Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | nuclear hormone receptor | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.01 | 0.4377 | 0.1071 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.01 | 0.4377 | 0.1071 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | nuclear receptor NHR-67 | 0.0089 | 0.3703 | 0.3703 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.01 | 0.4377 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.01 | 0.4377 | 0.4377 |
Brugia malayi | tailless protein | 0.0089 | 0.3703 | 0.3703 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.01 | 0.4377 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | ecdysone receptor | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | nuclear receptor RXR | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | conserved hypotetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | nuclear receptor RXR | 0.01 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4377 | 0.4377 |
Brugia malayi | nuclear receptor NHR-88 | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | DR-78 | 0.0089 | 0.3703 | 0.3703 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.