Detailed information for compound 1402107

Basic information

Technical information
  • TDR Targets ID: 1402107
  • Name: NCGC00102930-01
  • MW: 406.54 | Formula: C24H26N2O2S
  • H donors: 0 H acceptors: 1 LogP: 4.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(SC)ccc1C(=O)N1CCn2c3C1CCCc3c1c2ccc(c1)C
  • InChi: 1S/C24H26N2O2S/c1-15-7-10-20-19(13-15)17-5-4-6-21-23(17)25(20)11-12-26(21)24(27)18-9-8-16(29-3)14-22(18)28-2/h7-10,13-14,21H,4-6,11-12H2,1-3H3
  • InChiKey: KCWZXVUZRVQYAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A3760/0159466

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni helicase 0.0066 0.0737 0.1472
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0012 0.0048 0.0095
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.095 0.1897
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0003 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0141 0.0313
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0141 0.0141
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0167 0.0371
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0061 0.0061
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3124 0.927
Brugia malayi nuclear receptor RXR 0.0044 0.0455 0.1011
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0229 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3124 0.927
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1193 0.2652
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.095 0.1897
Schistosoma mansoni hypothetical protein 0.0013 0.0061 0.0121
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0118
Trypanosoma brucei unspecified product 0.0013 0.0066 0.0147
Echinococcus multilocularis Chromo domain 0.0011 0.0046 0.0046
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0396 0.0396
Echinococcus multilocularis ets variant gene 4 0.0013 0.0061 0.0061
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 0.5704
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0045 0.0045
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.0003 0.0005
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0396 0.0396
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0455 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.095 0.2112
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0006 0.0006
Loa Loa (eye worm) DR-78 0.0039 0.0396 0.0768
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0396 0.079
Onchocerca volvulus 0.0035 0.0345 0.1015
Schistosoma mansoni thyroid hormone receptor 0.0235 0.2866 0.5725
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0396 0.0879
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.095 0.095
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.095 0.095
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0003 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2845 0.5526
Loa Loa (eye worm) hypothetical protein 0.0234 0.2852 0.5541
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.095 0.1897
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1003 0.1948
Schistosoma mansoni hypothetical protein 0.0047 0.0499 0.0996
Schistosoma mansoni inositol monophosphatase 0.0037 0.0362 0.0722
Onchocerca volvulus 0.0142 0.169 0.5011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0396 0.079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0345 0.0688
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0061 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0141 0.0313
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1817 0.1817
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.095 0.2112
Brugia malayi hypothetical protein 0.0026 0.0229 0.0508
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.095 0.1897
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0875 1
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.095 0.2112
Brugia malayi ecdysteroid receptor 0.0083 0.095 0.2112
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0005
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0396 0.0396
Trichomonas vaginalis mgm1, putative 0.0021 0.0167 0.0487
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0539 0.1077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.095 0.095
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0826 0.1605
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0518 0.1035
Leishmania major DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Trichomonas vaginalis dynamin, putative 0.0021 0.0167 0.0487
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0875 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0235 0.2866 0.2866
Onchocerca volvulus 0.0083 0.095 0.2813
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.0884
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1003 0.2004
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.1427 0.2851
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0362 0.1066
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0131
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0396 0.1167
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0141 0.041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.095 0.1845
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0061 0.0061
Plasmodium vivax dynamin-like protein, putative 0.0021 0.0167 0.1907
Brugia malayi hypothetical protein 0.0044 0.0455 0.1011
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0061 0.0121
Echinococcus multilocularis protein C ets 2 0.0013 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.095 0.2112
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.095 0.2112
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.095 0.095
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0045 0.0045
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0141 0.0141
Loa Loa (eye worm) inositol-1 0.0037 0.0362 0.0703
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0045 0.0045
Onchocerca volvulus Huntingtin homolog 0.0121 0.1426 0.4228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0455 0.0909
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0061 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.095 0.1845
Schistosoma mansoni vesicular acetylcholine transporter 0.0227 0.2767 0.5528
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0455 0.0884
Leishmania major hypothetical protein, conserved 0.0026 0.0229 0.0508
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2852 0.5698
Schistosoma mansoni hypothetical protein 0.0405 0.5006 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0002 0.0004
Echinococcus multilocularis dynamin 1 0.0023 0.0187 0.0187
Plasmodium vivax DEAD/DEAH helicase, putative 0.001 0.0031 0.0353
Brugia malayi G-protein alpha subunit 0.0008 0.0003 0.0006
Trichomonas vaginalis dynamin, putative 0.0021 0.0167 0.0487
Schistosoma mansoni thyroid hormone receptor 0.0235 0.2866 0.5725
