Detailed information for compound 1403491

Basic information

Technical information
  • TDR Targets ID: 1403491
  • Name: 2,4,6-trimethyl-N-(1,2,4-triazol-4-yl)benzene sulfonamide
  • MW: 266.319 | Formula: C11H14N4O2S
  • H donors: 1 H acceptors: 4 LogP: 1.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)cc(c1S(=O)(=O)Nn1cnnc1)C
  • InChi: 1S/C11H14N4O2S/c1-8-4-9(2)11(10(3)5-8)18(16,17)14-15-6-12-13-7-15/h4-7,14H,1-3H3
  • InChiKey: PFFIRTAFBDIMPV-UHFFFAOYSA-N  

Network

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Synonyms

  • 2,4,6-Trimethyl-N-[1,2,4]triazol-4-yl-benzenesulfonamide
  • BAS 00627728
  • STK083252
  • ZINC04672238
  • MLS000714280
  • SMR000274260

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.002 0.0019
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0282 0.0789 0.0788
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0054 0.0117
Schistosoma mansoni dihydrofolate reductase 0.005 0.0071 0.0071
Echinococcus granulosus Tubulin alpha 1 chain 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin beta chain, putative 0.2412 0.7371 0.7371
Plasmodium falciparum tubulin gamma chain 0.1813 0.552 0.552
Echinococcus granulosus tubulin subunit TubB 0.2412 0.7371 0.7371
Brugia malayi Gooseberry protein 0.0029 0.0006 0.0005
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0787 0.235 0.2349
Brugia malayi nuclear hormone receptor 0.0149 0.0377 0.0376
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0046 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0176 0.0175
Plasmodium falciparum histone deacetylase, putative 0.0336 0.0955 0.0953
Trypanosoma brucei epsilon tubulin 0.1813 0.552 0.552
Toxoplasma gondii histone deacetylase HDAC1 0.0336 0.0955 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0149 0.0377 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0249 0.0248
Onchocerca volvulus 0.0075 0.0148 0.0323
Schistosoma mansoni nuclear hormone receptor 0.0149 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Brugia malayi dihydrofolate reductase family protein 0.005 0.0071 0.007
Echinococcus multilocularis tubulin subunit TubB 0.2412 0.7371 0.7371
Schistosoma mansoni hypothetical protein 0.0604 0.1786 0.1786
Toxoplasma gondii histone deacetylase HDAC4 0.0212 0.0573 0.0572
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0119 0.0119
Giardia lamblia Delta tubulin 0.0787 0.235 0.2349
Schistosoma mansoni ap endonuclease 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0084 0.0176 0.0175
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.002 0.0019
Trichomonas vaginalis tubulin beta chain, putative 0.1026 0.3088 0.3087
Loa Loa (eye worm) hypothetical protein 0.0084 0.0176 0.0175
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0006 0.0005
Schistosoma mansoni lamin 0.0059 0.0101 0.0101
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0144 0.0143
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0282 0.0789 0.0788
Plasmodium falciparum alpha tubulin 1 0.2412 0.7371 0.7371
Brugia malayi Histone deacetylase family protein 0.0336 0.0955 0.0953
Brugia malayi chromobox protein homolog 3 0.0044 0.0054 0.0053
Brugia malayi Heterochromatin protein 1 0.0079 0.0161 0.016
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.002 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.0149 0.0377 0.0827
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0177 0.0464 0.0462
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.009 0.009
Schistosoma mansoni coup transcription factor 0.0149 0.0377 0.0377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0023 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0249 0.0248
Echinococcus granulosus intermediate filament protein 0.0059 0.0101 0.01
Onchocerca volvulus 0.0041 0.0044 0.0093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0149 0.0377 0.0377
Trypanosoma cruzi histone deacetylase, putative 0.0336 0.0955 0.0953
Chlamydia trachomatis dihydrofolate reductase 0.005 0.0071 0.3056
Echinococcus granulosus histone deacetylase 0.0336 0.0955 0.0953
Trichomonas vaginalis tubulin beta chain, putative 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin beta chain, putative 0.2412 0.7371 0.7371
Brugia malayi ecdysone receptor 0.0065 0.0119 0.0118
Brugia malayi p25-alpha family protein 0.0414 0.1197 0.1196
Loa Loa (eye worm) hypothetical protein 0.0092 0.0203 0.0202
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.0337 0.1346
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0054 0.0084 0.0083
Entamoeba histolytica acetyltransferase, GNAT family 0.0087 0.0186 0.0185
Schistosoma mansoni histone deacetylase hda2 0.0363 0.1038 0.1038
Brugia malayi nuclear hormone receptor 0.0065 0.0119 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0149 0.0377 0.0376
Echinococcus granulosus histone deacetylase 3 0.0611 0.1805 0.1804
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0604 0.1786 0.1785
Trichomonas vaginalis tubulin epsilon chain, putative 0.2412 0.7371 0.7371
Echinococcus granulosus chromobox protein 1 0.0079 0.0161 0.016
Echinococcus granulosus chromobox protein 1 0.0079 0.0161 0.016
Brugia malayi hypothetical protein 0.0185 0.0488 0.0487
Plasmodium falciparum glutathione reductase 0.0053 0.0083 0.0082
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0023
Echinococcus granulosus CREB binding protein 0.0123 0.0296 0.0295
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0298 0.0298
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0018 0.0017
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0149 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0121 0.0293 0.0292
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0022
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0282 0.0789 0.0788
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0171 0.0446 0.0445
Trichomonas vaginalis histone deacetylase, putative 0.0611 0.1805 0.1804
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0024 0.0024
Schistosoma mansoni chromobox protein 0.0079 0.0161 0.0161
Echinococcus multilocularis GPCR, family 2 0.0034 0.0023 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0295 0.1165
Brugia malayi Smad1 0.0121 0.0291 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0149 0.0377 0.0376
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0029 0.0006 0.0005
Leishmania major histone deacetylase, putative 0.0336 0.0955 0.0953
Trypanosoma brucei alpha tubulin 0.2412 0.7371 0.7371
Echinococcus granulosus Tubulin alpha 1 chain 0.2412 0.7371 0.7371
Entamoeba histolytica hypothetical protein 0.0604 0.1786 0.1785
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0044 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0149 0.0377 0.0377
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0065 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0517 0.0517
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0122 0.0295 0.0294
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.005 0.0071 0.0262
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0119 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0024 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.0216 0.0215
