Detailed information for compound 1402408

Basic information

Technical information
  • TDR Targets ID: 1402408
  • Name: 2-[(4-acetylphenyl)amino]-3-morpholin-4-ylnap hthalene-1,4-dione
  • MW: 376.405 | Formula: C22H20N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=C(N2CCOCC2)C(=O)c2c1cccc2)Nc1ccc(cc1)C(=O)C
  • InChi: 1S/C22H20N2O4/c1-14(25)15-6-8-16(9-7-15)23-19-20(24-10-12-28-13-11-24)22(27)18-5-3-2-4-17(18)21(19)26/h2-9,23H,10-13H2,1H3
  • InChiKey: QVZQFHHACGJXKD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-acetylphenyl)amino]-3-morpholino-naphthalene-1,4-dione
  • 2-[(4-acetylphenyl)amino]-3-morpholinonaphthalene-1,4-dione
  • 2-[(4-acetylphenyl)amino]-3-morpholino-1,4-naphthoquinone
  • 2-[(4-ethanoylphenyl)amino]-3-morpholin-4-yl-naphthalene-1,4-dione
  • STOCK1S-34782
  • ZINC04785588
  • 2-[(4-acetylphenyl)amino]-3-(4-morpholinyl)naphthoquinone
  • MLS000579716
  • SMR000186447

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 6 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens SUMO/sentrin specific peptidase family member 8 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 7 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens protein phosphatase 5, catalytic subunit Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis Sentrin-specific protease, putative Get druggable targets OG5_129942 All targets in OG5_129942
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni protein phosphatase-5 Get druggable targets OG5_128254 All targets in OG5_128254
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii serine/threonine protein phosphatase PP5 Get druggable targets OG5_128254 All targets in OG5_128254
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans potential calcineurin-like serine/threonine phosphatase similar to S. cerevisiae PPT1 (YGR123C) Get druggable targets OG5_128254 All targets in OG5_128254
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum Serine/threonine protein phosphatase 5 (EC 3.1.3.16), related Get druggable targets OG5_128254 All targets in OG5_128254
Plasmodium berghei serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Echinococcus multilocularis sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans potential calcineurin-like Serine/Threonine phosphatase similar to S. cerevisiae PPT1 (YGR123C) Get druggable targets OG5_128254 All targets in OG5_128254
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Cryptosporidium parvum phosphoprotein phosphatase related, putative Get druggable targets OG5_128254 All targets in OG5_128254
Leishmania infantum serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Schistosoma japonicum ko:K08597 sentrin-specific protease 8, putative Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi serine/threonine protein phosphatase 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_129942 All targets in OG5_129942
Toxoplasma gondii serine/threonine protein phosphatase Get druggable targets OG5_128254 All targets in OG5_128254
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Schistosoma japonicum ko:K08596 sentrin-specific protease 7, putative Get druggable targets OG5_131076 All targets in OG5_131076
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis protein phosphatase-1, putative Get druggable targets OG5_128254 All targets in OG5_128254
Schistosoma japonicum ko:K04460 protein phosphatase 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Loa Loa (eye worm) serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_131076 All targets in OG5_131076
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Echinococcus granulosus sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva serine/threonine protein phosphatase, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis phosphoprotein phosphatase -related Get druggable targets OG5_128254 All targets in OG5_128254
Brugia malayi serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Loa Loa (eye worm) protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Leishmania braziliensis serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis protein phosphatase-5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Loa Loa (eye worm) Ulp1 protease Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis protein phosphatase-1, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trypanosoma brucei gambiense serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_131076 All targets in OG5_131076
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Babesia bovis serine/threonine protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax serine/threonine protein phosphatase 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica protein phosphatase, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Leishmania major serine/threonine protein phosphatase type 5, putative Get druggable targets OG5_128254 All targets in OG5_128254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis protein phosphatase 5 Get druggable targets OG5_128254 All targets in OG5_128254
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Plasmodium falciparum sentrin-specific protease 1 SUMO/sentrin specific peptidase family member 8 212 aa 197 aa 23.4 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Trypanosoma brucei kinetoplastid-specific phospho-protein phosphatase, putative protein phosphatase 5, catalytic subunit 477 aa 397 aa 27.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Brugia malayi TAR-binding protein 0.0193 0.4043 0.4617
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0047 0.0797 0.2661
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0797 1
Loa Loa (eye worm) RNA binding protein 0.0193 0.4043 0.4592
Loa Loa (eye worm) hypothetical protein 0.0027 0.0356 0.0361
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0749 0.9304
Echinococcus granulosus expressed conserved protein 0.0163 0.3376 0.7619
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0276 0.0514
Loa Loa (eye worm) TAR-binding protein 0.0193 0.4043 0.4592
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.359 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0797 0.6466
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0749 0.5801
Brugia malayi Pre-SET motif family protein 0.0405 0.8757 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0463 0.0942
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.091
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0111 0.2233 0.5057
