Detailed information for compound 1403785

Basic information

Technical information
  • TDR Targets ID: 1403785
  • Name: 2-naphthalen-1-yl-N'-(2-naphthalen-2-yloxyace tyl)acetohydrazide
  • MW: 384.427 | Formula: C24H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 4.84 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccc2c(c1)cccc2)NNC(=O)Cc1cccc2c1cccc2
  • InChi: 1S/C24H20N2O3/c27-23(15-20-10-5-9-18-7-3-4-11-22(18)20)25-26-24(28)16-29-21-13-12-17-6-1-2-8-19(17)14-21/h1-14H,15-16H2,(H,25,27)(H,26,28)
  • InChiKey: KWUITRCMWYPRFN-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(1-naphthyl)-N'-[2-(2-naphthyloxy)acetyl]acetohydrazide
  • 2-(1-naphthyl)-N'-[2-(2-naphthyloxy)-1-oxoethyl]acetohydrazide
  • 2-naphthalen-1-yl-N'-(2-naphthalen-2-yloxyethanoyl)ethanehydrazide
  • SMR000175176
  • Naphthalen-1-yl-acetic acid N'-[2-(naphthalen-2-yloxy)-acetyl]-hydrazide
  • ZINC00829252
  • BAS 00475491
  • MLS000552400

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0797 0.0797
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.006 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0105 0.0089
Brugia malayi Tubulin alpha-2 chain 0.1204 0.7445 0.7436
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.006 0.0025
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0181 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0025 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.006 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.006 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0046 0.0043
Brugia malayi Cell division protein ftsZ 0.0379 0.2293 0.2265
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0181 0.0178
Brugia malayi CXXC zinc finger family protein 0.0063 0.0323 0.0288
Brugia malayi MH1 domain containing protein 0.0041 0.0181 0.0146
Echinococcus granulosus tubulin alpha chain 0.1204 0.7445 0.7439
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0103
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0419 0.0395
Leishmania major epsilon tubulin, putative 0.0873 0.5375 0.5354
Mycobacterium leprae cell division protein FtsZ 0.0379 0.2293 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0076 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0316 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0797 0.0797
Echinococcus multilocularis tubulin gamma 1 chain 0.0873 0.5375 0.5364
Schistosoma mansoni coup transcription factor 0.0021 0.006 0.006
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0029 0.0105 0.0089
Loa Loa (eye worm) Smad1 0.0041 0.0181 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.006 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0557 0.0484
Trichomonas vaginalis tubulin, putative 0.0494 0.301 0.2998
Trypanosoma cruzi tubulin delta chain 0.0379 0.2293 0.229
Entamoeba histolytica Ran family GTPase 0.0026 0.0087 0.0087
Echinococcus granulosus snurportin 1 0.0372 0.2247 0.2228
Loa Loa (eye worm) hypothetical protein 0.1204 0.7445 0.7445
Brugia malayi RNA, U transporter 1 0.0099 0.0545 0.0511
Schistosoma mansoni DNA helicase recq5 0.0024 0.0076 0.0076
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0041 0.0016
Schistosoma mansoni lamin 0.0033 0.013 0.013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.006 0.0035
Schistosoma mansoni alpha tubulin 0.1204 0.7445 0.7445
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0087 0.0084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0181 0.0178
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0323 0.032
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0419 0.0375
Trichomonas vaginalis tubulin beta chain, putative 0.1204 0.7445 0.7441
Schistosoma mansoni smad1 5 8 and 0.0041 0.0181 0.0181
Toxoplasma gondii alpha-tubulin I, putative 0.1204 0.7445 0.7445
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.006 0.006
Leishmania major zeta tubulin, putative 0.0379 0.2293 0.2257
Trypanosoma brucei tubulin delta chain 0.0379 0.2293 0.2257
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.006 0.0035
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0076 0.0051
Treponema pallidum cell division protein FtsZ 0.0379 0.2293 1
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0419 0.0419
Trichomonas vaginalis tubulin gamma chain, putative 0.0873 0.5375 0.5368
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0181 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0557 0.0484
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0105 0.0089
Echinococcus granulosus lamin dm0 0.0033 0.013 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.006 0.0057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0087 0.0011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0181 0.0157
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.013 0.0127