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0044 0.0042
Brugia malayi Tubulin gamma chain 0.1813 0.552 0.552
Toxoplasma gondii alpha-tubulin I, putative 0.2412 0.7371 0.7371
Brugia malayi Pax transcription factor protein 2 0.1498 0.4547 0.4546
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0044 0.0086
Trypanosoma brucei alpha tubulin 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin alpha chain, putative 0.1026 0.3088 0.3087
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0298 0.0296
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0149 0.0377 0.0376
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0046 0.0045
Trypanosoma cruzi histone deacetylase, putative 0.0212 0.0573 0.0572
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0009 0.0007
Brugia malayi hypothetical protein 0.0084 0.0176 0.0175
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0113 0.0113
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0065 0.0119 0.0119
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0298 0.0296
Echinococcus granulosus transcription factor eb 0.0122 0.0295 0.0294
Trypanosoma cruzi cytochrome P450, putative 0.003 0.001 0.0008
Echinococcus granulosus cpg binding protein 0.0034 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0282 0.0789 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0014 0.0013
Giardia lamblia Gamma tubulin 0.1813 0.552 0.552
Echinococcus granulosus smad 0.0121 0.0291 0.0289
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2622 0.8021 0.8021
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0298 0.0296
Trypanosoma brucei histone deacetylase 2 0.0212 0.0573 0.0572
Echinococcus multilocularis tubulin alpha chain 0.2412 0.7371 0.7371
Giardia lamblia Alpha-tubulin 0.2412 0.7371 0.7371
Brugia malayi hypothetical protein 0.0084 0.0176 0.0175
Plasmodium vivax histone deacetylase 1, putative 0.0611 0.1805 0.1804
Brugia malayi 'Paired box' domain containing protein 0.0029 0.0006 0.0005
Leishmania major isocitrate dehydrogenase, putative 0.0034 0.0024 0.0022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0084 0.0176 0.0175
Brugia malayi Dihydrofolate reductase 0.005 0.0071 0.007
Echinococcus multilocularis tubulin alpha chain 0.2412 0.7371 0.7371
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0298 0.0296
Brugia malayi Tubulin beta chain 0.0787 0.235 0.2349
Brugia malayi TAZ zinc finger family protein 0.0123 0.0296 0.0295
Schistosoma mansoni retinoic acid receptor RXR 0.026 0.0722 0.0722
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0109 0.0255 0.0253
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0295 0.1165
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0083 0.0082
Brugia malayi MH1 domain containing protein 0.0067 0.0124 0.0123
Echinococcus multilocularis Smad4 0.0121 0.0291 0.0289
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0046 0.0045
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0044 0.0145
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0019
Brugia malayi phosphofructokinase 0.0123 0.0298 0.0296
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0119 0.0118
Echinococcus granulosus mothers against decapentaplegic 2 0.0054 0.0084 0.0083
Brugia malayi hypothetical protein 0.017 0.0443 0.0441
Plasmodium falciparum thioredoxin reductase 0.0053 0.0083 0.0082
Brugia malayi mothers against decapentaplegic homolog 3 0.0054 0.0084 0.0083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.0517 0.0516
Trypanosoma brucei histone deacetylase 1 0.0611 0.1805 0.1804
Loa Loa (eye worm) tubulin alpha-3 chain 0.1386 0.4201 0.4201
Echinococcus granulosus FTZ F1 alpha 0.0149 0.0377 0.0376
Schistosoma mansoni cpg binding protein 0.0034 0.0024 0.0024
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0282 0.0789 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0024 0.0024
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0034 0.0024 0.0022
Schistosoma mansoni paired box protein pax-1-related 0.0029 0.0006 0.0006
Brugia malayi nuclear hormone receptor family member odr-7 0.0065 0.0119 0.0118
Echinococcus multilocularis neuropeptide receptor A26 0.0528 0.1548 0.1547
Schistosoma mansoni paired box protein pax-6 0.0029 0.0006 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0282 0.0789 0.0788
Mycobacterium ulcerans cell division protein FtsZ 0.0787 0.235 1
Brugia malayi follicle stimulating hormone receptor 0.0267 0.0744 0.0743
Loa Loa (eye worm) tubulin alpha chain 0.2412 0.7371 0.7371
Echinococcus granulosus mothers against decapentaplegic 6 0.0054 0.0084 0.0083
Echinococcus multilocularis tubulin alpha 1C chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0023 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0604 0.1786 0.1785
Echinococcus granulosus tubulin alpha chain 0.2412 0.7371 0.7371
Toxoplasma gondii endonuclease IV APN 0.0087 0.0186 0.0184
Loa Loa (eye worm) histone deacetylase 0.0336 0.0955 0.0953
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0122 0.0293 0.1159
Brugia malayi Steroid receptor seven-up type 2 0.0149 0.0377 0.0376
Echinococcus multilocularis muscleblind protein 0.0329 0.0935 0.0934
Schistosoma mansoni smad1 5 8 and 0.0121 0.0291 0.0291
Loa Loa (eye worm) paired box protein 0.0029 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Echinococcus granulosus TGF beta signal transducer SmadC 0.0121 0.0291 0.0289
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.0337 0.1346
Schistosoma mansoni brca1-associated protein (brap2) 0.0027 0.0001 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0149 0.0377 0.0377
Echinococcus granulosus tumor protein p63 0.0745 0.222 0.2219
Echinococcus multilocularis FTZ F1 alpha 0.0149 0.0377 0.0376
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0517 0.0516
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0118 0.0282 0.0281
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0027 0.0001 0.0001
Brugia malayi paired box pox-meso protein 0.0029 0.0006 0.0005
Schistosoma mansoni histone deacetylase hda2 0.0212 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0024 0.0023
Schistosoma mansoni brca1-associated protein (brap2) 0.0027 0.0001 0.0001
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0054 0.0084 0.0183
Trichomonas vaginalis histone deacetylase, putative 0.0611 0.1805 0.1804
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0044 0.0042
Brugia malayi Muscleblind-like protein 0.0329 0.0935 0.0934
Trichomonas vaginalis tubulin gamma chain, putative 0.1813 0.552 0.552
Entamoeba histolytica histone deacetylase, putative 0.0611 0.1805 0.1804
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0787 0.235 0.2349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0149 0.0377 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0149 0.0377 0.0376
Trichomonas vaginalis tubulin beta chain, putative 0.2412 0.7371 0.7371
Echinococcus granulosus paired box protein pax 6 0.0029 0.0006 0.0005
Loa Loa (eye worm) histone deacetylase 7A 0.0336 0.0955 0.0953
Leishmania major trypanothione reductase 0.0053 0.0083 0.0082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0065 0.0139
Trichomonas vaginalis histone deacetylase, putative 0.0611 0.1805 0.1804
