Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ubiquitin specific protease, putative | ubiquitin specific peptidase 2 | 362 aa | 378 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.21 | 0.21 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0378 | 0.0774 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0896 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1869 | 0.4427 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0896 | 0.0869 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0045 | 0.2077 | 0.5 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0045 | 0.2077 | 0.4545 |
Brugia malayi | Bromodomain containing protein | 0.0088 | 0.5675 | 0.5675 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0564 | 0.1188 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0089 | 0.006 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.2077 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0896 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0564 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2106 | 0.2083 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1869 | 0.4427 |
Brugia malayi | hypothetical protein | 0.003 | 0.0896 | 0.0896 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0045 | 0.2077 | 1 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.2077 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.2077 | 0.4927 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.2077 | 0.4927 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0045 | 0.2077 | 0.4927 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.2077 | 0.4927 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.4534 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2077 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0275 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2077 | 0.2053 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0896 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0275 | 0.0546 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0045 | 0.2077 | 0.4545 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0896 | 0.5 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.2077 | 0.5 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0045 | 0.2077 | 0.5 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.2077 | 0.4927 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.007 | 0.4185 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0564 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2523 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2337 | 0.2314 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.2077 | 0.5 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0045 | 0.2077 | 0.4927 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.5259 | 0.5245 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0275 | 0.0592 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.007 | 0.4185 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0795 | 0.0795 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.2077 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0378 | 0.035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.