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.006 0.0035
Loa Loa (eye worm) hypothetical protein 0.0067 0.0343 0.034
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0105 0.0103
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0103 0.0087
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0067 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Loa Loa (eye worm) RNA binding protein 0.0062 0.0316 0.0314
Trypanosoma brucei alpha tubulin 0.1204 0.7445 0.7433
Schistosoma mansoni hypothetical protein 0.1018 0.6279 0.6279
Loa Loa (eye worm) beta-lactamase 0.0111 0.0619 0.0616
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0419 0.0395
Schistosoma mansoni hypothetical protein 0.1018 0.6279 0.6279
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.006 0.0035
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0087 0.0062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.006 0.006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0619 0.2548
Echinococcus granulosus lamin 0.0033 0.013 0.0105
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0619 0.1061
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.006 0.0025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0087 0.0011
Echinococcus multilocularis Tubulin alpha 1 chain 0.1204 0.7445 0.7439
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0419 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.006 0.0057
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0205 0.0189
Schistosoma mansoni alpha tubulin 0.1204 0.7445 0.7445
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.006 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.000000000061711
Brugia malayi Smad1 0.0041 0.0181 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.000000000061711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.006 0.0057
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0076 0.0051
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.013 0.0095
Schistosoma mansoni Smad4 0.0018 0.0041 0.0041
Echinococcus multilocularis musashi 0.0033 0.013 0.0105
Brugia malayi MH2 domain containing protein 0.0018 0.0041 0.0005
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.071 0.4362 0.4353
Loa Loa (eye worm) transcription factor SMAD2 0.0599 0.3665 0.3663
Schistosoma mansoni hypothetical protein 0.0425 0.2582 0.2582
Trichomonas vaginalis ran, putative 0.0026 0.0087 0.007
Schistosoma mansoni tubulin subunit delta 0.0379 0.2293 0.2293
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0316 0.0292
Brugia malayi tubulin alpha chain - mouse 0.1204 0.7445 0.7436
Loa Loa (eye worm) hypothetical protein 0.0095 0.0522 0.0519
Echinococcus granulosus tubulin alpha chain 0.1204 0.7445 0.7439
Echinococcus granulosus Tubulin alpha 1 chain 0.1204 0.7445 0.7439
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0379 0.2293 0.228
Echinococcus multilocularis Smad4 0.0041 0.0181 0.0157
Trichomonas vaginalis tubulin beta chain, putative 0.1204 0.7445 0.7441
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0557 0.0554
Loa Loa (eye worm) alpha-tubulin 0.1204 0.7445 0.7445
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0076 0.006
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.2582 0.2564
Giardia lamblia Epsilon tubulin 0.0379 0.2293 0.2233
Trypanosoma brucei alpha tubulin 0.1204 0.7445 0.7433
Brugia malayi alpha-tubulin 0.1204 0.7445 0.7436
Entamoeba histolytica hypothetical protein 0.0028 0.0103 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.000000000061711
Trypanosoma brucei epsilon tubulin 0.0873 0.5375 0.5354
Mycobacterium tuberculosis Cell division protein FtsZ 0.0379 0.2293 0.5075
Echinococcus multilocularis tubulin alpha 1C chain 0.1204 0.7445 0.7439
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0087 0.0062
Schistosoma mansoni smad1 5 8 and 0.0041 0.0181 0.0181
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.0105 0.0089
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.0105 0.0089
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0181 0.0181
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Giardia lamblia Alpha-tubulin 0.1204 0.7445 0.7426
Trichomonas vaginalis tubulin beta chain, putative 0.1204 0.7445 0.7441
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0003 0.0003
Trichomonas vaginalis tubulin beta chain, putative 0.1204 0.7445 0.7441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.006 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0124 0.0121
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0419 0.0395
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Echinococcus granulosus Tubulin alpha 1 chain 0.1204 0.7445 0.7439
Toxoplasma gondii exonuclease III APE 0.0041 0.0181 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0316 0.0316
