Detailed information for compound 1400535

Basic information

Technical information
  • TDR Targets ID: 1400535
  • Name: 3-(adamantane-1-carbonylamino)-N-(4-methylphe nyl)-1-benzofuran-2-carboxamide
  • MW: 428.523 | Formula: C27H28N2O3
  • H donors: 2 H acceptors: 2 LogP: 6.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)c1oc2c(c1NC(=O)C13CC4CC(C3)CC(C1)C4)cccc2
  • InChi: 1S/C27H28N2O3/c1-16-6-8-20(9-7-16)28-25(30)24-23(21-4-2-3-5-22(21)32-24)29-26(31)27-13-17-10-18(14-27)12-19(11-17)15-27/h2-9,17-19H,10-15H2,1H3,(H,28,30)(H,29,31)
  • InChiKey: VWZPSGZHGJIZDQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(adamantane-1-carbonylamino)-N-(4-methylphenyl)benzofuran-2-carboxamide
  • 3-[(1-adamantyl-oxomethyl)amino]-N-(4-methylphenyl)-2-benzofurancarboxamide
  • 3-(1-adamantylcarbonylamino)-N-(4-methylphenyl)-1-benzofuran-2-carboxamide
  • C686-1189
  • NCGC00111666-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cathepsin CPL 0.002 0.0022 0.0209
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0517 0.071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0142 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0142 0.0185
Onchocerca volvulus 0.0049 0.0371 0.0401
Leishmania major cathepsin L-like protease 0.0077 0.0719 0.0988
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0214 0.2016
Schistosoma mansoni nuclear hormone receptor 0.003 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.5119 0.5108
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0027 0.0005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0022 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.1724 0.1706
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Schistosoma mansoni glutaminase 0.0554 0.6566 0.6566
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0142 0.0137
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1485 1
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0031 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Giardia lamblia GTOR 0.0046 0.0339 0.1035
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0214 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.187 0.1852
Echinococcus granulosus cpg binding protein 0.0035 0.0199 0.0177
Trypanosoma brucei glucosidase, putative 0.0038 0.0239 0.0329
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0562 0.529
Plasmodium vivax vivapain-2 0.002 0.0022 0.0209
Leishmania major cysteine peptidase A (CPA) 0.002 0.0022 0.003
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0022 0.0029
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.187 0.2443
Schistosoma mansoni zinc finger protein 0.0025 0.0086 0.0086
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0239 0.0667
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0142 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0142 0.012
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0009 0.0012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0642 0.7655 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0022 0.0209
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0027 0.0027
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0339 0.0466
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0142 0.0142
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0105 0.1062 0.6673
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0022 0.0209
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0214 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0142 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Loa Loa (eye worm) hypothetical protein 0.0046 0.0343 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Schistosoma mansoni hypothetical protein 0.0079 0.0746 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Schistosoma mansoni hypothetical protein 0.0025 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0112 0.0103
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0339 0.0339
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0142 0.012
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0027 0.0005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0637 0.0876
Loa Loa (eye worm) ctsf protein 0.002 0.0022 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0328 0.3086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0239 0.0329
Onchocerca volvulus 0.0029 0.0131 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0112 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0214 0.022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0911 0.0911
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0105 0.1062 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0784 0.1024
Schistosoma mansoni ap endonuclease 0.0057 0.0477 0.0477
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0142 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0223 0.0231
Leishmania major hypothetical protein, conserved 0.0036 0.0214 0.0294
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.3325 0.4569
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0502 0.055
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0142 0.012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0461 0.0704
Echinococcus multilocularis dna polymerase eta 0.0086 0.083 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0153 0.015
Echinococcus granulosus dna polymerase kappa 0.0059 0.0502 0.0481
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1251 0.1635
Schistosoma mansoni intermediate filament proteins 0.0029 0.0131 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0108 0.0099
Giardia lamblia DINP protein human, muc B family 0.0059 0.0502 0.1533
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0612 0.0612
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0502 0.082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0911 0.0911
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.083 0.1084
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0241 0.022
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0289 0.3325 0.4569
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.028
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0239 0.0249
Mycobacterium ulcerans lipase LipD 0.0036 0.0214 0.0326
