Detailed information for compound 1402109

Basic information

Technical information
  • TDR Targets ID: 1402109
  • Name: tert-butyl 4-[(4-methoxyphenyl)amino]piperidi ne-1-carboxylate
  • MW: 306.4 | Formula: C17H26N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC1CCN(CC1)C(=O)OC(C)(C)C
  • InChi: 1S/C17H26N2O3/c1-17(2,3)22-16(20)19-11-9-14(10-12-19)18-13-5-7-15(21-4)8-6-13/h5-8,14,18H,9-12H2,1-4H3
  • InChiKey: ZSUFBKHEFBKBDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-methoxyphenyl)amino]-1-piperidinecarboxylic acid tert-butyl ester
  • 4-[(4-methoxyphenyl)amino]piperidine-1-carboxylic acid tert-butyl ester
  • ZINC00158460
  • 12P-542S
  • Oprea1_100046
  • MLS000721224
  • SMR000335650
  • tert-butyl 4-(4-methoxyanilino)tetrahydro-1(2H)-pyridinecarboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0063
Plasmodium vivax SET domain protein, putative 0.0036 0.0113 0.0081
Onchocerca volvulus 0.0116 0.0589 0.3401
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni peptidase Clp (S14 family) 0.0243 0.1349 0.1349
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0116 0.0589 0.0589
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.034 0.034
Onchocerca volvulus 0.0116 0.0589 0.3401
Brugia malayi Dopamine receptor 0.0116 0.0589 0.061
Onchocerca volvulus 0.0036 0.0113 0.0321
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0229 0.1267 0.3233
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0064 0.0066
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0365 0.0365
Echinococcus granulosus tm gpcr rhodopsin 0.0116 0.0589 0.0589
Echinococcus granulosus hypothetical protein 0.0116 0.0589 0.0589
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0105 0.0105
Echinococcus multilocularis fmrfamide receptor 0.0116 0.0589 0.0589
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0059 0.0252 0.0197
Schistosoma mansoni biogenic amine receptor 0.0116 0.0589 0.0589
Echinococcus granulosus fmrfamide receptor 0.0116 0.0589 0.0589
Schistosoma mansoni lamin 0.0028 0.0064 0.0064
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0229 0.1267 0.2905
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0146 0.0768 0.0996
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0059 0.0252 0.0322
Onchocerca volvulus 0.0116 0.0589 0.3401
Chlamydia trachomatis biotin carboxylase 0.0585 0.3392 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0116 0.0589 0.0589
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0059 0.0252 0.0322
Echinococcus granulosus lamin dm0 0.0028 0.0064 0.0064
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0159 0.0849 0.1709
Brugia malayi Serotonin receptor 0.0116 0.0589 0.061
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0365 0.0378
Onchocerca volvulus 0.0116 0.0589 0.3401
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Mycobacterium ulcerans glutaminase 0.0577 0.3347 0.8858
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0365 0.0365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0116 0.0589 0.0589
Schistosoma mansoni hypothetical protein 0.0205 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni microtubule-associated protein tau 0.1458 0.8605 0.8605
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0059 0.0252 0.0252
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0059 0.0252 0.0197
Trypanosoma brucei unspecified product 0.0423 0.2428 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0365 0.0816
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0159 0.0849 0.0849
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0116 0.0589 0.0589
Schistosoma mansoni biogenic amine receptor 0.0116 0.0589 0.0589
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0229 0.1267 0.1218
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0059 0.0252 0.0274
Brugia malayi neuropeptide F receptor 0.0116 0.0589 0.061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.022 0.0228
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 0.3139
Schistosoma mansoni opsin-like receptor 0.0116 0.0589 0.0589
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0275 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0336 0.0241
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0644 0.3746 0.3746
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0398 0.1331
Echinococcus granulosus serotonin receptor 0.0116 0.0589 0.0589
Echinococcus multilocularis neuropeptide Y receptor 0.0116 0.0589 0.0589
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.022 0.0228
Brugia malayi Dopamine receptor protein 2 0.0116 0.0589 0.061
Schistosoma mansoni opsin-like receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1607 0.4641
Brugia malayi neuropeptide F receptor 0.0116 0.0589 0.061
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0243 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0644 0.3746 1
Brugia malayi RE15519p 0.0116 0.0589 0.061
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi follicle stimulating hormone receptor 0.0116 0.0589 0.061
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0229 0.1267 0.2905
Echinococcus multilocularis serotonin receptor 0.1279 0.7541 0.7541
Echinococcus multilocularis neuropeptide s receptor 0.0116 0.0589 0.0589
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0059 0.0252 0.0274
Echinococcus multilocularis neuropeptides capa receptor 0.0116 0.0589 0.0589
Brugia malayi Probable ClpP-like protease 0.0243 0.1349 0.1398
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0336 0.0282
Echinococcus multilocularis lamin dm0 0.0028 0.0064 0.0064
Echinococcus granulosus biogenic amine 5HT receptor 0.0116 0.0589 0.0589
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0275 0.0285
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0116 0.0589 0.0589
Echinococcus multilocularis sex peptide receptor 0.0116 0.0589 0.0589