Echinococcus multilocularis tubulin alpha chain 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin alpha chain, putative 0.1026 0.3088 0.3087
Echinococcus multilocularis histone deacetylase 6 0.0363 0.1038 0.1037
Brugia malayi Probable isocitrate dehydrogenase 0.0034 0.0024 0.0022
Brugia malayi 6-phosphofructokinase 0.0123 0.0298 0.0296
Onchocerca volvulus 0.0149 0.0377 0.0827
Loa Loa (eye worm) thymidylate synthase 0.0122 0.0293 0.0292
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0149 0.0377 0.0827
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.0337 0.1346
Brugia malayi glutathione reductase 0.0053 0.0083 0.0082
Loa Loa (eye worm) tubulin beta chain 0.0787 0.235 0.2349
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0023 0.0021
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Schistosoma mansoni jun-related protein 0.0077 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Giardia lamblia Alpha-tubulin 0.2412 0.7371 0.7371
Loa Loa (eye worm) tubulin alpha chain 0.2412 0.7371 0.7371
Brugia malayi Tubulin alpha chain 0.2412 0.7371 0.7371
Schistosoma mansoni alpha tubulin 0.2412 0.7371 0.7371
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0065 0.0119 0.0118
Loa Loa (eye worm) tubulin alpha-2 chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) hypothetical protein 0.0212 0.0573 0.0572
Loa Loa (eye worm) hypothetical protein 0.015 0.0383 0.0381
Echinococcus granulosus Tubulin alpha 1 chain 0.2412 0.7371 0.7371
Echinococcus multilocularis cpg binding protein 0.0034 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.0142 0.0358 0.0358
Entamoeba histolytica tubulin alpha-1 chain 0.2412 0.7371 0.7371
Echinococcus multilocularis isocitrate dehydrogenase 0.0282 0.0789 0.0788
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0034 0.0024 0.006
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0295 0.1165
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.002 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.1625 0.4939 0.4938
Leishmania major hypothetical protein, conserved 0.0263 0.0731 0.073
Schistosoma mansoni Smad4 0.0121 0.0291 0.0291
Brugia malayi jmjC domain containing protein 0.0065 0.0119 0.0117
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0119 0.0118
Brugia malayi tailless protein 0.0065 0.0119 0.0118
Brugia malayi hypothetical protein 0.0322 0.0912 0.0911
Giardia lamblia Histone deacetylase 0.0611 0.1805 0.1804
Schistosoma mansoni cpg binding protein 0.0032 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Brugia malayi 6-phosphofructokinase 0.0123 0.0298 0.0296
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0046 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0024 0.0023
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0171 0.0446 0.0445
Brugia malayi nuclear receptor NHR-88 0.0065 0.0119 0.0118
Echinococcus multilocularis tubulin gamma 1 chain 0.1813 0.552 0.552
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.0298 0.1231
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Echinococcus multilocularis chromobox protein 1 0.0079 0.0161 0.016
Onchocerca volvulus 0.0041 0.0044 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0019
Trypanosoma cruzi epsilon tubulin, putative 0.1813 0.552 0.552
Schistosoma mansoni smad1 5 8 and 0.0121 0.0291 0.0291
Plasmodium falciparum histone deacetylase 2 0.0336 0.0955 0.0953
Echinococcus granulosus tubulin alpha chain 0.2412 0.7371 0.7371
Echinococcus multilocularis Tubulin alpha 1 chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) dihydrofolate reductase 0.005 0.0071 0.007
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0084 0.0176 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Plasmodium vivax histone deacetylase, putative 0.0212 0.0573 0.0572
Loa Loa (eye worm) vab-3 0.0029 0.0006 0.0005
Brugia malayi intermediate filament protein 0.0059 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0263 0.0731 0.073
Echinococcus granulosus thymidylate synthase 0.0122 0.0293 0.0292
Loa Loa (eye worm) CBP-B 0.0087 0.0188 0.0187
Entamoeba histolytica hypothetical protein 0.0604 0.1786 0.1785
Loa Loa (eye worm) hypothetical protein 0.0073 0.0144 0.0143
Toxoplasma gondii ABC1 family protein 0.0041 0.0044 0.0042
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0282 0.0789 0.0788
Trypanosoma brucei alpha tubulin 0.2412 0.7371 0.7371
Schistosoma mansoni histone deacetylase 4 5 0.0336 0.0955 0.0955
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0044 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0019
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0044 0.0086
Echinococcus granulosus dihydrofolate reductase 0.005 0.0071 0.007
Echinococcus multilocularis transcription factor eb 0.0122 0.0295 0.0294
Loa Loa (eye worm) cytochrome P450 family protein 0.0083 0.0176 0.0174
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0142 0.0358 0.0357
Echinococcus granulosus neuropeptide s receptor 0.0528 0.1548 0.1547
Echinococcus granulosus geminin 0.3197 0.9798 0.9798
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.0186 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0149 0.0377 0.0376
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0084 0.0176 0.0176
Loa Loa (eye worm) hypoxia-induced factor 1 0.017 0.0444 0.0443
Loa Loa (eye worm) hypothetical protein 0.2412 0.7371 0.7371
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0282 0.0789 0.0789
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1625 0.4939 0.4938
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1386 0.4201 0.4201
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0046 0.0096
Schistosoma mansoni steroid hormone receptor ad4bp 0.0149 0.0377 0.0377
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0119 0.0119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Brugia malayi MH2 domain containing protein 0.0121 0.0291 0.0289
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Plasmodium falciparum histone acetyltransferase GCN5 0.0087 0.0186 0.0185
Echinococcus granulosus histone deacetylase 8 0.0212 0.0573 0.0572
Brugia malayi alpha-tubulin 0.2412 0.7371 0.7371
Echinococcus granulosus histone acetyltransferase KAT2B 0.0313 0.0884 0.0883
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0023 0.0021
Plasmodium falciparum tubulin delta chain, putative 0.0787 0.235 0.2349
Echinococcus multilocularis thymidylate synthase 0.0122 0.0293 0.0292
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0064 0.0064
Trypanosoma brucei zeta tubulin, putative 0.0787 0.235 0.2349
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0324 0.0918 0.0917
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Mycobacterium tuberculosis Conserved protein 0.0041 0.0044 0.0086
Echinococcus granulosus Smad4 0.0121 0.0291 0.0289
Trypanosoma cruzi tubulin delta chain 0.0787 0.235 0.2349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.0377 0.0376
Echinococcus multilocularis lamin dm0 0.0059 0.0101 0.01
Trichomonas vaginalis tubulin beta chain, putative 0.2412 0.7371 0.7371
Trypanosoma brucei alpha tubulin 0.2412 0.7371 0.7371
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Brugia malayi MH2 domain containing protein 0.0054 0.0084 0.0083
