Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0033 | 0.0581 | 0.5359 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1 | 0.1518 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1 | 0.1518 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Echinococcus granulosus | lamin | 0.0033 | 0.0581 | 0.5359 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0581 | 0.5359 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0097 | 0.0147 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1 | 0.1391 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1 | 1 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0581 | 0.0882 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1 | 0.1518 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0558 | 0.0847 |
Onchocerca volvulus | 0.0043 | 0.1 | 0.1391 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0581 | 0.0882 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0581 | 0.5359 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0097 | 0.0147 |
Onchocerca volvulus | 0.0033 | 0.0581 | 0.0746 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0097 | 0.0147 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0581 | 0.5359 |
Onchocerca volvulus | 0.0043 | 0.1 | 0.1391 | |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0189 | 0.6589 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1 | 0.1518 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.6589 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0581 | 0.5359 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0097 | 0.0147 |
Onchocerca volvulus | 0.0033 | 0.0581 | 0.0746 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0581 | 0.5359 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0581 | 0.0882 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0097 | 0.0147 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1 | 0.1518 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1 | 0.1518 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0581 | 0.0882 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0097 | 0.0147 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0189 | 0.6589 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0097 | 0.0147 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1 | 0.1518 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0581 | 0.0882 |
Schistosoma mansoni | lamin | 0.0033 | 0.0581 | 0.5359 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0097 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0097 | 0.0147 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0097 | 0.0147 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0581 | 0.5359 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1 | 0.1518 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0097 | 0.0147 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.