Detailed information for compound 1404305

Basic information

Technical information
  • TDR Targets ID: 1404305
  • Name: 2-(phenylmethylcarbamothioylamino)butanoic ac id
  • MW: 252.333 | Formula: C12H16N2O2S
  • H donors: 2 H acceptors: 2 LogP: 2.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)O)N=C(NCc1ccccc1)S
  • InChi: 1S/C12H16N2O2S/c1-2-10(11(15)16)14-12(17)13-8-9-6-4-3-5-7-9/h3-7,10H,2,8H2,1H3,(H,15,16)(H2,13,14,17)
  • InChiKey: OJMMRLKOPRWRDP-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[[(phenylmethylamino)-thioxomethyl]amino]butanoic acid
  • 2-(benzylthiocarbamoylamino)butyric acid
  • SMR000135483
  • Oprea1_410053
  • MLS000530505
  • 2-{[(benzylamino)carbonothioyl]amino}butanoic acid
  • STOCK1S-91237

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0028 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 0.0145 0.0455 0.0449
Loa Loa (eye worm) hypothetical protein 0.0104 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.126 0.4316 0.4316
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0049 0.0123 0.0116
Brugia malayi nuclear receptor NHR-67 0.005 0.0125 0.0125
Echinococcus granulosus GPCR family 2 0.0019 0.0018 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0019 0.0055
Brugia malayi hypothetical protein 0.005 0.0125 0.0125
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0042 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Brugia malayi hypothetical protein 0.0256 0.0838 0.0838
Echinococcus granulosus tubulin alpha chain 0.2146 0.7388 0.7386
Brugia malayi hypothetical protein 0.0161 0.0511 0.0511
Echinococcus multilocularis chromobox protein 1 0.0067 0.0185 0.0179
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0013 0.0006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0146 0.0139
Echinococcus multilocularis GPCR, family 2 0.0019 0.0018 0.0011
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0456 0.0456
Echinococcus granulosus lamin dm0 0.0026 0.0042 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0256 0.0838 0.0832
Trypanosoma brucei alpha tubulin, putative 0.0887 0.3024 0.3019
Echinococcus granulosus geminin 0.1559 0.5353 0.535
Plasmodium falciparum tubulin gamma chain 0.1567 0.5381 0.5378
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0146 0.0459 0.0452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0054 0.0047
Echinococcus multilocularis tubulin subunit TubB 0.2146 0.7388 0.7386
Brugia malayi Tubulin alpha chain 0.068 0.2309 0.2309
Onchocerca volvulus 0.0887 0.3024 1
Schistosoma mansoni jun-related protein 0.0066 0.018 0.0174
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0125 0.0119
Trichomonas vaginalis tubulin beta chain, putative 0.2146 0.7388 0.7387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0431 0.0425
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0072 0.0286
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0146 0.0146
Schistosoma mansoni lamin 0.0026 0.0042 0.0035
Loa Loa (eye worm) tubulin alpha chain 0.2146 0.7388 0.7388
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0094 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0106 0.0319 0.0313
Schistosoma mansoni hypothetical protein 0.005 0.0125 0.0119
Trypanosoma brucei zeta tubulin, putative 0.068 0.2309 0.2304
Schistosoma mansoni nuclear receptor 0.005 0.0125 0.0119
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0015 0.0008
Loa Loa (eye worm) dihydrofolate reductase 0.0042 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Brugia malayi Tubulin alpha chain 0.2146 0.7388 0.7388
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0028 0.0022
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.068 0.2309 1
Schistosoma mansoni tubulin subunit gamma 0.1567 0.5381 0.5378
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0233 0.0227
Giardia lamblia Alpha-tubulin 0.2146 0.7388 0.7386
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0028 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0094 0.0094
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0018 0.0013 0.0027
Echinococcus multilocularis tubulin alpha chain 0.2146 0.7388 0.7386
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.005 0.0049
Brugia malayi hypothetical protein 0.0158 0.0499 0.0499
Schistosoma mansoni alpha tubulin 0.2146 0.7388 0.7386
Onchocerca volvulus Bile acid receptor homolog 0.0106 0.0319 0.0998
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0106 0.0319 0.0319
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0006 0.0005
Trypanosoma cruzi zeta tubulin, putative 0.068 0.2309 0.2304
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0145 0.0455 0.0449
Trichomonas vaginalis tubulin epsilon chain, putative 0.068 0.2309 0.2308
Brugia malayi mothers against decapentaplegic homolog 3 0.0026 0.0042 0.0042
Mycobacterium ulcerans hypothetical protein 0.002 0.0019 0.0055
Brugia malayi Pre-SET motif family protein 0.0029 0.0054 0.0054
Plasmodium vivax tubulin gamma chain, putative 0.1567 0.5381 0.5378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.0319 0.0319
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0125 0.0119
Brugia malayi Tubulin beta chain 0.0887 0.3024 0.3024
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0145 0.0455 0.0449
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.0744 0.0744
Entamoeba histolytica hypothetical protein 0.0256 0.0838 0.0826
Echinococcus granulosus muscleblind protein 0.0145 0.0452 0.0446
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0316 0.1344
Brugia malayi Probable isocitrate dehydrogenase 0.0018 0.0013 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0054
Trypanosoma cruzi epsilon tubulin, putative 0.1567 0.5381 0.5378
Echinococcus multilocularis tubulin alpha 1C chain 0.2146 0.7388 0.7386
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0106 0.0319 0.0319
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.005 0.0044
Echinococcus granulosus chromobox protein 1 0.0067 0.0185 0.0179
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0125 0.0119
Plasmodium falciparum tubulin epsilon chain, putative 0.1567 0.5381 0.5378
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1466 0.503 0.503
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0123 0.0121
