TDR Targets

Basic information

Technical information

TDR Targets ID: 1402491
Name: 2-bromo-N-[5-(4-methylpiperidin-1-yl)sulfonyl -1,3,4-thiadiazol-2-yl]benzamide
MW: 445.354 | Formula: C15H17BrN4O3S2
H donors: 1 H acceptors: 5 LogP: 2.99 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)S(=O)(=O)c1nnc(s1)NC(=O)c1ccccc1Br
InChi: 1S/C15H17BrN4O3S2/c1-10-6-8-20(9-7-10)25(22,23)15-19-18-14(24-15)17-13(21)11-4-2-3-5-12(11)16/h2-5,10H,6-9H2,1H3,(H,17,18,21)
InChiKey: WJXOAIYIBNJNFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-bromo-N-[5-[(4-methyl-1-piperidyl)sulfonyl]-1,3,4-thiadiazol-2-yl]benzamide
2-bromo-N-[5-[(4-methyl-1-piperidinyl)sulfonyl]-1,3,4-thiadiazol-2-yl]benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	dna polymerase eta	0.0023	0.2167	0.2167
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.4842	0.4842
Brugia malayi	nuclear hormone receptor family member odr-7	0.0019	0.1472	0.1472
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.5333	0.5333
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Brugia malayi	nuclear receptor NHR-88	0.0041	0.5333	0.5333
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.1886	0.1886
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0041	0.5333	0.5333
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0023	0.2167	0.2167
Brugia malayi	tailless protein	0.0019	0.1472	0.1472
Leishmania major	DNA polymerase eta, putative	0.0023	0.2167	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.4394	1
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.1472	0.1472
Echinococcus multilocularis	FTZ F1 alpha	0.0041	0.5333	0.5333
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.2167	0.2167
Echinococcus granulosus	dna polymerase kappa	0.0023	0.2167	0.2167
Schistosoma mansoni	zinc finger protein	0.0019	0.1472	0.1472
Brugia malayi	nuclear hormone receptor	0.0041	0.5333	0.5333
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.2167	0.2167
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1886	0.1886
Brugia malayi	hypothetical protein	0.0022	0.1886	0.1886
Brugia malayi	ecdysone receptor	0.0019	0.1472	0.1472
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.1886	0.1886
Brugia malayi	conserved hypotetical protein	0.0019	0.1472	0.1472
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.2167	1
Loa Loa (eye worm)	DR-78	0.0019	0.1472	0.1472
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0019	0.1472	0.1472
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0041	0.5333	0.5333
Trypanosoma brucei	unspecified product	0.0023	0.2167	1
Entamoeba histolytica	hypothetical protein	0.0043	0.5747	1
Brugia malayi	ecdysteroid receptor	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3942	0.3942
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.5468	0.5468
Entamoeba histolytica	hypothetical protein	0.0043	0.5747	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0041	0.5333	0.5333
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0041	0.5333	0.5333
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.5333	0.5333
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.2167	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0041	0.5333	0.5333
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.4842	0.4842
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.5333	0.5333
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0041	0.5333	0.5333
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.2167	0.2167
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0041	0.5333	0.5333
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0041	0.5333	0.4527
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0041	0.5333	0.5333
Brugia malayi	hypothetical protein	0.0043	0.5747	0.5747
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.2167	0.5
Brugia malayi	steroid hormone receptor	0.0041	0.5333	0.5333
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.4842	0.4842
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.1472	0.1472
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.5333	0.5333
Brugia malayi	nuclear receptor RXR	0.0022	0.1886	0.1886
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.1472	0.1472
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0041	0.5333	0.5333
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.2167	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0041	0.5333	0.5333
Brugia malayi	hypothetical protein	0.0019	0.1472	0.1472
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0041	0.5333	0.5333
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.5333	0.5333
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.1472	0.1472
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0041	0.5333	0.5333
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0041	0.5333	0.5333
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.2167	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0019	0.1472	0.1472
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.1886	0.1886
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0041	0.5333	0.5333
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0019	0.1472	0.1472
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1886	0.1886
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.2167	0.2167
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0041	0.5333	0.5333
Schistosoma mansoni	hypothetical protein	0.0043	0.5747	0.5747
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0041	0.5333	0.5333
Brugia malayi	hypothetical protein	0.0019	0.1472	0.1472
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.5333	0.5333
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0041	0.5333	0.5333
