Detailed information for compound 1401324

Basic information

Technical information
  • TDR Targets ID: 1401324
  • Name: 1-(4-fluorobenzoyl)-N-(4-fluorophenyl)piperid ine-4-carboxamide
  • MW: 344.355 | Formula: C19H18F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)F
  • InChi: 1S/C19H18F2N2O2/c20-15-3-1-14(2-4-15)19(25)23-11-9-13(10-12-23)18(24)22-17-7-5-16(21)6-8-17/h1-8,13H,9-12H2,(H,22,24)
  • InChiKey: NKZUMAJMIIODQV-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-fluorophenyl)-1-[(4-fluorophenyl)-oxomethyl]-4-piperidinecarboxamide
  • 1-(4-fluorobenzoyl)-N-(4-fluorophenyl)isonipecotamide
  • N-(4-fluorophenyl)-1-(4-fluorophenyl)carbonyl-piperidine-4-carboxamide
  • T5546398
  • ZINC05558731

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0443 0.0687
Brugia malayi Cytochrome P450 family protein 0.0028 0.0153 0.0237
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Plasmodium vivax phosphodiesterase gamma, putative 0.0044 0.0318 0.0448
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Brugia malayi Tubulin alpha-2 chain 0.0448 0.4685 0.7263
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.041 0.2684
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Leishmania major cytochrome p450-like protein 0.0028 0.0153 0.0191
Echinococcus granulosus nuclear factor of activated T cells 5 0.0362 0.3754 0.5819
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0333 0.0515
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0153 0.0868
Loa Loa (eye worm) hypothetical protein 0.0448 0.4685 0.4685
Trichomonas vaginalis tubulin epsilon chain, putative 0.0612 0.6451 1
Trypanosoma brucei zeta tubulin, putative 0.0148 0.1443 0.2199
Loa Loa (eye worm) DNA topoisomerase I 0.0182 0.1808 0.1808
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0048 0.0074
Echinococcus granulosus tubulin beta 1 chain 0.0612 0.6451 1
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0124 0.0145
Leishmania major beta tubulin 0.0612 0.6451 1
Toxoplasma gondii beta-1 tubulin, putative 0.0612 0.6451 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.1841 0.282
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0153 0.0868
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0362 0.3754 0.5819
Loa Loa (eye worm) TK protein kinase 0.0039 0.0263 0.0263
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0705 0.1094
Loa Loa (eye worm) tubulin beta-1 chain 0.0612 0.6451 0.6451
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Loa Loa (eye worm) tubulin alpha chain 0.0448 0.4685 0.4685
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0448 0.4685 0.7263
Entamoeba histolytica protein kinase, putative 0.0032 0.0192 0.0225
Echinococcus granulosus tubulin alpha 3 chain 0.0448 0.4685 0.7263
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0245 0.1515
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1443 0.2199
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.144 0.2233
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0153 0.0868
Echinococcus multilocularis tubulin beta 1 chain 0.0612 0.6451 1
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.5573 0.8639
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0153 0.0868
Loa Loa (eye worm) hypothetical protein 0.025 0.2551 0.2551
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Trichomonas vaginalis tubulin gamma chain, putative 0.0333 0.3437 0.5306
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0044 0.0318 0.0493
Onchocerca volvulus Peroxidase homolog 0.0026 0.0133 0.0409
Plasmodium falciparum phosphodiesterase delta, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0051 0.0394 0.0394
Echinococcus multilocularis tubulin alpha 0.0333 0.3437 0.5328
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0027
Brugia malayi hypothetical protein 0.0026 0.0133 0.0205
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0153 0.0868
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0333 0.0515
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1191 0.8064
Leishmania major beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0044 0.0318 0.0494
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Brugia malayi Tubulin alpha-2 chain 0.0448 0.4685 0.7263
Schistosoma mansoni tubulin subunit beta 0.0148 0.1443 0.2237
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0027
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus granulosus geminin 0.0352 0.3645 0.565
Schistosoma mansoni DNA topoisomerase type I 0.0182 0.1808 0.2803
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0031 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Plasmodium vivax glutathione reductase, putative 0.0049 0.0377 0.054
Brugia malayi Cytochrome P450 family protein 0.0028 0.0153 0.0237
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0153 0.0868
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus multilocularis tyrosine protein kinase ABL1 0.021 0.2118 0.3284
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0048 0.0027
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Loa Loa (eye worm) PDE1B protein 0.0044 0.0318 0.0318
Leishmania major DNA topoisomerase IB, large subunit 0.0136 0.1316 0.2001
Schistosoma mansoni tubulin subunit alpha 0.0448 0.4685 0.7263
Onchocerca volvulus 0.0051 0.0399 0.1483
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0377 0.0585
Loa Loa (eye worm) glutathione reductase 0.0049 0.0377 0.0377
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0099 0.092 0.1425
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0333 0.0515
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0182 0.0282
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0063
Leishmania major beta tubulin 0.0612 0.6451 1
Plasmodium falciparum thioredoxin reductase 0.0049 0.0377 0.054
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.1056 0.7262