Trichomonas vaginalis tubulin beta chain, putative 0.2146 0.7388 0.7387
Onchocerca volvulus 0.0035 0.0072 0.0177
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0042 0.0098 0.0399
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0018 0.0013 0.0011
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0452 0.0446
Echinococcus multilocularis FTZ F1 alpha 0.0106 0.0319 0.0313
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0145 0.0455 0.0449
Trichomonas vaginalis tubulin, putative 0.068 0.2309 0.2308
Trichomonas vaginalis tubulin alpha chain, putative 0.0887 0.3024 0.3023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0015 0.0002
Schistosoma mansoni smad 0.0058 0.0154 0.0148
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0042 0.0042
Echinococcus granulosus transcription factor eb 0.0104 0.0313 0.0307
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0019 0.0055
Schistosoma mansoni steroid hormone receptor ad4bp 0.0106 0.0319 0.0313
Trichomonas vaginalis tubulin beta-1 chain, putative 0.068 0.2309 0.2308
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0316 0.1344
Plasmodium vivax SET domain protein, putative 0.0029 0.0054 0.0047
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0125 0.0119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0106 0.0319 0.0313
Mycobacterium tuberculosis Conserved protein 0.0035 0.0072 0.0286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0072 0.0286
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0145 0.0452 0.0452
Brugia malayi Cell division protein ftsZ 0.068 0.2309 0.2309
Brugia malayi nuclear hormone receptor 0.0106 0.0319 0.0319
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.0312 0.1302
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0233 0.0227
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0058 0.0154 0.0148
Loa Loa (eye worm) isocitrate dehydrogenase 0.0145 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0072 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.005 0.0049
Leishmania major hypothetical protein, conserved 0.0156 0.0492 0.0485
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0201 0.0649 0.0643
Brugia malayi isocitrate dehydrogenase 0.0145 0.0455 0.0455
Brugia malayi Pax transcription factor protein 2 0.0729 0.2477 0.2477
Leishmania major hypothetical protein, conserved 0.0035 0.0072 0.0066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0072 0.0286
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0145 0.0455 0.0449
Trypanosoma brucei zeta tubulin 0.068 0.2309 0.2304
Schistosoma mansoni tubulin subunit beta 0.068 0.2309 0.2304
Echinococcus multilocularis cpg binding protein 0.0029 0.0053 0.0047
Mycobacterium ulcerans hypothetical protein 0.0035 0.0072 0.0286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0117 0.0117
Onchocerca volvulus 0.023 0.0748 0.2425
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.1515 0.1509
Echinococcus multilocularis tubulin alpha 3 chain 0.2146 0.7388 0.7386
Schistosoma mansoni retinoic acid receptor RXR 0.0201 0.0649 0.0643
Giardia lamblia Epsilon tubulin 0.068 0.2309 0.2304
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0015 0.0008
Plasmodium falciparum glutathione reductase 0.0046 0.011 0.0104
Schistosoma mansoni chromobox protein 0.0067 0.0185 0.0179
Plasmodium falciparum ataxin-2 like protein, putative 0.0156 0.0492 0.0485
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0072
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0018 0.0013 0.0013
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0125 0.0352
Mycobacterium leprae cell division protein FtsZ 0.068 0.2309 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0083 0.0076
Echinococcus granulosus TGF beta signal transducer SmadC 0.0058 0.0154 0.0148
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0316 0.1344
Trypanosoma brucei epsilon tubulin 0.1567 0.5381 0.5378
Brugia malayi Nuclear hormone receptor-like 1 0.0106 0.0319 0.0319
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0146 0.0459 0.0452
Leishmania major gamma-tubulin 0.1567 0.5381 0.5378
Brugia malayi bZIP transcription factor family protein 0.0081 0.0233 0.0233
Giardia lamblia Delta tubulin 0.068 0.2309 0.2304
Trichomonas vaginalis tubulin epsilon chain, putative 0.2146 0.7388 0.7387
Brugia malayi Cytochrome P450 family protein 0.0022 0.0028 0.0028
Brugia malayi p25-alpha family protein 0.0354 0.1178 0.1178
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0072 0.0071
Onchocerca volvulus 0.003 0.0054 0.0117
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0313 0.1332
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0012 0.001
Brugia malayi intermediate filament protein 0.0026 0.0042 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0106 0.0319 0.0313
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0145 0.0455 0.0449
Mycobacterium tuberculosis Conserved protein 0.0035 0.0072 0.0286
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0072 0.0286
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0039 0.0032
Loa Loa (eye worm) hypothetical protein 0.1466 0.503 0.503
Trypanosoma brucei tubulin gamma chain 0.1567 0.5381 0.5378
Brugia malayi beta-lactamase family protein 0.0035 0.0072 0.0072
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0044 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0106 0.0319 0.0319
Echinococcus multilocularis tubulin alpha chain 0.2146 0.7388 0.7386
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.0319 0.0313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.0319 0.0313
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0106 0.0319 0.0313
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0316 0.132
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0039 0.0026
Brugia malayi hypothetical protein 0.0101 0.03 0.03
Loa Loa (eye worm) glutathione reductase 0.0046 0.011 0.011
Brugia malayi nuclear receptor NHR-88 0.0106 0.0319 0.0319
Giardia lamblia Gamma tubulin 0.1567 0.5381 0.5378
Brugia malayi MH2 domain containing protein 0.0058 0.0154 0.0154
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.005 0.0049
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0039 0.0037
Trypanosoma brucei epsilon tubulin 0.1567 0.5381 0.5378
