidase homolog	0.0231	0.2775	1
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.002	0.0071
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0384	0.1384
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Echinococcus granulosus	neuropeptide s receptor	0.048	0.5977	1
Echinococcus granulosus	protein jagged 2	0.005	0.0447	0.0718
Loa Loa (eye worm)	animal heme peroxidase	0.0231	0.2775	1
Schistosoma mansoni	lamin	0.0028	0.0169	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0162	0.0585
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Brugia malayi	Animal haem peroxidase family protein	0.0231	0.2775	1
Schistosoma mansoni	slit	0.005	0.0447	0.1553
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0474	0.1709
Brugia malayi	Calcium binding EGF domain containing protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0384	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Schistosoma mansoni	septate junction protein	0.005	0.0447	0.1553
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Echinococcus multilocularis	neurogenic locus notch protein	0.005	0.0447	0.0429
Echinococcus granulosus	neurogenic locus notch protein 4	0.005	0.0447	0.0718
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Onchocerca volvulus	Phospholipase A2 homolog	0.0089	0.0953	0.3008
Brugia malayi	hypothetical protein	0.0231	0.2775	1
Schistosoma mansoni	notch	0.005	0.0447	0.1553
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Toxoplasma gondii	EGF family domain-containing protein	0.005	0.0447	0.5
Echinococcus granulosus	lamin	0.0028	0.0169	0.0251
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0474	0.1709
Echinococcus granulosus	intermediate filament protein	0.0028	0.0169	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Echinococcus granulosus	delta-like protein 1	0.005	0.0447	0.0718
Echinococcus multilocularis	neurogenic locus notch protein	0.005	0.0447	0.0429
Schistosoma mansoni	hypothetical protein	0.0035	0.0264	0.0886
Echinococcus multilocularis	neural cadherin	0.005	0.0447	0.0429
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Brugia malayi	Blistered cuticle protein 3	0.0231	0.2775	1
Loa Loa (eye worm)	animal heme peroxidase	0.0231	0.2775	1
Onchocerca volvulus		0.0231	0.2775	1
Brugia malayi	Cadherin domain containing protein	0.005	0.0447	0.1612
Echinococcus granulosus	peroxidasin	0.0231	0.2775	0.4625
Echinococcus granulosus	neurogenic locus notch protein	0.005	0.0447	0.0718
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Echinococcus multilocularis	fat cadherin tumor suppressor	0.005	0.0447	0.0429
Echinococcus granulosus	neuropeptide receptor A26	0.048	0.5977	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0169	0.0542
Brugia malayi	Calcium binding EGF domain containing protein	0.005	0.0447	0.1612
Brugia malayi	Cadherin domain containing protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Echinococcus granulosus	neurogenic locus notch protein	0.005	0.0447	0.0718
Echinococcus multilocularis	neuropeptide receptor A26	0.048	0.5977	0.597
Brugia malayi	Muscle positioning protein 4	0.005	0.0447	0.1612
Echinococcus granulosus	notch	0.005	0.0447	0.0718
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.005	0.0447	0.1069
Echinococcus multilocularis	slit 2 protein	0.005	0.0447	0.0429
Schistosoma mansoni	hypothetical protein	0.005	0.0447	0.1553
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0169	0.0609
Onchocerca volvulus	Peroxidase homolog	0.0231	0.2775	1
Loa Loa (eye worm)	Notch2	0.005	0.0447	0.1612
Onchocerca volvulus		0.005	0.0447	0.1069
Echinococcus multilocularis	neuropeptide s receptor	0.048	0.5977	0.597
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Echinococcus granulosus	lamin dm0	0.0028	0.0169	0.0251
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.005	0.0447	0.1612
Entamoeba histolytica	hypothetical protein	0.0035	0.0261	0.5
Echinococcus granulosus	protein jagged 2	0.005	0.0447	0.0718
Onchocerca volvulus	Chorion peroxidase homolog	0.0231	0.2775	1
Schistosoma mansoni	notch	0.005	0.0447	0.1553
Schistosoma mansoni	notch	0.005	0.0447	0.1553
Onchocerca volvulus		0.005	0.0447	0.1069
Echinococcus multilocularis	notch	0.005	0.0447	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.095
Loa Loa (eye worm)	blistered cuticle protein 3	0.0231	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.002	0.0071
Onchocerca volvulus	Peroxidasin homolog	0.0231	0.2775	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0384	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Schistosoma mansoni	notch	0.005	0.0447	0.1553
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0261	0.0242
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.002	0.0071
Echinococcus granulosus	protein jagged 1	0.005	0.0447	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0953	0.3434
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Brugia malayi	GCC2 and GCC3 family protein	0.005	0.0447	0.1612
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.002	0.0071
Loa Loa (eye worm)	notch protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	animal heme peroxidase	0.0231	0.2775	1
Echinococcus granulosus	fibropellin Ia	0.005	0.0447	0.0718
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0384	0.0365
Schistosoma mansoni	peroxidasin	0.0231	0.2775	1
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0169	0.0609
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0261	0.0406
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Onchocerca volvulus	Putative cubilin	0.005	0.0447	0.1069
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Loa Loa (eye worm)	hypothetical protein	0.005	0.0447	0.1612
Schistosoma mansoni	hypothetical protein	0.0035	0.0261	0.0877
Echinococcus granulosus	neural cadherin	0.005	0.0447	0.0718
Echinococcus multilocularis	fibropellin Ia	0.005	0.0447	0.0429
Brugia malayi	Animal haem peroxidase family protein	0.0231	0.2775	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0169	0.0609
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0384	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0169	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2775	1
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0384	0.0612
Brugia malayi	hypothetical protein	0.0035	0.0261	0.0942
Brugia malayi	Delta serrate ligand family protein	0.005	0.0447	0.1612
Brugia malayi	intermediate filament protein	0.0028	0.0169	0.0609
Onchocerca volvulus	Peroxidasin homolog	0.0231	0.2775	1
Onchocerca volvulus		0.005	0.0447	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0953	0.3434
Brugia malayi	EGF-like domain containing protein	0.005	0.0447	0.1612
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0474	0.1709
Echinococcus multilocularis	protein jagged 1	0.005	0.0447	0.0429
Schistosoma mansoni	peroxidasin	0.0231	0.2775	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (ADMET)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1523613

Bibliographic References

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Detailed information for compound 1399200