Detailed information for compound 1404658

Basic information

Technical information
  • TDR Targets ID: 1404658
  • Name: 2-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoe thoxy]benzamide
  • MW: 310.347 | Formula: C18H18N2O3
  • H donors: 1 H acceptors: 2 LogP: 1.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c(C1)cccc2)COc1ccccc1C(=O)N
  • InChi: 1S/C18H18N2O3/c19-18(22)15-7-3-4-8-16(15)23-12-17(21)20-10-9-13-5-1-2-6-14(13)11-20/h1-8H,9-12H2,(H2,19,22)
  • InChiKey: PLISDQXOMUITEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethoxy]benzamide
  • 2-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-keto-ethoxy]benzamide
  • T5328645
  • ZINC03357357

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens poly (ADP-ribose) polymerase 1 Starlite/ChEMBL References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (adp ribose) polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma brucei poly(adp-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus poly ADP ribose polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Poly [ADP-ribose] polymerase 2-A, putative Get druggable targets OG5_128423 All targets in OG5_128423
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) poly(ADP-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly adp ribose polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Neospora caninum hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma congolense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0037 0.0043
Echinococcus granulosus DNA methyltransferase 2, putative 0.0273 0.1859 0.2194
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0371 0.0438
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0091 0.0494 0.0611
Loa Loa (eye worm) hypothetical protein 0.1155 0.8474 0.9266
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0762 0.3246
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0012 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.016 0.101 0.1104
Schistosoma mansoni hypothetical protein 0.0091 0.0494 0.0583
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0012 0.0014
Loa Loa (eye worm) SET domain-containing protein 0.0135 0.0819 0.0896
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0273 0.1859 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0091 0.0494 0.261
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0561 0.4018 0.4394
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0147 0.091 0.115
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0273 0.1859 0.2378
Echinococcus multilocularis jumonji domain containing protein 0.004 0.011 0.013
Entamoeba histolytica type A flavoprotein, putative 0.0091 0.0494 0.261
Loa Loa (eye worm) hypothetical protein 0.0887 0.6462 0.7066
Entamoeba histolytica hypothetical protein 0.0063 0.0281 0.1458
Leishmania major histone-lysine N-methyltransferase, putative 0.0147 0.091 0.115
Mycobacterium leprae conserved hypothetical protein 0.0205 0.1351 0.4195
Onchocerca volvulus 0.0091 0.0494 0.047
Trypanosoma brucei beta lactamase 0.0363 0.2536 0.3259
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0589 0.3124
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0059 0.025 0.0294
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0028 0.0023 0.0027
Echinococcus granulosus SET and MYND domain containing protein 3 0.007 0.0332 0.0392
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0091 0.0494 0.054
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0104 0.0589 0.0465
Echinococcus multilocularis ETHE1 protein 0.0091 0.0494 0.0583
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0422 0.2974 0.3827
Schistosoma mansoni phd finger protein 0.0063 0.0281 0.0332
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.0428 0.0505
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0083 0.043 0.0525
Mycobacterium tuberculosis Probable lipase LipE 0.0205 0.1351 0.0935
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0028 0.0023 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0494 0.0472
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0205 0.1351 0.1477
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0233 0.156 0.184
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0291 0.1993 0.2352
Brugia malayi CXXC zinc finger family protein 0.016 0.101 0.1092
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0525 0.0651
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0757 0.549 0.5453
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0059 0.025 0.0294
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Brugia malayi beta-lactamase family protein 0.0205 0.1351 0.1466
Trichomonas vaginalis beta lactamase domain, putative 0.0091 0.0494 0.0472
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0135 0.0819 0.0967
