Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 1 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 1 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 1 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.3523 | 0.3523 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 1 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 1 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 1 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 1 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.3523 | 0.3523 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 1 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.3523 | 0.3523 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 1 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (binding) | = 5.35 | Binding affinity for 5-hydroxytryptamine 2A receptor of rabbit aorta ring preparations | ChEMBL. | 10411472 |
pKB (binding) | = 5.57 | Binding affinity against vascular 5-hydroxytryptamine 1B receptor, measured using ring preparations of rabbit saphenous vein (RbSV) | ChEMBL. | 10411472 |
pKB (binding) | = 5.35 | Binding affinity for 5-hydroxytryptamine 2A receptor of rabbit aorta ring preparations | ChEMBL. | 10411472 |
pKB (binding) | = 5.57 | Binding affinity against vascular 5-hydroxytryptamine 1B receptor, measured using ring preparations of rabbit saphenous vein (RbSV) | ChEMBL. | 10411472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.