Detailed information for compound 139926

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.573 | Formula: C26H26N4O5S
  • H donors: 2 H acceptors: 4 LogP: 3.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2ccnc(c2cc1CN1CC[C@@H](C1=O)NS(=O)(=O)c1ccc2c(c1)cc(cc2)OC)N
  • InChi: 1S/C26H26N4O5S/c1-34-20-5-3-16-4-6-21(12-18(16)11-20)36(32,33)29-23-8-10-30(26(23)31)15-19-13-22-17(14-24(19)35-2)7-9-28-25(22)27/h3-7,9,11-14,23,29H,8,10,15H2,1-2H3,(H2,27,28)/t23-/m0/s1
  • InChiKey: RTZPSFNQGNYELJ-QHCPKHFHSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni slit 0.0006 0.0014 0.0018
Echinococcus multilocularis protein jagged 2 0.0006 0.0014 0.0018
Onchocerca volvulus 0.0007 0.0044 0.0079
Schistosoma mansoni ferritin light chain 0.0009 0.0072 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0338
Echinococcus multilocularis neurogenic locus notch protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0046 0.0996 0.1291
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0261 0.0338
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0074 0.0054
Onchocerca volvulus Arrow homolog 0.0016 0.0261 0.0646
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.0096
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0261 0.0679
Toxoplasma gondii hypothetical protein 0.0018 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0181 0.4352 0.5641
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0018 0.0319 0.6983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0044 0.0057
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0044 0.0079
Loa Loa (eye worm) hypothetical protein 0.0131 0.3108 0.4028
Mycobacterium ulcerans hypothetical protein 0.0007 0.0027 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0044 0.0114
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0018 0.0319 0.0414
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0018 0.0319 0.196
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0044 0.0114
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0007 0.0027 0.0035
Leishmania major glutaminyl cyclase, putative 0.0007 0.0027 0.0584
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0074 0.0165
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0019 0.033 0.0428
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0338
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0072 0.0052
Echinococcus granulosus protein jagged 1 0.0006 0.0014 0.0018
Echinococcus multilocularis geminin 0.0181 0.4352 0.5641
Toxoplasma gondii hypothetical protein 0.0007 0.0027 0.0027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0009 0.0074 0.0054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0044 0.0057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0044 0.0057
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0319 0.5355
Schistosoma mansoni notch 0.0006 0.0014 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0788 0.1021
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0402 0.6744
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0159 0.3808 0.3795
Brugia malayi FXNA 0.0007 0.0027 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0319 0.6796
Loa Loa (eye worm) hypothetical protein 0.0161 0.3845 0.4983
Echinococcus granulosus tyrosine protein kinase shark 0.0066 0.1494 0.1937
Brugia malayi leucyl aminopeptidase 0.0007 0.0027 0.007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0044 0.0114
Echinococcus granulosus slit 2 protein 0.0006 0.0014 0.0018
Schistosoma mansoni ferritin 0.0009 0.0072 0.0093
Schistosoma mansoni apoferritin-2 0.0009 0.0072 0.0093
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0044 0.0057
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0044 0.0057
Chlamydia trachomatis dehyroquinate synthase 0.0159 0.3808 0.3795
Entamoeba histolytica hypothetical protein 0.0037 0.0788 0.4833
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0026
Echinococcus granulosus protein jagged 2 0.0006 0.0014 0.0018
Onchocerca volvulus 0.0018 0.0319 0.0798
Brugia malayi nuclear hormone receptor 0.0007 0.0044 0.0114
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Echinococcus multilocularis protein jagged 1 0.0006 0.0014 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Brugia malayi notch-like transmembrane receptor 0.0006 0.0014 0.0035
Echinococcus multilocularis Protein lozenge 0.002 0.0361 0.0467
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.025 0.6053 0.6434
Entamoeba histolytica acyl-CoA synthetase, putative 0.0009 0.0074 0.0455
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0006 0.0014 0.0035
Brugia malayi hypothetical protein 0.0161 0.3845 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0457 0.2807
Treponema pallidum HPr kinase/phosphorylase 0.0383 0.9369 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0044 0.0057
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0007 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0018 0.0319 0.5355
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0018 0.0319 0.0414
Plasmodium vivax importin-beta 2, putative 0.003 0.0597 0.3661
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.01 0.2351 0.3047
Loa Loa (eye worm) notch protein 0.0006 0.0014 0.0018
Echinococcus multilocularis fibropellin Ia 0.0006 0.0014 0.0018
Schistosoma mansoni egf-like domain protein 0.0016 0.0261 0.0338
Echinococcus multilocularis neurogenic locus protein delta 0.0006 0.0014 0.0018
Echinococcus multilocularis fibrillin 1 0.0016 0.0261 0.0338
Echinococcus granulosus neurogenic locus notch protein 0.0006 0.0014 0.0018
Echinococcus granulosus ferritin 0.0009 0.0072 0.0093
Plasmodium vivax acyl-CoA synthetase, putative 0.0006 0.002 0.0124