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.053 0.5573 0.8633
Loa Loa (eye worm) BEN-1 protein 0.0612 0.6451 0.6451
Toxoplasma gondii beta tubulin 0.0612 0.6451 1
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.1181 0.1831
Mycobacterium leprae cell division protein FtsZ 0.0148 0.1443 1
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0124 0.0145
Brugia malayi glutathione reductase 0.0049 0.0377 0.0584
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.053 0.5573 0.8633
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Loa Loa (eye worm) tubulin beta chain 0.0612 0.6451 0.6451
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) SRC-1 0.0045 0.0333 0.0333
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0048 0.0027
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0063 0.0051
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0063 0.0098
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0245 0.0333
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0494
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0153 0.0868
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0124 0.0192
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0377 0.2453
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0153 0.0191
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0717 0.1112
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0048 0.0027
Loa Loa (eye worm) TK protein kinase 0.0032 0.0192 0.0192
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0245 0.0333
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0063 0.0098
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0244 0.0378
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0164 0.0164
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.1841 0.282
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0124 0.0191
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0245 0.0245
Echinococcus granulosus carbonic anhydrase 0.0339 0.3507 0.5437
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0153 0.0238
Trypanosoma cruzi beta tubulin, putative 0.0612 0.6451 1
Brugia malayi Protein kinase domain containing protein 0.0049 0.0377 0.0584
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi protein-tyrosine kinase 0.0039 0.0263 0.0408
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0044 0.0318 0.0494
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.008 0.0705 0.0705
Onchocerca volvulus 0.002 0.0063 0.0129
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0318 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1443 0.2199
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Plasmodium vivax tubulin alpha chain, putative 0.0448 0.4685 0.725
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0705 0.1094
Echinococcus granulosus insulin receptor 0.0049 0.0377 0.0585
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Schistosoma mansoni carbonic anhydrase-related 0.0339 0.3507 0.5437
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni tyrosine kinase 0.0148 0.144 0.2233
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0027 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0153 0.0868
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.0031
Echinococcus granulosus tubulin alpha 1C chain 0.0448 0.4685 0.7263
Plasmodium falciparum alpha tubulin 1 0.0448 0.4685 0.725
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0048 0.0122
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis geminin 0.0352 0.3645 0.565
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0318 0.0448
Echinococcus multilocularis tubulin alpha 1C chain 0.0448 0.4685 0.7263
Echinococcus multilocularis tyrosine protein kinase Abl 0.0093 0.0853 0.1323
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0027 0.0042
Trypanosoma brucei alpha tubulin, putative 0.0185 0.1841 0.282
Entamoeba histolytica tubulin alpha chain, putative 0.0448 0.4685 0.7242
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.041 0.2053
Schistosoma mansoni tyrosine kinase 0.0049 0.0377 0.0585
Schistosoma mansoni hypothetical protein 0.0035 0.0221 0.0343
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0124 0.0118
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0333 0.0515
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0048
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Treponema pallidum cell division protein FtsZ 0.0148 0.1443 1
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0377 0.054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0443 0.0687
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0333 0.0515
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0153 0.0868
Loa Loa (eye worm) hypothetical protein 0.0031 0.0182 0.0182
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0318 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Schistosoma mansoni hypothetical protein 0.0352 0.3645 0.565
Giardia lamblia Beta tubulin 0.0612 0.6451 1
Brugia malayi Tubulin beta chain 0.0185 0.1841 0.2854
Schistosoma mansoni hypothetical protein 0.0051 0.0399 0.0618
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0124 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0044 0.0318 0.0494
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0333 0.0515
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1191 0.8217
Trichomonas vaginalis tubulin, putative 0.0148 0.1443 0.2199
Toxoplasma gondii DNA topoisomerase I, putative 0.0182 0.1808 0.2769
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.053 0.5573 0.5573
Trypanosoma brucei carbonic anhydrase-like protein 0.053 0.5573 0.8633
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0027 0.0042
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.1056 0.7262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0182 0.0282
