Detailed information for compound 140015

Basic information

Technical information
  • TDR Targets ID: 140015
  • Name: (2S)-3-[4-[3-(4-methylpiperazin-1-yl)propoxy] phenyl]-2-(phenylmethoxycarbonylamino)propano ic acid
  • MW: 455.547 | Formula: C25H33N3O5
  • H donors: 2 H acceptors: 3 LogP: 0.92 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCCOc1ccc(cc1)C[C@@H](C(=O)O)NC(=O)OCc1ccccc1
  • InChi: 1S/C25H33N3O5/c1-27-13-15-28(16-14-27)12-5-17-32-22-10-8-20(9-11-22)18-23(24(29)30)26-25(31)33-19-21-6-3-2-4-7-21/h2-4,6-11,23H,5,12-19H2,1H3,(H,26,31)(H,29,30)/t23-/m0/s1
  • InChiKey: ZVGNEAQCBGKTTQ-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-(benzyloxycarbonylamino)-3-[4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]propanoic acid
  • (2S)-2-(benzyloxycarbonylamino)-3-[4-[3-(4-methyl-1-piperazinyl)propoxy]phenyl]propanoic acid
  • (2S)-2-(benzyloxycarbonylamino)-3-[4-[3-(4-methylpiperazino)propoxy]phenyl]propionic acid
  • (2S)-3-[4-[3-(4-methyl-1-piperazinyl)propoxy]phenyl]-2-[[oxo-(phenylmethoxy)methyl]amino]propanoic acid
  • (2S)-2-(benzyloxycarbonylamino)-3-[4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum ko:K06476 integrin alpha 2B, putative Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) integrin alpha pat-2 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma mansoni integrin alpha Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Brugia malayi Integrin alpha pat-2 precursor Get druggable targets OG5_129341 All targets in OG5_129341
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.0553 0.0534
Loa Loa (eye worm) hypothetical protein 0.0145 0.1782 0.1766
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.0498
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Loa Loa (eye worm) glutaminase 2 0.0179 0.2226 0.2211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0938 0.2124
Brugia malayi Carboxylesterase family protein 0.0058 0.0656 0.0637
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0043
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0393 0.0864
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.006 0.0682 0.1531
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0045 0.0488 0.1083
Schistosoma mansoni hypothetical protein 0.0241 0.303 0.6965
Schistosoma mansoni zinc finger protein 0.0038 0.0393 0.0864
Brugia malayi Integrin alpha cytoplasmic region family protein 0.014 0.1714 0.1697
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.2893
Schistosoma mansoni neuroligin 3 (S09 family) 0.0058 0.0656 0.1472
Onchocerca volvulus 0.0058 0.0656 0.6779
Mycobacterium ulcerans aldehyde dehydrogenase 0.0091 0.1087 0.4725
Loa Loa (eye worm) acetylcholinesterase 1 0.0343 0.4342 0.4331
Schistosoma mansoni integrin alpha-ps 0.0083 0.0978 0.2216
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0393 0.0374
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.0498
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0255 0.4631
Entamoeba histolytica hypothetical protein 0.0066 0.076 0.3099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.0031 0.0129
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0393 0.0864
Trichomonas vaginalis spcc417.12 protein, putative 0.0058 0.0656 0.2749
Mycobacterium ulcerans glutaminase 0.0179 0.2226 1
Brugia malayi steroid hormone receptor 0.008 0.0938 0.092
Brugia malayi hypothetical protein 0.0066 0.076 0.0742
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0451 0.0999
Echinococcus multilocularis GPCR, family 2 0.0045 0.0488 0.1083
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0047 0.0367
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0142 0.1744 0.1727
Echinococcus granulosus dna polymerase eta 0.0009 0.0029 0.0022
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0066 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0274 0.3451 0.7939
Echinococcus granulosus Polycystic kidney disease protein 0.0012 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.0343 0.4342 0.4331
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0134 0.0317
Echinococcus granulosus dna polymerase kappa 0.0027 0.0255 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.006 0.0682 0.1531
Schistosoma mansoni cpg binding protein 0.0021 0.0175 0.0358
Brugia malayi Steroid receptor seven-up type 2 0.008 0.0938 0.092
Schistosoma mansoni hypothetical protein 0.0045 0.0488 0.1083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0066
Schistosoma mansoni polycystin 1-related 0.0012 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Brugia malayi Heterochromatin protein 1 0.0032 0.0315 0.0295
Schistosoma mansoni chromobox protein 0.0032 0.0315 0.0682
Echinococcus granulosus beta LACTamase domain containing family member 0.0047 0.0517 0.1149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0938 0.2124
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0656 0.166
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0066 0.0749
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0301 0.3804 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 0.0938 0.092
Schistosoma mansoni rab6-interacting 0.0012 0.0063 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.006 0.0682 0.1531
Mycobacterium ulcerans DNA polymerase IV 0.0027 0.0255 0.0875