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Brugia malayi Peptidase family M28 containing protein 0.0007 0.0027 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0044 0.0114
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0044 0.0079
Echinococcus multilocularis tyrosine protein kinase shark 0.0066 0.1494 0.1937
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0074 0.162
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0044 0.0114
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0074 0.0193
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0007 0.0027 0.0035
Schistosoma mansoni tyrosine kinase 0.0064 0.1457 0.1889
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0044 0.0057
Plasmodium falciparum acyl-CoA synthetase 0.0006 0.002 0.0124
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0007 0.0027 0.0164
Echinococcus multilocularis laminin 0.0016 0.0261 0.0338
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0409 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0044 0.0114
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0044 0.0114
Entamoeba histolytica acyl-coA synthetase, putative 0.0009 0.0074 0.0455
Trichomonas vaginalis ran, putative 0.0022 0.0402 0.2469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0044 0.0057
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0071 0.163 1
Schistosoma mansoni tyrosine kinase 0.0066 0.1494 0.1937
Loa Loa (eye worm) hypothetical protein 0.0071 0.163 0.2112
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.0096
Leishmania major hypothetical protein, conserved 0.0007 0.0027 0.0584
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0338
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0026
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0071 0.163 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0007 0.0027 0.0035
Schistosoma mansoni nicalin (M28 family) 0.0007 0.0027 0.0035
Onchocerca volvulus Huntingtin homolog 0.0131 0.3108 0.8077
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0402 0.1046
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0018 0.0319 0.0414
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0071 0.163 0.2112
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0018 0.0319 0.196
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0009 0.0074 0.0054
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0072 0.0159
Entamoeba histolytica hypothetical protein 0.0037 0.0788 0.4833
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0071 0.163 0.2112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0319 0.0414
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0261 0.0338
Schistosoma mansoni notch 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Brugia malayi nicalin 0.0007 0.0027 0.007
Mycobacterium ulcerans hypothetical protein 0.0009 0.0074 0.0054
Echinococcus multilocularis slit 2 protein 0.0006 0.0014 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0068 0.1553 0.2013
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0402 0.0521
Schistosoma mansoni ran 0.0022 0.0402 0.0521
Schistosoma mansoni ran 0.0022 0.0402 0.0521
Echinococcus granulosus importin subunit beta 1 0.003 0.0597 0.0773
Echinococcus granulosus neurogenic locus notch protein 4 0.0006 0.0014 0.0018
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0402 0.2469
Schistosoma mansoni hypothetical protein 0.0181 0.4352 0.5641
Loa Loa (eye worm) hypothetical protein 0.0094 0.2185 0.2832
Toxoplasma gondii peptidase, M28 family protein 0.0007 0.0027 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0044 0.0057
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0072 0.0159
Echinococcus multilocularis protein jagged 1 0.0006 0.0014 0.0018
Loa Loa (eye worm) leucyl aminopeptidase 0.0007 0.0027 0.0035
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Onchocerca volvulus Fxna peptidase homolog 0.0007 0.0027 0.0034
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0007 0.0027 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0044 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0044 0.0114
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0261 0.0338
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0071 0.163 1
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0402 0.0521
Loa Loa (eye worm) Notch2 0.0006 0.0014 0.0018
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0018 0.0319 0.0831
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0071 0.163 1
Brugia malayi Importin beta-1 subunit 0.003 0.0597 0.1552
Echinococcus granulosus Tolloid protein 1 0.0016 0.0261 0.0338
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0261 0.0679
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0044 0.0057
Trichomonas vaginalis ferritin, putative 0.0009 0.0072 0.0442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0044 0.0057
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0018 0.0319 0.196
Brugia malayi ecdysteroid receptor 0.0007 0.0044 0.0114
Mycobacterium tuberculosis Conserved protein 0.0007 0.0027 0.004
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0018 0.0319 0.196
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0071 0.163 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0044 0.0114
Echinococcus multilocularis neurogenic locus protein delta 0.0006 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0317 0.7715 1
Echinococcus granulosus expressed protein 0.0009 0.0072 0.0093
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0074 0.0054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Brugia malayi hypothetical protein 0.0131 0.3108 0.8084
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0014 0.0035
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0071 0.163 0.2112
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0402 0.2469