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.5747	0.5747
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.2167	0.2167
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.2167	1
Entamoeba histolytica	hypothetical protein	0.0043	0.5747	1
Schistosoma mansoni	coup transcription factor	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1886	0.1886
Schistosoma mansoni	DNA polymerase eta	0.0023	0.2167	0.2167
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.2167	0.2167
Onchocerca volvulus	Bile acid receptor homolog	0.0041	0.5333	0.4527
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.1472	0.1472
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.2167	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.1886	0.1886
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1886	0.1886
Echinococcus granulosus	ecdysone induced protein 78C	0.0041	0.5333	0.5333
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.1472	0.1472
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.5333	0.5333
Brugia malayi	nuclear receptor NHR-67	0.0019	0.1472	0.1472
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.2167	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0041	0.5333	0.5333
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.1472	0.1472
Brugia malayi	hypothetical protein	0.0022	0.1886	0.1886
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.1886	0.1886
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1886	0.1886
Onchocerca volvulus		0.0041	0.5333	0.4527
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.5333	0.5333
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0041	0.5333	0.5333
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.2167	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.2167	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0019	0.1472	0.1472
Brugia malayi	nuclear receptor NHR-88	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Leishmania major	DNA polymerase kappa, putative	0.0023	0.2167	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0041	0.5333	0.5333
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.4394	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0041	0.5333	0.5333
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.2167	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0019	0.1472	0.1472
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.2167	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0041	0.5333	0.5333
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.5333	0.5333
Entamoeba histolytica	hypothetical protein	0.0043	0.5747	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0019	0.1472	0.1472
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.1472	0.1472
Schistosoma mansoni	nuclear receptor	0.0019	0.1472	0.1472
Schistosoma mansoni	retinoic acid receptor RXR	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Echinococcus granulosus	nuclear receptor nhr 48	0.0019	0.1472	0.1472
Schistosoma mansoni	nuclear receptor	0.0019	0.1472	0.1472
Brugia malayi	orphan nuclear receptor NR2E1	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0041	0.5333	0.5333
Brugia malayi	photoreceptor-specific nuclear receptor	0.0041	0.5333	0.5333
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0041	0.5333	0.5333
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.2167	0.2167
Onchocerca volvulus	Protein ultraspiracle homolog	0.0041	0.5333	0.4527
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.2167	1
Echinococcus granulosus	dna polymerase eta	0.0023	0.2167	0.2167
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.1886	0.1886
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.5333	0.5333
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.5747	0.5747
Loa Loa (eye worm)	steroid hormone receptor	0.0041	0.5333	0.5333
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0041	0.5333	0.5333
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0019	0.1472	0.1472
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.5333	0.5333
Brugia malayi	Steroid receptor seven-up type 2	0.0041	0.5333	0.5333
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.1472	0.1472
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0041	0.5333	0.5333
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.5333	0.5333
Brugia malayi	nuclear receptor RXR	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0019	0.1472	0.1472
Echinococcus granulosus	FTZ F1 alpha	0.0041	0.5333	0.5333
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.2167	0.5
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.2167	0.2167
Giardia lamblia	DINP protein human, muc B family	0.0023	0.2167	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.4842	0.4842
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.5333	0.5333
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.5747	0.5747
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.1886	0.1886
Brugia malayi	nuclear hormone receptor	0.0019	0.1472	0.1472
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.5333	0.5333
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0019	0.1472	0.1472
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0019	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5333	0.5333
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0041	0.5333	0.5333
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.5468	0.5468
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.2167	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0041	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1472	0.1472

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1564984

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1402491