Detailed information for compound 1400802

Basic information

Technical information
  • TDR Targets ID: 1400802
  • Name: 3-(3,4-difluorophenyl)-1-naphthalen-1-ylthiou rea
  • MW: 314.352 | Formula: C17H12F2N2S
  • H donors: 1 H acceptors: 0 LogP: 4.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC(=Nc1cccc2c1cccc2)Nc1ccc(c(c1)F)F
  • InChi: 1S/C17H12F2N2S/c18-14-9-8-12(10-15(14)19)20-17(22)21-16-7-3-5-11-4-1-2-6-13(11)16/h1-10H,(H2,20,21,22)
  • InChiKey: JYFLCWDHGRAKNA-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(3,4-difluorophenyl)-1-(1-naphthyl)thiourea
  • 3-(3,4-difluorophenyl)-1-naphthalen-1-yl-thiourea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0059
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0078 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1312 0.3322
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Loa Loa (eye worm) RNA binding protein 0.0199 0.395 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0197
Echinococcus granulosus GPCR family 2 0.0032 0.0544 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0132 0.0334
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0014 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.1529 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0036
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0078 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0132 0.0132
Schistosoma mansoni cpg binding protein 0.0035 0.0592 0.0592
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0132 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0132 0.0132
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0132 0.0132
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0078 0.5
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0078 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1228 0.7925
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0132 0.0334
Echinococcus multilocularis tar DNA binding protein 0.0199 0.395 0.395
Chlamydia trachomatis DNA ligase 0.001 0.0078 0.5
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0078 0.0197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0544 0.0544
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0102 0.0102
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0078 0.5
Brugia malayi nuclear hormone receptor 0.0012 0.0132 0.0334
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0132 0.0132
Schistosoma mansoni topbp1 0.001 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0132 0.0334
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0544 0.0544
Brugia malayi CXXC zinc finger family protein 0.0035 0.0592 0.15
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1974 0.4998
Echinococcus multilocularis cpg binding protein 0.0037 0.0633 0.0633
Brugia malayi RNA recognition motif domain containing protein 0.0199 0.395 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0059
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.1529 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0132 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.1529 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0197
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0621 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0078 1
Schistosoma mansoni tar DNA-binding protein 0.0199 0.395 0.395
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0132 0.0334
Loa Loa (eye worm) hypothetical protein 0.0032 0.0544 0.1377
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0014 0.0014
Echinococcus granulosus tar DNA binding protein 0.0199 0.395 0.395
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0078 0.5
Brugia malayi hypothetical protein 0.0006 0.0014 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0132 0.0132
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0078 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0132 0.0334
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0132 0.2229
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0078 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0014 0.0036
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0102 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0544 0.1377
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0132 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0199 0.395 0.395
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0059 0.0059
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0078 0.0078
Echinococcus granulosus cpg binding protein 0.0037 0.0633 0.0633
Echinococcus multilocularis GPCR, family 2 0.0032 0.0544 0.0544
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0132 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0132 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0197
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0132 0.0334
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0032 0.0544 0.0544
Schistosoma mansoni coup transcription factor 0.0012 0.0132 0.0132
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0199 0.395 1
Leishmania major hypothetical protein, conserved 0.008 0.1529 0.5
Brugia malayi hypothetical protein 0.001 0.0078 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.1529 1
Brugia malayi RNA binding protein 0.0199 0.395 1
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.1529 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0132 0.0132
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0078 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0132 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0132 0.0132
Onchocerca volvulus 0.0035 0.0592 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0032 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0102 0.1974 0.4998
Schistosoma mansoni hypothetical protein 0.0032 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0132 0.0334
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0132 0.2229
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.1529 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Brugia malayi DKFZp564C0469 protein 0.001 0.0078 0.0197
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0078 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0132 0.0334
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.1529 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1974 0.4998
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0197
Entamoeba histolytica hypothetical protein 0.001 0.0078 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0132 0.0334
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0132 0.0132
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0078 1
Schistosoma mansoni tar DNA-binding protein 0.0199 0.395 0.395
Brugia malayi hypothetical protein 0.0006 0.0014 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0078 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0014 0.0036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0014 0.0014
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0132 0.0132
Echinococcus multilocularis nibrin 0.001 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.007 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0132 0.0334
Loa Loa (eye worm) hypothetical protein 0.008 0.1529 0.3871
Schistosoma mansoni tar DNA-binding protein 0.0199 0.395 0.395
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0621 0.0621
Schistosoma mansoni tar DNA-binding protein 0.0199 0.395 0.395
Brugia malayi TAR-binding protein 0.0199 0.395 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1389 0.1389
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0132 0.0132
Schistosoma mansoni cpg binding protein 0.0037 0.0633 0.0633
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0078 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0132 0.0334
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0078 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0132 0.0132
Brugia malayi steroid hormone receptor 0.0012 0.0132 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0132 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0132 0.0334
Brugia malayi nuclear receptor RXR 0.0006 0.0014 0.0036
Schistosoma mansoni hypothetical protein 0.0032 0.0544 0.0544
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0132 0.0132
Brugia malayi nuclear receptor NHR-88 0.0012 0.0132 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0132 0.0334
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0078 1
Echinococcus granulosus nibrin 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0132 0.0334
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0132 0.0132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0544 0.1377
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0132 0.0334
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0099 0.0251
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0132 0.0334
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0544 0.0544
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0132 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1974 0.4998
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0132 0.0132
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0132 0.0334
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0592 0.15
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0102 0.0102
Echinococcus granulosus replication factor c subunit 1 0.001 0.0078 0.0078
Onchocerca volvulus 0.0012 0.0132 0.2229
Treponema pallidum DNA ligase (lig) 0.001 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1312 0.3322
Schistosoma mansoni cpg binding protein 0.0037 0.0633 0.0633
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0132 0.0334
Giardia lamblia Replication factor C, subunit 1 0.001 0.0078 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0014 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0132 0.0334
Brugia malayi topoisomerase 0.001 0.0078 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0014 0.0036
Schistosoma mansoni topbp1 0.001 0.0078 0.0078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0132 0.2229
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0544 0.0544
Loa Loa (eye worm) TAR-binding protein 0.0199 0.395 1
Schistosoma mansoni DNA ligase IV 0.001 0.0078 0.0078
Onchocerca volvulus 0.001 0.0078 0.1314
Brugia malayi hypothetical protein 0.0052 0.0945 0.2393
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0132 0.0132
Brugia malayi hypothetical protein 0.008 0.1529 0.3871
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0132 0.0334
Brugia malayi hypothetical protein 0.001 0.0078 0.0197
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0059 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0544 0.1377
Brugia malayi ecdysteroid receptor 0.0012 0.0132 0.0334
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0132 0.0334
Schistosoma mansoni hypothetical protein 0.0036 0.0621 0.0621

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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