Detailed information for compound 1401958

Basic information

Technical information
  • TDR Targets ID: 1401958
  • Name: methyl 2-(4-methyl-2-oxochromen-6-yl)oxyaceta te
  • MW: 248.231 | Formula: C13H12O5
  • H donors: 0 H acceptors: 2 LogP: 1.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)COc1ccc2c(c1)c(C)cc(=O)o2
  • InChi: 1S/C13H12O5/c1-8-5-12(14)18-11-4-3-9(6-10(8)11)17-7-13(15)16-2/h3-6H,7H2,1-2H3
  • InChiKey: KECDOAHYSVDJHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-(4-methyl-2-oxo-chromen-6-yl)oxyacetate
  • 2-[(4-methyl-2-oxo-6-chromenyl)oxy]acetic acid methyl ester
  • 2-(2-keto-4-methyl-chromen-6-yl)oxyacetic acid methyl ester
  • methyl 2-(4-methyl-2-oxo-chromen-6-yl)oxyethanoate
  • MLS000063314
  • SMR000074967
  • methyl [(4-methyl-2-oxo-2H-chromen-6-yl)oxy]acetate
  • ZINC00617706

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.004 0.0672 0.9309
Schistosoma mansoni tar DNA-binding protein 0.0134 0.332 0.3279
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.332 0.9215
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Toxoplasma gondii thioredoxin reductase 0.0053 0.1025 0.4502
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.2204 0.2156
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0581 0.1611
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0702 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0702 0.2994
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.2204 1
Plasmodium falciparum glutathione reductase 0.0053 0.1025 0.4502
Entamoeba histolytica hypothetical protein 0.004 0.0672 0.9309
Echinococcus granulosus lamin dm0 0.003 0.0391 0.0332
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0464 0.188
Trichomonas vaginalis ran, putative 0.0026 0.0269 0.3254
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0269 0.2164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.2793 0.7752
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0672 0.0616
Echinococcus granulosus tar DNA binding protein 0.0134 0.332 0.3279
Schistosoma mansoni hypothetical protein 0.0079 0.1766 0.1716
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0269 0.021
Echinococcus granulosus GPCR family 2 0.0037 0.0575 0.0518
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0702 1
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.1025 0.1025
Schistosoma mansoni hypothetical protein 0.0037 0.0575 0.0518
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0528 0.4843
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0702 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0575 0.1597
Loa Loa (eye worm) hypothetical protein 0.0029 0.0376 0.0376
Onchocerca volvulus 0.003 0.0391 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0575 0.0575
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0702 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0269 0.2164
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.1025 0.0971
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.1289 0.3801
Loa Loa (eye worm) inositol-1 0.0041 0.0702 0.0702
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0464 0.188
Echinococcus granulosus lamin 0.003 0.0391 0.0332
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2204 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Schistosoma mansoni hypothetical protein 0.004 0.0672 0.0616
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3602 0.3602
Plasmodium falciparum thioredoxin reductase 0.0053 0.1025 0.4502
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0269 0.021
Loa Loa (eye worm) hypothetical protein 0.0079 0.1766 0.1766
Entamoeba histolytica hypothetical protein 0.004 0.0672 0.9309
Leishmania major importin beta-1 subunit, putative 0.0028 0.0343 0.2924
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1289 0.2918
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.2917 0.8837
Loa Loa (eye worm) RNA binding protein 0.0134 0.332 0.332
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.3293 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0061 0.0168
Brugia malayi Inositol-1 0.0041 0.0702 0.195
Brugia malayi hypothetical protein 0.004 0.0672 0.1867
Echinococcus multilocularis lamin 0.003 0.0391 0.0332
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.2204 0.2156
Plasmodium vivax glutathione reductase, putative 0.0053 0.1025 0.4502
Entamoeba histolytica hypothetical protein 0.0028 0.0343 0.1694
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0391 0.0391
Echinococcus multilocularis tar DNA binding protein 0.0134 0.332 0.3279
Echinococcus multilocularis GPCR, family 2 0.0037 0.0575 0.0518
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 0.0974
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.1289 0.3801
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0528 0.218
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 1
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.2917 0.8837
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.2917 0.8837
Brugia malayi glutathione reductase 0.0053 0.1025 0.2847
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Trypanosoma brucei trypanothione reductase 0.0053 0.1025 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0702 0.6651
Schistosoma mansoni tar DNA-binding protein 0.0134 0.332 0.3279
Loa Loa (eye worm) hypothetical protein 0.0037 0.0575 0.0575
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.2917 0.8672
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0702 0.6651
Plasmodium falciparum importin beta, putative 0.0035 0.0528 0.218