Loa Loa (eye worm) hypothetical protein 0.0043 0.0464 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Loa Loa (eye worm) hypothetical protein 0.0102 0.1225 0.1207
Schistosoma mansoni ap endonuclease 0.0012 0.0066 0.0106
Schistosoma mansoni terminal deoxycytidyl transferase 0.0009 0.0029 0.0022
Brugia malayi Doublecortin family protein 0.0012 0.0063 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.006 0.0682 0.1531
Brugia malayi Carboxylesterase family protein 0.0058 0.0656 0.0637
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 0.0938 0.2124
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0028 0.0272 0.1139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0091 0.1087 0.2801
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0009 0.0029 0.001
Onchocerca volvulus 0.002 0.016 0.1116
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0072 0.084 0.1896
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0393 0.0374
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0938 0.092
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0009 0.0029 0.0022
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0134 0.0115
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0058 0.0656 0.1472
Brugia malayi beta-lactamase family protein 0.0047 0.0517 0.0498
Schistosoma mansoni rab6-interacting 0.0012 0.0063 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 0.0938 0.092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0047 0.0517 0.0498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Echinococcus granulosus chromobox protein 1 0.0032 0.0315 0.0682
Brugia malayi ecdysteroid receptor 0.008 0.0938 0.092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.001 0.0031 0.0129
Loa Loa (eye worm) hypothetical protein 0.0042 0.0451 0.0432
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0192 0.2387 1
Schistosoma mansoni cpg binding protein 0.002 0.016 0.0325
Mycobacterium ulcerans lipase LipD 0.0047 0.0517 0.2086
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0019 0.0153 0.1031
Brugia malayi CXXC zinc finger family protein 0.002 0.016 0.0141
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0051 0.0571 0.1275
Echinococcus granulosus carboxylesterase 5A 0.0343 0.4342 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 0.0938 0.092
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0393 0.0864
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.003 0.0298 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0517 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.0018
Echinococcus granulosus integrin alpha ps 0.0083 0.0978 0.2216
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 0.0938 0.092
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.0498
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0315 0.1319
Brugia malayi Integrin alpha pat-2 precursor 0.0185 0.2296 0.228
Brugia malayi latrophilin 2 splice variant baaae 0.0097 0.1162 0.1145
Onchocerca volvulus 0.0014 0.0086 0.0268
Mycobacterium tuberculosis Probable lipase LipD 0.0047 0.0517 0.1291
Toxoplasma gondii histone lysine methyltransferase SET1 0.0037 0.0387 0.3559
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0393 0.0864
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0938 0.092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0445 0.0983
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0199 0.3482
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0393 0.0864
Brugia malayi follicle stimulating hormone receptor 0.0158 0.1952 0.1936
Schistosoma mansoni hypothetical protein 0.0045 0.0488 0.1083
Brugia malayi nuclear hormone receptor 0.008 0.0938 0.092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0136 0.1666 0.3809
Echinococcus multilocularis integrin alpha ps 0.0083 0.0978 0.2216
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0045 0.0488 0.1083
Echinococcus multilocularis integrin alpha ps 0.0083 0.0978 0.2216
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Schistosoma mansoni hypothetical protein 0.004 0.042 0.0926
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0194 0.242 0.5552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 0.0938 0.092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.008 0.0938 0.092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Brugia malayi nuclear receptor NHR-88 0.008 0.0938 0.092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Onchocerca volvulus Protein ultraspiracle homolog 0.008 0.0938 1
Onchocerca volvulus 0.0047 0.0517 0.5187
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0047 0.0517 0.1291
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.2893
Brugia malayi nuclear receptor RXR 0.0038 0.0393 0.0374
Toxoplasma gondii aldehyde dehydrogenase 0.0091 0.1087 1
Schistosoma mansoni hypothetical protein 0.0045 0.0488 0.1083
Schistosoma mansoni nuclear receptor 0.0038 0.0393 0.0864
Loa Loa (eye worm) doublecortin family protein 0.0012 0.0063 0.0043
Trichomonas vaginalis DNA polymerase eta, putative 0.0027 0.0255 0.1069
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Leishmania major DNA polymerase kappa, putative 0.0014 0.0085 0.0529
Brugia malayi hypothetical protein 0.0058 0.0656 0.0637
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0066 0.0106
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0094 0.1118 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.006 0.0682 0.1531