Mycobacterium ulcerans beta-lactamase 0.0205 0.1351 0.1541
Loa Loa (eye worm) Carm1-pending protein 0.0143 0.0886 0.0969
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0059 0.025 0.0294
Loa Loa (eye worm) hypothetical protein 0.0357 0.2484 0.2716
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0422 0.2974 0.351
Brugia malayi PWWP domain containing protein 0.0063 0.0281 0.0294
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.003 0.0037 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0205 0.1351 0.1722
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Echinococcus granulosus poly ADP ribose polymerase 1 0.0174 0.1111 0.1312
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0091 0.0494 0.0527
Trypanosoma brucei poly(adp-ribose) polymerase 0.0095 0.0525 0.0651
Plasmodium falciparum purine nucleoside phosphorylase 0.0104 0.0589 0.0731
Trypanosoma brucei spermidine synthase 0.1057 0.7735 1
Entamoeba histolytica alkyl sulfatase, putative 0.0091 0.0494 0.261
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0037 0.0014
Schistosoma mansoni histone J3 methyltransferase 0.1155 0.8474 1
Brugia malayi uridine phosphorylase family protein 0.0104 0.0589 0.0631
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0589 0.0104
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Entamoeba histolytica metallo-beta-lactamase family protein 0.0091 0.0494 0.261
Loa Loa (eye worm) hypothetical protein 0.0186 0.1203 0.1315
Echinococcus granulosus poly adp ribose polymerase 2 0.0095 0.0525 0.0619
Trichomonas vaginalis beta lactamase domain, putative 0.0091 0.0494 0.0472
Echinococcus multilocularis poly (ADP ribose) polymerase 0.004 0.0108 0.0128
Schistosoma mansoni uridine phosphorylase 0.0104 0.0589 0.0695
Toxoplasma gondii phosphorylase family protein 0.0104 0.0589 0.2486
Echinococcus granulosus zinc phosphodiesterase 0.0091 0.0494 0.0583
Loa Loa (eye worm) hypothetical protein 0.0151 0.0943 0.1032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0186 0.1203 0.142
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.1477
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0457 0.3239 0.2997
Entamoeba histolytica hypothetical protein 0.0059 0.025 0.1289
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0494 0.0472
Mycobacterium tuberculosis Conserved protein 0.0205 0.1351 0.0935
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0091 0.0494 0.2068
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0561 0.4018 0.4742
Loa Loa (eye worm) uridine phosphorylase 0.0104 0.0589 0.0644
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0104 0.0589 0.0104
Onchocerca volvulus 0.0233 0.156 0.1538
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0307 0.125
Leishmania major hypothetical protein, conserved 0.0147 0.091 0.115
Trypanosoma brucei glyoxalase II 0.0091 0.0494 0.0611
Onchocerca volvulus Putative hydrolase PNKD 0.0091 0.0494 0.047
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0731
Loa Loa (eye worm) hypothetical protein 0.0091 0.0494 0.054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0516 0.0609
Brugia malayi Carm1-pending protein 0.0143 0.0886 0.0957
Entamoeba histolytica type A flavoprotein, putative 0.0091 0.0494 0.261
Mycobacterium ulcerans lipoprotein LpqF 0.0363 0.2536 0.3672
Echinococcus granulosus spermidine synthase 0.1057 0.7735 0.9128
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0025 0.0028
Schistosoma mansoni methylthioadenosine phosphorylase 0.0561 0.4018 0.4742
Echinococcus granulosus ETHE1 protein 0.0091 0.0494 0.0583
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.4947 0.5838
Loa Loa (eye worm) hypothetical protein 0.0063 0.0281 0.0307
Treponema pallidum uridine phosphorylase (udp) 0.0104 0.0589 1
Echinococcus granulosus histone h3 methyltransferase 0.1155 0.8474 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0205 0.1351 0.1594
Leishmania major arginine N-methyltransferase-like protein 0.003 0.0037 0.0018
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0104 0.0589 0.0631
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0026 0.0031
Mycobacterium tuberculosis Probable hydrolase 0.0205 0.1351 0.0935
Toxoplasma gondii hypothetical protein 0.0332 0.23 1
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0143 0.0886 0.1045
Plasmodium vivax spermidine synthase, putative 0.1057 0.7735 1
Leishmania major modification methylase-like protein 0.0273 0.1859 0.2381
Echinococcus granulosus methyltransferase protein 5 0.0028 0.0023 0.0027
Echinococcus granulosus geminin 0.0205 0.1344 0.1587
Trypanosoma cruzi glyoxalase II 0.0091 0.0494 0.0611
Brugia malayi hypothetical protein 0.0063 0.0281 0.0294
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0091 0.0494 0.0583
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0104 0.0589 0.0734
