Detailed information for compound 1400084

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.589 | Formula: C23H40N4O3
  • H donors: 2 H acceptors: 3 LogP: 4.77 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1CCC(CC1)C(=O)N(c1c(=O)[nH]c(=O)n(c1N)CCCC)CCCC
  • InChi: 1S/C23H40N4O3/c1-4-7-10-17-11-13-18(14-12-17)22(29)26(15-8-5-2)19-20(24)27(16-9-6-3)23(30)25-21(19)28/h17-18H,4-16,24H2,1-3H3,(H,25,28,30)
  • InChiKey: MFGUMQDQSZWCCQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Cyclin dependent kinase 2 associated protein 0.2982 0.304 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0083 0.0061 1
Leishmania major UDP-galactopyranose mutase 0.0083 0.0061 0.6502
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.006 0.0067
Echinococcus granulosus peregrin 0.0029 0.0006 0.0001
Onchocerca volvulus 0.0082 0.006 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0037 0.0038
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0061 0.6291
Brugia malayi heat shock protein 90 0.0035 0.0013 0.0007
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Trypanosoma brucei polo-like protein kinase 0.0115 0.0095 1
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Echinococcus multilocularis protoporphyrinogen oxidase 0.0083 0.0061 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Schistosoma mansoni hypothetical protein 0.0068 0.0046 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0012 0.0008
Echinococcus multilocularis peregrin 0.0029 0.0006 0.0001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0019 0.0016
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.8015 0.8211 1
Giardia lamblia Kinase, PLK 0.0115 0.0095 1
Schistosoma mansoni kinase 0.0069 0.0048 0.0051
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0083 0.0061 0.0068
Mycobacterium ulcerans hypothetical protein 0.0043 0.0021 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0033 0.0091
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0018 0.1563
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0055 0.0033 0.0033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0021 0.0191
Schistosoma mansoni chromobox protein 0.0069 0.0047 0.005
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0018 0.1563
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0095 0.0108
Schistosoma mansoni endoplasmin 0.0035 0.0013 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0118
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0021 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0061 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0021 0.0019
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0095 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Loa Loa (eye worm) hypothetical protein 0.0068 0.0046 0.0049
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Onchocerca volvulus 0.0043 0.0021 0.005
Loa Loa (eye worm) endoplasmin 0.0035 0.0013 0.0008
Chlamydia trachomatis protoporphyrinogen oxidase 0.0083 0.0061 1
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0061 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0047 0.4709
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0095 1
Brugia malayi Heterochromatin protein 1 0.0069 0.0047 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0021 0.1851
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0009 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0012 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0118
Mycobacterium ulcerans oxidoreductase 0.0083 0.0061 0.0519
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0166 0.0529
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0009 0.0003
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0005 0.0049
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Brugia malayi hypothetical protein 0.0083 0.0061 0.0056
Schistosoma mansoni hypothetical protein 0.0337 0.0323 0.0386
Onchocerca volvulus 0.003 0.0007 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.0221 0.0262
Echinococcus multilocularis heat shock protein 0.0035 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Brugia malayi MH2 domain containing protein 0.0238 0.0221 0.0215
Plasmodium falciparum plasmepsin VI 0.0055 0.0033 0.5369
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0021 0.0019
Echinococcus multilocularis chromobox protein 1 0.0069 0.0047 0.0137
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.0444 0.1445
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.0166 0.0529
Schistosoma mansoni amine oxidase 0.0083 0.0061 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0078 0.0073
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0005 1
Toxoplasma gondii aspartyl protease ASP1 0.0055 0.0033 0.5369
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0018 0.1948
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Echinococcus multilocularis 0.0083 0.0061 0.0185
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.006 0.0181
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0013 0.2083
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Echinococcus granulosus neuropeptide s receptor 0.0455 0.0444 0.1445
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0095 0.0292
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0078 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0021 0.0019
Brugia malayi jmjC domain containing protein 0.0094 0.0073 0.0067
Plasmodium vivax aspartyl proteinase, putative 0.0055 0.0033 0.5369
Echinococcus granulosus heat shock protein 0.0035 0.0013 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Schistosoma mansoni hypothetical protein 0.0035 0.0013 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0021 0.1851
Brugia malayi beta-lactamase 0.0043 0.0021 0.0015
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0018 0.1948
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0021 0.3419
Mycobacterium tuberculosis Conserved protein 0.0043 0.0021 0.0191
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0016
Brugia malayi Endoplasmin precursor 0.0035 0.0013 0.0007
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.0221 0.0262
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0016 0.1278
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0013 0.0941
Leishmania major hypothetical protein, conserved 0.0043 0.0021 0.2223
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0118