Schistosoma mansoni paired box protein pax-6 0.0029 0.0006 0.0006
Leishmania major gamma-tubulin 0.1813 0.552 0.552
Echinococcus granulosus nuclear receptor nhr 48 0.0065 0.0119 0.0118
Mycobacterium ulcerans thymidylate synthase 0.0122 0.0293 0.1212
Echinococcus multilocularis tubulin alpha 3 chain 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin, putative 0.0787 0.235 0.2349
Echinococcus granulosus tubulin alpha 1C chain 0.2412 0.7371 0.7371
Giardia lamblia Epsilon tubulin 0.0787 0.235 0.2349
Trypanosoma brucei alpha tubulin, putative 0.1026 0.3088 0.3087
Treponema pallidum cell division protein FtsZ 0.0787 0.235 1
Echinococcus granulosus flap endonuclease 1 0.0029 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0084 0.0083
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0009 0.0007
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0009 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0149 0.0377 0.0376
Onchocerca volvulus 0.0035 0.0025 0.0052
Brugia malayi hypothetical protein 0.0065 0.0119 0.0118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0121 0.0291 0.0289
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0122 0.0293 0.0293
Echinococcus multilocularis hypothetical protein 0.2412 0.7371 0.7371
Brugia malayi acetyltransferase, GNAT family protein 0.0324 0.0918 0.0917
Loa Loa (eye worm) histone deacetylase 1 0.0611 0.1805 0.1804
Brugia malayi thymidylate synthase 0.0122 0.0293 0.0292
Brugia malayi hypoxia-induced factor 1 0.017 0.0444 0.0443
Brugia malayi Pre-SET motif family protein 0.0236 0.0647 0.0646
Echinococcus multilocularis thyroid hormone receptor alpha 0.0291 0.0817 0.0816
Echinococcus granulosus tubulin alpha 3 chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0161 0.016
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0161 0.016
Echinococcus granulosus paired box protein pax 1 0.0029 0.0006 0.0005
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0016 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0149 0.0377 0.0376
Plasmodium vivax glutathione reductase, putative 0.0053 0.0083 0.0082
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0282 0.0789 0.0788
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.002 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0249 0.0248
Schistosoma mansoni histone deacetylase 0.0611 0.1805 0.1805
Leishmania major delta tubulin, putative 0.0787 0.235 0.2349
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0122 0.0293 0.1159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Trypanosoma brucei tubulin delta chain 0.0787 0.235 0.2349
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0149 0.0377 0.0376
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.0298 0.119
Schistosoma mansoni single-minded 0.0055 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0149 0.0377 0.0376
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0329 0.0935 0.0934
Echinococcus multilocularis tubulin alpha 0.1813 0.552 0.552
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0065 0.0119 0.0119
Onchocerca volvulus 0.0122 0.0293 0.0642
Trypanosoma brucei cytochrome P450, putative 0.003 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Echinococcus multilocularis jun protein 0.0095 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0123 0.0299 0.0298
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.005 0.0071 0.0203
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.0176 0.0176
Echinococcus granulosus retinoic acid receptor rxr beta a 0.026 0.0722 0.0721
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.0298 0.0296
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Schistosoma mansoni chromobox protein 0.0079 0.0161 0.0161
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0009 0.0007
Onchocerca volvulus 0.0041 0.0044 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0298 0.0296
Echinococcus multilocularis Tubulin alpha 1 chain 0.2412 0.7371 0.7371
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0119 0.0259
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0029 0.0006 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0046 0.0045
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0097 0.0216 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0096 0.0095
Toxoplasma gondii histone deacetylase HDAC3 0.0611 0.1805 0.1804
Loa Loa (eye worm) hypothetical protein 0.0107 0.0249 0.0248
Echinococcus granulosus CREB binding protein 0.0079 0.0161 0.0159
Loa Loa (eye worm) nuclear factor I 0.0067 0.0124 0.0123
Echinococcus multilocularis ecdysone induced protein 78C 0.0149 0.0377 0.0376
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0024 0.0023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0065 0.0119 0.0118
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0101 0.01
Echinococcus multilocularis tubulin epsilon chain 0.1813 0.552 0.552
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0282 0.0789 0.0788
Mycobacterium leprae cell division protein FtsZ 0.0787 0.235 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0149 0.0377 0.0376
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0123 0.0296 0.0296
Echinococcus granulosus tubulin alpha 3 chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) histone deacetylase 11 0.0212 0.0573 0.0572
Trypanosoma brucei zeta tubulin 0.0787 0.235 0.2349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0149 0.0377 0.0376
Mycobacterium ulcerans lipase LipD 0.0041 0.0044 0.0145
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.001 0.0008
Trichomonas vaginalis tubulin alpha chain, putative 0.1813 0.552 0.552
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0611 0.1805 0.1804
Brugia malayi CXXC zinc finger family protein 0.0032 0.0018 0.0017
Brugia malayi MH1 domain containing protein 0.0121 0.0291 0.0289
Trypanosoma cruzi histone deacetylase, putative 0.0212 0.0573 0.0572
Brugia malayi vab-3 gene. 0.0029 0.0006 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0044 0.0042
Echinococcus granulosus GPCR family 2 0.0034 0.0023 0.0021
Onchocerca volvulus 0.0029 0.0006 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0176 0.0175
Brugia malayi hypothetical protein 0.0058 0.0096 0.0095
Schistosoma mansoni nuclear receptor 0.0065 0.0119 0.0119
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0044 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0149 0.0377 0.0376
Brugia malayi Probable isocitrate dehydrogenase 0.0034 0.0024 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0298 0.0296
Schistosoma mansoni hypothetical protein 0.0118 0.0282 0.0282
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.002 0.0019
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0009 0.0007
Schistosoma mansoni nuclear receptor 0.0065 0.0119 0.0119
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0058 0.0096 0.0095
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0058 0.0098 0.0097
Loa Loa (eye worm) hypothetical protein 0.0329 0.0935 0.0934
Onchocerca volvulus 0.0059 0.0101 0.022
Schistosoma mansoni Smad4 0.0054 0.0084 0.0084
Brugia malayi Pre-SET motif family protein 0.0034 0.0024 0.0023
Echinococcus multilocularis nuclear receptor nhr 48 0.0065 0.0119 0.0118