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0273 0.1859 0.8061
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0525 0.0651
Entamoeba histolytica metallo-beta-lactamase family protein 0.0091 0.0494 0.261
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0214 0.0252
Brugia malayi Protein arginine N-methyltransferase 0.0028 0.0023 0.0012
Toxoplasma gondii DNA methyltransferase 2, putative 0.0273 0.1859 0.8061
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0494 0.0472
Schistosoma mansoni methylthioadenosine phosphorylase 0.0561 0.4018 0.4742
Brugia malayi SET domain containing protein 0.0291 0.1993 0.2169
Mycobacterium ulcerans hypothetical protein 0.0205 0.1351 0.1541
Trichomonas vaginalis beta lactamase domain, putative 0.0091 0.0494 0.0472
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0422 0.2974 0.3827
Echinococcus multilocularis protein arginine N methyltransferase 8 0.003 0.0037 0.0043
Schistosoma mansoni enhancer of zeste ezh 0.0291 0.1993 0.2352
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0095 0.0525 0.0619
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0091 0.0494 0.0583
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0104 0.0589 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0494 0.0472
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0091 0.0494 0.5
Onchocerca volvulus 0.0091 0.0494 0.047
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0025 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0589 0.0567
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Loa Loa (eye worm) hypothetical protein 0.0068 0.0319 0.0349
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0091 0.0494 0.8314
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0422 0.2974 0.3827
Plasmodium falciparum spermidine synthase 0.1057 0.7735 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0068 0.0323 0.0353
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.1351 0.1722
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Trichomonas vaginalis esterase, putative 0.0205 0.1351 0.1331
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0091 0.0494 0.8314
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0091 0.0494 0.0583
Loa Loa (eye worm) hypothetical protein 0.0357 0.2484 0.2716
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0091 0.0494 0.047
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0561 0.4018 0.5181
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0273 0.1859 0.2194
Toxoplasma gondii hypothetical protein 0.0147 0.091 0.3893
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0205 0.1351 0.0935
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0356 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0494 0.0472
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0037 0.0014
Trichomonas vaginalis beta lactamase domain, putative 0.0091 0.0494 0.0472
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0063 0.0281 0.0335
Schistosoma mansoni protein arginine n-methyltransferase 0.0143 0.0886 0.1045
Schistosoma mansoni zinc phosphodiesterase 0.0091 0.0494 0.0583
Trypanosoma brucei transcription elongation factor s-II, putative 0.0063 0.0281 0.0335
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Entamoeba histolytica hypothetical protein 0.0104 0.0589 0.3124
Mycobacterium tuberculosis Probable lipase LipD 0.0205 0.1351 0.0935
Brugia malayi PHD-finger family protein 0.0029 0.0025 0.0014
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.0494 0.054
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1313 0.9656 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0525 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0494 0.0472
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0091 0.0494 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0186 0.1203 0.142
Trypanosoma brucei uridine phosphorylase 0.0104 0.0589 0.0734
Plasmodium falciparum protein arginine N-methyltransferase 1 0.003 0.0037 0.0015
Brugia malayi hypothetical protein 0.0091 0.0494 0.0527
Brugia malayi SET domain containing protein 0.0032 0.005 0.0041
Trypanosoma cruzi glyoxalase II 0.0091 0.0494 0.0611
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0363 0.2536 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0494 0.054
Trichomonas vaginalis apoptosis inducing factor, putative 0.0091 0.0494 0.0472
Brugia malayi MTAP 0.0561 0.4018 0.4387
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0205 0.1351 0.1594
Brugia malayi Disco-interacting protein 2 homolog 0.0151 0.0943 0.102
Onchocerca volvulus 0.0115 0.0673 0.0649
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0589 0.3124
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0076 0.0379 0.0447
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0174 0.1111 0.1312