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0396 0.079
Brugia malayi transcription factor E74 isoform 0.0013 0.0061 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.2279 0.4552
Loa Loa (eye worm) hypothetical protein 0.0186 0.225 0.437
Onchocerca volvulus 0.0028 0.0259 0.0761
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0003 0.0005
Brugia malayi Pre-SET motif family protein 0.0035 0.0345 0.0766
Echinococcus granulosus Smad4 0.0008 0.0002 0.0004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.095 0.2112
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0396 0.079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0321 0.0641
Echinococcus multilocularis geminin 0.0168 0.2016 0.2016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Loa Loa (eye worm) hypothetical protein 0.0365 0.4497 0.8735
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.0884
Echinococcus multilocularis dynamin 1 protein 0.0021 0.0167 0.0167
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.0053 0.0149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0362 0.0804
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Schistosoma mansoni ets-related 0.0013 0.0061 0.0121
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.0003 0.0005
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0061 0.0121
Loa Loa (eye worm) helicase DNA-binding protein 0.0011 0.0045 0.0088
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.3124 0.6069
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0061 0.0118
Echinococcus granulosus dynamin 0.0021 0.0167 0.0333
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0005
Echinococcus multilocularis smad 0.0008 0.0002 0.0002
Echinococcus granulosus dynamin 1 protein 0.0021 0.0167 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.095 0.2112
Echinococcus granulosus expressed protein 0.0008 0.0003 0.0006
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0026 0.0058
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Loa Loa (eye worm) hypothetical protein 0.0047 0.0499 0.0969
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0229 0.2612
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.095 0.2112
Brugia malayi MH1 domain containing protein 0.0008 0.0002 0.0004
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0396 0.0768
Brugia malayi conserved hypotetical protein 0.0039 0.0396 0.0879
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.095 0.1897
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0003 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0002 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.095 0.2813
Schistosoma mansoni hypothetical protein 0.0048 0.0503 0.1004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.2279 0.2279
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0503 0.1118
Echinococcus granulosus dna polymerase eta 0.0019 0.0141 0.0282
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1003 0.1003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0345 0.0688
Brugia malayi hypothetical protein 0.0039 0.0396 0.0879
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1427 0.2851
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0499 0.1109
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0396 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.095 0.1845
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0141 0.0313
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.095 0.1897
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.0003 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0396 0.0396
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0259 0.0503
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0364
Echinococcus multilocularis GPCR, family 2 0.0047 0.0499 0.0499
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0396 0.0396
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0048 0.0095
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0006 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.095 0.1897
Echinococcus granulosus dnaJ subfamily B 0.0405 0.5006 1
Echinococcus multilocularis vesicular acetylcholine transporter 0.0227 0.2767 0.2767
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 1
Echinococcus granulosus Chromo domain 0.0011 0.0046 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0396 0.079
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0003 0.0006
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0021 0.0167 0.0487
Echinococcus multilocularis global transcription activator snf2l2 0.0066 0.0737 0.0737
Schistosoma mansoni cpg binding protein 0.0028 0.0259 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Brugia malayi hypothetical protein 0.0039 0.0396 0.0879
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0003 0.0006
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0003 0.0006
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.0003 0.0006
Onchocerca volvulus 0.0039 0.0396 0.1167
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Echinococcus granulosus FTZ F1 alpha 0.0083 0.095 0.1897
Echinococcus granulosus cpg binding protein 0.003 0.028 0.0558
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0005
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0003 0.0005
Echinococcus granulosus global transcription activator snf2l2 0.0066 0.0737 0.1473
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.213 0.6316
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0875 0.1747
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3124 0.927
Trypanosoma brucei unspecified product 0.0019 0.0141 0.0313
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1388 0.2695
Schistosoma mansoni cpg binding protein 0.003 0.028 0.0558
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0003 0.0006
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 0.5704
Brugia malayi hypothetical protein 0.0234 0.2852 0.6343
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0345 0.2247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.095 0.2112
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0066 0.0147
Brugia malayi ecdysone receptor 0.0039 0.0396 0.0879
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.0884
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Brugia malayi CXXC zinc finger family protein 0.0028 0.0259 0.0576
Schistosoma mansoni smad 0.0008 0.0002 0.0004
Brugia malayi Dynamin 0.0023 0.0187 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.095 0.1845
Brugia malayi Inositol-1 0.0037 0.0362 0.0804
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1427 0.2851
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0006 0.0011
Schistosoma mansoni elf1 0.0013 0.0061 0.0121
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Leishmania major DNA polymerase eta, putative 0.0019 0.0141 0.0313
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0396 0.079
