Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.6344 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.6344 | 0.6344 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.3489 | 0.55 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.6344 | 0.6344 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.3113 | 0.3113 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.6344 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.6344 | 0.4504 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.6344 | 0.4504 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.6344 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.3489 | 0.55 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.6344 | 0.4504 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.6344 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.6344 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.6344 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.6344 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.6344 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.6344 | 0.6344 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.3113 | 0.3113 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.6344 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.6344 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.6344 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.4031 | 0.4031 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.6344 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.6344 | 0.6344 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.6344 | 0.6344 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.3489 | 0.55 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.6344 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.3349 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9765 | 0.9765 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.6344 | 0.4504 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.6344 | 0.6344 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.4031 | 0.4031 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.6344 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.3489 | 0.55 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.6344 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.6344 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.6344 | 0.6344 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.3489 | 0.55 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 24.5297 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948] | ChEMBL. | No reference |
Potency (functional) | 27.5227 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] | ChEMBL. | No reference |
Potency (functional) | 30.881 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 34.6491 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.