Echinococcus granulosus Tubulin alpha 1 chain 0.1204 0.7445 0.7439
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0067 0.0343 0.034
Echinococcus granulosus bloom syndrome protein 0.0024 0.0076 0.0051
Loa Loa (eye worm) tubulin alpha-3 chain 0.071 0.4362 0.4361
Echinococcus multilocularis aryl hydrocarbon receptor 0.0096 0.0524 0.05
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2247 0.2245
Schistosoma mansoni Smad4 0.0018 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.000000000061627
Trichomonas vaginalis adenylate cyclase, putative 0.0029 0.0105 0.0089
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0598 0.0598
Trypanosoma brucei epsilon tubulin 0.0873 0.5375 0.5354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.006 0.0025
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0205 0.0116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0018
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0873 0.5375 0.5375
Schistosoma mansoni intermediate filament proteins 0.0033 0.013 0.013
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0105 0.0103
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0046 0.0043
Mycobacterium tuberculosis Conserved protein 0.0111 0.0619 0.1061
Brugia malayi isocitrate dehydrogenase 0.0079 0.0419 0.0385
Onchocerca volvulus 0.0476 0.2899 0.9626
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0419 0.0375
Plasmodium vivax tubulin alpha chain, putative 0.1204 0.7445 0.7445
Echinococcus multilocularis hypothetical protein 0.1204 0.7445 0.7439
Loa Loa (eye worm) hypothetical protein 0.0067 0.0343 0.034
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0557 0.0554
Schistosoma mansoni DNA helicase recq1 0.0024 0.0076 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0181 0.0178
Loa Loa (eye worm) hypothetical protein 0.0101 0.0557 0.0554
Schistosoma mansoni nuclear hormone receptor 0.0021 0.006 0.006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0087 0.0084
Mycobacterium ulcerans lipase LipD 0.0111 0.0619 0.2548
Schistosoma mansoni tubulin subunit alpha 0.1204 0.7445 0.7445
Loa Loa (eye worm) nuclear factor I 0.0023 0.0068 0.0065
Schistosoma mansoni inositol monophosphatase 0.0045 0.0205 0.0205
Onchocerca volvulus 0.0033 0.013 0.0301
Brugia malayi Tubulin alpha chain 0.0379 0.2293 0.2265
Echinococcus granulosus intermediate filament protein 0.0033 0.013 0.0105
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0123
Trypanosoma brucei zeta tubulin 0.0379 0.2293 0.2257
Loa Loa (eye worm) tubulin alpha 2 0.0332 0.1997 0.1994
Plasmodium falciparum tubulin epsilon chain, putative 0.0873 0.5375 0.534
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0181 0.0135
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0181 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0797 0.0774
Trypanosoma brucei PAB1-binding protein , putative 0.0101 0.0557 0.0513
Brugia malayi TAR-binding protein 0.0062 0.0316 0.0282
Mycobacterium tuberculosis Conserved protein 0.0111 0.0619 0.1061
Echinococcus granulosus tubulin alpha 3 chain 0.1204 0.7445 0.7439
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0619 0.0616
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0619 0.1061
Trichomonas vaginalis tubulin alpha chain, putative 0.0494 0.301 0.2998
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.006 0.0035
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0316 0.0314
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0105 0.0103
Onchocerca volvulus 0.0033 0.013 0.0301
Entamoeba histolytica tubulin alpha-1 chain 0.1204 0.7445 0.7445
Trichomonas vaginalis tubulin, putative 0.0494 0.301 0.2998
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0419 0.0395
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0087 0.0051
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0105 0.0103
Echinococcus multilocularis tubulin alpha chain 0.1204 0.7445 0.7439
Echinococcus granulosus tubulin alpha 0.0873 0.5375 0.5364
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0316 0.0316
Schistosoma mansoni tubulin subunit alpha 0.1204 0.7445 0.7445
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0105 0.0089
Echinococcus multilocularis tubulin epsilon chain 0.0873 0.5375 0.5364
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0076 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Echinococcus multilocularis snurportin 1 0.0372 0.2247 0.2228
Trypanosoma cruzi tubulin delta chain 0.0379 0.2293 0.229
Schistosoma mansoni single-minded 0.0029 0.0105 0.0105
Onchocerca volvulus 0.0063 0.0323 0.0951
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0029 0.0105 0.5
Entamoeba histolytica tubulin alpha chain, putative 0.1204 0.7445 0.7445
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0105 0.0103