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0396 0.0879
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.2279 0.4552
Brugia malayi hypothetical protein 0.0121 0.1426 0.3172
Echinococcus granulosus muscleblind protein 0.0148 0.1761 0.3518
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.2279 0.4427
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0539 0.3095
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0236 0.27
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0499 0.1109
Schistosoma mansoni survival motor neuron protein 0.0048 0.0503 0.1004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0396 0.079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.095 0.2112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0141 0.0281
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.1427 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.4497 1
Entamoeba histolytica G protein alpha subunit, putative 0.0008 0.0003 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0345 0.0688
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.095 0.1897
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0362 0.0723
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.001 0.0031 0.0353
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0396 0.0879
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0061 0.0121
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.095 0.1897
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0455 0.0909
Brugia malayi nuclear hormone receptor 0.0039 0.0396 0.0879
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0362 0.0804
Loa Loa (eye worm) RNA binding protein 0.0073 0.0826 0.1605
Plasmodium vivax SET domain protein, putative 0.0035 0.0345 0.3941
Leishmania major GTP-binding protein, putative 0.0021 0.0167 0.0371
Onchocerca volvulus 0.0048 0.0503 0.1485
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3124 0.927
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0045 0.0045
Echinococcus granulosus vesicular acetylcholine transporter 0.0227 0.2767 0.5528
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0066 0.0147
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0362 0.1066
Brugia malayi hypothetical protein 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0061 0.0121
Brugia malayi hypothetical protein 0.0017 0.0112 0.025
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0003 0.0005
Brugia malayi tailless protein 0.0039 0.0396 0.0879
Loa Loa (eye worm) hypothetical protein 0.0103 0.1193 0.2317
Trichomonas vaginalis set domain proteins, putative 0.0275 0.337 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0274
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0539 0.0539
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0002 0.0004
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0061 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0229 0.2612
Schistosoma mansoni hypothetical protein 0.0047 0.0499 0.0996
Schistosoma mansoni nuclear receptor 0.0039 0.0396 0.079
Toxoplasma gondii dynamin-related protein DRPB 0.0021 0.0167 0.0973
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0875 0.1747
Brugia malayi MH2 domain containing protein 0.0008 0.0002 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.095 0.1845
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0826 0.0826
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0053 0.0158
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0499 0.0969
Loa Loa (eye worm) hypothetical protein 0.0035 0.0345 0.067
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.095 0.1897
Schistosoma mansoni hypothetical protein 0.0103 0.1193 0.2382
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2852 0.2852
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0141 0.0282
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0061 0.0121
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0396 0.079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0499 0.0996
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0002 0.0004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0362 0.1716
Loa Loa (eye worm) hypothetical protein 0.0416 0.5148 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0826 0.165
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.095 0.1897
Schistosoma mansoni dynamin 0.0021 0.0167 0.0333
Loa Loa (eye worm) Smad1 0.0008 0.0002 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0499 0.0499
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0396 0.079
Schistosoma mansoni nuclear receptor 0.0039 0.0396 0.079
Loa Loa (eye worm) hypothetical protein 0.0077 0.0875 0.1699
Brugia malayi nuclear receptor RXR 0.0039 0.0396 0.0879
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.095 0.095
Schistosoma mansoni zinc finger protein 0.0039 0.0396 0.079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0499 0.0499
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0003 0.0005
Brugia malayi Ets-domain containing protein 0.0087 0.1003 0.223
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2845 0.6326
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0066 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.095 0.2112
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0539 0.4744
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0396 0.1167
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.095 0.2112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0118
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0061 0.0118
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.295 0.573
Trichomonas vaginalis dynamin, putative 0.0021 0.0167 0.0487
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0455 0.0455
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.095 0.095
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0229 0.1415
Brugia malayi Dynamin central region family protein 0.0021 0.0167 0.0371
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1791 0.3982
Brugia malayi Ets-domain containing protein 0.0087 0.1003 0.223
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.095 0.095
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2016 0.5978
Leishmania major hypothetical protein, conserved 0.0142 0.169 0.3758
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Trypanosoma brucei Emopamil binding protein, putative 0.0142 0.169 0.3758
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0051 0.0546 0.1091
Echinococcus granulosus dna polymerase kappa 0.0019 0.0141 0.0282
Entamoeba histolytica dynamin-1-like protein, putative 0.0021 0.0167 0.4611
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1427 1
Brugia malayi Ets-domain containing protein 0.0013 0.0061 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.095 0.2112
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0061 0.0118