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0117 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.0106 0.0319 0.0319
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1567 0.5381 0.5378
Schistosoma mansoni smad1 5 8 and 0.0058 0.0154 0.0148
Brugia malayi Muscleblind-like protein 0.0145 0.0452 0.0452
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0316 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0431 0.0425
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0145 0.0455 0.0449
Entamoeba histolytica tubulin alpha chain, putative 0.2146 0.7388 0.7384
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0072 0.0286
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0015 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0228 0.0741 0.0735
Echinococcus granulosus jun protein 0.0081 0.0233 0.0227
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0018 0.0013 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0431 0.0431
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0102 0.0303 0.0297
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0042 0.0042
Trypanosoma cruzi alpha tubulin, putative 0.2146 0.7388 0.7386
Plasmodium vivax tubulin alpha chain, putative 0.2146 0.7388 0.7386
Loa Loa (eye worm) beta-lactamase 0.0035 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Brugia malayi alpha-tubulin 0.2146 0.7388 0.7388
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0011
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0125 0.0119
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.005 0.0049
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0015 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0072 0.0071
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0028 0.0022
Schistosoma mansoni tubulin subunit delta 0.068 0.2309 0.2304
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.005 0.0049
Schistosoma mansoni tubulin subunit epsilon 0.1567 0.5381 0.5378
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0044 0.0043
Onchocerca volvulus 0.0041 0.0092 0.0242
Echinococcus multilocularis tubulin alpha chain 0.2146 0.7388 0.7386
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2146 0.7388 0.7387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0106 0.0319 0.0319
Echinococcus multilocularis Tubulin alpha 1 chain 0.2146 0.7388 0.7386
Brugia malayi Heterochromatin protein 1 0.0067 0.0185 0.0185
Echinococcus granulosus tubulin gamma 1 chain 0.1567 0.5381 0.5378
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.011 0.045
Brugia malayi MH1 domain containing protein 0.0058 0.0154 0.0154
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.005 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0106 0.0319 0.0319
Echinococcus granulosus tubulin alpha chain 0.2146 0.7388 0.7386
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0039 0.0032
Brugia malayi tubulin alpha chain - mouse 0.2146 0.7388 0.7388
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.0312 0.1326
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0106 0.0319 0.0313
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0054 0.0047
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0104 0.0312 0.0312
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0313 0.1332
Toxoplasma gondii exonuclease III APE 0.0018 0.0015 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0353 0.1507
Loa Loa (eye worm) Smad1 0.0058 0.0154 0.0154
Loa Loa (eye worm) MH1 domain-containing protein 0.0058 0.0154 0.0154
Brugia malayi phosphofructokinase 0.0105 0.0316 0.0316
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.005 0.2154
Echinococcus multilocularis thyroid hormone receptor alpha 0.0228 0.0741 0.0735
Brugia malayi conserved hypotetical protein 0.005 0.0125 0.0125
Brugia malayi steroid hormone receptor 0.0106 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.1559 0.5353 0.535
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0125 0.0125
Leishmania major trypanothione reductase 0.0046 0.011 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0054 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0048 0.0048
Brugia malayi hypoxia-induced factor 1 0.0146 0.0456 0.0456
Echinococcus granulosus tubulin alpha chain 0.2146 0.7388 0.7386
Onchocerca volvulus 0.0104 0.0312 0.0974
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0039 0.0039
Toxoplasma gondii endonuclease IV APN 0.0074 0.0208 0.0202
Trichomonas vaginalis tubulin gamma chain, putative 0.1567 0.5381 0.538
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0146 0.0459 0.0452
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0125 0.0119
Echinococcus granulosus FTZ F1 alpha 0.0106 0.0319 0.0313
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0015 0.0035
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0374 0.0367
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.005 0.0189
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Trypanosoma cruzi zeta tubulin, putative 0.068 0.2309 0.2304
Brugia malayi follicle stimulating hormone receptor 0.0229 0.0744 0.0744
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0125 0.0119
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0042 0.0042
Plasmodium falciparum alpha tubulin 2 0.2146 0.7388 0.7386
Echinococcus multilocularis CREB binding protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0019
Echinococcus multilocularis mothers against decapentaplegic 5 0.0058 0.0154 0.0148
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Onchocerca volvulus Protein ultraspiracle homolog 0.0106 0.0319 0.0998
Toxoplasma gondii thioredoxin reductase 0.0046 0.011 0.0104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0012 0.001
Echinococcus granulosus CREB binding protein 0.0102 0.0303 0.0297
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0082 0.0211
Brugia malayi Dihydrofolate reductase 0.0042 0.0098 0.0098
Echinococcus multilocularis tubulin delta chain 0.068 0.2309 0.2304
Trichomonas vaginalis tubulin alpha chain, putative 0.0887 0.3024 0.3023
Echinococcus multilocularis transcription factor eb 0.0104 0.0313 0.0307
Chlamydia trachomatis dihydrofolate reductase 0.0042 0.0098 0.4552
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.0319 0.0319
Echinococcus multilocularis thymidylate synthase 0.0104 0.0312 0.0305