Schistosoma mansoni smad 0.0054 0.0084 0.0084
Trichomonas vaginalis tubulin alpha chain, putative 0.1026 0.3088 0.3087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0023 0.0021
Echinococcus granulosus tubulin alpha chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0046 0.0045
Brugia malayi orphan nuclear receptor NR2E1 0.0065 0.0119 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0517 0.0517
Echinococcus multilocularis paired box protein pax 1 0.0029 0.0006 0.0005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0149 0.0377 0.0376
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0046 0.0096
Brugia malayi Flap endonuclease-1 0.0029 0.0009 0.0007
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Brugia malayi nuclear receptor RXR 0.0065 0.0119 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0291 0.0289
Plasmodium vivax ataxin-2 like protein, putative 0.0263 0.0731 0.073
Plasmodium falciparum flap endonuclease 1 0.0029 0.0009 0.0007
Plasmodium vivax tubulin epsilon chain, putative 0.1813 0.552 0.552
Brugia malayi Cell division protein ftsZ 0.0787 0.235 0.2349
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Echinococcus multilocularis histone deacetylase 1 0.0611 0.1805 0.1804
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.0377 0.0376
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0324 0.0918 0.0918
Echinococcus multilocularis paired box protein pax 6 0.0029 0.0006 0.0005
Loa Loa (eye worm) Smad1 0.0121 0.0291 0.0289
Echinococcus granulosus lamin dm0 0.0059 0.0101 0.01
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0119 0.0117
Mycobacterium tuberculosis Cell division protein FtsZ 0.0787 0.235 1
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Brugia malayi MH1 domain containing protein 0.0121 0.0291 0.0289
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0149 0.0377 0.0376
Echinococcus granulosus tubulin alpha 1C chain 0.2412 0.7371 0.7371
Brugia malayi Histone deacetylase family protein 0.0336 0.0955 0.0953
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0046 0.0045
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0121 0.0291 0.0289
Schistosoma mansoni ap endonuclease 0.0041 0.0046 0.0046
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0087 0.0186 0.0184
Brugia malayi 'Paired box' domain containing protein 0.0029 0.0006 0.0005
Mycobacterium ulcerans beta-lactamase 0.0041 0.0044 0.0145
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0065 0.0119 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0119 0.0118
Trypanosoma brucei histone deacetylase, putative 0.0336 0.0955 0.0953
Loa Loa (eye worm) tubulin alpha 2 0.0599 0.1769 0.1768
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0034 0.0024 0.0022
Leishmania major epsilon tubulin, putative 0.1813 0.552 0.552
Brugia malayi jmjC domain containing protein 0.0063 0.0113 0.0112
Loa Loa (eye worm) tubulin alpha 2 0.1625 0.4939 0.4938
Loa Loa (eye worm) isocitrate dehydrogenase 0.0282 0.0789 0.0788
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0044 0.0042
Trypanosoma cruzi histone deacetylase 1, putative 0.0611 0.1805 0.1804
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2412 0.7371 0.7371
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0149 0.0377 0.0377
Schistosoma mansoni lamin 0.0059 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0023
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Leishmania major cytochrome p450-like protein 0.003 0.001 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0046 0.0045
Loa Loa (eye worm) DR-78 0.0065 0.0119 0.0118
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0023 0.0021
Echinococcus multilocularis smad 0.0121 0.0291 0.0289
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Giardia lamblia Histone acetyltransferase GCN5 0.0087 0.0186 0.0185
Schistosoma mansoni thyroid hormone receptor 0.0291 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Loa Loa (eye worm) acetyltransferase 0.0324 0.0918 0.0917
Echinococcus multilocularis histone deacetylase 3 0.0611 0.1805 0.1804
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0298 0.0296
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0044 0.0086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0044 0.0044
Onchocerca volvulus 0.0322 0.0912 0.2004
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Entamoeba histolytica tubulin alpha chain, putative 0.2412 0.7371 0.7371
Echinococcus multilocularis CREB binding protein 0.0087 0.0185 0.0184
Trypanosoma cruzi epsilon tubulin, putative 0.1813 0.552 0.552
Loa Loa (eye worm) hypothetical protein 0.0059 0.0101 0.01
Schistosoma mansoni tubulin subunit alpha 0.2412 0.7371 0.7371
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0044 0.0086
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Schistosoma mansoni hypothetical protein 0.0077 0.0156 0.0156
Brugia malayi isocitrate dehydrogenase 0.0282 0.0789 0.0788
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1625 0.4939 0.4938
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.002 0.0019
Brugia malayi histone deacetylase 3 (HD3) 0.0611 0.1805 0.1804
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0097 0.0216 0.0215
Schistosoma mansoni cellular tumor antigen P53 0.0109 0.0255 0.0255
Trypanosoma brucei PAB1-binding protein , putative 0.0263 0.0731 0.073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0149 0.0377 0.0377
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0018 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0298 0.0296
Schistosoma mansoni CREB-binding protein 2 0.0123 0.0296 0.0296
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0046 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0149 0.0377 0.0376
Schistosoma mansoni unc-13 (munc13) 0.0034 0.0024 0.0024
Trypanosoma cruzi tubulin delta chain 0.0787 0.235 0.2349
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1813 0.552 0.552
Echinococcus multilocularis geminin 0.3197 0.9798 0.9798
Trichomonas vaginalis tubulin beta chain, putative 0.2412 0.7371 0.7371
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.005 0.0071 0.0203
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0034 0.0024 0.0024
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0009 0.0007
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0295 0.1165
Leishmania major histone deacetylase, putative 0.0611 0.1805 0.1804
Echinococcus multilocularis paired box protein pax 6 0.0029 0.0006 0.0005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0016 0.0015
Schistosoma mansoni transcription factor LCR-F1 0.0604 0.1786 0.1786
Entamoeba histolytica tubulin gamma chain 0.1813 0.552 0.552
Leishmania major histone deacetylase, putative 0.0336 0.0955 0.0953
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.0211 0.021
Trichomonas vaginalis esterase, putative 0.0041 0.0044 0.0042
Onchocerca volvulus 0.0269 0.0748 0.1642
Loa Loa (eye worm) pax transcription factor protein 2 0.1498 0.4547 0.4546
Echinococcus multilocularis histone deacetylase 7 0.0336 0.0955 0.0953
Brugia malayi hypothetical protein 0.0263 0.0731 0.073
Brugia malayi hypothetical protein 0.0075 0.0148 0.0147