Echinococcus multilocularis zinc phosphodiesterase 0.0091 0.0494 0.0583
Mycobacterium leprae probable uridine phosphorylase 0.0104 0.0589 0.0465
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0037 0.0043
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0104 0.0589 0.0734
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0104 0.0589 0.0104
Schistosoma mansoni hypothetical protein 0.0091 0.0494 0.0583
Brugia malayi beta-lactamase 0.0205 0.1351 0.1466
Loa Loa (eye worm) hypothetical protein 0.0049 0.018 0.0196
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0091 0.0494 0.261
Trypanosoma cruzi spermidine synthase, putative 0.1057 0.7735 1
Leishmania major metallo-beta-lactamase family-like protein 0.0091 0.0494 0.0611
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0033 0.006 0.0071
Echinococcus granulosus protein arginine N methyltransferase 7 0.0028 0.0023 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0363 0.2536 0.2229
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0147 0.091 0.115
Entamoeba histolytica alkyl sulfatase, putative 0.0091 0.0494 0.261
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0104 0.0589 0.3124
Schistosoma mansoni zinc phosphodiesterase 0.0091 0.0494 0.0583
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0083 0.0098
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0091 0.0494 0.2068
Mycobacterium tuberculosis Conserved protein 0.0205 0.1351 0.0935
Mycobacterium tuberculosis Hypothetical protein 0.0104 0.0589 0.0104
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0132 0.0801 0.0875
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0561 0.4018 0.5181
Echinococcus granulosus cpg binding protein 0.0162 0.1022 0.1206
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0091 0.0494 0.054
Schistosoma mansoni hypothetical protein 0.0063 0.0281 0.0332
Echinococcus granulosus microtubule associated protein 2 0.0685 0.4947 0.5838
Leishmania major metallo-beta-lactamase family protein-like protein 0.0091 0.0494 0.0611
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Loa Loa (eye worm) hypothetical protein 0.0106 0.0607 0.0664
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0255 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0083 0.0091
Brugia malayi hypothetical protein 0.0357 0.2484 0.2706
Echinococcus multilocularis peregrin 0.0092 0.0497 0.0586
Mycobacterium ulcerans lipase LipD 0.0205 0.1351 0.1541
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0037 0.0043
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0174 0.1111 0.1312
Mycobacterium ulcerans esterase/lipase LipP 0.0205 0.1351 0.1541
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0037 0.0014
Plasmodium vivax unspecified product 0.0091 0.0494 0.0608
Loa Loa (eye worm) hypothetical protein 0.0887 0.6462 0.7066
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Onchocerca volvulus 0.0151 0.0943 0.092
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0012 0.0014
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0143 0.0886 0.379
Schistosoma mansoni hypothetical protein 0.0063 0.0281 0.0332
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.1155 0.8474 0.9265
Echinococcus granulosus disco interacting protein 2 0.0151 0.0943 0.1113
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0273 0.1859 0.2194
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0135 0.0819 0.0967
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0589 0.3124
Schistosoma mansoni cpg binding protein 0.016 0.101 0.1191
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0762 0.0899
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0025 0.0012
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0561 0.4018 0.5181
Brugia malayi metallo-beta-lactamase superfamily protein 0.0091 0.0494 0.0527
Onchocerca volvulus 0.0063 0.0281 0.0256
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.003 0.0037 0.0015
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0033 0.006 0.0071
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0028 0.0023 0.0059
Echinococcus multilocularis geminin 0.0205 0.1344 0.1587
Trichomonas vaginalis beta lactamase domain, putative 0.0091 0.0494 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.1351 0.1722
Trypanosoma cruzi spermidine synthase, putative 0.1057 0.7735 1
Echinococcus multilocularis cpg binding protein 0.0162 0.1022 0.1206
Loa Loa (eye worm) hypothetical protein 0.0111 0.0641 0.0701
Echinococcus granulosus methylthioadenosine phosphorylase 0.0561 0.4018 0.4742
Echinococcus granulosus PWWP domain containing protein 2A 0.0063 0.0281 0.0332
Leishmania major hypothetical protein, conserved 0.0091 0.0494 0.0611
Brugia malayi WGR domain containing protein 0.0174 0.1111 0.1204
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0332 0.23 0.2951
