Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0128 | 0.1168 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0128 | 0.1168 | 0.1168 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0128 | 0.1168 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0128 | 0.1168 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0046 | 0.0392 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0128 | 0.1168 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0324 | 0.362 | 0.362 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0046 | 0.0046 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0128 | 0.1168 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.0599 | 0.5131 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0046 | 0.0046 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.0046 | 0.0392 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0128 | 0.1168 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.026 | 0.026 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0305 | 0.3392 | 0.3392 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0128 | 0.1168 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0046 | 0.0046 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.0046 | 0.0046 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0046 | 0.0046 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.1076 | 0.9214 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0046 | 0.0046 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0128 | 0.1168 | 0.1168 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.026 | 0.2229 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.1076 | 0.9214 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1076 | 0.9214 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0324 | 0.362 | 0.362 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.0046 | 0.0392 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0074 | 0.0494 | 0.0494 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.026 | 0.026 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.0046 | 0.0392 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.026 | 0.026 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0074 | 0.0494 | 0.0494 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0599 | 0.0599 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0599 | 0.5131 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.026 | 0.2229 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.1076 | 0.9214 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.026 | 0.026 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0046 | 0.0046 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.026 | 0.026 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.026 | 0.026 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0128 | 0.1168 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.026 | 0.026 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0046 | 0.0046 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.