Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.4 mg kg-1 | Inhibition of mouse intraperitoneally. | ChEMBL. | 1671416 |
ED50 (functional) | = 2.4 mg kg-1 | Inhibition of mouse intraperitoneally. | ChEMBL. | 1671416 |
ED50 (functional) | = 4.3 mg kg-1 | Inhibition of rat locomotor activity after being administered perorally. | ChEMBL. | 1671416 |
Inhibition (binding) | = 20 % | Inhibitory binding activity against dopamine receptor in rat striatal membranes using [3H]-HAL as the the radioligand. | ChEMBL. | 1671416 |
Inhibition (binding) | = 20 % | Inhibitory binding activity against dopamine receptor in rat striatal membranes using [3H]-HAL as the the radioligand. | ChEMBL. | 1671416 |
Inhibition (functional) | = 68 % | Compound tested for % inhibition of DA neuronal firing at an intraperitoneal dose of 2.5 mg/kg. | ChEMBL. | 1671416 |
Reversal (functional) | = 56 % | Compound tested for % reversal of DOPA accumulation at an intraperitoneal dose of 30 mg/kg. | ChEMBL. | 1671416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.