Loa Loa (eye worm) histone methyltransferase 0.002 0.0049 0.0046
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0076 0.0051
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.006 0.0035
Schistosoma mansoni ran 0.0026 0.0087 0.0087
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0205 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.000000000061711
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0619 0.0603
Trichomonas vaginalis tubulin alpha chain, putative 0.0494 0.301 0.2998
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0181 0.0165
Schistosoma mansoni hypothetical protein 0.0045 0.0209 0.0209
Schistosoma mansoni smad 0.0018 0.0041 0.0041
Onchocerca volvulus 0.0021 0.006 0.0066
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0105 0.0089
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0619 0.0585
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0041 0.0038
Echinococcus multilocularis tubulin alpha 1C chain 0.1204 0.7445 0.7439
Loa Loa (eye worm) tubulin alpha-2 chain 0.1204 0.7445 0.7445
Entamoeba histolytica hypothetical protein 0.0107 0.0598 0.0598
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0205 0.0189
Brugia malayi beta-lactamase family protein 0.0111 0.0619 0.0585
Echinococcus multilocularis tubulin subunit TubB 0.1204 0.7445 0.7439
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0021 0.006 0.006
Brugia malayi MH2 domain containing protein 0.0041 0.0181 0.0146
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0797 0.0764
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0619 0.1061
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0105 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0105 0.0089
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0419 0.0416
Echinococcus multilocularis peroxisome assembly protein 26 0.1204 0.7445 0.7439
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0127
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0076 0.0076
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0619 0.0616
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0205 0.0202
Brugia malayi beta-lactamase 0.0111 0.0619 0.0585
Schistosoma mansoni ran 0.0026 0.0087 0.0087
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0076 0.0041
Brugia malayi intermediate filament protein 0.0033 0.013 0.0095
Brugia malayi steroid hormone receptor 0.0021 0.006 0.0025
Leishmania major GTP-binding protein, putative 0.0026 0.0087 0.0041
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0041 0.0016
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0205 0.0205
Echinococcus multilocularis lamin dm0 0.0033 0.013 0.0105
Schistosoma mansoni alpha tubulin 0.1204 0.7445 0.7445
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0619 0.0603
Echinococcus granulosus tubulin alpha chain 0.1204 0.7445 0.7439
Loa Loa (eye worm) MH2 domain-containing protein 0.0599 0.3665 0.3663
Echinococcus granulosus tubulin alpha chain 0.1204 0.7445 0.7439
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.006 0.006
Trypanosoma cruzi epsilon tubulin, putative 0.0873 0.5375 0.5374
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.000000000061711
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Trichomonas vaginalis tubulin epsilon chain, putative 0.1204 0.7445 0.7441
Trypanosoma cruzi epsilon tubulin, putative 0.0873 0.5375 0.5374
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0419 0.0419
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0144 0.012
Schistosoma mansoni tubulin subunit beta 0.0379 0.2293 0.2293
Brugia malayi nuclear receptor NHR-88 0.0021 0.006 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.006 0.0035
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0181 0.0777
Mycobacterium tuberculosis Conserved protein 0.0111 0.0619 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.006 0.0025
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0619 0.0595
Plasmodium vivax tubulin epsilon chain, putative 0.0873 0.5375 0.5375
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0619 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0316 0.0316
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0046 0.0043
Echinococcus multilocularis Tubulin alpha 1 chain 0.1204 0.7445 0.7439
Schistosoma mansoni importin beta-1 0.0035 0.0144 0.0144
Brugia malayi Tubulin beta chain 0.0494 0.301 0.2985
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.006 0.006
Trypanosoma brucei zeta tubulin, putative 0.0379 0.2293 0.2257
Echinococcus granulosus FTZ F1 alpha 0.0021 0.006 0.0035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0598 0.0574
Echinococcus granulosus peroxisome assembly protein 26 0.1204 0.7445 0.7439
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.006 0.0035