Echinococcus multilocularis chromobox protein 1 0.0032 0.0315 0.0682
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0047 0.0367
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0393 0.0374
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0031 0.0129
Loa Loa (eye worm) steroid hormone receptor 0.008 0.0938 0.092
Echinococcus granulosus acetylcholinesterase 0.0343 0.4342 1
Loa Loa (eye worm) carboxylesterase 0.0058 0.0656 0.0637
Onchocerca volvulus 0.0058 0.0656 0.6779
Schistosoma mansoni hypothetical protein 0.0042 0.0446 0.0987
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.006 0.0682 0.1531
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Echinococcus multilocularis acetylcholinesterase 0.0343 0.4342 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0393 0.0864
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0058 0.0656 0.2749
Brugia malayi ecdysone receptor 0.0038 0.0393 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Echinococcus multilocularis carboxylesterase 5A 0.0343 0.4342 1
Leishmania major hypothetical protein, conserved 0.0047 0.0517 0.4608
Schistosoma mansoni aldehyde dehydrogenase 0.0091 0.1087 0.2468
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0938 0.092
Onchocerca volvulus 0.0058 0.0656 0.6779
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0158 0.1952 0.1936
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Mycobacterium tuberculosis Probable lipase LipE 0.0047 0.0517 0.1291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.076 0.1712
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0031 0.0129
Schistosoma mansoni hypothetical protein 0.0241 0.303 0.6965
Brugia malayi Cytochrome P450 family protein 0.0018 0.0134 0.0115
Echinococcus multilocularis Polycystic kidney disease protein 0.0012 0.0063 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.076 0.1712
Mycobacterium ulcerans aldehyde dehydrogenase 0.0091 0.1087 0.4725
Mycobacterium tuberculosis Carboxylesterase LipT 0.0058 0.0656 0.166
Schistosoma mansoni hypothetical protein 0.0194 0.242 0.5552
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0066 0.0155
Brugia malayi Carboxylesterase family protein 0.0343 0.4342 0.4331
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0069 0.0287
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 0.0938 0.2124
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.076 0.1712
Echinococcus multilocularis beta LACTamase domain containing family member 0.0047 0.0517 0.1149
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 0.0938 0.2124
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0938 0.2124
Onchocerca volvulus 0.0038 0.0393 0.3776
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0134 0.2153
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0066 0.0749
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0134 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0451 0.0432
Mycobacterium tuberculosis Probable esterase LipL 0.0047 0.0517 0.1291
Echinococcus granulosus jun protein 0.0051 0.0571 0.1275
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0451 0.0999
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 0.0938 0.2124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0031 0.0129
Onchocerca volvulus 0.008 0.0938 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.008 0.0938 0.2124
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0063 0.0099
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0018 0.0135 0.0832
Mycobacterium ulcerans DNA polymerase IV 0.0027 0.0255 0.0875
Toxoplasma gondii exonuclease III APE 0.0012 0.0066 0.0601
Echinococcus multilocularis RUN 0.0012 0.0063 0.0099
Schistosoma mansoni cpg binding protein 0.0021 0.0175 0.0358
Brugia malayi hypothetical protein 0.0042 0.0451 0.0432
Schistosoma mansoni thyroid hormone receptor 0.0274 0.3451 0.7939
Echinococcus granulosus para nitrobenzyl esterase 0.0058 0.0656 0.1472
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.0498
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0393 0.0864
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0656 0.1472
Loa Loa (eye worm) hypothetical protein 0.078 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0938 0.092
Loa Loa (eye worm) beta-lactamase 0.0047 0.0517 0.0498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0246 0.0227
Echinococcus multilocularis chromobox protein 1 0.0032 0.0315 0.0682
Schistosoma mansoni hypothetical protein 0.0279 0.352 0.8097
Mycobacterium tuberculosis Probable hydrolase 0.0047 0.0517 0.1291
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0393 0.0864
Brugia malayi nuclear receptor NHR-67 0.0038 0.0393 0.0374
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 0.0938 0.2124
Echinococcus granulosus BC026374 protein S09 family 0.0058 0.0656 0.1472
Loa Loa (eye worm) hypothetical protein 0.0042 0.0451 0.0432
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0066 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 0.0938 0.092
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0938 0.092
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0047 0.0367
Brugia malayi hypothetical protein 0.0042 0.0451 0.0432
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0517 0.2165