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.002 0.0019
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0087 0.0186 0.0697
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0611 0.1805 0.1804
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0034 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0185 0.0488 0.0487
Brugia malayi histone deacetylase 1 (HD1) 0.0611 0.1805 0.1804
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0149 0.0377 0.0376
Onchocerca volvulus 0.0041 0.0045 0.0097
Brugia malayi Histone deacetylase 1 0.0611 0.1805 0.1804
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0046 0.0045
Trichomonas vaginalis tubulin, putative 0.1026 0.3088 0.3087
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.0211 0.021
Loa Loa (eye worm) transcription factor SMAD2 0.1771 0.5391 0.5391
Brugia malayi Thioredoxin reductase 0.0053 0.0083 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.0377 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0517 0.0516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Brugia malayi Tubulin beta chain 0.1026 0.3088 0.3087
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0123
Trichomonas vaginalis tubulin epsilon chain, putative 0.0787 0.235 0.2349
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0149 0.0377 0.0376
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0065 0.0119 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0024 0.0024
Brugia malayi Cytochrome P450 family protein 0.0083 0.0176 0.0174
Toxoplasma gondii isocitrate dehydrogenase 0.0282 0.0789 0.0788
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.0298 0.0296
Schistosoma mansoni hypothetical protein 0.3197 0.9798 0.9798
Trypanosoma cruzi cytochrome P450, putative 0.003 0.001 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0044 0.0086
Brugia malayi Tubulin alpha-2 chain 0.2412 0.7371 0.7371
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0021
Mycobacterium ulcerans endonuclease IV 0.0087 0.0186 0.0752
Loa Loa (eye worm) hypothetical protein 0.0611 0.1805 0.1804
Trichomonas vaginalis tubulin gamma chain, putative 0.0787 0.235 0.2349
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Echinococcus multilocularis mothers against decapentaplegic 6 0.0054 0.0084 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0291 0.0817 0.0817
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0044 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0647 0.0646
Onchocerca volvulus TPPP family protein homolog 0.0414 0.1197 0.263
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0097 0.0216 0.0215
Trypanosoma brucei tubulin gamma chain 0.1813 0.552 0.552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0149 0.0377 0.0376
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0044 0.0145
Brugia malayi ecdysteroid receptor 0.0149 0.0377 0.0376
Echinococcus granulosus tubulin alpha chain 0.2412 0.7371 0.7371
Mycobacterium tuberculosis Hypothetical protein 0.0058 0.0096 0.0313
Trypanosoma brucei trypanothione reductase 0.0053 0.0083 0.0082
Echinococcus granulosus histone deacetylase 6 0.0363 0.1038 0.1037
Echinococcus multilocularis chromobox protein 1 0.0079 0.0161 0.016
Onchocerca volvulus 0.0109 0.0255 0.0557
Trypanosoma brucei epsilon tubulin 0.1813 0.552 0.552
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0282 0.0789 0.0788
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0087 0.0186 0.0697
Schistosoma mansoni histone deacetylase 0.0611 0.1805 0.1805
Loa Loa (eye worm) glutathione reductase 0.0053 0.0083 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.0377 0.0376
Mycobacterium tuberculosis Probable reductase 0.0122 0.0295 0.1165
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.0298 0.1178
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0044 0.0042
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0282 0.0789 0.329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0149 0.0377 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0149 0.0377 0.0376
Brugia malayi Cytochrome P450 family protein 0.003 0.001 0.0008
Onchocerca volvulus 0.0029 0.0006 0.0011
Echinococcus granulosus lamin 0.0059 0.0101 0.01
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0171 0.0446 0.0445
Brugia malayi nuclear receptor NHR-88 0.0149 0.0377 0.0376
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0046 0.0045
Plasmodium vivax tubulin alpha chain, putative 0.2412 0.7371 0.7371
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0009 0.0007
Echinococcus granulosus alpha tubulin 0.2412 0.7371 0.7371
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0083 0.0082
Onchocerca volvulus Histone deacetylase 10 homolog 0.0212 0.0573 0.1258
Loa Loa (eye worm) phosphofructokinase 0.0123 0.0298 0.0296
Loa Loa (eye worm) hypothetical protein 0.0084 0.0176 0.0175
Trypanosoma cruzi tubulin gamma chain 0.1813 0.552 0.552
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0009 0.0007
Schistosoma mansoni paired box protein pax-6 0.0029 0.0006 0.0006
Echinococcus multilocularis Tubulin alpha 1 chain 0.2412 0.7371 0.7371
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.002 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0517 0.0516
Loa Loa (eye worm) alpha-tubulin 0.2412 0.7371 0.7371
Plasmodium vivax tubulin alpha chain, putative 0.2412 0.7371 0.7371
Loa Loa (eye worm) nuclear hormone receptor 0.0065 0.0119 0.0118
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0083 0.0082
Brugia malayi 'Paired box' domain containing protein 0.0029 0.0006 0.0005
Echinococcus granulosus tubulin epsilon chain 0.1813 0.552 0.552
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0083 0.0255
Schistosoma mansoni tubulin subunit delta 0.0787 0.235 0.235
Brugia malayi beta-lactamase 0.0041 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0083 0.0082
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0044 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.001 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0118 0.0282 0.0281
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.0186 0.0184
Brugia malayi tubulin alpha-2 chain 0.2412 0.7371 0.7371
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0044 0.0042
Toxoplasma gondii histone deacetylase HDAC5 0.0212 0.0573 0.0572
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0119 0.0118
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Echinococcus multilocularis tubulin alpha chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) hypothetical protein 0.0149 0.0377 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0054 0.0053
Echinococcus granulosus muscleblind protein 0.0329 0.0935 0.0934
Trichomonas vaginalis histone deacetylase, putative 0.0611 0.1805 0.1804
Schistosoma mansoni cpg binding protein 0.0034 0.0024 0.0024
Brugia malayi steroid hormone receptor 0.0149 0.0377 0.0376
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0046 0.0045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0044 0.0042
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0065 0.0119 0.0118
Toxoplasma gondii alpha tubulin TUBA1 0.2412 0.7371 0.7371
Trypanosoma brucei histone deacetylase 4 0.0336 0.0955 0.0953
Loa Loa (eye worm) hypothetical protein 0.0322 0.0912 0.0911
