Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.3265 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0437 | 0.0401 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0038 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0438 | 0.1341 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0223 | 0.061 |
Brugia malayi | hypothetical protein | 0.0286 | 0.3265 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.308 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.027 | 0.308 | 0.9432 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3265 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0474 | 0.1434 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0132 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.027 | 0.308 | 0.9425 |
Onchocerca volvulus | 0.0058 | 0.0474 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0132 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0132 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0038 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.027 | 0.308 | 0.9425 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0223 | 0.0575 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0132 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.027 | 0.308 | 0.9425 |
Brugia malayi | hypothetical protein | 0.003 | 0.0132 | 0.0406 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0437 | 0.1338 |
Brugia malayi | TAR-binding protein | 0.027 | 0.308 | 0.9432 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.308 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0437 | 0.1313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0437 | 0.1313 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0438 | 0.1241 |
Echinococcus multilocularis | tar DNA binding protein | 0.027 | 0.308 | 0.3054 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0038 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0132 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.027 | 0.308 | 0.9425 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0132 | 0.0294 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0437 | 0.1237 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0038 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.308 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0437 | 0.1237 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0038 | 0.5 |
Brugia malayi | RNA binding protein | 0.027 | 0.308 | 0.9432 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0038 | 0.0115 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0132 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0038 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0474 | 0.1434 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0474 | 0.1451 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0438 | 0.1341 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0438 | 0.1241 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0223 | 0.0683 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0038 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0437 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.308 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0132 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.3265 | 0.324 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0437 | 0.1237 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0437 | 0.1313 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0038 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0002 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.