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Echinococcus granulosus chromobox protein 1 0.0069 0.0047 0.0137
Loa Loa (eye worm) hypothetical protein 0.0038 0.0016 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0033 0.0091
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0095 1
Brugia malayi beta-lactamase family protein 0.0043 0.0021 0.0015
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0019 0.0044
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Echinococcus multilocularis heat shock protein 90 0.0035 0.0013 0.0024
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0013 0.2083
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1094 0.11 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1177 0.1185 1
Plasmodium vivax endoplasmin, putative 0.0035 0.0013 0.2083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0021 0.0015
Trichomonas vaginalis esterase, putative 0.0043 0.0021 0.1851
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Brugia malayi Protein kinase domain containing protein 0.8015 0.8211 0.821
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0166 0.0529
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0013 0.1354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0033 0.0033
Mycobacterium tuberculosis Conserved protein 0.0043 0.0021 0.0191
Echinococcus granulosus heat shock protein 90 0.0035 0.0013 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0018 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0021 0.1754
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0033 0.0091
Plasmodium vivax plasmepsin IV, putative 0.0055 0.0033 0.5369
Loa Loa (eye worm) hypothetical protein 0.0055 0.0033 0.0033
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0073 0.0223
Mycobacterium ulcerans beta-lactamase 0.0043 0.0021 0.0177
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0021 0.0191
Schistosoma mansoni deleted in oral cancer 1/cdk2-associated protein-like 0.2982 0.304 0.3698
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0013 0.0832
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0053 0.0058
Echinococcus granulosus geminin 0.0337 0.0323 0.1046
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0095 0.0294
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0013 0.0832
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0095 1
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0047 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0046 0.004
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0055 0.0033 0.318
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0021 0.1851
Onchocerca volvulus 0.0043 0.0021 0.005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0021 0.0191
Plasmodium falciparum plasmepsin IV 0.0055 0.0033 0.5369
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0021 0.3419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0078 0.0073
Onchocerca volvulus 0.0107 0.0086 0.0264
Plasmodium falciparum phd finger protein, putative 0.0029 0.0006 0.0949
Brugia malayi hypothetical protein 0.0035 0.0013 0.0007
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0083 0.0061 1
Plasmodium falciparum plasmepsin II 0.0055 0.0033 0.5369
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0009 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0016 0.1278
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0018 0.0043
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0083 0.0061 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0018 0.1462
Mycobacterium tuberculosis Conserved protein 0.0043 0.0021 0.0191
Schistosoma mansoni alpha-glucosidase 0.0159 0.014 0.0163
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0009 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0019 0.161
Schistosoma mansoni cathepsin D (A01 family) 0.0163 0.0143 0.0168
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.0444 0.1445
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0021 0.0052
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0055 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0021 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0033 0.0091
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0061 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0021 0.0177
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0019 0.0043
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0061 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0095 0.0108
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Schistosoma mansoni heat shock protein 0.0035 0.0013 0.0008
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0013 0.0832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0033 0.0027
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.0166 0.0195
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0061 0.0559
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0046 0.4655
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0018 0.2996
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0019 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0021 0.1851
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Echinococcus granulosus chromobox protein 1 0.0069 0.0047 0.0137
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0061 0.0185
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0005 0.0045
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0016
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0083 0.0061 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Plasmodium falciparum plasmepsin I 0.0055 0.0033 0.5369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0016 0.0033
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Echinococcus multilocularis GPCR, family 2 0.0031 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0021 0.0191
Schistosoma mansoni endoplasmin 0.0035 0.0013 0.0008
Schistosoma mansoni alpha-glucosidase 0.0159 0.014 0.0163
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0019 0.0013
Schistosoma mansoni cathepsin D (A01 family) 0.0163 0.0143 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.8015 0.8211 1
Schistosoma mansoni chromobox protein 0.0069 0.0047 0.005
Schistosoma mansoni amine oxidase 0.0083 0.0061 0.0068
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0083 0.0061 0.0519
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0018 0.1563
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0013 0.0024
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0018 0.0043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0018 0.0015