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0419 0.0385
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0181 0.0105
Loa Loa (eye worm) inositol-1 0.0045 0.0205 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0181 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0619 0.2548
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.006 0.006
Schistosoma mansoni Smad4 0.0041 0.0181 0.0181
Schistosoma mansoni tubulin subunit epsilon 0.0873 0.5375 0.5375
Echinococcus granulosus tubulin delta chain 0.0379 0.2293 0.2273
Trypanosoma brucei alpha tubulin 0.1204 0.7445 0.7433
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0144 0.0098
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0046 0.0043
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0076 0.0073
Brugia malayi Tubulin beta chain 0.0379 0.2293 0.2265
Brugia malayi MH1 domain containing protein 0.0023 0.0068 0.0032
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0048 0.0012
Brugia malayi Tubulin alpha-2 chain 0.1204 0.7445 0.7436
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0087 0.0087
Loa Loa (eye worm) tubulin alpha chain 0.1204 0.7445 0.7445
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0205 0.0202
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0046 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.006 0.0057
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0494 0.301 0.2998
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0029 0.0105 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.006 0.0025
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Leishmania major hypothetical protein, conserved 0.0101 0.0557 0.0513
Toxoplasma gondii ABC1 family protein 0.0111 0.0619 0.0619
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0076 0.0051
Trypanosoma cruzi tubulin gamma chain 0.0873 0.5375 0.5374
Trichomonas vaginalis tubulin beta chain, putative 0.0494 0.301 0.2998
Loa Loa (eye worm) hypothetical protein 0.0155 0.0893 0.089
Loa Loa (eye worm) hypothetical protein 0.0111 0.0619 0.0616
Trypanosoma cruzi alpha tubulin, putative 0.1204 0.7445 0.7445
Trichomonas vaginalis tubulin epsilon chain, putative 0.0379 0.2293 0.228
Echinococcus granulosus geminin 0.1018 0.6279 0.627
Brugia malayi Cytochrome P450 family protein 0.0032 0.0124 0.0089
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0619 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.006 0.0025
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0076 0.006
Brugia malayi hypothetical protein 0.0155 0.0893 0.086
Echinococcus granulosus tubulin alpha 1C chain 0.1204 0.7445 0.7439
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0825 0.508 0.5071
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0111 0.0619 0.0616
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0181 0.0156
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.006 0.006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0076 0.0076
Echinococcus granulosus Smad4 0.0041 0.0181 0.0157
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0065
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0419 0.0416
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0103 0.0087
Brugia malayi RNA binding protein 0.0062 0.0316 0.0282
Brugia malayi MH1 domain containing protein 0.0041 0.0181 0.0146
Echinococcus granulosus dnaJ subfamily B 0.0425 0.2582 0.2564
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0049 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0598 0.0574
Brugia malayi hypothetical protein 0.0107 0.0598 0.0564
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0316 0.0314
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0708 0.4346 1
Giardia lamblia Delta tubulin 0.0379 0.2293 0.2233
Onchocerca volvulus Protein cycle homolog 0.0067 0.0345 0.1026
Echinococcus granulosus tubulin gamma 1 chain 0.0873 0.5375 0.5364
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0105 0.0103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.006 0.0035
Loa Loa (eye worm) hypothetical protein 0.0825 0.508 0.5078
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.006 0.0035
Echinococcus multilocularis geminin 0.1018 0.6279 0.627
Loa Loa (eye worm) alpha-tubulin 0.1204 0.7445 0.7445
Trichomonas vaginalis esterase, putative 0.0111 0.0619 0.0603
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0797 0.0794
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.0677 0.0677
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0209 0.0185
Brugia malayi hypothetical protein 0.0067 0.0345 0.0311
Schistosoma mansoni cpg binding protein 0.0067 0.0346 0.0346
Leishmania major gamma-tubulin 0.0873 0.5375 0.5354
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.006 0.0035
Schistosoma mansoni tubulin subunit alpha 0.1204 0.7445 0.7445