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1466 0.503 0.503
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.005 0.0044
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0125 0.0125
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0039 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0857 0.2922 0.2922
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0651 0.0651
Onchocerca volvulus 0.0026 0.0042 0.0076
Brugia malayi TAZ zinc finger family protein 0.0102 0.0303 0.0303
Echinococcus granulosus tumor protein p63 0.0327 0.1084 0.1078
Brugia malayi Probable isocitrate dehydrogenase 0.0018 0.0013 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0256 0.0838 0.0832
Onchocerca volvulus 0.005 0.0125 0.0352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0106 0.0319 0.0319
Schistosoma mansoni coup transcription factor 0.0106 0.0319 0.0313
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.01 0.0094
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0145 0.0455 0.0449
Brugia malayi photoreceptor-specific nuclear receptor 0.0106 0.0319 0.0319
Trichomonas vaginalis tubulin alpha chain, putative 0.0887 0.3024 0.3023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0015 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0125 0.0119
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0145 0.0455 0.0449
Leishmania major epsilon tubulin, putative 0.1567 0.5381 0.5378
Trypanosoma brucei PAB1-binding protein , putative 0.0156 0.0492 0.0485
Schistosoma mansoni thyroid hormone receptor 0.0228 0.0741 0.0735
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0146 0.0146
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0072
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0042 0.0042
Trichomonas vaginalis tubulin gamma chain, putative 0.1567 0.5381 0.538
Schistosoma mansoni tubulin subunit alpha 0.2146 0.7388 0.7386
Loa Loa (eye worm) tubulin alpha-2 chain 0.2146 0.7388 0.7388
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0018 0.0013 0.0013
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.068 0.2309 0.2304
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0313 0.1308
Onchocerca volvulus 0.0064 0.0173 0.0511
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0018 0.0013 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.016 0.016
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.0208 0.0852
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0106 0.0319 0.0998
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0125 0.0119
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0256 0.0838 0.0832
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0106 0.0319 0.0313
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0887 0.3024 0.3023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.01 0.0094
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0011
Echinococcus granulosus peroxisome assembly protein 26 0.2146 0.7388 0.7386
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0042
Brugia malayi Tubulin gamma chain 0.1567 0.5381 0.5381
Mycobacterium leprae Probable lipase LipE 0.0035 0.0072 0.0259
Echinococcus multilocularis tubulin alpha 3 chain 0.2146 0.7388 0.7386
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0125 0.0119
Trypanosoma brucei alpha tubulin 0.2146 0.7388 0.7386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0431 0.0425
Echinococcus granulosus Smad4 0.0058 0.0154 0.0148
Entamoeba histolytica hypothetical protein 0.0256 0.0838 0.0826
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0122 0.0374 0.0367
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0072 0.0066
Schistosoma mansoni nuclear hormone receptor 0.005 0.0125 0.0119
Schistosoma mansoni isocitrate dehydrogenase 0.0018 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0146
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0018 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0072 0.0259
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.001
Loa Loa (eye worm) nuclear factor I 0.0032 0.0064 0.0064
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0723 0.311
Brugia malayi 6-phosphofructokinase 0.0105 0.0316 0.0316
Echinococcus granulosus tubulin alpha 3 chain 0.2146 0.7388 0.7386
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0039 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0106 0.0319 0.0319
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0072 0.0066
Loa Loa (eye worm) tubulin alpha 2 0.1466 0.503 0.503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.001
Loa Loa (eye worm) tubulin alpha 2 0.1466 0.503 0.503
Plasmodium falciparum ataxin-2 like protein, putative 0.0156 0.0492 0.0485
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0145 0.0455 0.0449
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0072
Mycobacterium ulcerans epimerase 0.002 0.0019 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0011
Brugia malayi nuclear receptor NHR-88 0.005 0.0125 0.0125
Loa Loa (eye worm) DR-78 0.005 0.0125 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0018 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0145 0.0455 0.0449
Trichomonas vaginalis tubulin beta chain, putative 0.2146 0.7388 0.7387
Brugia malayi hypothetical protein 0.005 0.0125 0.0125
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0316 0.0304
Trichomonas vaginalis tubulin beta chain, putative 0.2146 0.7388 0.7387
Loa Loa (eye worm) tubulin beta chain 0.068 0.2309 0.2309
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0083 0.007
Brugia malayi MH1 domain containing protein 0.0032 0.0064 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0127 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0431 0.0425
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0316 0.0316
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.1515 0.1509
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0072 0.0286
Echinococcus granulosus tubulin alpha 0.1567 0.5381 0.5378
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.068 0.2309 0.2304
Echinococcus granulosus ecdysone induced protein 78C 0.0106 0.0319 0.0313
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0125 0.0125
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0072 0.0071