Echinococcus granulosus RUN 0.0012 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0066 0.0106
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0058 0.0656 0.1472
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0393 0.0864
Brugia malayi ImpB/MucB/SamB family protein 0.0009 0.0029 0.001
Mycobacterium ulcerans beta-lactamase 0.0047 0.0517 0.2086
Trichomonas vaginalis penicillin-binding protein, putative 0.0047 0.0517 0.2165
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0063 0.0099
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0656 0.166
Brugia malayi hypothetical protein 0.0012 0.0063 0.0043
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0066 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0194 0.242 0.5552
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Onchocerca volvulus 0.0058 0.0656 0.6779
Toxoplasma gondii ABC1 family protein 0.0047 0.0517 0.4751
Brugia malayi ImpB/MucB/SamB family protein 0.0009 0.0029 0.001
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Loa Loa (eye worm) hypothetical protein 0.0042 0.0451 0.0432
Schistosoma mansoni chromobox protein 0.0032 0.0315 0.0682
Schistosoma mansoni hypothetical protein 0.0097 0.1162 0.2644
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0091 0.1087 0.2468
Schistosoma mansoni RAR-like nuclear receptor 0.008 0.0938 0.2124
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0085 0.0148
Brugia malayi beta-lactamase 0.0047 0.0517 0.0498
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0049
Giardia lamblia DINP protein human, muc B family 0.0014 0.0085 0.0084
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.006 0.0682 0.0663
Brugia malayi hypothetical protein 0.004 0.0428 0.0409
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0517 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0045 0.0488 0.1083
Trypanosoma brucei unspecified product 0.0023 0.0199 0.3482
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0072 0.084 0.1896
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0047 0.0517 0.1291
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0656 0.1472
Echinococcus granulosus integrin alpha ps 0.004 0.042 0.0926
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0393 0.0864
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0028 0.0272 0.1139
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0393 0.0374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0047 0.0517 0.1149
Echinococcus granulosus geminin 0.0241 0.303 0.6965
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0009 0.0029 0.0022
Treponema pallidum fructose-bisphosphate aldolase 0.0192 0.2387 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0066 0.5
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0094 0.1118 0.2884
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0393 0.3776
Brugia malayi polk-prov protein 0.002 0.017 0.0151
Schistosoma mansoni jun-related protein 0.0042 0.0446 0.0987
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0451 0.0999
Echinococcus multilocularis thyroid hormone receptor alpha 0.0274 0.3451 0.7939
Schistosoma mansoni loxhd1 0.0012 0.0063 0.0099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0.0066 0.0749
Echinococcus granulosus FTZ F1 alpha 0.008 0.0938 0.2124
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0451 0.0432
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 0.0938 0.2124
Loa Loa (eye worm) carboxylesterase 0.0058 0.0656 0.0637
Echinococcus granulosus acetylcholinesterase 0.0343 0.4342 1
Echinococcus multilocularis ecdysone induced protein 78C 0.008 0.0938 0.2124
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.016 0.0141
Echinococcus multilocularis acetylcholinesterase 0.0343 0.4342 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0047 0.0517 0.2086
Brugia malayi Calcitonin receptor-like protein seb-1 0.0142 0.1744 0.1727
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 0.0938 0.2124
Brugia malayi hypothetical protein 0.0012 0.0063 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0334 0.0726
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0012 0.0066 0.0097
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0.0066 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Echinococcus granulosus chromobox protein 1 0.0032 0.0315 0.0682
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0134 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0135 0.0567
Onchocerca volvulus 0.0047 0.0517 0.5187
Echinococcus multilocularis dnaJ subfamily B 0.0279 0.352 0.8097
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0315 0.1319
Echinococcus multilocularis integrin alpha ps 0.004 0.042 0.0926
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0091 0.1087 0.4725
Echinococcus multilocularis cpg binding protein 0.0021 0.0175 0.0358
Trichomonas vaginalis glutaminase, putative 0.0179 0.2226 0.9328
Loa Loa (eye worm) heterochromatin protein 1 0.0032 0.0315 0.0295
Loa Loa (eye worm) hypothetical protein 0.0097 0.1162 0.1145
Onchocerca volvulus 0.0058 0.0656 0.6779
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0031 0.0129
Schistosoma mansoni BC026374 protein (S09 family) 0.0058 0.0656 0.1472
Brugia malayi Nuclear hormone receptor family member nhr-49 0.008 0.0938 0.092
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.008 0.0938 0.2124