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus granulosus GPCR family 2 0.0016 0.002 0.0031
Leishmania major beta tubulin 0.0612 0.6451 1
Schistosoma mansoni DNA topoisomerase type I 0.0136 0.1316 0.2039
Trypanosoma cruzi epsilon tubulin, putative 0.0333 0.3437 0.5306
Schistosoma mansoni hypothetical protein 0.002 0.0063 0.0098
Leishmania major gamma-tubulin 0.0333 0.3437 0.5306
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Echinococcus multilocularis RUN 0.002 0.0063 0.0098
Echinococcus multilocularis 0.0045 0.0331 0.0512
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Echinococcus multilocularis Ankyrin 0.0015 0.0004 0.0007
Schistosoma mansoni survival motor neuron protein 0.0051 0.0399 0.0618
Echinococcus granulosus Ankyrin 0.0015 0.0004 0.0007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Mycobacterium tuberculosis Cell division protein FtsZ 0.0148 0.1443 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0153 0.0868
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus beta tubulin 0.0612 0.6451 1
Echinococcus granulosus tubulin gamma 1 chain 0.0333 0.3437 0.5328
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0443 0.0443
Echinococcus multilocularis beta tubulin 0.0612 0.6451 1
Echinococcus granulosus alpha tubulin 0.0448 0.4685 0.7263
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0153 0.0191
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus granulosus RUN 0.002 0.0063 0.0098
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0133 0.0409
Echinococcus granulosus Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Thioredoxin reductase 0.0049 0.0377 0.0584
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.218 0.218
Leishmania major beta tubulin 0.0612 0.6451 1
Schistosoma mansoni tubulin subunit epsilon 0.0333 0.3437 0.5328
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Leishmania major hypothetical protein, conserved 0.0044 0.0318 0.0448
Plasmodium falciparum tubulin epsilon chain, putative 0.0333 0.3437 0.5306
Loa Loa (eye worm) BEN-1 protein 0.0612 0.6451 0.6451
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0494
Trypanosoma cruzi zeta tubulin, putative 0.0148 0.1443 0.2199
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0164 0.0534
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0182 0.0282
Trypanosoma brucei epsilon tubulin 0.0333 0.3437 0.5306
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.1051
Echinococcus granulosus carbonic anhydrase 0.0339 0.3507 0.5437
Toxoplasma gondii exonuclease III APE 0.0019 0.0048 0.0027
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.0377 0.0585
Echinococcus multilocularis DNA topoisomerase 1 0.0182 0.1808 0.2803
Trichomonas vaginalis tubulin gamma chain, putative 0.0612 0.6451 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0394 0.0611
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni loxhd1 0.002 0.0063 0.0098
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0074
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Echinococcus multilocularis tubulin alpha 1C chain 0.0448 0.4685 0.7263
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Entamoeba histolytica hypothetical protein 0.0041 0.0292 0.0381
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0318 0.0494
Schistosoma mansoni peroxidasin 0.0026 0.0133 0.0206
Loa Loa (eye worm) TK/ABL protein kinase 0.021 0.2118 0.2118
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Giardia lamblia hypothetical protein 0.0044 0.0318 0.0448
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Mycobacterium tuberculosis Probable reductase 0.0112 0.1056 0.7262
Brugia malayi Cell division protein ftsZ 0.0148 0.1443 0.2236
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0153 0.0868
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0494
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0048 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni hypothetical protein 0.0037 0.0244 0.0378
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0153 0.0191
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0099 0.092 0.1425
Loa Loa (eye worm) hypothetical protein 0.0263 0.2691 0.2691
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0153 0.0868
Schistosoma mansoni tyrosine kinase 0.0099 0.092 0.1425
Brugia malayi Cytochrome P450 family protein 0.0037 0.0245 0.0379
Onchocerca volvulus 0.002 0.0063 0.0129
Brugia malayi Putative carbonic anhydrase 5 precursor 0.053 0.5573 0.8639
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Echinococcus multilocularis tubulin subunit beta 0.0612 0.6451 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0048 0.0074
Giardia lamblia NADPH oxidoreductase, putative 0.0165 0.1627 0.2487
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0153 0.0868
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0153 0.0868
Schistosoma mansoni tyrosine kinase 0.0077 0.0678 0.105
Toxoplasma gondii hypothetical protein 0.0027 0.0143 0.0175
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0705 0.1051
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Giardia lamblia Hypothetical protein 0.0044 0.0318 0.0448
Loa Loa (eye worm) tubulin alpha 2 0.03 0.3089 0.3089
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0044 0.0318 0.0494
Brugia malayi tubulin alpha-2 chain 0.0448 0.4685 0.7263
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0315 0.3249 0.5035
Trypanosoma brucei epsilon tubulin 0.0333 0.3437 0.5306
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.1443 0.2199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0443 0.0687
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Giardia lamblia Beta tubulin 0.0612 0.6451 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0153 0.0868
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0394 0.0394
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.041 0.0635