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0028 0.0022
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0316 0.031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0106 0.0319 0.0313
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0072 0.0286
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0011
Echinococcus multilocularis jun protein 0.0081 0.0233 0.0227
Echinococcus granulosus tubulin alpha chain 0.2146 0.7388 0.7386
Onchocerca volvulus 0.0729 0.2477 0.8179
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.005 0.0049
Mycobacterium tuberculosis Conserved protein 0.0035 0.0072 0.0286
Brugia malayi CXXC zinc finger family protein 0.0028 0.0048 0.0048
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0054 0.0047
Loa Loa (eye worm) acetyltransferase 0.0142 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0054
Echinococcus granulosus lamin 0.0026 0.0042 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0054 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0072 0.0071
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0125 0.0125
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0155 0.0149
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0015 0.0008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0313 0.1332
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0028 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0072 0.0071
Plasmodium vivax glutathione reductase, putative 0.0046 0.011 0.0104
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0054 0.0047
Echinococcus granulosus CREB binding protein 0.0016 0.0007 0.0001
Plasmodium falciparum flap endonuclease 1 0.0025 0.0039 0.0032
Brugia malayi tailless protein 0.005 0.0125 0.0125
Schistosoma mansoni RAR-like nuclear receptor 0.0106 0.0319 0.0313
Schistosoma mansoni hypothetical protein 0.0256 0.0838 0.0832
Trypanosoma cruzi epsilon tubulin, putative 0.1567 0.5381 0.5378
Brugia malayi Cytochrome P450 family protein 0.0022 0.0028 0.0028
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0104 0.0313 0.0313
Leishmania major zeta tubulin, putative 0.068 0.2309 0.2304
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0106 0.0319 0.0313
Echinococcus granulosus CREB binding protein 0.0064 0.0173 0.0167
Echinococcus granulosus Tubulin alpha 1 chain 0.2146 0.7388 0.7386
Loa Loa (eye worm) thymidylate synthase 0.0104 0.0312 0.0312
Schistosoma mansoni tubulin subunit alpha 0.068 0.2309 0.2304
Trypanosoma cruzi tubulin gamma chain 0.1567 0.5381 0.5378
Brugia malayi ecdysteroid receptor 0.0106 0.0319 0.0319
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0072 0.0286
Echinococcus granulosus CREB binding protein 0.0016 0.0007 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0072 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0313 0.1332
Brugia malayi dihydrofolate reductase family protein 0.0042 0.0098 0.0098
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.01 0.0094
Brugia malayi nuclear hormone receptor 0.005 0.0125 0.0125
Entamoeba histolytica hypothetical protein 0.0256 0.0838 0.0826
Schistosoma mansoni cpg binding protein 0.0029 0.0053 0.0047
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0018 0.0013 0.0027
Brugia malayi ecdysone receptor 0.005 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.006 0.016 0.016
Echinococcus multilocularis Tubulin alpha 1 chain 0.2146 0.7388 0.7386
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0083 0.0076
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0039 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0208 0.0202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0159 0.0153
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.0319 0.0313
Brugia malayi hypothetical protein 0.0049 0.0123 0.0123
Echinococcus multilocularis mothers against decapentaplegic 2 0.0026 0.0042 0.0036
Echinococcus granulosus smad 0.0058 0.0154 0.0148
Brugia malayi Nuclear hormone receptor E75 0.005 0.0125 0.0125
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0313 0.1332
Schistosoma mansoni smad1 5 8 and 0.0058 0.0154 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0015 0.0015
Trichomonas vaginalis tubulin alpha chain, putative 0.1567 0.5381 0.538
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0443 0.0443
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0316 0.0314
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0054 0.0047
Schistosoma mansoni hypothetical protein 0.0066 0.018 0.0174
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.0208 0.0877
Trypanosoma cruzi tubulin delta chain 0.068 0.2309 0.2304
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0146
Echinococcus granulosus tubulin delta chain 0.068 0.2309 0.2304
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.1515 0.1509
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0125 0.0125
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0106 0.0319 0.0313
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.005 0.2154
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0316 0.0304
Trypanosoma brucei alpha tubulin 0.2146 0.7388 0.7386
Toxoplasma gondii alpha-tubulin I, putative 0.2146 0.7388 0.7386
Brugia malayi glutathione reductase 0.0046 0.011 0.011
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.01 0.0099
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0072 0.0072
Trypanosoma brucei alpha tubulin 0.2146 0.7388 0.7386
Echinococcus multilocularis ecdysone induced protein 78C 0.0106 0.0319 0.0313
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0374 0.0367
Brugia malayi 6-phosphofructokinase 0.0105 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0431 0.0425
Loa Loa (eye worm) hypothetical protein 0.2146 0.7388 0.7388
Echinococcus granulosus neuropeptide s receptor 0.0451 0.1515 0.1509
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0146
Brugia malayi Nuclear hormone receptor E75 0.005 0.0125 0.0125
Brugia malayi chromobox protein homolog 3 0.0038 0.0082 0.0082
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0018 0.0013 0.0027
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.007 0.0194 0.0187
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.005 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.068 0.2309 0.2308
Loa Loa (eye worm) MH2 domain-containing protein 0.0857 0.2922 0.2922