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0298 0.0296
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0149 0.0377 0.0376
Echinococcus granulosus histone deacetylase 6 0.0336 0.0955 0.0953
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0044 0.0042
Schistosoma mansoni tubulin subunit epsilon 0.1813 0.552 0.552
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0171 0.0446 0.0445
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0084 0.0176 0.0175
Plasmodium falciparum tubulin epsilon chain, putative 0.1813 0.552 0.552
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0046 0.0045
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0009 0.0007
Onchocerca volvulus 0.0032 0.0018 0.0037
Loa Loa (eye worm) MH1 domain-containing protein 0.0054 0.0084 0.0083
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0295 0.1165
Brugia malayi Isocitrate dehydrogenase 0.0282 0.0789 0.0788
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0161 0.016
Echinococcus granulosus tubulin gamma 1 chain 0.1813 0.552 0.552
Brugia malayi photoreceptor-specific nuclear receptor 0.0149 0.0377 0.0376
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0044 0.0042
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0149 0.0377 0.0377
Toxoplasma gondii isocitrate dehydrogenase 0.0282 0.0789 0.0788
Schistosoma mansoni isocitrate dehydrogenase 0.0034 0.0024 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0269 0.0748 0.0747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.0517 0.0516
Brugia malayi Tubulin alpha-2 chain 0.2412 0.7371 0.7371
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.0722 0.3001
Toxoplasma gondii thioredoxin reductase 0.0053 0.0083 0.0082
Schistosoma mansoni alpha tubulin 0.2412 0.7371 0.7371
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0119 0.0259
Plasmodium vivax tubulin gamma chain, putative 0.1813 0.552 0.552
Loa Loa (eye worm) MH2 domain-containing protein 0.1771 0.5391 0.5391
Leishmania major hypothetical protein, conserved 0.0041 0.0044 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0101 0.01
Trypanosoma brucei histone deacetylase 3 0.0336 0.0955 0.0953
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0113 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0263 0.0731 0.073
Entamoeba histolytica tartrate dehydrogenase, putative 0.0034 0.0024 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0046 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0149 0.0377 0.0376
Onchocerca volvulus 0.0059 0.0101 0.022
Onchocerca volvulus 0.0065 0.0119 0.0259
Brugia malayi beta-lactamase family protein 0.0041 0.0044 0.0042
Plasmodium falciparum histone deacetylase 1 0.0611 0.1805 0.1804
Schistosoma mansoni hypothetical protein 0.3197 0.9798 0.9798
Trypanosoma cruzi zeta tubulin, putative 0.0787 0.235 0.2349
Echinococcus granulosus ecdysone induced protein 78C 0.0149 0.0377 0.0376
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0027 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Trichomonas vaginalis tubulin gamma chain, putative 0.1813 0.552 0.552
Echinococcus granulosus neuropeptide receptor A26 0.0528 0.1548 0.1547
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0282 0.0789 0.0788
Schistosoma mansoni tubulin subunit gamma 0.1813 0.552 0.552
Brugia malayi Nuclear hormone receptor-like 1 0.0149 0.0377 0.0376
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0119 0.0118
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0298 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.235 0.2349
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0097 0.0216 0.0215
Schistosoma mansoni tubulin subunit alpha 0.2412 0.7371 0.7371
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0044 0.0042
Echinococcus granulosus thyroid hormone receptor alpha 0.0065 0.0119 0.0118
Entamoeba histolytica hypothetical protein 0.0604 0.1786 0.1785
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0119 0.0118
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.0337 0.1346
Loa Loa (eye worm) hypothetical protein 0.0084 0.0176 0.0175
Echinococcus granulosus single minded 2 0.0041 0.0044 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0517 0.0516
Brugia malayi paired box protein 0.0029 0.0006 0.0005
Leishmania major zeta tubulin, putative 0.0787 0.235 0.2349
Leishmania major alpha tubulin 0.2412 0.7371 0.7371
Trichomonas vaginalis histone deacetylase, putative 0.0611 0.1805 0.1804
Echinococcus multilocularis tumor protein p63 0.0745 0.222 0.2219
Trichomonas vaginalis histone deacetylase, putative 0.0611 0.1805 0.1804
Loa Loa (eye worm) hypothetical protein 0.0065 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0084 0.0176 0.0175
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0101 0.01
Schistosoma mansoni tubulin subunit alpha 0.0787 0.235 0.235
Plasmodium vivax delta tubulin, putative 0.0787 0.235 0.2349
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0034 0.0024 0.0022
Trypanosoma cruzi histone deacetylase, putative 0.0336 0.0955 0.0953
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0113 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0119 0.0119
Onchocerca volvulus 0.1026 0.3088 0.679
Echinococcus multilocularis histone deacetylase 6 0.0336 0.0955 0.0953
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0611 0.1805 0.1804
Entamoeba histolytica hypothetical protein 0.0604 0.1786 0.1785
Loa Loa (eye worm) MH2 domain-containing protein 0.0054 0.0084 0.0083
Schistosoma mansoni zinc finger protein 0.0065 0.0119 0.0119
Brugia malayi MH2 domain containing protein 0.0121 0.0291 0.0289
Echinococcus granulosus histone deacetylase 6 0.0336 0.0955 0.0953
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0298 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0149 0.0377 0.0376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0517 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0149 0.0377 0.0376
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0027 0.0001 0.0001
Trypanosoma cruzi zeta tubulin, putative 0.0787 0.235 0.2349
Echinococcus multilocularis histone deacetylase 0.0336 0.0955 0.0953
Brugia malayi beta-lactamase family protein 0.0041 0.0044 0.0042
Brugia malayi nuclear hormone receptor family member nhr-6 0.0065 0.0119 0.0118
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0119 0.0119
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0034 0.0024 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0023 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0282 0.0789 0.0788
Echinococcus granulosus mothers against decapentaplegic 5 0.0121 0.0291 0.0289
Onchocerca volvulus Protein ultraspiracle homolog 0.0149 0.0377 0.0827
Schistosoma mansoni intermediate filament proteins 0.0059 0.0101 0.0101
Schistosoma mansoni tubulin subunit beta 0.0787 0.235 0.235
Schistosoma mansoni histone deacetylase 1 2 3 0.0212 0.0573 0.0573
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0044 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0149 0.0377 0.0376
Onchocerca volvulus 0.0047 0.0064 0.0138
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.0298 0.1178
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0034 0.0024 0.0022