Entamoeba histolytica hypothetical protein, conserved 0.0091 0.0494 0.261
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0091 0.0494 0.0611
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0422 0.2974 0.3252
Echinococcus multilocularis PWWP domain containing protein 2A 0.0063 0.0281 0.0332
Echinococcus granulosus peregrin 0.0092 0.0497 0.0586
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0147 0.091 0.115
Loa Loa (eye worm) SET domain-containing protein 0.0291 0.1993 0.2179
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0104 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.1477
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0206 0.1351 0.1719
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0422 0.2974 0.3243
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0561 0.4018 0.6338
Brugia malayi metallo-beta-lactamase superfamily protein 0.0091 0.0494 0.0527
Schistosoma mansoni hypothetical protein 0.0051 0.0195 0.023
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.1477
Schistosoma mansoni hypothetical protein 0.0205 0.1344 0.1587
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0887 0.6462 0.7066
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0422 0.2974 0.3827
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0091 0.0494 0.0583
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0063 0.0281 0.0335
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0091 0.0494 0.0583
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0091 0.0494 0.054
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0025 0.003
Echinococcus granulosus hepatoma derived growth factor protein 0.0063 0.0281 0.0332
Leishmania major nucleoside phosphorylase-like protein 0.0104 0.0589 0.0734
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0186 0.1203 0.142
Trichomonas vaginalis beta lactamase domain, putative 0.0091 0.0494 0.0472
Brugia malayi hypothetical protein 0.0059 0.025 0.026
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0104 0.0589 0.0734
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0063 0.0281 0.0335
Loa Loa (eye worm) hypothetical protein 0.0059 0.025 0.0273
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0091 0.0494 0.0611
Toxoplasma gondii Purine nucleoside phosphorylase 0.0104 0.0589 0.2486
Brugia malayi jmjC domain containing protein 0.0094 0.0516 0.0552
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0091 0.0494 0.0611
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0104 0.0589 1
Echinococcus granulosus PWWP domain containing protein 2A 0.0063 0.0281 0.0332
Giardia lamblia UPL-1 0.0104 0.0589 1
Schistosoma mansoni hypothetical protein 0.0205 0.1344 0.1587
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0012 0.0014
Loa Loa (eye worm) beta-lactamase 0.0205 0.1351 0.1477
Trichomonas vaginalis penicillin-binding protein, putative 0.0205 0.1351 0.1331
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.1477
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0281 0.0335
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0091 0.0494 0.0611
Brugia malayi SET domain containing protein 0.0135 0.0819 0.0883
Echinococcus granulosus jumonji domain containing protein 0.004 0.011 0.013
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0422 0.2974 0.351
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0147 0.091 0.115
Toxoplasma gondii phosphorylase family protein 0.0104 0.0589 0.2486
Toxoplasma gondii ABC1 family protein 0.0205 0.1351 0.583
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0589 0.3124
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0104 0.0589 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0205 0.1351 0.1466
Brugia malayi Spermidine synthase 0.1057 0.7735 0.8456
Echinococcus granulosus histone lysine methyltransferase setb 0.0186 0.1203 0.142
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0273 0.1859 0.2378
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0281 0.0335
Brugia malayi SET domain containing protein 0.0119 0.0705 0.0758
Onchocerca volvulus 0.0205 0.1351 0.1329
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0174 0.1111 0.5953
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Schistosoma mansoni SET domain protein 0.0077 0.0391 0.0461
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0147 0.0915 0.108
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0757 0.549 0.8984
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0147 0.091 0.115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0205 0.1351 0.0935
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0273 0.1859 0.2381
Leishmania major methylthioadenosine phosphorylase, putative 0.0561 0.4018 0.5181
Trichomonas vaginalis D-aminoacylase, putative 0.0205 0.1351 0.1331