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0239 0.0217
Brugia malayi beta-lactamase family protein 0.0036 0.0214 0.028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.1114 0.1455
Schistosoma mansoni survival motor neuron protein 0.0049 0.0371 0.0371
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0911 0.0911
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0829 0.1139
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3276 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1357 0.1338
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0241 0.022
Trypanosoma brucei ISWI complex protein 0.0018 0.0001 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0022 0.0209
Schistosoma mansoni hypothetical protein 0.0038 0.0241 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Leishmania major cathepsin L-like protease 0.002 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0163
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0129 0.0129
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0339 0.0443
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0112 0.0103
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0224 0.0308
Loa Loa (eye worm) fibroinase 0.002 0.0022 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0436 0.5119 0.5108
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0339 0.0466
Schistosoma mansoni lamin 0.0029 0.0131 0.0131
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0031 0.0031
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0829 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0108 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0911 0.0891
Schistosoma mansoni hypothetical protein 0.0038 0.0241 0.0241
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0477 0.4492
Schistosoma mansoni hypothetical protein 0.0436 0.5119 0.5119
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0502 0.0656
Echinococcus granulosus lamin dm0 0.0029 0.0131 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0142 0.012
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0829 0.1139
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0031 0.004
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0239 0.2252
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0371
Brugia malayi cytosol aminopeptidase 0.0021 0.0031 0.004
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0502 0.0481
Schistosoma mansoni bromodomain containing protein 0.0078 0.0733 0.0733
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0502 0.0502
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0142 0.0137
Schistosoma mansoni alpha-glucosidase 0.0147 0.1578 0.1578
Schistosoma mansoni ap endonuclease 0.0057 0.0477 0.0477
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0149 0.0195
Echinococcus multilocularis zinc finger protein 0.0025 0.0086 0.0064
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0239 0.0312
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0214 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.3276 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.083 0.1084
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0142 0.0142
Mycobacterium ulcerans glutaminase 0.0554 0.6566 1
Onchocerca volvulus 0.0099 0.0986 0.1106
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0239 0.0249
Echinococcus granulosus lamin 0.0029 0.0131 0.011
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0031 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0477 0.0655
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0214 0.0214
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0339 0.0974
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0719 0.0988
Echinococcus granulosus GPCR family 2 0.0038 0.0241 0.022
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0031 0.0042
Echinococcus granulosus FTZ F1 alpha 0.0403 0.4718 0.4706
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0461 0.044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0142 0.0185
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0214 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0142 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0223 0.0231
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0502 0.1475
Echinococcus granulosus zinc finger protein 0.0025 0.0086 0.0064
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0224 0.0308
Brugia malayi Cathepsin L-like precursor 0.002 0.0022 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0214 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0612 0.7278 1
Onchocerca volvulus 0.0036 0.0214 0.022
Plasmodium falciparum M17 leucyl aminopeptidase 0.0105 0.1062 1
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2703 0.2687
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0239 0.0249
Trypanosoma brucei unspecified product 0.0041 0.0276 0.0379
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0461 0.0603
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0339 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0477 0.4492
Loa Loa (eye worm) hypothetical protein 0.0239 0.2703 0.3531
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0109 0.1114 0.1114
Toxoplasma gondii leucyl aminopeptidase LAP 0.0105 0.1062 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0142 0.0185
Schistosoma mansoni alpha-glucosidase 0.0147 0.1578 0.1578
Brugia malayi Cathepsin L-like precursor 0.002 0.0022 0.0029
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Leishmania major hypothetical protein, conserved 0.0018 0.0001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0142 0.012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0194 0.183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0142 0.012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0339 0.0443
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0105 0.1062 0.1459
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0214 0.022
Schistosoma mansoni hypothetical protein 0.0082 0.0784 0.0784
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0142 0.0185
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3276 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0502 0.0481
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0502 0.0656