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0048 0.0048
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0362 0.0804
Brugia malayi steroid hormone receptor 0.0083 0.095 0.2112
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.5006 0.5006
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0396 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.095 0.2112
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0004
Trypanosoma cruzi dynamin-1-like protein 0.0021 0.0167 0.0371
Onchocerca volvulus 0.0275 0.337 1
Brugia malayi Probable ClpP-like protease 0.0077 0.0875 0.1945
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1791 0.3982
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.4497 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0875 0.6043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.2279 0.4552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.095 0.1845
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3124 0.927
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0045 0.0045
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0061 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.095 0.1897
Brugia malayi Muscleblind-like protein 0.0148 0.1761 0.3916
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Echinococcus granulosus tumor protein p63 0.0335 0.4118 0.8226
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0141 0.0313
Loa Loa (eye worm) hypothetical protein 0.0121 0.1426 0.2771
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Brugia malayi nuclear receptor NHR-88 0.0039 0.0396 0.0879
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0168 0.2016 0.4026
Echinococcus multilocularis BRK domain 0.0011 0.0045 0.0045
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0004
Schistosoma mansoni dynamin 0.0023 0.0187 0.0374
Loa Loa (eye worm) hypothetical protein 0.0148 0.1761 0.3421
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.095 0.2813
Trypanosoma cruzi Emopamil binding protein, putative 0.0142 0.169 0.3758
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1427 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0396 0.0768
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0045 0.0045
Echinococcus granulosus BRK domain containing protein 0.0011 0.0045 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0539 0.3095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Echinococcus multilocularis dna polymerase eta 0.0019 0.0141 0.0141
Brugia malayi BRM protein 0.0066 0.0737 0.1639
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0499 0.0996
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.1427 0.3173
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0396 0.0879
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0455 0.1011
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0142 0.169 0.3758
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1427 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0396 0.079
Brugia malayi Dynamin 0.0023 0.0187 0.0416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.2279 0.4552
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.2016 0.5978
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0003 0.0006
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0141 0.3897
Brugia malayi Smad1 0.0008 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.0884
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0236 0.27
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0362 0.1066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.095 0.1897
Plasmodium falciparum dynamin-like protein 0.0021 0.0167 0.1907
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0362 0.0804
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0677 0.1352
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0455 0.0884
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.2279 0.5067
Schistosoma mansoni coup transcription factor 0.0083 0.095 0.1897
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0826 0.165
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0061 0.0061
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0345 0.0689
Brugia malayi Pre-SET motif family protein 0.0242 0.295 0.656
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0167 0.0371
Brugia malayi RNA binding protein 0.0073 0.0826 0.1837
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0003 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0875 0.6043
Echinococcus granulosus smad 0.0008 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0148 0.1761 0.3421
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0142 0.169 0.3758
Schistosoma mansoni inositol monophosphatase 0.0037 0.0362 0.0722
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0003 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.095 0.1897
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0826 0.165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.2279 0.4552
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.095 0.2813
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.4497 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0141 0.0281
Echinococcus granulosus tar DNA binding protein 0.0073 0.0826 0.1651
Loa Loa (eye worm) hypothetical protein 0.0121 0.1426 0.2771
Echinococcus multilocularis dynamin 0.0021 0.0167 0.0167
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0141 0.0274
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0396 0.0879
Echinococcus granulosus protein C ets 2 0.0013 0.0061 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0229 0.0508
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0061 0.0061
Loa Loa (eye worm) fli-1 protein 0.0265 0.3247 0.6308
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.1427 0.1427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.095 0.1845
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0061 0.0118
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0011 0.0045 0.0045
Onchocerca volvulus 0.0049 0.0518 0.153
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0005
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0227 0.2767 0.8211
Brugia malayi nuclear receptor NHR-88 0.0083 0.095 0.2112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Schistosoma mansoni hypothetical protein 0.0011 0.0046 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0345 0.0345
Toxoplasma gondii hypothetical protein 0.0027 0.0236 0.147
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0227 0.2767 0.5376
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0003 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0083 0.095 0.1897
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0362 0.2369
Trichomonas vaginalis dynamin, putative 0.0021 0.0167 0.0487
Onchocerca volvulus 0.0039 0.0396 0.1167
Trypanosoma brucei unspecified product 0.0013 0.0066 0.0147