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0229 0.1267 0.1267
Onchocerca volvulus 0.0116 0.0589 0.3401
Schistosoma mansoni amine GPCR 0.0116 0.0589 0.0589
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1399 0.1451
Echinococcus granulosus somatostatin receptor 0.0116 0.0589 0.0589
Echinococcus multilocularis somatostatin receptor 0.0116 0.0589 0.0589
Brugia malayi G-protein coupled receptor 0.0116 0.0589 0.061
Brugia malayi DnaJ domain containing protein 0.0074 0.034 0.0352
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0644 0.3746 1
Loa Loa (eye worm) hypothetical protein 0.1279 0.7541 0.7818
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0059 0.0252 0.0261
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0114 0.0118
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0243 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0031 0.0085 0.0089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0117
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0059 0.0252 0.0274
Echinococcus granulosus geminin 0.0205 0.112 0.112
Schistosoma mansoni hypothetical protein 0.0116 0.0589 0.0589
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0059 0.0252 0.0197
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0336 0.0336
Onchocerca volvulus 0.0116 0.0589 0.3401
Echinococcus multilocularis neuropeptide receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni aspartate carbamoyltransferase 0.0146 0.0768 0.0768
Mycobacterium ulcerans pyruvate carboxylase 0.0644 0.3746 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.022 0.0228
Echinococcus multilocularis G protein coupled receptor 139 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0365 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0113 0.0113
Echinococcus granulosus neuropeptide receptor 0.0116 0.0589 0.0589
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0365 0.0365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Loa Loa (eye worm) G-protein coupled receptor 0.0116 0.0589 0.061
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0116 0.0589 0.0589
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0116 0.0589 0.061
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0644 0.3746 0.3746
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0059 0.0252 0.0197
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0113 0.0058
Echinococcus granulosus Biotin lipoyl attachment 0.0059 0.0252 0.0252
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0336 0.0336
Schistosoma mansoni alpha-1 adrenergic receptor 0.0116 0.0589 0.0589
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0644 0.3746 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0113 0.0113
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0059 0.0252 0.0252
Onchocerca volvulus 0.0116 0.0589 0.3401
Plasmodium falciparum carbamoyl phosphate synthetase 0.0146 0.0768 0.0996
Echinococcus granulosus lamin 0.0028 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus g protein coupled receptor 0.0116 0.0589 0.0589
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0644 0.3746 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0365 0.0507
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus tm gpcr rhodopsin 0.0116 0.0589 0.0589
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0116 0.0589 0.061
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1632 0.9646 1
Brugia malayi sulfakinin receptor protein 0.0116 0.0589 0.061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0116 0.0589 0.0589
Schistosoma mansoni neuropeptide receptor 0.0116 0.0589 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni lamin 0.0028 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus multilocularis neuropeptide FF receptor 2 0.0116 0.0589 0.0589
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0116 0.0589 0.0589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0228 0.0228
Brugia malayi ORL1-like opioid receptor 0.0116 0.0589 0.061
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0146 0.0768 0.1476
Echinococcus multilocularis G-protein coupled receptor, putative 0.0116 0.0589 0.0589
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0118 0.0123
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0644 0.3746 0.3711
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0114 0.0114
Brugia malayi Pre-SET motif family protein 0.0036 0.0113 0.0117
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0116 0.0589 0.0589
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0644 0.3746 1
Schistosoma mansoni hypothetical protein 0.0116 0.0589 0.0589
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.034 0.034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0228 0.0228
Echinococcus multilocularis g protein coupled receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0058
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0116 0.0589 0.061
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0336 0.0241
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0229 0.1267 0.1218
Schistosoma mansoni amine GPCR 0.0116 0.0589 0.0589
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0243 0.1349 0.13
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0365 0.0365
Echinococcus multilocularis neuropeptide receptor 0.0116 0.0589 0.0589
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni biogenic amine receptor 0.0116 0.0589 0.0589
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0059 0.0252 0.0261
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0059 0.0252 0.0197
Schistosoma mansoni neuropeptide receptor 0.0116 0.0589 0.0589
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0059 0.0252 0.0252
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0116 0.0589 0.061