Brugia malayi beta-lactamase family protein 0.0111 0.0619 0.0585
Trichomonas vaginalis tubulin alpha chain, putative 0.0494 0.301 0.2998
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Echinococcus granulosus tubulin alpha chain 0.1204 0.7445 0.7439
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0619 0.1061
Plasmodium falciparum tubulin delta chain, putative 0.0379 0.2293 0.2233
Echinococcus granulosus tar DNA binding protein 0.0062 0.0316 0.0292
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0067 0.0345 0.0311
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0067 0.0345 0.0311
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0379 0.2293 0.2293
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0619 0.0616
Echinococcus multilocularis tubulin delta chain 0.0379 0.2293 0.2273
Echinococcus granulosus importin subunit beta 1 0.0035 0.0144 0.012
Schistosoma mansoni hypothetical protein 0.0372 0.2247 0.2247
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.0041 0.0181 0.0146
Loa Loa (eye worm) hypothetical protein 0.0111 0.0619 0.0616
Plasmodium falciparum tubulin gamma chain 0.0873 0.5375 0.534
Trichomonas vaginalis tubulin, putative 0.0379 0.2293 0.228
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.006 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0041 0.0038
Leishmania major protein kinase, putative 0.0029 0.0105 0.006
Schistosoma mansoni ap endonuclease 0.0041 0.0181 0.0181
Echinococcus granulosus tubulin epsilon chain 0.0873 0.5375 0.5364
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0079 0.0419 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.006 0.0025
Schistosoma mansoni aryl hydrocarbon receptor 0.0029 0.0107 0.0107
Mycobacterium ulcerans hypothetical protein 0.0111 0.0619 0.2548
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.000000000061711
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0379 0.2293 1
Trypanosoma cruzi zeta tubulin, putative 0.0379 0.2293 0.229
Leishmania major hypothetical protein, conserved 0.0111 0.0619 0.0575
Echinococcus multilocularis Tubulin alpha 1 chain 0.1204 0.7445 0.7439
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0205 0.0708
Onchocerca volvulus 0.0111 0.0619 0.1946
Schistosoma mansoni tubulin subunit alpha 0.0379 0.2293 0.2293
Loa Loa (eye worm) tubulin beta chain 0.0379 0.2293 0.229
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0797 0.0774
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.006 0.0025
Loa Loa (eye worm) RecQ helicase 0.0024 0.0076 0.0073
Entamoeba histolytica hypothetical protein 0.0107 0.0598 0.0598
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.000000000061711
Entamoeba histolytica hypothetical protein 0.0107 0.0598 0.0598
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0619 0.1061
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0619 0.0603
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0003 0.0003
Brugia malayi Pax transcription factor protein 2 0.0476 0.2899 0.2873
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0619 0.2346
Leishmania major delta tubulin, putative 0.0379 0.2293 0.2257
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0144 0.0098
Leishmania major importin beta-1 subunit, putative 0.0028 0.0103 0.0057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0181 0.0156
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0205 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.006 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.2293 0.228
Plasmodium vivax importin-beta 2, putative 0.0035 0.0144 0.0144
Plasmodium vivax tubulin alpha chain, putative 0.1204 0.7445 0.7445
Echinococcus multilocularis tubulin alpha chain 0.1204 0.7445 0.7439
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0316 0.0282
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.006 0.0066
Echinococcus multilocularis tubulin alpha chain 0.1204 0.7445 0.7439
Echinococcus granulosus alpha tubulin 0.1204 0.7445 0.7439
Toxoplasma gondii LsmAD domain-containing protein 0.0101 0.0557 0.0557
Plasmodium falciparum importin beta, putative 0.0035 0.0144 0.0068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0619 0.1061
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0205 0.0205
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0103 0.01
Entamoeba histolytica hypothetical protein 0.0107 0.0598 0.0598
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0181 0.0157
Trypanosoma brucei epsilon tubulin 0.0873 0.5375 0.5354
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0619 0.0575
Echinococcus granulosus aryl hydrocarbon receptor 0.0096 0.0524 0.05
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0087 0.0087
Trypanosoma brucei beta tubulin 0.0873 0.5375 0.5354
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0067 0.0343 0.034