Echinococcus multilocularis cpg binding protein 0.003 0.028 0.028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0345 0.0345
Echinococcus multilocularis expressed protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.015 0.1791 0.3479
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.1427 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.0055
Echinococcus granulosus GPCR family 2 0.0047 0.0499 0.0996
Schistosoma mansoni dynamin 0.0023 0.0187 0.0374
Schistosoma mansoni ets 0.0013 0.0061 0.0121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0826 0.1605
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.0003 0.0005
Schistosoma mansoni Smad4 0.0008 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0168 0.2016 0.4026
Brugia malayi MH2 domain containing protein 0.0008 0.0002 0.0004
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0875 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.095 0.1897
Loa Loa (eye worm) hypothetical protein 0.0083 0.095 0.1845
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0141 0.041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.095 0.1845
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.3124 0.6947
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0003 0.0005
Echinococcus multilocularis tumor protein p63 0.0335 0.4118 0.4118
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0826 0.165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0345 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0046 0.0101
Brugia malayi MH2 domain containing protein 0.0118 0.1388 0.3085
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0141 0.0313
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.095 0.2112
Schistosoma mansoni hypothetical protein 0.0047 0.0499 0.0996
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1817 0.363
Entamoeba histolytica dynamin-like protein 0.0021 0.0167 0.4611
Echinococcus multilocularis Smad4 0.0008 0.0002 0.0002
Brugia malayi vesicular acetylcholine transporter unc-17 0.0227 0.2767 0.6154
Schistosoma mansoni ets-related 0.0265 0.3247 0.6487
Brugia malayi nuclear hormone receptor 0.0083 0.095 0.2112
Loa Loa (eye worm) BRM protein 0.0034 0.0333 0.0647
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Brugia malayi hypothetical protein 0.0044 0.0455 0.1011
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0142 0.169 0.3758
Plasmodium vivax dynamin protein, putative 0.0021 0.0167 0.1907
Schistosoma mansoni hypothetical protein 0.0047 0.0499 0.0996
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0362 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0003 0.0006
Schistosoma mansoni cpg binding protein 0.003 0.028 0.0558
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0003 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0455 0.1011
Loa Loa (eye worm) BRM protein 0.0042 0.0435 0.0845
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0003 0.0003
Schistosoma mansoni gabp alpha 0.0087 0.1003 0.2003
Brugia malayi nuclear receptor NHR-67 0.0039 0.0396 0.0879
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Trypanosoma cruzi Emopamil binding protein, putative 0.0142 0.169 0.3758
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.095 0.1897
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0826 0.1837
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1388 0.2695
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.0003 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0618 0.4204
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.213 0.6316
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.095 0.2112
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.095 0.095
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0002 0.0004
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1761 0.1761
Loa Loa (eye worm) histone methyltransferase 0.001 0.0028 0.0054
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0396 0.0768
Schistosoma mansoni DNA polymerase eta 0.0019 0.0141 0.0281
Loa Loa (eye worm) DRP-1 protein 0.0021 0.0167 0.0324
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.4497 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0002 0.0004
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0152 0.1817 0.3629
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0229 0.0508
Toxoplasma gondii dynamin-related protein DRPA 0.0021 0.0167 0.0973
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0141 0.0313
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Brugia malayi TAR-binding protein 0.0073 0.0826 0.1837
Toxoplasma gondii dynamin gtpase 0.0014 0.0076 0.0323
Trichomonas vaginalis dynamin, putative 0.0021 0.0167 0.0487
Loa Loa (eye worm) hypothetical protein 0.0049 0.0518 0.1006
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.0003 0.0003
Plasmodium falciparum dynamin-like protein 0.0021 0.0167 0.1907
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0768
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0003 0.0006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0313 0.134
Trichomonas vaginalis dynamin, putative 0.0021 0.0167 0.0487
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0006 0.0006
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0003 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1791 0.3479
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0141 0.0313
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0396 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3124 0.927
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.095 0.1897
Brugia malayi MH1 domain containing protein 0.0008 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0075 0.0843 0.1638
Loa Loa (eye worm) hypothetical protein 0.0416 0.5148 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0826 0.165
Onchocerca volvulus Huntingtin homolog 0.0121 0.1426 0.4228
Schistosoma mansoni hypothetical protein 0.0013 0.0061 0.0121
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0061 0.0134
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0229 0.2612
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0003 0.0003
Giardia lamblia Dynamin 0.0021 0.0167 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0003 0.0005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0141 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0141 0.0313
Brugia malayi Fli-1 protein 0.0265 0.3247 0.7221
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0229 0.0508
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0313 0.1209
Echinococcus multilocularis muscleblind protein 0.0148 0.1761 0.1761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.2279 0.2279
Echinococcus granulosus geminin 0.0168 0.2016 0.4027
Echinococcus granulosus dynamin 1 0.0023 0.0187 0.0374
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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