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Onchocerca volvulus 0.0116 0.0589 0.3401
Schistosoma mansoni amine GPCR 0.0116 0.0589 0.0589
Leishmania major carboxylase, putative 0.0644 0.3746 0.3711
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0229 0.1267 0.1218
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Loa Loa (eye worm) hypothetical protein 0.0243 0.1349 0.1398
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0229 0.1267 0.1218
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0116 0.0589 0.0589
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0229 0.1267 0.1267
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0146 0.0768 0.0716
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0116 0.0589 0.061
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0059 0.0252 0.0322
Brugia malayi glutaminase DH11.1 0.0577 0.3347 0.347
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0644 0.3746 0.3711
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus tachykinin peptides receptor 99D 0.0116 0.0589 0.0589
Schistosoma mansoni intermediate filament proteins 0.0028 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus microtubule associated protein 2 0.1458 0.8605 0.8605
Echinococcus granulosus neuropeptide Y receptor 0.0116 0.0589 0.0589
Echinococcus granulosus peptide allatostatin:somatostatin 0.0116 0.0589 0.0589
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0114 0.0118
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0229 0.1267 0.2905
Echinococcus granulosus alpha 1A adrenergic receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0064 0.0066
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0365 0.0311
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0059 0.0252 0.0252
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0159 0.0849 0.1709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0228 0.0228
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0275 0.022
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0336 0.0336
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni neuropeptide F-like receptor 0.0116 0.0589 0.0589
Echinococcus multilocularis g protein coupled receptor 0.0116 0.0589 0.0589
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 0.1808
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0116 0.0589 0.0589
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0229 0.1267 0.2905
Echinococcus multilocularis orexin receptor type 2 0.0116 0.0589 0.0589
Schistosoma mansoni biogenic amine (5HT) receptor 0.1279 0.7541 0.7541
Onchocerca volvulus 0.0116 0.0589 0.3401
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0116 0.0589 0.0589
Echinococcus granulosus neuropeptide receptor 0.0116 0.0589 0.0589
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0336 0.0241
Trypanosoma cruzi acetyl-CoA carboxylase 0.1047 0.6152 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0116 0.0589 0.061
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0644 0.3746 0.6053
Echinococcus granulosus biogenic amine 5HT receptor 0.1279 0.7541 0.7541
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0228 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0229 0.1267 0.1267
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0113 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0336 0.0336
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0064 0.0066
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0644 0.3746 1
Echinococcus multilocularis neuropeptide Y receptor 0.0116 0.0589 0.0589
Onchocerca volvulus 0.0116 0.0589 0.3401
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0059 0.0252 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Onchocerca volvulus 0.0116 0.0589 0.3401
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0059 0.0252 0.0197
Schistosoma mansoni neuropeptide F-like receptor 0.0116 0.0589 0.0589
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0059 0.0252 0.0322
Schistosoma mansoni hypothetical protein 0.0116 0.0589 0.0589
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0059 0.0252 0.0197
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0228 0.0236
Echinococcus granulosus 7tm_1 domain containing protein 0.0116 0.0589 0.0589
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0159 0.0849 0.1709
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni hypothetical protein 0.0205 0.112 0.112
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0229 0.1267 0.2905
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0116 0.0589 0.061
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0059 0.0252 0.0197
Brugia malayi larval opioid receptor 0.0116 0.0589 0.061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0059 0.0252 0.0197
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0146 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0116 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0365 0.0816
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0146 0.0768 0.1476
Onchocerca volvulus 0.0116 0.0589 0.3401
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0243 0.1349 0.3139
Echinococcus granulosus neuropeptide receptor A26 0.0116 0.0589 0.0589
Echinococcus multilocularis Biotin lipoyl attachment 0.0059 0.0252 0.0252
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 0.3493
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0113 0.0113
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0229 0.1267 0.1987
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0059 0.0252 0.0261
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0059 0.0252 0.0322
Loa Loa (eye worm) hypothetical protein 0.1279 0.7541 0.7818
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0288 0.1621 1
Schistosoma mansoni neuropeptide receptor 0.0116 0.0589 0.0589
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0059 0.0252 0.0252