Echinococcus granulosus alpha tubulin 0.2146 0.7388 0.7386
Trypanosoma cruzi tubulin delta chain 0.068 0.2309 0.2304
Brugia malayi Tubulin beta chain 0.068 0.2309 0.2309
Echinococcus granulosus mothers against decapentaplegic 5 0.0058 0.0154 0.0148
Brugia malayi Tubulin alpha-2 chain 0.2146 0.7388 0.7388
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0072 0.0066
Plasmodium vivax tubulin epsilon chain, putative 0.1567 0.5381 0.5378
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0048 0.0041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0015 0.0008
Echinococcus granulosus tubulin subunit TubB 0.2146 0.7388 0.7386
Echinococcus granulosus tubulin alpha 1C chain 0.2146 0.7388 0.7386
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0072 0.0066
Echinococcus granulosus thymidylate synthase 0.0104 0.0312 0.0305
Mycobacterium tuberculosis Cell division protein FtsZ 0.068 0.2309 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Leishmania major cytochrome p450-like protein 0.0022 0.0028 0.0022
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0431 0.0425
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Leishmania major delta tubulin, putative 0.068 0.2309 0.2304
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0026 0.0042 0.0076
Plasmodium vivax delta tubulin, putative 0.068 0.2309 0.2304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0146 0.0139
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0424 0.0418
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.0319 0.0313
Echinococcus multilocularis tubulin alpha chain 0.2146 0.7388 0.7386
Onchocerca volvulus 0.0035 0.0072 0.0177
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0125 0.0119
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0072 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0081
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0011
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0208 0.0202
Echinococcus granulosus single minded 2 0.0035 0.0072 0.0066
Trichomonas vaginalis esterase, putative 0.0035 0.0072 0.0071
Schistosoma mansoni flap endonuclease-1 0.0023 0.003 0.0024
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.126 0.4316 0.4315
Trichomonas vaginalis tubulin, putative 0.0887 0.3024 0.3023
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0353 0.1507
Brugia malayi Tubulin alpha-2 chain 0.2146 0.7388 0.7388
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0316 0.031
Plasmodium falciparum thioredoxin reductase 0.0046 0.011 0.0104
Mycobacterium ulcerans thymidylate synthase 0.0104 0.0312 0.1326
Brugia malayi beta-lactamase family protein 0.0035 0.0072 0.0072
Loa Loa (eye worm) alpha-tubulin 0.2146 0.7388 0.7388
Brugia malayi nuclear receptor RXR 0.005 0.0125 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0156 0.0492 0.0485
Echinococcus multilocularis chromobox protein 1 0.0067 0.0185 0.0179
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.011 0.011
Echinococcus multilocularis Smad4 0.0058 0.0154 0.0148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0011
Brugia malayi MH2 domain containing protein 0.0026 0.0042 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0145 0.0455 0.0449
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0039 0.0032
Echinococcus multilocularis tubulin gamma 1 chain 0.1567 0.5381 0.5378
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0353 0.1484
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0018 0.0018
Echinococcus multilocularis dihydrofolate reductase 0.0042 0.0098 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0156 0.0492 0.0485
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0125 0.0119
Brugia malayi hypothetical protein 0.0056 0.0146 0.0146
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0106 0.0319 0.0313
Brugia malayi MH1 domain containing protein 0.0032 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.0319 0.0319
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0015 0.0013
Onchocerca volvulus 0.0048 0.0117 0.0327
Schistosoma mansoni tubulin subunit alpha 0.2146 0.7388 0.7386
Schistosoma mansoni Smad4 0.0026 0.0042 0.0036
Entamoeba histolytica tubulin gamma chain 0.1567 0.5381 0.5375
Brugia malayi Isocitrate dehydrogenase 0.0145 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Trypanosoma brucei beta tubulin 0.1567 0.5381 0.5378
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.011 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.016 0.016
Echinococcus multilocularis CREB binding protein 0.0071 0.0196 0.019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0106 0.0319 0.0319
Echinococcus granulosus tubulin epsilon chain 0.1567 0.5381 0.5378
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0072 0.0072
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0019 0.0019
Brugia malayi MH2 domain containing protein 0.0058 0.0154 0.0154
Mycobacterium ulcerans beta-lactamase 0.0035 0.0072 0.0286
Onchocerca volvulus 0.0035 0.0072 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0431 0.0425
Loa Loa (eye worm) p25-alpha family protein 0.0354 0.1178 0.1178
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0092 0.0091
Brugia malayi beta-lactamase 0.0035 0.0072 0.0072
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0125 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.0319 0.0313
Loa Loa (eye worm) tubulin alpha-3 chain 0.126 0.4316 0.4316
Brugia malayi MH1 domain containing protein 0.0058 0.0154 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.001
Echinococcus granulosus tubulin alpha 1C chain 0.2146 0.7388 0.7386
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0106 0.0319 0.0319
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0185 0.0185
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0015 0.0013
Echinococcus granulosus tubulin alpha chain 0.2146 0.7388 0.7386
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0316 0.0304
Echinococcus multilocularis Tubulin alpha 1 chain 0.2146 0.7388 0.7386
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0072 0.0286
Schistosoma mansoni alpha tubulin 0.2146 0.7388 0.7386
Plasmodium falciparum alpha tubulin 1 0.2146 0.7388 0.7386