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) TK/EGFR protein kinase 0.0148 0.144 0.144
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0124 0.0145
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0377 0.0585
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0318 0.0493
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0339 0.3507 0.5437
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0153 0.0868
Trichomonas vaginalis tubulin, putative 0.0185 0.1841 0.282
Echinococcus multilocularis carbonic anhydrase 0.0339 0.3507 0.5437
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Toxoplasma gondii alpha tubulin TUBA1 0.0448 0.4685 0.725
Echinococcus granulosus fibroblast growth factor receptor 4 0.0099 0.092 0.1425
Schistosoma mansoni tyrosine kinase 0.0081 0.0717 0.1112
Brugia malayi Tubulin beta chain 0.0148 0.1443 0.2236
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0124 0.0192
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0192 0.0298
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0124 0.0191
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0315 0.3249 0.5036
Brugia malayi Peroxidasin 0.0029 0.0164 0.0253
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0153 0.0868
Trypanosoma brucei tubulin gamma chain 0.0333 0.3437 0.5306
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.0031
Giardia lamblia Gamma tubulin 0.0333 0.3437 0.5306
Brugia malayi hypothetical protein 0.002 0.0063 0.0098
Echinococcus multilocularis Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0318
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0333 0.3437 0.5306
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Giardia lamblia NADPH oxidoreductase, putative 0.0165 0.1627 0.2487
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0063 0.0098
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus granulosus ankyrin repeat protein 0.0155 0.1521 0.2357
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0223 0.0346
Trichomonas vaginalis tubulin epsilon chain, putative 0.0612 0.6451 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0705 0.1051
Trichomonas vaginalis tubulin, putative 0.0185 0.1841 0.282
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0048 0.0027
Plasmodium falciparum tubulin gamma chain 0.0333 0.3437 0.5306
Loa Loa (eye worm) carbonic anhydrase 3 0.053 0.5573 0.5573
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0333 0.0515
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0044 0.0318 0.0494
Schistosoma mansoni tyrosine kinase 0.0204 0.2047 0.3174
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0377 0.0377
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Giardia lamblia Delta tubulin 0.0148 0.1443 0.2199
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0009 0.0013
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Plasmodium falciparum glutathione reductase 0.0049 0.0377 0.054
Leishmania major cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus peroxidasin 0.0029 0.0164 0.0254
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0153 0.0868
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0448
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0153 0.0868
Trypanosoma brucei trypanothione reductase 0.0049 0.0377 0.054
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0048 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0153 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0318 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0221 0.0342
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1191 0.8217
Giardia lamblia Alpha-tubulin 0.0448 0.4685 0.725
Trypanosoma brucei epsilon tubulin 0.0333 0.3437 0.5306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.0951 0.1473
Loa Loa (eye worm) hypothetical protein 0.0029 0.0164 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0182 0.0282
Leishmania major zeta tubulin, putative 0.0148 0.1443 0.2199
Trichomonas vaginalis tubulin epsilon chain, putative 0.0148 0.1443 0.2199
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus tubulin beta 4A class IVa 0.0612 0.6451 1
Echinococcus multilocularis tubulin subunit TubB 0.0448 0.4685 0.7263
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0153 0.0191
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.041 0.2684
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.0031
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0333 0.0515
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0027 0.0042
Echinococcus granulosus tyrosine protein kinase Blk 0.0039 0.0263 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Leishmania major DNA topoisomerase type IB small subunit 0.0046 0.034 0.0482
Trypanosoma cruzi tubulin delta chain 0.0148 0.1443 0.2199
Loa Loa (eye worm) tubulin beta-2A chain 0.0612 0.6451 0.6451
Trichomonas vaginalis tubulin epsilon chain, putative 0.0448 0.4685 0.725
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0047 0.0353 0.0501
Entamoeba histolytica tubulin family protein 0.0612 0.6451 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0133 0.0133
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0153 0.0868
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0339 0.3507 0.5437
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0359 0.372 0.5746
Brugia malayi Tubulin beta-1 chain 0.0612 0.6451 1
Trypanosoma brucei beta tubulin 0.0333 0.3437 0.5306
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Trypanosoma cruzi tubulin delta chain 0.0148 0.1443 0.2199
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0063 0.0098
Loa Loa (eye worm) alpha-tubulin isotype 2 0.03 0.3089 0.3089
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0339 0.3507 0.3507
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Leishmania major cytochrome p450-like protein 0.0037 0.0245 0.0333
Loa Loa (eye worm) tubulin alpha chain 0.0448 0.4685 0.4685