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0797 0.6466
Echinococcus granulosus dna polymerase kappa 0.0023 0.0276 0.0514
Schistosoma mansoni inositol monophosphatase 0.0045 0.0749 0.1697
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.091
Brugia malayi hypothetical protein 0.0182 0.3814 0.4355
Brugia malayi serine/threonine protein phosphatase 5 0.0026 0.0336 0.0383
Echinococcus granulosus sentrin specific protease 1 0.0047 0.0797 0.1707
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0797 0.0702
Echinococcus multilocularis dna polymerase eta 0.0023 0.0276 0.0514
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0276 0.0514
Brugia malayi RNA binding protein 0.0193 0.4043 0.4617
Plasmodium vivax SET domain protein, putative 0.0058 0.1049 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0797 0.0867
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0084 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.1049 0.2375
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.1049 0.2285
Loa Loa (eye worm) hypothetical protein 0.0058 0.1049 0.1157
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0749 0.1599
Schistosoma mansoni inositol monophosphatase 0.0045 0.0749 0.1697
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0749 0.0864
Trypanosoma brucei unspecified product 0.0023 0.0276 0.2359
Echinococcus granulosus intermediate filament protein 0.0027 0.0367 0.0722
Trypanosoma brucei SUMO1/Ulp2, putative 0.0047 0.0797 1
Schistosoma mansoni hypothetical protein 0.0032 0.0463 0.1048
Plasmodium vivax sentrin-specific protease 1, putative 0.0047 0.0797 0.6466
Echinococcus multilocularis tar DNA binding protein 0.0193 0.4043 0.9146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0749 0.0654
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0749 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0463 0.0942
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0749 0.1428
Brugia malayi Inositol-1 0.0045 0.0749 0.0856
Schistosoma mansoni hypothetical protein 0.0069 0.1281 0.2901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0986 0.2232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.1049 0.2375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0986 0.2232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0986 0.1084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Echinococcus granulosus sentrin specific protease 7 0.021 0.4415 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.359 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0749 0.2419
Loa Loa (eye worm) hypothetical protein 0.0182 0.3814 0.4329
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7603 1
Brugia malayi MH2 domain containing protein 0.0123 0.2485 0.2838
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Loa Loa (eye worm) protein phosphatase 5 0.0026 0.0328 0.0329
Echinococcus multilocularis lamin 0.0027 0.0367 0.0722
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.1049 0.2375
Echinococcus granulosus lamin dm0 0.0027 0.0367 0.0722
Brugia malayi Pre-SET motif family protein 0.0058 0.1049 0.1198
Leishmania major serine/threonine protein phosphatase type 5, putative 0.0026 0.0336 0.1148
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.7603 0.5
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0749 0.0654
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0797 0.0702
Loa Loa (eye worm) hypothetical protein 0.0047 0.0797 0.0867
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1986 0.2232
Schistosoma mansoni lamin 0.0027 0.0367 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.021 0.4415 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0276 0.0514
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0367 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2485 0.2805
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.1001 0.2176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.0927
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0276 0.2359
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0463 0.0528
Loa Loa (eye worm) Ulp1 protease 0.0111 0.2233 0.2515
Loa Loa (eye worm) hypothetical protein 0.01 0.1986 0.2232
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0276 0.0176
Schistosoma mansoni hypothetical protein 0.0032 0.0463 0.1048
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.7603 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0797 0.6466
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0367 0.0374
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0276 0.0315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0986 0.214
Echinococcus granulosus tar DNA binding protein 0.0193 0.4043 0.9146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0027 0.0367 0.0466
Schistosoma mansoni tar DNA-binding protein 0.0193 0.4043 0.9156
Schistosoma mansoni tar DNA-binding protein 0.0193 0.4043 0.9156
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0276 0.2359
Onchocerca volvulus 0.0182 0.3814 0.3578
Schistosoma mansoni hypothetical protein 0.0032 0.0463 0.1048
Echinococcus multilocularis musashi 0.0027 0.0367 0.0722
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0276 0.2359
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0276 0.2359
Schistosoma mansoni protein phosphatase-5 0.0027 0.0367 0.0831
Loa Loa (eye worm) hypothetical protein 0.0047 0.0797 0.0867
Loa Loa (eye worm) Ulp1 protease 0.0047 0.0797 0.0867
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0797 0.1804
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.1049 0.2375
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.0927
Echinococcus multilocularis protein phosphatase 5 0.0026 0.0336 0.0651
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0797 0.1804
Schistosoma mansoni lamin 0.0027 0.0367 0.0831
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0463 0.0484
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0463 0.0528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0986 0.214
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0047 0.0797 0.0702
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0749 0.0654
Echinococcus granulosus protein phosphatase 5 0.0026 0.0336 0.0651
Giardia lamblia Sentrin specific protease, putative 0.0047 0.0797 0.0711
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0276 0.0315
Echinococcus granulosus sentrin specific protease 8 0.0111 0.2233 0.4999
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1986 0.2268
Loa Loa (eye worm) serine/threonine protein phosphatase 5 0.0026 0.0336 0.0339