Schistosoma mansoni importin beta-1 0.003 0.0597 0.0773
Echinococcus granulosus neurogenic locus notch protein 0.0006 0.0014 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0074 0.0193
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0071 0.163 0.4239
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0072 0.0052
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0066 0.1492 0.1934
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.7715 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0044 0.0057
Schistosoma mansoni coup transcription factor 0.0007 0.0044 0.0057
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0009 0.0087 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0044 0.0114
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0044 0.0114
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0007 0.0027 0.0035
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0071 0.163 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0044 0.0114
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0044 0.0057
Echinococcus multilocularis importin subunit beta 1 0.003 0.0597 0.0773
Onchocerca volvulus 0.0161 0.3845 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0044 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0074 0.0054
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Brugia malayi hypothetical protein 0.0037 0.0788 0.2049
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0164
Onchocerca volvulus 0.0009 0.0074 0.0158
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Echinococcus multilocularis expressed protein 0.0009 0.0072 0.0093
Schistosoma mansoni laminin gamma-3 chain 0.0006 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0009 0.0074 0.0455
Loa Loa (eye worm) hypothetical protein 0.0007 0.0027 0.0035
Onchocerca volvulus Tyrosine kinase homolog 0.0043 0.0922 0.2371
Onchocerca volvulus 0.0007 0.0027 0.0034
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0007 0.0027 0.0035
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0006 0.002 0.0023
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0009 0.0074 0.0002
Echinococcus multilocularis neurogenic locus notch protein 4 0.0006 0.0014 0.0018
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0014 0.0035
Brugia malayi Fibulin-1 precursor 0.0016 0.0261 0.0679
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0402 0.8721
Echinococcus multilocularis neural cadherin 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0402 0.0402
Leishmania major importin beta-1 subunit, putative 0.0024 0.0457 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0402 0.8721
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0788 0.1021
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0597 0.0773
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0044 0.0057
Schistosoma mansoni ferritin 0.0009 0.0072 0.0093
Onchocerca volvulus 0.0041 0.0887 0.2281
Brugia malayi steroid hormone receptor 0.0007 0.0044 0.0114
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0044 0.0057
Echinococcus granulosus geminin 0.0181 0.4352 0.5641
Schistosoma mansoni notch 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Echinococcus multilocularis notch 0.0006 0.0014 0.0018
Brugia malayi GCC2 and GCC3 family protein 0.0006 0.0014 0.0035
Entamoeba histolytica hypothetical protein 0.0037 0.0788 0.4833
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0037 0.0788 0.1021
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Echinococcus granulosus fibropellin Ia 0.0006 0.0014 0.0018
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0044 0.0057
Trypanosoma brucei glutaminyl cyclase, putative 0.0007 0.0027 0.0448
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Toxoplasma gondii hypothetical protein 0.0053 0.1171 0.1171
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.0096
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0409 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0009 0.0074 0.0054
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0261 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0044 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0044 0.0114
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Giardia lamblia Rab geranylgeranyltransferase 0.0018 0.0319 0.1893
Loa Loa (eye worm) hypothetical protein 0.0131 0.3108 0.4028
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0018 0.0319 0.0414
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0018 0.0319 0.5355
Loa Loa (eye worm) hypothetical protein 0.0161 0.3845 0.4983
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0044 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0164
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0402 0.2406
Echinococcus granulosus neurogenic locus protein delta 0.0006 0.0014 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0074 0.0193
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0018 0.0319 0.6796
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0597 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0457 0.2807
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0044 0.0057
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0044 0.0057
Onchocerca volvulus Huntingtin homolog 0.0131 0.3108 0.8077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0044 0.0057
Echinococcus granulosus snurportin 1 0.0317 0.7715 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0006 0.0014 0.0018
Schistosoma mansoni Fxna peptidase (M28 family) 0.0007 0.0027 0.0035
Brugia malayi nuclear receptor NHR-88 0.0007 0.0044 0.0114
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Schistosoma mansoni 3-dehydroquinate synthase 0.0159 0.3808 0.4935
Onchocerca volvulus Fxna peptidase homolog 0.0007 0.0027 0.0034