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Brugia malayi Pre-SET motif family protein 0.0031 0.0182 0.0281
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0318 0.0448
Onchocerca volvulus 0.0246 0.2506 1
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0041 0.0292 0.0381
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0039 0.0263 0.0408
Loa Loa (eye worm) alpha-tubulin 0.0448 0.4685 0.4685
Brugia malayi hypothetical protein 0.025 0.2551 0.3954
Plasmodium vivax tubulin gamma chain, putative 0.0333 0.3437 0.5306
Echinococcus granulosus tubulin epsilon chain 0.0333 0.3437 0.5328
Loa Loa (eye worm) hypothetical protein 0.03 0.3089 0.3089
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Brugia malayi SRC-1 0.0045 0.0333 0.0515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0443 0.0687
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 1
Trypanosoma brucei tubulin delta chain 0.0148 0.1443 0.2199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0362 0.3754 0.5799
Leishmania major cytochrome p450-like protein 0.0028 0.0153 0.0191
Toxoplasma gondii hypothetical protein 0.0339 0.3507 0.5415
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Loa Loa (eye worm) hypothetical protein 0.0359 0.372 0.372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0443 0.0687
Schistosoma mansoni hypothetical protein 0.0028 0.0153 0.0238
Schistosoma mansoni rab6-interacting 0.002 0.0063 0.0098
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 0.4778
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0244 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Echinococcus granulosus tubulin alpha 3 chain 0.0448 0.4685 0.7263
Entamoeba histolytica tubulin gamma chain 0.0333 0.3437 0.5293
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni tyrosine kinase 0.0049 0.0377 0.0585
Plasmodium falciparum alpha tubulin 2 0.0448 0.4685 0.725
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Brugia malayi Tyrosine-protein kinase abl-1 0.0093 0.0853 0.1322
Leishmania major trypanothione reductase 0.0049 0.0377 0.054
Plasmodium falciparum phosphodiesterase gamma, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni tubulin subunit beta 0.0612 0.6451 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Onchocerca volvulus Peroxidase homolog 0.0026 0.0133 0.0409
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) tubulin gamma chain 0.0333 0.3437 0.3437
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0153 0.0868
Schistosoma mansoni tyrosine kinase 0.0017 0.0027 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0182 0.0282
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0333 0.0515
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Trypanosoma cruzi alpha tubulin, putative 0.0448 0.4685 0.725
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Echinococcus multilocularis transient receptor potential cation channel 0.0159 0.1559 0.2416
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0133 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0318 0.0494
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0453 0.0702
Echinococcus granulosus tubulin alpha 1C chain 0.0448 0.4685 0.7263
Schistosoma mansoni cytochrome P450 0.0028 0.0153 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.1182 0.1794
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Brugia malayi Tubulin alpha chain 0.0148 0.1443 0.2236
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.144 0.2233
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0164 0.0534
Trichomonas vaginalis tubulin beta chain, putative 0.0612 0.6451 1
Echinococcus multilocularis beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.03 0.3089 0.4764
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Loa Loa (eye worm) tubulin beta chain 0.0148 0.1443 0.1443
Schistosoma mansoni alpha tubulin 0.0448 0.4685 0.7263
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0153 0.0868
Echinococcus granulosus tyrosine kinase 0.0039 0.0263 0.0408
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0169 0.0263
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0153 0.0153
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0182 0.0282
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.002 0.0031
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0124 0.0145
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0044 0.0318 0.0493
Leishmania major beta tubulin 0.0612 0.6451 1
Leishmania major beta tubulin 0.0612 0.6451 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0153 0.0868
Schistosoma mansoni lipoxygenase 0.0056 0.0453 0.0702
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Leishmania major beta tubulin 0.0612 0.6451 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0148 0.1443 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0185 0.1841 0.282
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0124 0.0145
Schistosoma mansoni carbonic anhydrase-related 0.0339 0.3507 0.5437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0443 0.0687
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Onchocerca volvulus 0.0026 0.0133 0.0409
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Schistosoma mansoni DNA topoisomerase type I 0.0136 0.1316 0.2039
Loa Loa (eye worm) tubulin alpha-3 chain 0.0263 0.2691 0.2691
Plasmodium vivax topoisomerase I, putative 0.0182 0.1808 0.2769
Schistosoma mansoni tyrosine kinase 0.0045 0.0333 0.0515
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2551 0.3954
Loa Loa (eye worm) TK protein kinase 0.0102 0.0951 0.0951
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0124 0.0192
Toxoplasma gondii alpha-tubulin I, putative 0.0448 0.4685 0.725
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Echinococcus multilocularis Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Loa Loa (eye worm) hypothetical protein 0.0339 0.3507 0.3507