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Trichomonas vaginalis tubulin beta chain, putative 0.2146 0.7388 0.7387
Mycobacterium ulcerans lipase LipD 0.0035 0.0072 0.0286
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.01 0.0099
Loa Loa (eye worm) alpha-tubulin 0.2146 0.7388 0.7388
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0006 0.0006
Trichomonas vaginalis tubulin gamma chain, putative 0.068 0.2309 0.2308
Schistosoma mansoni cpg binding protein 0.0028 0.0048 0.0041
Echinococcus granulosus chromobox protein 1 0.0067 0.0185 0.0179
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0316 0.0314
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0146 0.0139
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0316 0.031
Brugia malayi Smad1 0.0058 0.0154 0.0154
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0146 0.0459 0.0452
Brugia malayi MH2 domain containing protein 0.0857 0.2922 0.2922
Trichomonas vaginalis tubulin epsilon chain, putative 0.2146 0.7388 0.7387
Schistosoma mansoni intermediate filament proteins 0.0026 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0161 0.0511 0.0511
Echinococcus multilocularis musashi 0.0026 0.0042 0.0035
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0145 0.0455 0.0449
Toxoplasma gondii alpha tubulin TUBA1 0.2146 0.7388 0.7386
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0316 0.0314
Treponema pallidum cell division protein FtsZ 0.068 0.2309 1
Schistosoma mansoni hypothetical protein 0.1559 0.5353 0.535
Echinococcus multilocularis tumor protein p63 0.0327 0.1084 0.1078
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0316 0.031
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0443 0.0437
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0039 0.0032
Trichomonas vaginalis set domain proteins, putative 0.023 0.0748 0.0746
Onchocerca volvulus 0.0028 0.0048 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0015 0.0035
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0018 0.0013 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0106 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Chlamydia trachomatis endonuclease IV 0.0074 0.0208 1
Loa Loa (eye worm) CBP-B 0.0072 0.0199 0.0199
Loa Loa (eye worm) tubulin alpha 2 0.0579 0.1958 0.1958
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0125 0.0125
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0185 0.0184
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0443 0.0437
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.0312 0.0305
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0146 0.0139
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0125 0.0119
Loa Loa (eye worm) hypothetical protein 0.0145 0.0452 0.0452
Trypanosoma brucei alpha tubulin 0.2146 0.7388 0.7386
Loa Loa (eye worm) hypothetical protein 0.0156 0.0492 0.0492
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.005 0.0044
Echinococcus multilocularis peroxisome assembly protein 26 0.2146 0.7388 0.7386
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.0319 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.068 0.2309 0.2308
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0106 0.0319 0.0313
Toxoplasma gondii LsmAD domain-containing protein 0.0156 0.0492 0.0485
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0092 0.0244
Leishmania major isocitrate dehydrogenase, putative 0.0018 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0015 0.0008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0316 0.031
Onchocerca volvulus 0.0161 0.0511 0.1635
Trichomonas vaginalis tubulin, putative 0.0887 0.3024 0.3023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0106 0.0319 0.0319
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.005 0.0044
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.005 0.0044
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0316 0.0316
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0072 0.0072
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.016 0.016
Onchocerca volvulus 0.0026 0.0042 0.0076
Echinococcus granulosus flap endonuclease 1 0.0025 0.0039 0.0032
Brugia malayi Cytochrome P450 family protein 0.0051 0.0127 0.0127
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0042 0.0098 0.0373
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0146
Schistosoma mansoni nuclear hormone receptor 0.005 0.0125 0.0119
Schistosoma mansoni Smad4 0.0026 0.0042 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0106 0.0319 0.0313
Schistosoma mansoni chromobox protein 0.0067 0.0185 0.0179
Trypanosoma brucei tubulin delta chain 0.068 0.2309 0.2304
Schistosoma mansoni smad1 5 8 and 0.0058 0.0154 0.0148
Echinococcus granulosus Tubulin alpha 1 chain 0.2146 0.7388 0.7386
Echinococcus multilocularis lamin dm0 0.0026 0.0042 0.0035
Schistosoma mansoni single-minded 0.0047 0.0115 0.0108
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0015 0.0035
Brugia malayi PAS domain containing protein 0.0047 0.0115 0.0115
Onchocerca volvulus TPPP family protein homolog 0.0354 0.1178 0.3858
Loa Loa (eye worm) tubulin gamma chain 0.1567 0.5381 0.5381
Brugia malayi tubulin alpha-2 chain 0.2146 0.7388 0.7388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0106 0.0319 0.0319
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.0154 0.0154
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Echinococcus multilocularis tubulin epsilon chain 0.1567 0.5381 0.5378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.0319 0.0313
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0015 0.0015
Echinococcus multilocularis CREB binding protein 0.0016 0.0007 0.0001
Brugia malayi nuclear receptor RXR 0.0056 0.0146 0.0146
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0058 0.0154 0.0148
Toxoplasma gondii ABC1 family protein 0.0035 0.0072 0.0066
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0072 0.0066
Mycobacterium tuberculosis Hypothetical protein 0.0049 0.0123 0.0506
Onchocerca volvulus 0.0106 0.0319 0.0998
Mycobacterium ulcerans endonuclease IV 0.0074 0.0208 0.0877
Brugia malayi Flap endonuclease-1 0.0025 0.0039 0.0039
Schistosoma mansoni Smad4 0.0058 0.0154 0.0148
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.267 0.2665
Entamoeba histolytica tubulin alpha-1 chain 0.2146 0.7388 0.7384