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0116 0.0589 0.061
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni hypothetical protein 0.0074 0.034 0.034
Loa Loa (eye worm) TYRA-2 protein 0.0116 0.0589 0.061
Loa Loa (eye worm) G-protein coupled receptor 0.0116 0.0589 0.061
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0288 0.1621 1
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0229 0.1267 0.2905
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0398 0.0478
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0084 0.0398 0.0418
Toxoplasma gondii carbamoylphosphate synthetase 0.0146 0.0768 0.0716
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0229 0.1267 0.1987
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0116 0.0589 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni growth hormone secretagogue receptor 0.0116 0.0589 0.0589
Schistosoma mansoni neuropeptide f receptor 76f 0.0116 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0059 0.0252 0.0261
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0059 0.0252 0.0274
Brugia malayi G-protein coupled receptor 0.0116 0.0589 0.061
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0227 0.0235
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0113 0.0113
Echinococcus multilocularis fmrfamide receptor 0.0116 0.0589 0.0589
Echinococcus granulosus dro:myosuppressin receptor 0.0116 0.0589 0.0589
Onchocerca volvulus 0.0116 0.0589 0.3401
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0116 0.0589 0.0589
Echinococcus granulosus peptidase Clp S14 family 0.0159 0.0849 0.0849
Echinococcus multilocularis serotonin receptor 0.1279 0.7541 0.7541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi Melatonin receptor type 1A 0.0116 0.0589 0.061
Echinococcus multilocularis g protein coupled receptor 0.0116 0.0589 0.0589
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0275 0.0275
Echinococcus granulosus neuropeptide Y receptor 0.0116 0.0589 0.0589
Schistosoma mansoni opsin-like receptor 0.0116 0.0589 0.0589
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0275 0.0065
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0116 0.0589 0.0589
Echinococcus granulosus g protein coupled receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0336 0.0241
Toxoplasma gondii pyruvate carboxylase 0.0644 0.3746 0.3711
Echinococcus multilocularis lamin 0.0028 0.0064 0.0064
Schistosoma mansoni histamine h1 receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus neuropeptides capa receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0078 0.0365 0.0378
Brugia malayi G protein-coupled receptor 0.0116 0.0589 0.061
Brugia malayi Dopamine receptor protein 1 0.0116 0.0589 0.061
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0059 0.0252 0.0252
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0229 0.1267 0.2905
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0116 0.0589 0.061
Loa Loa (eye worm) glutaminase 2 0.0577 0.3347 0.347
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0134 0.0134
Echinococcus multilocularis allatostatin A receptor 0.0116 0.0589 0.0589
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1224 0.7208 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0059 0.0252 0.0197
Leishmania major carbamoyl-phosphate synthase, putative 0.0146 0.0768 0.0716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0228 0.0236
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0644 0.3746 0.6053
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0113 0.0113
Onchocerca volvulus 0.0116 0.0589 0.3401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Echinococcus multilocularis geminin 0.0205 0.112 0.112
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0116 0.0589 0.0589
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0113 0.0113
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0116 0.0589 0.0589
Brugia malayi Carboxyl transferase domain containing protein 0.1632 0.9646 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 0.3139
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0059 0.0252 0.0197
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0059 0.0252 0.0322
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0365 0.0311
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0336 0.0282
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0365 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0037 0.0118 0.0118
Schistosoma mansoni amine GPCR 0.0116 0.0589 0.0589
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0229 0.1267 0.2905
Brugia malayi AKH receptor 0.0116 0.0589 0.061
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0365 0.0365
Schistosoma mansoni pyruvate carboxylase 0.0644 0.3746 0.3746
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0116 0.0589 0.0589
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0116 0.0589 0.3401
Brugia malayi intermediate filament protein 0.0028 0.0064 0.0066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0116 0.0589 0.0589
Onchocerca volvulus 0.0286 0.1607 1
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0059 0.0252 0.0322
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0229 0.1267 0.2905
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0365 0.0365
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0114 0.0114
Echinococcus multilocularis musashi 0.0028 0.0064 0.0064
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0116 0.0589 0.0589
Echinococcus granulosus 7TM GPCR rhodopsin 0.0116 0.0589 0.0589
Echinococcus granulosus tm gpcr rhodopsin 0.0116 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Trichomonas vaginalis glutaminase, putative 0.0577 0.3347 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0116 0.0589 0.061