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0419 0.0395
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0181 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.006 0.0025
Trypanosoma brucei tubulin gamma chain 0.0873 0.5375 0.5354
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0144 0.0144
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0067 0.0345 0.0342
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0036 0.0033
Giardia lamblia Gamma tubulin 0.0873 0.5375 0.534
Trichomonas vaginalis tubulin beta chain, putative 0.1204 0.7445 0.7441
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0205 0.0181
Brugia malayi hypothetical protein 0.0065 0.0334 0.0299
Brugia malayi tubulin alpha-2 chain 0.1204 0.7445 0.7436
Loa Loa (eye worm) hypothetical protein 0.0111 0.0619 0.0616
Brugia malayi hypothetical protein 0.0067 0.0343 0.0309
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0825 0.508 0.5078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.006 0.0035
Giardia lamblia Alpha-tubulin 0.1204 0.7445 0.7426
Loa Loa (eye worm) hypothetical protein 0.0111 0.0619 0.0616
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0079 0.0419 0.0419
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.006 0.006
Echinococcus multilocularis tubulin alpha 0.0873 0.5375 0.5364
Brugia malayi PAS domain containing protein 0.0029 0.0105 0.007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0087 0.0041
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0181 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0619 0.0619
Echinococcus multilocularis smad 0.0041 0.0181 0.0157
Schistosoma mansoni ap endonuclease 0.0041 0.0181 0.0181
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0419 0.0375
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0316 0.0316
Trichomonas vaginalis tubulin beta chain, putative 0.1204 0.7445 0.7441
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0181 0.0181
Echinococcus multilocularis tubulin alpha 3 chain 0.1204 0.7445 0.7439
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0205 0.016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.006 0.0025
Leishmania major protein kinase, putative 0.0029 0.0105 0.006
Loa Loa (eye worm) intermediate filament protein 0.0033 0.013 0.0127
Trichomonas vaginalis tubulin alpha chain, putative 0.0873 0.5375 0.5368
Brugia malayi Tubulin gamma chain 0.0873 0.5375 0.5359
Brugia malayi Cytochrome P450 family protein 0.0019 0.0046 0.0011
Brugia malayi Inositol-1 0.0045 0.0205 0.017
Plasmodium falciparum alpha tubulin 2 0.1204 0.7445 0.7426
Echinococcus multilocularis tubulin alpha 3 chain 0.1204 0.7445 0.7439
Brugia malayi Tubulin alpha chain 0.1204 0.7445 0.7436
Plasmodium vivax tubulin gamma chain, putative 0.0873 0.5375 0.5375
Onchocerca volvulus 0.0111 0.0619 0.1946
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.006 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0619 0.0603
Onchocerca volvulus 0.0494 0.301 1
Onchocerca volvulus 0.0155 0.0893 0.287
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0176 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0021 0.006 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0797 0.0774
Schistosoma mansoni inositol monophosphatase 0.0045 0.0205 0.0205
Brugia malayi MH2 domain containing protein 0.0599 0.3665 0.3643
Echinococcus granulosus cpg binding protein 0.0067 0.0346 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.006 0.0025
Schistosoma mansoni hypothetical protein 0.0107 0.0598 0.0598
Echinococcus multilocularis cpg binding protein 0.0067 0.0346 0.0321
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.006 0.0066
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0181 0.0105
Trypanosoma brucei alpha tubulin, putative 0.0494 0.301 0.2977
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0049 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0181 0.0599
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0205 0.0181
Loa Loa (eye worm) tubulin alpha 2 0.0825 0.508 0.5078
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0105 0.0089
Loa Loa (eye worm) tubulin alpha chain 0.1204 0.7445 0.7445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.006 0.0025
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0419 0.0583
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0141
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0041 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.2293 0.228
Brugia malayi Cytochrome P450 family protein 0.0019 0.0046 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0767 0.0767
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.006 0.006
Echinococcus granulosus tubulin subunit TubB 0.1204 0.7445 0.7439
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0379 0.2293 0.2293