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0013 0.2083
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0016
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0055 0.0033 0.0091
Echinococcus granulosus expressed protein 0.0367 0.0354 0.1148
Treponema pallidum heat shock protein 90 0.0028 0.0005 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0005 0.0569
Schistosoma mansoni alpha glucosidase 0.0041 0.0018 0.0015
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0018 0.1563
Schistosoma mansoni hypothetical protein 0.0337 0.0323 0.0386
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0006 0.0949
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0021 0.0052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0021 0.0177
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0013 0.0832
Brugia malayi jmjC domain containing protein 0.0035 0.0012 0.0006
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0021 0.0019
Toxoplasma gondii ABC1 family protein 0.0043 0.0021 0.3419
Echinococcus multilocularis Cyclin dependent kinase 2 associated protein 0.2982 0.304 1
Schistosoma mansoni heat shock protein 0.0035 0.0013 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0021 0.1754
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0083 0.0061 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0009 0.0011
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0095 0.0294
Echinococcus granulosus jumonji domain containing protein 0.004 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.006 0.0067
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0061 0.6291
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0021 0.0191
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0018 0.1563
Entamoeba histolytica hypothetical protein 0.0035 0.0013 0.1347
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0055 0.0033 0.5369
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0005 0.0875
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0013 0.0024
Mycobacterium leprae Probable lipase LipE 0.0043 0.0021 0.3419
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0006 0.0001
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0083 0.0061 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0095 0.0089
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Onchocerca volvulus 0.0043 0.0021 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0018 0.1462
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0083 0.0061 0.0185
Echinococcus multilocularis geminin 0.0337 0.0323 0.1046
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0021 0.1851
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0013 0.0008
Mycobacterium ulcerans dehydrogenase 0.0083 0.0061 0.0519
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.0166 0.016
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0019 0.161
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.006 0.0055
Brugia malayi chromobox protein homolog 3 0.0038 0.0016 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.0444 0.1445
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Trypanosoma brucei glucosidase, putative 0.0041 0.0018 0.1948
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0013 0.0832
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0083 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0019
Mycobacterium tuberculosis Possible oxidoreductase 0.0083 0.0061 0.0559
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.2982 0.304 0.3698
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0046 0.4655
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0009 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Brugia malayi beta-lactamase family protein 0.0043 0.0021 0.0015
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0055 0.0033 0.0091
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0073 0.0223
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0012 0.0008
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0013 0.1354
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0006 0.0949
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0019 0.0044
Brugia malayi amine oxidase, flavin-containing family protein 0.0083 0.0061 0.0056
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0018 0.1948
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0262 0.2379
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0009 0.0003
Onchocerca volvulus Diphthamide biosynthesis protein 7 homolog 0.2982 0.304 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0006 0.0001
Toxoplasma gondii histone lysine-specific demethylase 0.0083 0.0061 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0013 0.1354
Leishmania major heat shock protein 83-1 0.0035 0.0013 0.1354
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0012 0.0008
Echinococcus multilocularis expressed protein 0.0367 0.0354 0.1148
Plasmodium falciparum heat shock protein 90 0.0035 0.0013 0.2083
Mycobacterium ulcerans monoamine oxidase 0.0083 0.0061 0.0519
Giardia lamblia PHD finger protein 15 0.0029 0.0006 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0006 0.0949
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Onchocerca volvulus 0.0083 0.0061 0.0183
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0017 0.004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1177 0.1185 1
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0013 0.1354
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0021 0.2223
Echinococcus multilocularis chromobox protein 1 0.0069 0.0047 0.0137
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0099 0.0078 0.0088
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0013 0.0832
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Brugia malayi SWIRM domain containing protein 0.0083 0.0061 0.0056
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.0068
Echinococcus granulosus GPCR family 2 0.0031 0.0009 0.0011
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.006 0.0181
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0021 0.0191
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0013 0.1354
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0047 0.4709
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0013 0.1354

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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