Trypanosoma brucei unspecified product 0.0041 0.0276 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Loa Loa (eye worm) hypothetical protein 0.006 0.0507 0.0662
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.028
Schistosoma mansoni thyroid hormone receptor 0.0159 0.1724 0.1724
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0477 0.0655
Schistosoma mansoni cpg binding protein 0.0035 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Schistosoma mansoni cpg binding protein 0.0035 0.0199 0.0199
Toxoplasma gondii hypothetical protein 0.0099 0.0984 0.927
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0142 0.0185
Mycobacterium ulcerans hypothetical protein 0.0322 0.3727 0.5676
Trypanosoma brucei unspecified product 0.0059 0.0502 0.069
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0241 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0159 0.1724 0.1724
Schistosoma mansoni hypothetical protein 0.0038 0.0241 0.0241
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0239 0.0249
Echinococcus granulosus dna polymerase eta 0.0086 0.083 0.0809
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0031 0.004
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1485 0.3617
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0306 0.0285
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0477 0.1456
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0142 0.0185
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0315
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0022 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0502 0.069
Brugia malayi hypothetical protein 0.0239 0.2703 0.3531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0612 0.7278 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0131 0.0172
Leishmania major DNA polymerase eta, putative 0.0086 0.083 0.114
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.083 0.114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0142 0.0185
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0461 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Onchocerca volvulus 0.0036 0.0214 0.022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0214 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0239 0.0329
Loa Loa (eye worm) hypothetical protein 0.0053 0.0427 0.0558
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0105 0.1062 0.1459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0223 0.0231
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0461 0.0461
Brugia malayi Bromodomain containing protein 0.0092 0.0907 0.1185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0911 0.0891
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0142 0.0142
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0461 0.0703
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2549 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0379
Leishmania major cathepsin L-like protease 0.0077 0.0719 0.0988
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0214 0.022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0131 0.0172
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0239 0.0249
Echinococcus granulosus leucine aminopeptidase protein 0.0105 0.1062 0.1042
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0142 0.012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0477 0.0623
Loa Loa (eye worm) hypothetical protein 0.0085 0.0822 0.1074
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0105 0.1062 0.1459
Echinococcus multilocularis geminin 0.0525 0.6218 0.621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0031 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0239 0.0249
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.068 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.187 0.1852
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0477 0.0655
Echinococcus multilocularis musashi 0.0029 0.0131 0.011
Leishmania major mitochondrial DNA polymerase beta 0.0612 0.7278 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0379
Trypanosoma cruzi ISWI complex protein 0.0018 0.0001 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0109 0.1114 0.1094
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0477 0.0522
Brugia malayi nuclear receptor NHR-88 0.003 0.0142 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0108 0.1103 0.1103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Toxoplasma gondii exonuclease III APE 0.0057 0.0477 0.4492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0911 0.0911
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2586 0.6751
Leishmania major DNA polymerase eta, putative 0.0045 0.0328 0.045
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0477 0.0623
Mycobacterium tuberculosis Conserved hypothetical protein 0.0322 0.3727 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0339 0.0466
Loa Loa (eye worm) hypothetical protein 0.0029 0.0131 0.0172
Leishmania major cathepsin L-like protease 0.002 0.0022 0.003
Toxoplasma gondii ABC1 family protein 0.0036 0.0214 0.2016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0142 0.0185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0862 0.0841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Trichomonas vaginalis esterase, putative 0.0036 0.0214 0.022
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1103 0.1103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0223 0.0231
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0415 0.0542
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0477 0.0522
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0142 0.012
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0185
Loa Loa (eye worm) hypothetical protein 0.012 0.1251 0.1635
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2703 0.2687
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0142 0.0142
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0306 0.0285
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0105 0.1062 0.1459
Brugia malayi hypothetical protein 0.0108 0.1103 0.1441
Brugia malayi Bromodomain containing protein 0.0046 0.0342 0.0446
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0502 0.055
