Detailed information for compound 1404090

Basic information

Technical information
  • TDR Targets ID: 1404090
  • Name: N-[2-(1-cyclohexenyl)ethyl]-2-phenylbutanamid e
  • MW: 271.397 | Formula: C18H25NO
  • H donors: 1 H acceptors: 1 LogP: 4.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(c1ccccc1)C(=O)NCCC1=CCCCC1
  • InChi: 1S/C18H25NO/c1-2-17(16-11-7-4-8-12-16)18(20)19-14-13-15-9-5-3-6-10-15/h4,7-9,11-12,17H,2-3,5-6,10,13-14H2,1H3,(H,19,20)
  • InChiKey: DDDOZMFVJSGHSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(1-cyclohexenyl)ethyl]-2-phenyl-butanamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-phenyl-butyramide
  • AK-968/12121642
  • MLS000578622
  • N-[2-(1-cyclohexen-1-yl)ethyl]-2-phenylbutanamide
  • SMR000197808
  • IVK/8074535
  • Oprea1_818216

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0007 0.0043 0.0043
Onchocerca volvulus 0.0024 0.0379 0.5955
Loa Loa (eye worm) TK/EGFR protein kinase 0.0056 0.1043 0.2119
Schistosoma mansoni hypothetical protein 0.0007 0.0043 0.0043
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.001 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni opsin-like receptor 0.0007 0.0043 0.0043
Onchocerca volvulus 0.001 0.0106 0.1116
Schistosoma mansoni cpg binding protein 0.0037 0.0648 0.0648
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0059 0.00000000015311
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Brugia malayi Furin-like cysteine rich region family protein 0.0056 0.1043 0.2119
Brugia malayi celfurPC protein 0.0192 0.3822 0.8006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Brugia malayi CXXC zinc finger family protein 0.0035 0.0608 0.1195
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0115 0.0152
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.001 0.0106 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.001 0.0106 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni biogenic amine receptor 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Brugia malayi proprotein convertase 2 0.0149 0.2956 0.617
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.00000000015311
Schistosoma mansoni cpg binding protein 0.0035 0.0608 0.0608
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.1043 0.1004
Loa Loa (eye worm) hypothetical protein 0.0238 0.4764 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Echinococcus granulosus Furin 1 0.0056 0.1047 0.1008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni opsin-like receptor 0.0007 0.0043 0.0043
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.001 0.0106 0.5
Schistosoma mansoni neuropeptide receptor 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Brugia malayi endoprotease bli-4 precursor 0.0238 0.4764 1
Loa Loa (eye worm) proprotein convertase 2 0.0056 0.1047 0.2127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0043 0.0043
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0043 0.0043
Brugia malayi Subtilase family protein 0.001 0.0106 0.0133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0043 0.0043
Loa Loa (eye worm) subtilase 0.001 0.0106 0.0133
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0043 0.0043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0043 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0608 0.1195
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0043 0.0043
Schistosoma mansoni neuropeptide receptor 0.0007 0.0043 0.0043
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.001 0.0106 0.0063
Mycobacterium leprae Possible secreted protease 0.001 0.0106 0.5
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.001 0.0106 0.0133
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.001 0.0106 0.5
Schistosoma mansoni site-1 peptidase (S08 family) 0.001 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.001 0.0106 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0106 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0074 0.0031
Brugia malayi neuroendocrine convertase 1 precursor 0.0149 0.2956 0.617
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Schistosoma mansoni cpg binding protein 0.0037 0.0648 0.0648
Plasmodium falciparum subtilisin-like protease 1 0.001 0.0106 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0145 0.2855 1
Schistosoma mansoni amine GPCR 0.0007 0.0043 0.0043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0043 0.0043
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.001 0.0106 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0043 0.0043
Echinococcus multilocularis neuroendocrine convertase 2 0.0149 0.2956 0.2925
Schistosoma mansoni biogenic amine receptor 0.0007 0.0043 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Plasmodium vivax subtilisin-like protease 1 0.001 0.0106 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.001 0.0106 0.5
Schistosoma mansoni histamine h1 receptor 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trypanosoma cruzi subtilisin peptidase 0.001 0.0106 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.023 0.4601 0.4577
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.001 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0046 0.0839 0.0839
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0106 0.0169
Loa Loa (eye worm) endoprotease bli-4 0.0238 0.4764 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1403 0.1403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0046 0.0839 0.2791
Schistosoma mansoni adenoreceptor 0.0007 0.0043 0.0043
Schistosoma mansoni site-1 peptidase (S08 family) 0.001 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0106 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.1047 0.3535
