Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.3227 | 0.2988 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2258 | 0.2582 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.034 | 0.0389 |
Echinococcus granulosus | pyruvate kinase | 0.0039 | 0.1394 | 0.1091 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0039 | 0.1394 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.3227 | 0.3435 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.8744 | 0.87 |
Leishmania major | pyruvate kinase | 0.0039 | 0.1394 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3227 | 0.2988 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.8744 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0039 | 0.1394 | 0.1091 |
Echinococcus multilocularis | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1437 | 0.1644 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0039 | 0.1394 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2382 | 0.243 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0039 | 0.1394 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2258 | 0.2282 |
Echinococcus granulosus | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3227 | 0.2988 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2382 | 0.243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3227 | 0.2988 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2258 | 0.1985 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0039 | 0.1394 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0039 | 0.1394 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0039 | 0.1394 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0027 | 0.0789 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0027 | 0.0789 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.8744 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.3227 | 0.369 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0789 | 0.0534 |
Echinococcus multilocularis | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2382 | 0.2724 |
Echinococcus multilocularis | pyruvate kinase | 0.0039 | 0.1394 | 0.1091 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.3227 | 0.2988 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.3227 | 0.369 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1437 | 0.1135 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0039 | 0.1394 | 0.1594 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0039 | 0.1394 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0039 | 0.1394 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2258 | 0.1985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3227 | 0.2988 |
Echinococcus multilocularis | pyruvate kinase | 0.0039 | 0.1394 | 0.1091 |
Loa Loa (eye worm) | pyruvate kinase | 0.0039 | 0.1394 | 0.1254 |
Brugia malayi | RNA binding protein | 0.0074 | 0.3227 | 0.369 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.8744 | 0.87 |
Loa Loa (eye worm) | pyruvate kinase | 0.0039 | 0.1394 | 0.1254 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2258 | 0.1985 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2258 | 0.1985 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0039 | 0.1394 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Giardia lamblia | Pyruvate kinase | 0.0039 | 0.1394 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3227 | 0.2988 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2258 | 0.1985 |
Plasmodium vivax | pyruvate kinase, putative | 0.0039 | 0.1394 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.8744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1437 | 0.1305 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.3227 | 0.3435 |
Chlamydia trachomatis | pyruvate kinase | 0.0039 | 0.1394 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Echinococcus multilocularis | pyruvate kinase | 0.003 | 0.0973 | 0.0655 |
Echinococcus granulosus | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Loa Loa (eye worm) | pyruvate kinase | 0.0039 | 0.1394 | 0.1254 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2258 | 0.1985 |
Echinococcus granulosus | pyruvate kinase | 0.0039 | 0.1394 | 0.1091 |
Mycobacterium ulcerans | pyruvate kinase | 0.0039 | 0.1394 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.8744 | 0.87 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0039 | 0.1394 | 0.1594 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.3227 | 0.3435 |
Leishmania major | pyruvate kinase | 0.0039 | 0.1394 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0039 | 0.1394 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0039 | 0.1394 | 0.1091 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0039 | 0.1394 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.034 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1394 | 0.1254 |
Plasmodium falciparum | pyruvate kinase | 0.0039 | 0.1394 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0039 | 0.1394 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2258 | 0.1985 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2382 | 0.2724 |
Echinococcus granulosus | pyruvate kinase | 0.002 | 0.0421 | 0.0084 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 5.6234 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.