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0153 0.0868
Trypanosoma cruzi epsilon tubulin, putative 0.0333 0.3437 0.5306
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0124 0.0145
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Trichomonas vaginalis tubulin alpha chain, putative 0.0612 0.6451 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0244 0.0378
Trichomonas vaginalis tubulin gamma chain, putative 0.0333 0.3437 0.5306
Echinococcus granulosus carbonic anhydrase II 0.053 0.5573 0.8639
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0394 0.0611
Trypanosoma cruzi tubulin gamma chain 0.0333 0.3437 0.5306
Brugia malayi Blistered cuticle protein 3 0.0026 0.0133 0.0205
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0044 0.0318 0.0448
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Echinococcus multilocularis carbonic anhydrase 0.0339 0.3507 0.5437
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Loa Loa (eye worm) tubulin alpha 2 0.03 0.3089 0.3089
Schistosoma mansoni tyrosine kinase 0.0081 0.0717 0.1112
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0153 0.0191
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Mycobacterium leprae putative cytochrome p450 0.0028 0.0153 0.0081
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0048 0.0122
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0027 0.0042
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0153 0.0868
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0063 0.0098
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Brugia malayi cytochrome P450 0.0028 0.0153 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0153 0.0868
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0443 0.0687
Onchocerca volvulus 0.0026 0.0133 0.0409
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0359 0.372 0.5766
Leishmania major beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major hypothetical protein, conserved 0.0044 0.0318 0.0448
Giardia lamblia Beta tubulin 0.0612 0.6451 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0153 0.0868
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0333 0.0515
Schistosoma mansoni ap endonuclease 0.0019 0.0048 0.0074
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0136 0.1316 0.2001
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0377 0.0377
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0041 0.0292 0.0407
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.1841 0.282
Toxoplasma gondii beta-tubulin, putative 0.0612 0.6451 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0133 0.0133
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0124 0.0192
Echinococcus multilocularis GPCR, family 2 0.0016 0.002 0.0031
Leishmania major beta tubulin 0.0612 0.6451 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0048
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0448 0.4685 0.725
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0245 0.0245
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0315 0.3249 0.5036
Echinococcus granulosus carbonic anhydrase 0.0339 0.3507 0.5437
Loa Loa (eye worm) hypothetical protein 0.0339 0.3507 0.3507
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1191 0.8217
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0318 0.0448
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Mycobacterium ulcerans cell division protein FtsZ 0.0148 0.1443 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0148 0.1443 0.2199
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0245 0.0333
Entamoeba histolytica tubulin alpha-1 chain 0.0448 0.4685 0.7242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0315 0.3249 0.3249
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Echinococcus granulosus beta tubulin 0.0612 0.6451 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0333 0.3437 0.5328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0221
Brugia malayi beta-tubulin, identical 0.0612 0.6451 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0133 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0153 0.0868
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0153 0.0868
Echinococcus multilocularis hypothetical protein 0.0448 0.4685 0.7263
Plasmodium vivax tubulin epsilon chain, putative 0.0333 0.3437 0.5306
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0063 0.0051
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Plasmodium falciparum tubulin delta chain, putative 0.0148 0.1443 0.2199
Echinococcus multilocularis ankyrin repeat protein 0.0155 0.1521 0.2357
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0015 0.0009 0.0009
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0155 0.1521 0.2357
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.1056 0.7262
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0048 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Brugia malayi Doublecortin family protein 0.002 0.0063 0.0098
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0153 0.0868
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0333 0.0515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Schistosoma mansoni tubulin subunit delta 0.0148 0.1443 0.2237
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0717 0.1112
Mycobacterium leprae Conserved hypothetical protein 0.0028 0.0153 0.0081
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0448 0.4685 0.7263
Echinococcus granulosus tubulin alpha chain 0.0448 0.4685 0.7263
Echinococcus granulosus tyrosine protein kinase ABL1 0.021 0.2118 0.3284
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2502 0.385
Brugia malayi Furin-like cysteine rich region family protein 0.0148 0.144 0.2232
Schistosoma mansoni peroxidasin 0.0026 0.0133 0.0206
Echinococcus granulosus Tubulin alpha 1 chain 0.0448 0.4685 0.7263