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0261 0.0261
Schistosoma mansoni septate junction protein 0.0006 0.0014 0.0018
Echinococcus multilocularis ferritin 0.0009 0.0072 0.0093
Giardia lamblia Rab geranylgeranyltransferase 0.0071 0.163 1
Leishmania major GTP-binding protein, putative 0.0022 0.0402 0.8795
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0009 0.0074 0.0002
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0009 0.0087 0.02
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0402 0.0521
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0044 0.0057
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.025 0.6053 0.6045
Echinococcus multilocularis neurogenic locus notch protein 0.0006 0.0014 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0044 0.0057
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0014 0.0035
Brugia malayi Muscle positioning protein 4 0.0006 0.0014 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0044 0.0057
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.025 0.6053 0.6045
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0159 0.3808 0.3763
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0018 0.0319 0.6796
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0996 0.2591
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0044 0.0057
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0261 0.0338
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) runx1 0.002 0.0361 0.0467
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0009 0.0074 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0044 0.0057
Echinococcus granulosus protein jagged 1 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0027 0.0035
Onchocerca volvulus Fxna peptidase homolog 0.0007 0.0027 0.0034
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.025 0.6053 1
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0319 0.6796
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0053 0.1171 0.7186
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0044 0.0057
Echinococcus granulosus protein jagged 2 0.0006 0.0014 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0164
Echinococcus granulosus laminin 0.0016 0.0261 0.0338
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0597 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0402 0.2469
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0409 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0044 0.0057
Toxoplasma gondii EGF family domain-containing protein 0.0006 0.0014 0.0014
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0018 0.0319 0.0414
Echinococcus granulosus neural cadherin 0.0006 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Entamoeba histolytica hypothetical protein 0.0037 0.0788 0.4833
Loa Loa (eye worm) hypothetical protein 0.0016 0.0261 0.0338
Schistosoma mansoni notch 0.0006 0.0014 0.0018
Entamoeba histolytica hypothetical protein 0.0024 0.0457 0.2807
Schistosoma mansoni notch 0.0006 0.0014 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0074 0.162
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0159 0.3808 1
Plasmodium falciparum importin beta, putative 0.003 0.0597 0.3661
Echinococcus granulosus delta-like protein 1 0.0006 0.0014 0.0018
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0071 0.163 0.2112
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0044 0.0057
Brugia malayi EGF-like domain containing protein 0.0006 0.0014 0.0035
Brugia malayi Delta serrate ligand family protein 0.0006 0.0014 0.0035
Schistosoma mansoni ferritin 0.0009 0.0072 0.0093
Schistosoma mansoni lozenge 0.002 0.0361 0.0467
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0018 0.0319 0.6796
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0044 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0074 0.0054
Schistosoma mansoni ferritin light chain 0.0009 0.0072 0.0093
Schistosoma mansoni ferritin 0.0009 0.0072 0.0093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0044 0.0057
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0788 0.1021
Brugia malayi Cadherin domain containing protein 0.0006 0.0014 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0074 0.162
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0457 0.2807
Echinococcus multilocularis fat cadherin tumor suppressor 0.0006 0.0014 0.0018
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0159 0.3808 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0057
Brugia malayi RNA, U transporter 1 0.0084 0.1953 0.508
Echinococcus multilocularis snurportin 1 0.0317 0.7715 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0044 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0026
Schistosoma mansoni apoferritin-2 0.0009 0.0072 0.0093
Brugia malayi Cadherin domain containing protein 0.0006 0.0014 0.0035
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0018 0.0319 0.5355
Loa Loa (eye worm) hypothetical protein 0.0103 0.2411 0.3125
Onchocerca volvulus Glutaminyl cyclase homolog 0.0007 0.0027 0.0034
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0018
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0007 0.0027 0.0035
Schistosoma mansoni notch 0.0006 0.0014 0.0018
Schistosoma mansoni cell polarity protein 0.0006 0.0014 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0044 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0007 0.0027 0.0035
Echinococcus granulosus notch 0.0006 0.0014 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.89 uM In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex ChEMBL. 10498204
Ki (binding) = 0.89 uM In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex ChEMBL. 10498204

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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