Loa Loa (eye worm) hypothetical protein 0.0032 0.0463 0.0484
Echinococcus multilocularis sentrin specific protease 1 0.0047 0.0797 0.1707
Plasmodium falciparum sentrin-specific protease 1 0.0047 0.0797 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0797 0.0702
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.359 1
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2485 0.2805
Schistosoma mansoni hypothetical protein 0.0032 0.0463 0.1048
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0749 0.2419
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0986 0.214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.2233 0.2841
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0047 0.0797 0.5
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0797 0.0702
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.2233 0.2153
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.1049 0.2285
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0797 0.0702
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0986 0.1126
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.0927
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.1049 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.2233 0.2153
Echinococcus granulosus GPCR family 2 0.0032 0.0463 0.0942
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0276 0.0232
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0276 0.0625
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0276 0.0514
Trichomonas vaginalis Sentrin-specific protease, putative 0.0111 0.2233 0.2153
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0797 0.0702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0027 0.0367 0.0466
Echinococcus multilocularis lamin dm0 0.0027 0.0367 0.0722
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0749 0.9089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0193 0.4043 0.4592
Echinococcus multilocularis sentrin specific protease 8 0.0111 0.2233 0.4999
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0797 0.2661
Loa Loa (eye worm) hypothetical protein 0.0023 0.0276 0.027
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0027 0.0367 0.3696
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.2233 0.255
Schistosoma mansoni tar DNA-binding protein 0.0193 0.4043 0.9156
Schistosoma mansoni tar DNA-binding protein 0.0193 0.4043 0.9156
Schistosoma mansoni intermediate filament proteins 0.0027 0.0367 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0986 0.214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Echinococcus multilocularis expressed conserved protein 0.0163 0.3376 0.7619
Loa Loa (eye worm) hypothetical protein 0.0069 0.1281 0.1423
Onchocerca volvulus 0.0058 0.1049 0.0708
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0013
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0276 0.027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7603 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0749 0.1599
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0367 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0193 0.4043 0.9156
Loa Loa (eye worm) inositol-1 0.0045 0.0749 0.0813
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0797 0.0927
Plasmodium vivax sentrin-specific protease 2, putative 0.0047 0.0797 0.6466
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.2233 0.2153
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0276 0.0176
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0047 0.0797 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0463 0.0942
Brugia malayi intermediate filament protein 0.0027 0.0367 0.0419
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.8757 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1281 0.1463
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0276 0.0625
Brugia malayi RNA recognition motif domain containing protein 0.0193 0.4043 0.4617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7603 0.7578
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1986 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0797 0.0702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0986 0.2232
Echinococcus granulosus lamin 0.0027 0.0367 0.0722
Echinococcus multilocularis sentrin specific protease 7 0.021 0.4415 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0084 0.0096
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.021 0.4415 0.5751
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Onchocerca volvulus 0.0047 0.0797 0.0446
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0645 0.1115
Trypanosoma cruzi hypothetical protein 0.0111 0.2233 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0463 0.0942
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.1049 0.2285
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0276 0.2359
Schistosoma mansoni DNA polymerase eta 0.0023 0.0276 0.0625
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0463 0.0942

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 11.6 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2575, AID2582, AID2599] ChEMBL. No reference
IC50 (functional) = 18 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) = 18.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575, AID2582, AID434986] ChEMBL. No reference
IC50 (binding) = 19.259 um PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 5 (PP5). (Class of assay: confirmatory) [Related pubchem assays: 2034 (Summary (PP5 inhibitors)), 1987 (Primary screen (PP5 inhibitors)), 2235 (Counterscreen (PP1 inhibitors in singlate))] ChEMBL. No reference
IC50 (functional) = 28.7 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] ChEMBL. No reference
IC50 (functional) = 30 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
IC50 (binding) > 67.047 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1). (Class of assay: confirmatory) [Related pubchem assays: 2034 (Summary (PP5 inhibitors)), 1987 (Primary screen (PP5 inhibitors)), 2235 (Screening assay (PP1 inhibitors in singlate))] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] ChEMBL. No reference
IC50 (binding) 128.345 uM PubChem BioAssay. Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5221 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.8275 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9245 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.5068 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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