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Toxoplasma gondii thioredoxin reductase 0.0049 0.0377 0.054
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0223 0.0346
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0148 0.1443 0.2199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Brugia malayi alpha-tubulin 0.0448 0.4685 0.7263
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus tubulin delta chain 0.0148 0.1443 0.2237
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0044 0.0318 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1627 0.2487
Schistosoma mansoni tubulin subunit alpha 0.0448 0.4685 0.7263
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0048 0.0122
Echinococcus multilocularis carbonic anhydrase 0.0339 0.3507 0.5437
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0124 0.0124
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0377 0.054
Loa Loa (eye worm) hypothetical protein 0.008 0.0713 0.0713
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.041 0.0635
Schistosoma mansoni tyrosine kinase 0.0017 0.0027 0.0042
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.0377 0.0585
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0153 0.0868
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Trypanosoma brucei alpha tubulin 0.0448 0.4685 0.725
Onchocerca volvulus 0.0026 0.0133 0.0409
Entamoeba histolytica tubulin family protein 0.0612 0.6451 1
Echinococcus granulosus tubulin subunit TubB 0.0448 0.4685 0.7263
Loa Loa (eye worm) beta-tubulin 0.0612 0.6451 0.6451
Schistosoma mansoni hypothetical protein 0.0339 0.3507 0.5437
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0048
Leishmania major epsilon tubulin, putative 0.0333 0.3437 0.5306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni lipoxygenase 0.002 0.0063 0.0098
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0263 0.0408
Plasmodium falciparum tubulin beta chain 0.0612 0.6451 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0339 0.3507 0.5437
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0099 0.092 0.1425
Brugia malayi Cytochrome P450 family protein 0.0037 0.0245 0.0379
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0044 0.0318 0.0318
Schistosoma mansoni rab6-interacting 0.002 0.0063 0.0098
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.0031
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0143 0.0175
Onchocerca volvulus 0.0185 0.1841 0.7313
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0153 0.0868
Schistosoma mansoni tyrosine kinase 0.0045 0.0333 0.0515
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0124 0.0145
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0339 0.3507 0.5437
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus DNA topoisomerase 1 0.0182 0.1808 0.2803
Trichomonas vaginalis modulator of drug activity B, putative 0.0041 0.0292 0.0407
Echinococcus multilocularis tyrosine protein kinase Srms 0.0039 0.0263 0.0408
Trichomonas vaginalis tubulin epsilon chain, putative 0.0448 0.4685 0.725
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0143 0.0175
Echinococcus multilocularis Tubulin beta 2C chain 0.0612 0.6451 1
Echinococcus multilocularis 0.0028 0.0153 0.0238
Plasmodium falciparum topoisomerase I 0.0182 0.1808 0.2769
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.053 0.5573 0.8639
Leishmania major beta tubulin 0.0612 0.6451 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0359 0.372 0.5766
Trypanosoma brucei beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0245 0.0245
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0133 0.0133
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0133 0.0133
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0044 0.0318 0.0448
Echinococcus multilocularis carbonic anhydrase II 0.053 0.5573 0.8639
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0044 0.0318 0.0493
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.1056 0.7262
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0263 0.2691 0.4143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2551 0.3954
Echinococcus granulosus tubulin alpha 0.0333 0.3437 0.5328
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0153 0.0191
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0318 0.0448
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0165 0.1627 0.2487
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0153 0.0868
Plasmodium vivax tubulin alpha chain, putative 0.0448 0.4685 0.725
Schistosoma mansoni polycystin 1-related 0.002 0.0063 0.0098
Echinococcus multilocularis tyrosine protein kinase Blk 0.0039 0.0263 0.0408
Giardia lamblia Alpha-tubulin 0.0448 0.4685 0.725
Plasmodium vivax tubulin beta chain, putative 0.0612 0.6451 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0453 0.0702
Onchocerca volvulus 0.0031 0.0182 0.0607
Loa Loa (eye worm) alpha-tubulin 0.0448 0.4685 0.4685
Loa Loa (eye worm) doublecortin family protein 0.002 0.0063 0.0063
Plasmodium vivax delta tubulin, putative 0.0148 0.1443 0.2199
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.1056 0.7262
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0153 0.0868
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0143 0.0794
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0041 0.0292 0.0407
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0041 0.0292 0.0381
Leishmania major beta tubulin 0.0612 0.6451 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Schistosoma mansoni vesicular amine transporter 0.0014 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0292 0.0407
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.1056 0.7026
Schistosoma mansoni hypothetical protein 0.0352 0.3645 0.565
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.1841 0.282
Echinococcus multilocularis tubulin delta chain 0.0148 0.1443 0.2237