Entamoeba histolytica hypothetical protein 0.0108 0.1103 0.3323
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0719 0.0988
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0142 0.012
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0477 0.0726
Loa Loa (eye worm) cysteine protease 0.002 0.0022 0.0029
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0105 0.1062 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0239 0.0249
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Brugia malayi Cathepsin L-like precursor 0.002 0.0022 0.0029
Schistosoma mansoni hypothetical protein 0.0129 0.1357 0.1357
Mycobacterium ulcerans hypothetical protein 0.0036 0.0214 0.0326
Schistosoma mansoni alpha glucosidase 0.0038 0.0239 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.1114 0.1455
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0142 0.0185
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.068 0.0659
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0131 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0142 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0105 0.106 0.1456
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.187 0.2443
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0502 0.069
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0612 0.7278 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0113 0.1164 0.1145
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Brugia malayi glutaminase DH11.1 0.0554 0.6566 0.8578
Loa Loa (eye worm) glutaminase 0.0554 0.6566 0.8578
Schistosoma mansoni lamin 0.0029 0.0131 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0109 0.1114 0.1094
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0719 0.0988
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Echinococcus multilocularis tumor protein p63 0.0408 0.4781 0.477
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0719 0.0988
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0031 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Brugia malayi Pre-SET motif family protein 0.0642 0.7655 1
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0036 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0214 0.022
Onchocerca volvulus 0.006 0.0507 0.0556
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0031 0.0009
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0031 0.0009
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0105 0.1062 0.2414
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0142 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0142 0.0185
Trypanosoma cruzi ISWI complex protein 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0038 0.0241 0.0241
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0502 0.0481
Entamoeba histolytica hypothetical protein 0.0108 0.1103 0.3323
Entamoeba histolytica hypothetical protein 0.0108 0.1103 0.3323
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1357 0.1338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0256 0.0269
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.083 0.114
Onchocerca volvulus 0.003 0.0142 0.0137
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0477 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0113 0.1164 0.1164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0142 0.012
Onchocerca volvulus 0.0031 0.0149 0.0146
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0829 0.1139
Brugia malayi intermediate filament protein 0.0029 0.0131 0.0172
Onchocerca volvulus 0.0093 0.0911 0.102
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0502 0.082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.008 0.0104
Plasmodium vivax SET domain protein, putative 0.0093 0.0911 0.8583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0339 0.0363
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.3325 0.4569
Brugia malayi nuclear hormone receptor 0.003 0.0142 0.0185
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0031 0.0009
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0502 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0379
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0477 0.0748
Onchocerca volvulus 0.0036 0.0214 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0339 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0141 0.0136
Trichomonas vaginalis set domain proteins, putative 0.0731 0.8743 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0911 0.0891
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0502 0.069
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0339 0.0318
Brugia malayi beta-lactamase family protein 0.0036 0.0214 0.028
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0339 0.0466
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0239 0.0217
Loa Loa (eye worm) hypothetical protein 0.0082 0.0784 0.1024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0241 0.022
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0502 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0223 0.0231
Brugia malayi beta-lactamase 0.0036 0.0214 0.028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0378 0.0493
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0241 0.022
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Echinococcus multilocularis lamin dm0 0.0029 0.0131 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0911 0.8583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0911 0.0911
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0109 0.1114 0.1094
Loa Loa (eye worm) beta-lactamase 0.0036 0.0214 0.028
Brugia malayi CXXC zinc finger family protein 0.0031 0.0149 0.0195
Echinococcus granulosus geminin 0.0525 0.6218 0.621
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1251 0.1635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0142 0.0185
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2549 0.333
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0031 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0502 0.069
Mycobacterium ulcerans leucyl aminopeptidase 0.0105 0.1062 0.1617
Onchocerca volvulus 0.0731 0.8743 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0142 0.0185
Brugia malayi ecdysteroid receptor 0.003 0.0142 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0142 0.0185
