Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.686 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2925 | 0.4001 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2925 | 0.2925 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.686 | 0.686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.686 | 0.5562 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2925 | 0.4001 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2925 | 0.4263 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2925 | 0.2925 |
Echinococcus granulosus | lamin | 0.0033 | 0.2925 | 0.2925 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2925 | 0.4263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.686 | 0.686 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2925 | 0.2925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.686 | 0.5562 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.686 | 0.686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.686 | 0.5562 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.686 | 1 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.03 | 0.0438 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2925 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2821 | 0.4113 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.686 | 0.686 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.