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.001 0.0106 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0106 0.0169
Echinococcus granulosus neuroendocrine convertase 2 0.0149 0.2956 0.2925
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Echinococcus multilocularis Furin 1 0.0056 0.1047 0.1008
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.001 0.0106 0.5
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0074 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.00000000015311
Leishmania major subtilisin-like serine peptidase 0.001 0.0106 0.5
Schistosoma mansoni furin-1 (S08 family) 0.0103 0.2015 0.2015
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0056 0.1047 0.1047
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0043 0.0043
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0043 0.0043
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0043 0.0043
Schistosoma mansoni opsin-like receptor 0.0007 0.0043 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0118 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.00000000015311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.1047 0.3535
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0059 0.00000000015311
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Loa Loa (eye worm) hypothetical protein 0.023 0.4601 0.9655
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0145 0.2855 0.2824
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.001 0.0106 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni myosin xvIII 0.0007 0.0043 0.0043
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0046 0.0839 0.2791
Plasmodium vivax subtilisin-like serine protease, putative 0.001 0.0106 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0118 0.0075
Schistosoma mansoni amine GPCR 0.0007 0.0043 0.0043
Schistosoma mansoni neuropeptide receptor 0.0007 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0093 0.1807 0.3736
Onchocerca volvulus 0.0035 0.0608 1
Schistosoma mansoni amine GPCR 0.0007 0.0043 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0074 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.00000000015311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.1047 0.3535
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.1047 0.3535
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Echinococcus multilocularis membrane bound transcription factor site 1 0.001 0.0106 0.0063
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0145 0.2855 0.2824
Schistosoma mansoni neuropeptide receptor 0.0007 0.0043 0.0043
Schistosoma mansoni biogenic amine receptor 0.0007 0.0043 0.0043
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.1047 0.3535
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0031
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.1043 0.1004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Schistosoma mansoni hypothetical protein 0.0007 0.0043 0.0043
Echinococcus granulosus neuropeptide FF receptor 2 0.023 0.4601 0.4577
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0046 0.0839 0.2791
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0043 0.0043
Giardia lamblia High cysteine membrane protein Group 2 0.0088 0.1706 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.001 0.0106 0.5
Trypanosoma brucei subtilisin peptidase 0.001 0.0106 0.5
Schistosoma mansoni hypothetical protein 0.0007 0.0043 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0118 0.0158
Schistosoma mansoni amine GPCR 0.0007 0.0043 0.0043
Schistosoma mansoni amine GPCR 0.0007 0.0043 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.00000000015311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.1047 0.3535
Echinococcus granulosus membrane bound transcription factor site 1 0.001 0.0106 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Echinococcus multilocularis cpg binding protein 0.0037 0.0648 0.0607
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0145 0.2855 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0106 0.0169
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0031
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.001 0.0106 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0059 0.00000000015311
Echinococcus granulosus cpg binding protein 0.0037 0.0648 0.0607
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0043 0.0043
Plasmodium vivax subtilisin-like protease 2, putative 0.001 0.0106 0.5
Schistosoma mansoni tyrosine kinase 0.0056 0.1043 0.1043
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.001 0.0106 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1242 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.001 0.0106 0.0169
Brugia malayi Tachykinin-like peptides receptor 99D 0.023 0.4601 0.9655
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0839 0.2791
Echinococcus granulosus furin 0.0238 0.4764 0.4741
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0043 0.0043
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0238 0.4764 0.4764
Trichomonas vaginalis hypothetical protein 0.0046 0.0839 0.2791
Plasmodium falciparum subtilisin-like protease 2 0.001 0.0106 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0043 0.0043
Echinococcus multilocularis 0.0192 0.3822 0.3796
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0043 0.0043
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.001 0.0106 0.5
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.001 0.0106 0.5
Plasmodium falciparum subtilisin-like protease 3 0.001 0.0106 0.5
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.001 0.0106 0.0133

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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