Schistosoma mansoni zinc finger protein 0.0018 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.002 0.0022 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Schistosoma mansoni cpg binding protein 0.0031 0.0149 0.0149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0241 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0142 0.0142
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0113 0.1164 0.1145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0502 0.069
Leishmania major cathepsin L-like protease 0.002 0.0022 0.003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0911 0.119
Echinococcus granulosus tumor protein p63 0.0408 0.4781 0.477
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0239 0.0249
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0142 0.0142
Leishmania major cathepsin L-like protease 0.002 0.0022 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0461 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0142 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0022 0.003
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0142 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0214 0.0294
Leishmania major DNA polymerase kappa, putative 0.0059 0.0502 0.069
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0239 0.0667
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0241 0.0315
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0129 0.0108
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0129 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Trichomonas vaginalis glutaminase, putative 0.0554 0.6566 0.7504
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0142 0.0185
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0142 0.0137
Brugia malayi PHD-finger family protein 0.0032 0.0165 0.0215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1251 0.1635
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0502 0.069
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.187 0.1852
Echinococcus multilocularis lamin 0.0029 0.0131 0.011
Echinococcus multilocularis GPCR, family 2 0.0038 0.0241 0.022
Loa Loa (eye worm) hypothetical protein 0.0109 0.1114 0.1455
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.002 0.0022 0.003
Schistosoma mansoni DNA polymerase eta 0.0086 0.083 0.083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1103 0.1084
Schistosoma mansoni coup transcription factor 0.003 0.0142 0.0142
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0239 0.0249
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0911 0.0891
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0477 0.0456
Chlamydia trachomatis cytosol aminopeptidase 0.0105 0.1062 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0477 0.1398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0911 0.119
Brugia malayi Cathepsin L-like precursor 0.002 0.0022 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0328 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0339 0.0363
Entamoeba histolytica hypothetical protein 0.0108 0.1103 0.3323
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0339 0.0466
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0142 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0239 0.0329
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0371 0.0485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0113 0.1164 0.1164
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0339 0.0318
Leishmania major cathepsin L-like protease 0.0077 0.0719 0.0988
Brugia malayi steroid hormone receptor 0.003 0.0142 0.0185
Echinococcus multilocularis leucine aminopeptidase protein 0.0105 0.1062 0.1042
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0022 0.0029
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0525 0.6218 0.6218
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.3276 1
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0142 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Echinococcus granulosus intermediate filament protein 0.0029 0.0131 0.011
Onchocerca volvulus 0.0029 0.0131 0.0125
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0214 0.0326
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0502 0.0765
Loa Loa (eye worm) glutaminase 2 0.0554 0.6566 0.8578
Schistosoma mansoni hypothetical protein 0.0525 0.6218 0.6218
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1485 0.2261
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0477 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0142 0.012
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0339 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0719 0.0988
Brugia malayi Pre-SET motif family protein 0.0093 0.0911 0.1191
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0502 0.0765
Plasmodium vivax vivapain-2 0.002 0.0022 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0079 0.0065
Echinococcus multilocularis cpg binding protein 0.0035 0.0199 0.0177
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0239 0.0312
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1103 0.1084
Brugia malayi Cathepsin L-like precursor 0.002 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0113 0.1164 0.1521
Loa Loa (eye worm) hypothetical protein 0.0036 0.0214 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0031 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0194 0.0197
Mycobacterium ulcerans beta-lactamase 0.0036 0.0214 0.0326
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0224 0.0308
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0142 0.0185
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0214 0.0192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0911 0.0891
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0027 0.0027
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0031 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0214 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0502 0.069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3276 0.3731
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0461 0.044

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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