Echinococcus granulosus neuropeptide s receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) glutaminase 0.0577 0.3347 0.347
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus intermediate filament protein 0.0028 0.0064 0.0064
Schistosoma mansoni biogenic amine (5HT) receptor 0.0116 0.0589 0.0589
Toxoplasma gondii hypothetical protein 0.0084 0.0398 0.0344
Brugia malayi putative neuropeptide receptor NPR1 0.0116 0.0589 0.061
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.034 0.0352
Onchocerca volvulus 0.0116 0.0589 0.3401
Loa Loa (eye worm) hypothetical protein 0.0059 0.0252 0.0261
Echinococcus granulosus sex peptide receptor 0.0116 0.0589 0.0589
Onchocerca volvulus 0.0116 0.0589 0.3401
Brugia malayi Pre-SET motif family protein 0.0251 0.1399 0.1451
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0123
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0116 0.0589 0.0589
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0146 0.0768 0.0768
Echinococcus multilocularis g-protein coupled receptor 0.0116 0.0589 0.0589
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0229 0.1267 0.2905
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0116 0.0589 0.0589
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0229 0.1267 0.1987
Echinococcus granulosus g-protein coupled receptor 0.0116 0.0589 0.0589
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0243 0.1349 0.13
Echinococcus multilocularis dro:myosuppressin receptor 0.0116 0.0589 0.0589
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.022 0.0228
Loa Loa (eye worm) melatonin receptor type 1A 0.0116 0.0589 0.061
Echinococcus multilocularis neuropeptide receptor A26 0.0116 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0365 0.0816
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0059 0.0252 0.0274
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus neuropeptide FF receptor 2 0.0116 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi putative neuropeptide receptor 0.0116 0.0589 0.061
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Onchocerca volvulus Neuropeptide F receptor homolog 0.0116 0.0589 0.3401
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus neuropeptides capa receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0066
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0059 0.0252 0.0197
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 0.3139
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0116 0.0589 0.0589
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.034 0.074
Loa Loa (eye worm) neuropeptide F receptor 0.0116 0.0589 0.061
Loa Loa (eye worm) hypothetical protein 0.0059 0.0252 0.0261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni adenoreceptor 0.0116 0.0589 0.0589
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0116 0.0589 0.0589
Echinococcus multilocularis microtubule associated protein 2 0.1458 0.8605 0.8605
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0644 0.3746 0.3711
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1224 0.7208 1
Echinococcus granulosus g protein coupled receptor 0.0116 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi Serotonin receptor 0.0566 0.3282 0.3402
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0229 0.1267 0.2905
Echinococcus granulosus orexin receptor type 2 0.0116 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Brugia malayi GnHR receptor homolog 0.0116 0.0589 0.061
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0146 0.0768 0.1168
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0398 0.0478
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0059 0.0252 0.0197
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0243 0.1349 0.1808
Brugia malayi hypothetical protein 0.0026 0.0056 0.0058
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0644 0.3746 0.3746
Schistosoma mansoni amine GPCR 0.0116 0.0589 0.0589
Echinococcus granulosus G protein coupled receptor 139 0.0116 0.0589 0.0589
Brugia malayi Tachykinin-like peptides receptor 99D 0.0116 0.0589 0.061
Schistosoma mansoni glutaminase 0.0577 0.3347 0.3347
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0243 0.1349 0.3493
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0275 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0116 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0229 0.1267 0.2905
Schistosoma mansoni myosin xvIII 0.0116 0.0589 0.0589
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0116 0.0589 0.0589
Echinococcus granulosus allatostatin A receptor 0.0116 0.0589 0.0589
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0146 0.0768 0.1168
Loa Loa (eye worm) hypothetical protein 0.0116 0.0589 0.061
Echinococcus granulosus rhodopsin orphan GPCR 0.0116 0.0589 0.0589
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0116 0.0589 0.0589
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0644 0.3746 0.3746
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0059 0.0252 0.0252
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0644 0.3746 1
Loa Loa (eye worm) neuropeptide F receptor 0.0116 0.0589 0.061
Echinococcus multilocularis neuropeptides capa receptor 0.0116 0.0589 0.0589
Schistosoma mansoni hypothetical protein 0.0116 0.0589 0.0589
Brugia malayi hypothetical protein 0.0116 0.0589 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0116 0.0589 0.0589
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0134 0.0134
Onchocerca volvulus 0.0116 0.0589 0.3401
Brugia malayi G protein-coupled receptor F59B2.13 0.0116 0.0589 0.061
Schistosoma mansoni neuropeptide receptor 0.0116 0.0589 0.0589

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 24.34 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
Potency (functional) = 0.1122 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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