Trypanosoma brucei alpha tubulin 0.1204 0.7445 0.7433
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0181 0.0181
Entamoeba histolytica tubulin gamma chain 0.0873 0.5375 0.5375
Schistosoma mansoni lamin 0.0033 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0111 0.0619 0.0616
Schistosoma mansoni cpg binding protein 0.0063 0.0323 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.006 0.0057
Onchocerca volvulus 0.0095 0.0522 0.1621
Plasmodium falciparum alpha tubulin 1 0.1204 0.7445 0.7426
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0619 0.0619
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0181 0.0157
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0076 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.000000000061711
Plasmodium vivax ataxin-2 like protein, putative 0.0101 0.0557 0.0557
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0103 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0797 0.0797
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.006 0.0066
Brugia malayi hypothetical protein 0.0095 0.0522 0.0488
Echinococcus granulosus tubulin alpha 3 chain 0.1204 0.7445 0.7439
Trichomonas vaginalis tubulin gamma chain, putative 0.0873 0.5375 0.5368
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1204 0.7445 0.7441
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0057
Echinococcus multilocularis tubulin alpha chain 0.1204 0.7445 0.7439
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0096 0.0524 0.0521
Schistosoma mansoni cpg binding protein 0.0067 0.0346 0.0346
Brugia malayi ecdysteroid receptor 0.0021 0.006 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.006 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0797 0.0774
Brugia malayi nuclear hormone receptor 0.0021 0.006 0.0025
Loa Loa (eye worm) hypothetical protein 0.071 0.4362 0.4361
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0419 0.0419
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0181 0.0179
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0029 0.0107 0.0083
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0029 0.0107 0.0083
Echinococcus multilocularis lamin 0.0033 0.013 0.0105
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Loa Loa (eye worm) tubulin gamma chain 0.0873 0.5375 0.5374
Toxoplasma gondii alpha tubulin TUBA1 0.1204 0.7445 0.7445
Trichomonas vaginalis tubulin gamma chain, putative 0.0379 0.2293 0.228
Mycobacterium ulcerans beta-lactamase 0.0111 0.0619 0.2548
Onchocerca volvulus 0.0111 0.0619 0.1946
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0076 0.0051
Echinococcus granulosus tubulin alpha 1C chain 0.1204 0.7445 0.7439
Brugia malayi Importin beta-1 subunit 0.0035 0.0144 0.0109
Loa Loa (eye worm) pax transcription factor protein 2 0.0476 0.2899 0.2897
Echinococcus granulosus smad 0.0041 0.0181 0.0157
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0209 0.0185
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0076 0.003
Echinococcus multilocularis tubulin alpha chain 0.1204 0.7445 0.7439
Schistosoma mansoni smad1 5 8 and 0.0041 0.0181 0.0181
Trypanosoma cruzi zeta tubulin, putative 0.0379 0.2293 0.229
Brugia malayi hypothetical protein 0.0101 0.0557 0.0523
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0003 0.0003
Schistosoma mansoni tubulin subunit gamma 0.0873 0.5375 0.5375
Plasmodium vivax delta tubulin, putative 0.0379 0.2293 0.2293
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0067 0.0343 0.0309
Mycobacterium ulcerans cell division protein FtsZ 0.0379 0.2293 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.1204 0.7445 0.7441
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0041 0.0016
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0076 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.006 0.0035
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0076 0.006
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0619 0.0619
Schistosoma mansoni smad 0.0041 0.0181 0.0181
Leishmania major alpha tubulin 0.1204 0.7445 0.7433
Brugia malayi MH1 domain containing protein 0.0023 0.0068 0.0032
Mycobacterium leprae Probable lipase LipE 0.0111 0.0619 0.2346
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0619 0.0595
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0041 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0022
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0419 0.0416
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.5158 0.5146
Loa Loa (eye worm) tubulin alpha 2 0.0825 0.508 0.5078

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.398107171 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.3548 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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