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0269 0.2164
Loa Loa (eye worm) TAR-binding protein 0.0134 0.332 0.332
Onchocerca volvulus 0.003 0.0391 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0528 0.0528
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.1025 0.4502
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0702 0.6651
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.2917 0.8837
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0575 0.0518
Brugia malayi intermediate filament protein 0.003 0.0391 0.1085
Schistosoma mansoni intermediate filament proteins 0.003 0.0391 0.0332
Schistosoma mansoni lamin 0.003 0.0391 0.0332
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.1025 0.2985
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0702 0.6651
Leishmania major trypanothione reductase 0.0053 0.1025 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0575 0.0518
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0528 0.047
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0343 0.4397
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 0.0748
Loa Loa (eye worm) hypothetical protein 0.0115 0.2793 0.2793
Loa Loa (eye worm) hypothetical protein 0.003 0.0391 0.0391
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.2204 0.6151
Schistosoma mansoni importin beta-1 0.0035 0.0528 0.047
Schistosoma mansoni hypothetical protein 0.0037 0.0575 0.0518
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.3293 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0528 0.4843
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3602 0.3602
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0528 0.218
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.3293 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0528 0.047
Schistosoma mansoni lamin 0.003 0.0391 0.0332
Schistosoma mansoni hypothetical protein 0.0037 0.0575 0.0518
Loa Loa (eye worm) hypothetical protein 0.0094 0.2204 0.2204
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0575 0.0518
Echinococcus granulosus intermediate filament protein 0.003 0.0391 0.0332
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0343 0.4397
Schistosoma mansoni tar DNA-binding protein 0.0134 0.332 0.3279
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.1766 0.4903
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1289 0.1236
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0702 0.2994
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.332 0.332
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0702 0.0646
Echinococcus multilocularis musashi 0.003 0.0391 0.0332
Mycobacterium tuberculosis Probable reductase 0.012 0.2917 0.8837
Schistosoma mansoni ran 0.0026 0.0269 0.021
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.2917 0.8837
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.2793 0.7752
Schistosoma mansoni tar DNA-binding protein 0.0134 0.332 0.3279
Schistosoma mansoni ran 0.0026 0.0269 0.021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0581 0.0416
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0702 0.0646
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0343 0.4397
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0269 0.0269
Brugia malayi RNA, U transporter 1 0.0099 0.2333 0.6476
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0672 0.0616
Entamoeba histolytica hypothetical protein 0.004 0.0672 0.9309
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0575 0.1597
Schistosoma mansoni inositol monophosphatase 0.0041 0.0702 0.0646
Loa Loa (eye worm) glutathione reductase 0.0053 0.1025 0.1025
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0702 0.2994
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.1025 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0464 0.188
Loa Loa (eye worm) intermediate filament protein 0.003 0.0391 0.0391
Brugia malayi Importin beta-1 subunit 0.0035 0.0528 0.1465
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0391 0.1085
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0343 0.2924
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.2793 0.2793
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0575 0.0518
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.3293 1
Schistosoma mansoni tar DNA-binding protein 0.0134 0.332 0.3279
Brugia malayi Probable ClpP-like protease 0.0094 0.2204 0.6118
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2204 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.2204 0.2156
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0269 0.0974
Toxoplasma gondii hypothetical protein 0.0033 0.0464 0.188
Brugia malayi RNA binding protein 0.0134 0.332 0.9215
Schistosoma mansoni inositol monophosphatase 0.0041 0.0702 0.0646
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0672 0.0616
Schistosoma mansoni hypothetical protein 0.0037 0.0575 0.0518
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1289 0.1236
Brugia malayi Thioredoxin reductase 0.0053 0.1025 0.2847
Brugia malayi MH2 domain containing protein 0.0144 0.3602 1
Echinococcus multilocularis lamin dm0 0.003 0.0391 0.0332
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0269 0.0974
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.1025 0.0971
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2204 1
Brugia malayi TAR-binding protein 0.0134 0.332 0.9215
Leishmania major GTP-binding protein, putative 0.0026 0.0269 0.2164

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8356 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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