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0517 0.2165
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0135 0.0567
Schistosoma mansoni hypothetical protein 0.0045 0.0488 0.1083
Brugia malayi chromobox protein homolog 3 0.0018 0.0135 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 0.0938 0.092
Loa Loa (eye worm) DR-78 0.0038 0.0393 0.0374
Brugia malayi photoreceptor-specific nuclear receptor 0.008 0.0938 0.092
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0051 0.0571 0.1275
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 0.0938 0.2124
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0298 0.0643
Echinococcus multilocularis FTZ F1 alpha 0.008 0.0938 0.2124
Onchocerca volvulus 0.0038 0.0393 0.3776
Onchocerca volvulus Bile acid receptor homolog 0.008 0.0938 1
Schistosoma mansoni lipoxygenase 0.005 0.0559 0.1247
Schistosoma mansoni ap endonuclease 0.0012 0.0066 0.0106
Echinococcus granulosus integrin alpha 3 0.0142 0.1738 0.3975
Loa Loa (eye worm) hypothetical protein 0.0142 0.1744 0.1727
Brugia malayi Carboxylesterase family protein 0.0058 0.0656 0.0637
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0134 0.2153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 0.0938 0.2124
Brugia malayi Cytochrome P450 family protein 0.0018 0.0134 0.0115
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0451 0.0999
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0091 0.1087 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0085 0.0529
Echinococcus granulosus cpg binding protein 0.0021 0.0175 0.0358
Loa Loa (eye worm) hypothetical protein 0.0045 0.0488 0.0469
Brugia malayi Latrophilin receptor protein 2 0.0045 0.0488 0.0469
Loa Loa (eye worm) carboxylesterase 0.0343 0.4342 0.4331
Brugia malayi glutaminase DH11.1 0.0179 0.2226 0.2211
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0091 0.1087 0.2468
Trichomonas vaginalis esterase, putative 0.0047 0.0517 0.2165
Schistosoma mansoni glutaminase 0.0179 0.2226 0.5105
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0094 0.1118 0.4871
Brugia malayi tailless protein 0.0038 0.0393 0.0374
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0334 0.0726
Loa Loa (eye worm) hypothetical protein 0.0047 0.0517 0.0498
Onchocerca volvulus 0.0047 0.0517 0.5187
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Brugia malayi nuclear receptor NHR-88 0.0038 0.0393 0.0374
Mycobacterium ulcerans carboxylesterase, LipT 0.0058 0.0656 0.2732
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0085 0.1149
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0153 0.064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0451 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 0.0938 0.092
Brugia malayi Carboxylesterase family protein 0.0058 0.0656 0.0637
Schistosoma mansoni integrin alpha-ps 0.0043 0.0464 0.1028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 0.0938 0.2124
Loa Loa (eye worm) hypothetical protein 0.0343 0.4342 0.4331
Schistosoma mansoni nuclear receptor 0.0038 0.0393 0.0864
Schistosoma mansoni lipoxygenase 0.0072 0.084 0.1896
Entamoeba histolytica hypothetical protein 0.0066 0.076 0.3099
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0393 0.3776
Schistosoma mansoni gliotactin 0.0058 0.0656 0.1472
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0393 0.0864
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0063 0.0099
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.014 0.1714 0.1697
Brugia malayi beta-lactamase family protein 0.0047 0.0517 0.0498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0031 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0069 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 0.0938 0.092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0938 0.092
Echinococcus granulosus dnaJ subfamily B 0.0279 0.352 0.8097
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0343 0.4342 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0058 0.0656 0.1472
Schistosoma mansoni integrin alpha 0.0185 0.2296 0.5265
Entamoeba histolytica hypothetical protein 0.0066 0.076 0.3099
Brugia malayi Carboxylesterase family protein 0.0343 0.4342 0.4331
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0009 0.0029 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0656 0.1472
Onchocerca volvulus 0.004 0.0428 0.4176
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0393 0.0864
Echinococcus multilocularis dna polymerase kappa 0.0027 0.0255 0.0544
Echinococcus multilocularis jun protein 0.0051 0.0571 0.1275
Leishmania major cytochrome p450-like protein 0.0018 0.0134 0.0992
Echinococcus multilocularis dna polymerase eta 0.0009 0.0029 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0938 0.2124
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0393 0.0374
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0153 0.064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0142 0.1744 0.1727
Schistosoma mansoni hypothetical protein 0.0066 0.076 0.1712
Trichomonas vaginalis penicillin-binding protein, putative 0.0047 0.0517 0.2165
Brugia malayi nuclear receptor RXR 0.0042 0.0451 0.0432
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0094 0.1121 0.2548
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0255 0.4631