Mycobacterium leprae conserved hypothetical protein 0.002 0.0019 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.0887 0.3024 0.3023
Schistosoma mansoni alpha tubulin 0.2146 0.7388 0.7386
Echinococcus multilocularis geminin 0.1559 0.5353 0.535
Schistosoma mansoni zinc finger protein 0.005 0.0125 0.0119
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0018 0.0013 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0072 0.0286
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0042 0.0042
Brugia malayi hypothetical protein 0.0056 0.0146 0.0146
Schistosoma mansoni nuclear hormone receptor 0.0106 0.0319 0.0313
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0158 0.0499 0.0499
Giardia lamblia Alpha-tubulin 0.2146 0.7388 0.7386
Trichomonas vaginalis tubulin beta chain, putative 0.2146 0.7388 0.7387
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0145 0.0455 0.0449
Schistosoma mansoni hypothetical protein 0.007 0.0194 0.0187
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0146 0.0146
Schistosoma mansoni nuclear receptor 0.005 0.0125 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.001
Brugia malayi Thioredoxin reductase 0.0046 0.011 0.011
Brugia malayi Pre-SET motif family protein 0.0202 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0353 0.1507
Echinococcus multilocularis CREB binding protein 0.0016 0.0007 0.0001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.007 0.0194 0.0187
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Echinococcus multilocularis tubulin alpha chain 0.2146 0.7388 0.7386
Echinococcus multilocularis smad 0.0058 0.0154 0.0148
Brugia malayi hypothetical protein 0.0064 0.0173 0.0173
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0018 0.0013 0.0006
Schistosoma mansoni smad 0.0026 0.0042 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.0319 0.0319
Trypanosoma brucei trypanothione reductase 0.0046 0.011 0.0104
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.011 0.0104
Echinococcus multilocularis hypothetical protein 0.2146 0.7388 0.7386
Plasmodium vivax ataxin-2 like protein, putative 0.0156 0.0492 0.0485
Entamoeba histolytica hypothetical protein 0.0256 0.0838 0.0826
Mycobacterium tuberculosis Probable reductase 0.0104 0.0313 0.1332
Onchocerca volvulus 0.0035 0.0074 0.0183
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0146 0.0459 0.0452
Onchocerca volvulus 0.005 0.0125 0.0352
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.005 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0092 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0185 0.0184
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0125 0.0352
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0146 0.0459 0.0452
Leishmania major alpha tubulin 0.2146 0.7388 0.7386
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0081
Plasmodium vivax tubulin alpha chain, putative 0.2146 0.7388 0.7386
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0145 0.0455 0.0449
Echinococcus multilocularis mothers against decapentaplegic 6 0.0026 0.0042 0.0036
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0316 0.031
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0145 0.0455 0.1949
Echinococcus granulosus mothers against decapentaplegic 2 0.0026 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0125 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0012 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0316 0.0314
Echinococcus granulosus cpg binding protein 0.0029 0.0053 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0106 0.0319 0.0319
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0316 0.031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.01 0.0094
Echinococcus granulosus mothers against decapentaplegic 6 0.0026 0.0042 0.0036
Echinococcus multilocularis muscleblind protein 0.0145 0.0452 0.0446
Echinococcus granulosus tubulin alpha 3 chain 0.2146 0.7388 0.7386
Loa Loa (eye worm) hypothetical protein 0.0106 0.0319 0.0319
Echinococcus granulosus dihydrofolate reductase 0.0042 0.0098 0.0092
Schistosoma mansoni cpg binding protein 0.0029 0.0053 0.0047
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.011 0.0104
Loa Loa (eye worm) pax transcription factor protein 2 0.0729 0.2477 0.2477
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0116 0.011
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0018 0.0013 0.0013
Mycobacterium ulcerans cell division protein FtsZ 0.068 0.2309 1
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0072 0.0072
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.0319 0.0319
Brugia malayi hypothetical protein 0.0156 0.0492 0.0492
Echinococcus multilocularis tubulin alpha 1C chain 0.2146 0.7388 0.7386
Schistosoma mansoni lamin 0.0026 0.0042 0.0035
Schistosoma mansoni hypothetical protein 0.0041 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0079 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.005 0.0125 0.0125
Schistosoma mansoni dihydrofolate reductase 0.0042 0.0098 0.0092
Brugia malayi thymidylate synthase 0.0104 0.0312 0.0312
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0145 0.0455 0.0449
Echinococcus multilocularis tubulin alpha 0.1567 0.5381 0.5378
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.011 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0145 0.0455 0.0449
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0011
Schistosoma mansoni CREB-binding protein 2 0.0102 0.0303 0.0297
Plasmodium falciparum tubulin delta chain, putative 0.068 0.2309 0.2304
Loa Loa (eye worm) tubulin alpha chain 0.2146 0.7388 0.7388
Trypanosoma brucei epsilon tubulin 0.1567 0.5381 0.5378
Schistosoma mansoni tubulin subunit alpha 0.2146 0.7388 0.7386
Echinococcus granulosus Tubulin alpha 1 chain 0.2146 0.7388 0.7386
Echinococcus multilocularis lamin 0.0026 0.0042 0.0035
Echinococcus granulosus intermediate filament protein 0.0026 0.0042 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0106 0.0319 0.0319

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 106.767 uM PUBCHEM_BIOASSAY: HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2118] ChEMBL. No reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.0522 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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