Onchocerca volvulus 0.1498 0.4547 1
Brugia malayi Tubulin alpha chain 0.0787 0.235 0.2349
Echinococcus multilocularis histone deacetylase 6 0.0336 0.0955 0.0953
Brugia malayi histone deacetylase 11 0.0212 0.0573 0.0572
Echinococcus granulosus histone deacetylase 7 0.0336 0.0955 0.0953
Plasmodium vivax SET domain protein, putative 0.0034 0.0024 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0073 0.0142 0.0141
Brugia malayi conserved hypotetical protein 0.0065 0.0119 0.0118
Schistosoma mansoni tubulin subunit alpha 0.2412 0.7371 0.7371
Brugia malayi nuclear receptor RXR 0.0084 0.0176 0.0175
Brugia malayi MH2 domain containing protein 0.1771 0.5391 0.5391
Loa Loa (eye worm) tubulin gamma chain 0.1813 0.552 0.552
Chlamydia trachomatis endonuclease IV 0.0087 0.0186 1
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.0298 0.0296
Echinococcus multilocularis mothers against decapentaplegic 2 0.0054 0.0084 0.0083
Toxoplasma gondii LsmAD domain-containing protein 0.0263 0.0731 0.073
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0019
Echinococcus multilocularis tubulin alpha chain 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin epsilon chain, putative 0.2412 0.7371 0.7371
Echinococcus multilocularis lamin 0.0059 0.0101 0.01
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0034 0.0024 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0046 0.0109
Loa Loa (eye worm) CYP4Cod1 0.003 0.001 0.0008
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0171 0.0446 0.0445
Plasmodium vivax histone deacetylase 2, putative 0.0336 0.0955 0.0953
Trypanosoma cruzi histone deacetylase 1, putative 0.0611 0.1805 0.1804
Leishmania major histone deacetylase, putative 0.0611 0.1805 0.1804
Schistosoma mansoni histone deacetylase 4 5 0.0336 0.0955 0.0955
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1026 0.3088 0.3087
Brugia malayi bZIP transcription factor family protein 0.0095 0.0211 0.021
Loa Loa (eye worm) alpha-tubulin 0.2412 0.7371 0.7371
Trypanosoma cruzi PAB1-binding protein , putative 0.0263 0.0731 0.073
Plasmodium falciparum ataxin-2 like protein, putative 0.0263 0.0731 0.073
Echinococcus granulosus tubulin alpha 0.1813 0.552 0.552
Echinococcus multilocularis musashi 0.0059 0.0101 0.01
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0787 0.235 1
Echinococcus multilocularis dihydrofolate reductase 0.005 0.0071 0.007
Mycobacterium ulcerans hypothetical protein 0.0041 0.0044 0.0145
Trypanosoma cruzi histone deacetylase, putative 0.0336 0.0955 0.0953
Loa Loa (eye worm) hypothetical protein 0.0034 0.0024 0.0023
Echinococcus granulosus tubulin delta chain 0.0787 0.235 0.2349
Echinococcus multilocularis histone deacetylase 8 0.0212 0.0573 0.0572
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.0744 0.0743
Trypanosoma cruzi PAB1-binding protein , putative 0.0263 0.0731 0.073
Echinococcus granulosus paired box protein pax 6 0.0029 0.0006 0.0005
Echinococcus granulosus peroxisome assembly protein 26 0.2412 0.7371 0.7371
Brugia malayi hypothetical protein 0.0604 0.1786 0.1785
Schistosoma mansoni Smad4 0.0054 0.0084 0.0084
Trypanosoma cruzi alpha tubulin, putative 0.2412 0.7371 0.7371
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0046 0.0045
Brugia malayi nuclear receptor NHR-67 0.0065 0.0119 0.0118
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0044 0.0086
Mycobacterium tuberculosis Conserved protein 0.0041 0.0044 0.0086
Brugia malayi tubulin alpha chain - mouse 0.2412 0.7371 0.7371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0149 0.0377 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0014 0.0013
Trypanosoma brucei beta tubulin 0.1813 0.552 0.552
Trichomonas vaginalis conserved hypothetical protein 0.0787 0.235 0.2349
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0034 0.0024 0.0022
Mycobacterium tuberculosis Conserved protein 0.0041 0.0044 0.0086
Echinococcus multilocularis peroxisome assembly protein 26 0.2412 0.7371 0.7371
Schistosoma mansoni smad1 5 8 and 0.0121 0.0291 0.0291
Brugia malayi MH1 domain containing protein 0.0067 0.0124 0.0123
Toxoplasma gondii exonuclease III APE 0.0041 0.0046 0.0045
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0121 0.0293 0.0292
Echinococcus multilocularis tubulin delta chain 0.0787 0.235 0.2349
Schistosoma mansoni hypothetical protein 0.0111 0.0262 0.0262
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0171 0.0446 0.0445
Onchocerca volvulus 0.0065 0.0119 0.0259
Echinococcus multilocularis tubulin alpha 3 chain 0.2412 0.7371 0.7371
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0065 0.0063
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.002 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0295 0.1165
Brugia malayi hypothetical protein 0.0065 0.0119 0.0118
Schistosoma mansoni alpha tubulin 0.2412 0.7371 0.7371
Echinococcus multilocularis muscleblind protein 1 0.0329 0.0935 0.0934
Trichomonas vaginalis bromodomain-containing protein, putative 0.0097 0.0216 0.0215
Brugia malayi Cytochrome P450 family protein 0.003 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.1386 0.4201 0.4201
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0298 0.0298
Brugia malayi PAS domain containing protein 0.0055 0.0088 0.0087
Echinococcus multilocularis tubulin alpha 1C chain 0.2412 0.7371 0.7371
Loa Loa (eye worm) p25-alpha family protein 0.0414 0.1197 0.1196
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0787 0.235 0.2349
Echinococcus granulosus tubulin alpha chain 0.2412 0.7371 0.7371
Trichomonas vaginalis tubulin, putative 0.1026 0.3088 0.3087
Trypanosoma brucei epsilon tubulin 0.1813 0.552 0.552
Loa Loa (eye worm) hypothetical protein 0.0044 0.0054 0.0053
Echinococcus granulosus histone deacetylase 1 0.0611 0.1805 0.1804
Echinococcus multilocularis neuropeptide s receptor 0.0528 0.1548 0.1547
Mycobacterium leprae Probable lipase LipE 0.0041 0.0044 0.0086
Loa Loa (eye worm) MH1 domain-containing protein 0.0121 0.0291 0.0289
Loa Loa (eye worm) beta-lactamase 0.0041 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0142 0.0358 0.0357
Loa Loa (eye worm) histone deacetylase 3 0.0611 0.1805 0.1804
Plasmodium falciparum alpha tubulin 2 0.2412 0.7371 0.7371
Toxoplasma gondii histone deacetylase HDAC2 0.0611 0.1805 0.1804
Schistosoma mansoni smad 0.0121 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.0073 0.0144 0.0144
Echinococcus multilocularis paired box protein pax 6 0.0029 0.0006 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0121 0.0291 0.0291
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0044 0.0042
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0034 0.0024 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0044 0.0042
Echinococcus granulosus jun protein 0.0095 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0087 0.0186 0.0184
Loa Loa (eye worm) tubulin alpha 2 0.1625 0.4939 0.4938
Plasmodium vivax histone deacetylase, putative 0.0336 0.0955 0.0953
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0149 0.0377 0.0376
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0044 0.0042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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