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0045 0.0488 0.1083
Loa Loa (eye worm) integrin alpha pat-2 0.0285 0.3589 0.3577
Echinococcus granulosus GPCR family 2 0.0045 0.0488 0.1083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.006 0.0682 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0938 0.092
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0393 0.0374
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0401
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0393 0.0374
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 0.0938 0.2124
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0255 0.4631
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0047 0.0517 0.0498
Brugia malayi bZIP transcription factor family protein 0.0051 0.0571 0.0552
Echinococcus multilocularis integrin alpha 3 0.0142 0.1738 0.3975
Echinococcus multilocularis geminin 0.0241 0.303 0.6965
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0116
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 0.0938 1
Mycobacterium ulcerans esterase/lipase LipP 0.0047 0.0517 0.2086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0393 0.0864
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0393 0.0864
Loa Loa (eye worm) hypothetical protein 0.0058 0.0656 0.0637
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0393 0.0864
Echinococcus granulosus neuroligin 0.0058 0.0656 0.1472
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0192 0.2387 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Mycobacterium tuberculosis Conserved protein 0.0047 0.0517 0.1291
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0066 0.0276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.006 0.0682 0.1531
Loa Loa (eye worm) latrophilin receptor protein 2 0.0045 0.0488 0.0469
Mycobacterium ulcerans hypothetical protein 0.0047 0.0517 0.2086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0045 0.0488 0.0469
Brugia malayi conserved hypotetical protein 0.0038 0.0393 0.0374
Schistosoma mansoni hypothetical protein 0.0012 0.0063 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.001 0.0031 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0047 0.0517 0.1149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Entamoeba histolytica hypothetical protein 0.0066 0.076 0.3099
Giardia lamblia Fructose-bisphosphate aldolase 0.0192 0.2387 1
Echinococcus multilocularis neuroligin 0.0058 0.0656 0.1472
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 0.0938 0.092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Mycobacterium tuberculosis Conserved protein 0.0047 0.0517 0.1291
Brugia malayi hypothetical protein 0.0038 0.0393 0.0374
Schistosoma mansoni DNA polymerase eta 0.0009 0.0029 0.0022
Brugia malayi hypothetical protein 0.0038 0.0393 0.0374
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0192 0.2387 1
Loa Loa (eye worm) glutaminase 0.0179 0.2226 0.2211
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0517 1
Schistosoma mansoni coup transcription factor 0.008 0.0938 0.2124
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0393 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.017 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 0.0938 0.092
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0027 0.0255 0.1069
Loa Loa (eye worm) hypothetical protein 0.0042 0.0451 0.0432
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0393 0.0864
Brugia malayi nuclear hormone receptor 0.0038 0.0393 0.0374
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Schistosoma mansoni aldehyde dehydrogenase 0.0091 0.1087 0.2468
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Echinococcus granulosus ecdysone induced protein 78C 0.008 0.0938 0.2124
Schistosoma mansoni nuclear hormone receptor 0.008 0.0938 0.2124
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0018
Mycobacterium tuberculosis Conserved protein 0.0047 0.0517 0.1291
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0451 0.0432
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 0.0938 0.2124
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0517 0.2165
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0134 0.2153
Loa Loa (eye worm) hypothetical protein 0.008 0.0938 0.092
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0298 0.0643
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0066 0.0046
Schistosoma mansoni acetylcholinesterase 0.0058 0.0656 0.1472
Schistosoma mansoni retinoic acid receptor RXR 0.0136 0.1666 0.3809
Loa Loa (eye worm) hypothetical protein 0.0038 0.0393 0.0374
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0393 0.0374
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.003 0.0298 0.0278
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0047 0.0517 0.1291
Echinococcus multilocularis para nitrobenzyl esterase 0.0058 0.0656 0.1472
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 0.0938 0.092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0938 0.2124

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.2 uM Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light . ChEMBL. 8057299
IC50 (functional) = 5.2 uM Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light . ChEMBL. 8057299

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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