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0004 0.0007
Echinococcus multilocularis tubulin alpha chain 0.0448 0.4685 0.7263
Brugia malayi tubulin alpha chain - mouse 0.0448 0.4685 0.7263
Leishmania major carbonic anhydrase-like protein 0.053 0.5573 0.8633
Trypanosoma brucei zeta tubulin 0.0148 0.1443 0.2199
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0164 0.0253
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0136 0.1316 0.2001
Brugia malayi hypothetical protein 0.0037 0.0244 0.0377
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0705 1
Trichomonas vaginalis tubulin, putative 0.0612 0.6451 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0153 0.0868
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0044 0.0318 0.0494
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0046 0.034 0.0482
Trichomonas vaginalis tubulin beta chain, putative 0.0448 0.4685 0.725
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0399 0.0617
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus multilocularis peroxidasin 0.0029 0.0164 0.0254
Loa Loa (eye worm) tubulin alpha-2 chain 0.0448 0.4685 0.4685
Loa Loa (eye worm) tubulin beta-4 chain 0.0612 0.6451 0.6451
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0048 0.0074
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.1443 0.2199
Leishmania major beta tubulin 0.0612 0.6451 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0612 0.6451 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.053 0.5573 0.8639
Entamoeba histolytica hypothetical protein 0.0037 0.0244 0.0306
Schistosoma mansoni tubulin subunit gamma 0.0333 0.3437 0.5328
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0182 0.0282
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0044 0.0318 0.0494
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0165 0.1627 0.2487
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0044 0.0318 0.0448
Echinococcus granulosus peroxisome assembly protein 26 0.0448 0.4685 0.7263
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0333 0.0515
Echinococcus multilocularis insulin receptor 0.0049 0.0377 0.0585
Schistosoma mansoni carbonic anhydrase 0.0339 0.3507 0.5437
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0182 0.0235
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.1095 0.1095
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0705 0.4328
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Giardia lamblia NADPH oxidoreductase, putative 0.0165 0.1627 0.2487
Brugia malayi Probable ClpP-like protease 0.008 0.0705 0.1093
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0044 0.0318 0.0493
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0717 0.1112
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Plasmodium vivax SET domain protein, putative 0.0031 0.0182 0.0235
Schistosoma mansoni alpha tubulin 0.0448 0.4685 0.7263
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0705 0.1094
Trypanosoma cruzi zeta tubulin, putative 0.0148 0.1443 0.2199
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0044 0.0318 0.0494
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0165 0.1627 0.2487
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0046 0.034 0.0482
Leishmania major beta tubulin 0.0612 0.6451 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0044 0.0318 0.0494
Schistosoma mansoni tyrosine kinase 0.0077 0.0678 0.105
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0063 0.0098
Echinococcus granulosus tubulin subunit beta 0.0612 0.6451 1
Brugia malayi hypothetical protein 0.002 0.0063 0.0098
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0153 0.0868
Schistosoma mansoni carbonic anhydrase-related 0.0339 0.3507 0.5437
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Leishmania major alpha tubulin 0.0448 0.4685 0.725
Echinococcus granulosus Tubulin beta 2C chain 0.0612 0.6451 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.002 0.0031
Loa Loa (eye worm) cytochrome P450 0.0028 0.0153 0.0153
Schistosoma mansoni tubulin subunit alpha 0.0448 0.4685 0.7263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0443 0.0687
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0153 0.0868
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0705 0.1051
Brugia malayi DNA topoisomerase I 0.0182 0.1808 0.2803
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0192 0.0298
Trichomonas vaginalis chaperonin, putative 0.0026 0.0124 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0318 0.0448
Brugia malayi Tubulin gamma chain 0.0333 0.3437 0.5328
Giardia lamblia Epsilon tubulin 0.0148 0.1443 0.2199
Schistosoma mansoni alpha tubulin 0.0448 0.4685 0.7263
Trichomonas vaginalis tubulin alpha chain, putative 0.0333 0.3437 0.5306
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0124 0.0192
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Plasmodium falciparum carbonic anhydrase 0.0339 0.3507 0.5415
Schistosoma mansoni tyrosine kinase 0.0077 0.0678 0.105
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0153 0.0868
Echinococcus multilocularis tubulin epsilon chain 0.0333 0.3437 0.5328
Echinococcus multilocularis tubulin alpha 3 chain 0.0448 0.4685 0.7263
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0153 0.0868
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.1555 0.241
Brugia malayi Tubulin alpha chain 0.0448 0.4685 0.7263
Brugia malayi Pre-SET motif family protein 0.0216 0.218 0.3379
Schistosoma mansoni tubulin subunit alpha 0.0148 0.1443 0.2237
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0048 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0339 0.3507 0.5437
Leishmania major delta tubulin, putative 0.0148 0.1443 0.2199
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0044 0.0318 0.0448

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.