Leishmania major S-adenosylmethionine decarboxylase 0.0422 0.2974 0.3827
Schistosoma mansoni purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Mycobacterium ulcerans spermidine synthase 0.0833 0.6055 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.0104 0.0589 0.0695
Echinococcus multilocularis disco interacting protein 2 0.0151 0.0943 0.1113
Loa Loa (eye worm) hypothetical protein 0.0357 0.2484 0.2716
Schistosoma mansoni cpg binding protein 0.0162 0.1022 0.1206
Loa Loa (eye worm) hypothetical protein 0.0091 0.0494 0.054
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0091 0.0494 0.0608
Schistosoma mansoni hepatoma derived growth factor 0.0063 0.0281 0.0332
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0091 0.0494 0.0611
Brugia malayi hypothetical protein 0.0063 0.0281 0.0294
Leishmania major hypothetical protein, conserved 0.0063 0.0281 0.0335
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Echinococcus granulosus protein arginine N methyltransferase 8 0.003 0.0037 0.0043
Mycobacterium tuberculosis Conserved protein 0.0205 0.1351 0.0935
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0091 0.0494 0.8314
Onchocerca volvulus 0.0063 0.0281 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0205 0.1351 0.1331
Echinococcus multilocularis beta LACTamase domain containing family member 0.0205 0.1351 0.1594
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0151 0.0943 0.1113
Onchocerca volvulus 0.0205 0.1351 0.1329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0762 0.0899
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0076 0.0379 0.0447
Schistosoma mansoni hypothetical protein 0.0091 0.0494 0.0583
Echinococcus multilocularis spermidine synthase 0.1057 0.7735 0.9128
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0083 0.0098
Loa Loa (eye worm) hypothetical protein 0.0033 0.006 0.0066
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0104 0.0589 1
Schistosoma mansoni uridine phosphorylase 0.0104 0.0589 0.0695
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0104 0.0589 0.0567
Toxoplasma gondii hypothetical protein 0.0063 0.0281 0.1134
Echinococcus multilocularis uridine phosphorylase 1 0.0104 0.0589 0.0695
Plasmodium vivax SET domain protein, putative 0.0127 0.0762 0.0955
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0291 0.1993 0.2352
Trypanosoma cruzi spermidine synthase, putative 0.1057 0.7735 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0091 0.0494 0.0611
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0143 0.0886 0.1045
Echinococcus multilocularis histone h3 methyltransferase 0.1155 0.8474 1
Trypanosoma brucei histone-lysine n-methyltransferase 0.0147 0.091 0.115
Leishmania major hypothetical protein, conserved 0.0205 0.1351 0.1722
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Brugia malayi ethe1-prov protein 0.0091 0.0494 0.0527
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0589 0.3124
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0091 0.0494 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0589 0.0567
Plasmodium falciparum cytosolic glyoxalase II 0.0091 0.0494 0.0608
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0206 0.1351 0.1719
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0422 0.2974 0.3827
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0038 0.0028
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0025 0.003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0516 0.0609
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0091 0.0494 0.0583
Brugia malayi Pre-SET motif family protein 0.016 0.1012 0.1095
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0095 0.0525 0.0619
Echinococcus granulosus WGR domain containing protein 0.0054 0.0214 0.0252
Schistosoma mansoni suppressor of variegation 4-20-related 0.0135 0.0819 0.0967
Schistosoma mansoni hepatoma derived growth factor 0.0063 0.0281 0.0332
Schistosoma mansoni purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Entamoeba histolytica metallo-beta-lactamase family protein 0.0091 0.0494 0.261
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.4947 0.5838
Onchocerca volvulus 0.016 0.101 0.0987
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.1477
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0059 0.025 0.1289
Echinococcus multilocularis hepatoma derived growth factor protein 0.0063 0.0281 0.0332
Trichomonas vaginalis A-type flavoprotein 0.0091 0.0494 0.0472
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0071 0.0084
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0104 0.0589 0.0171
Mycobacterium leprae Probable lipase LipE 0.0205 0.1351 0.4195
Leishmania major hypothetical protein, conserved 0.0147 0.091 0.115
Echinococcus multilocularis PWWP domain containing protein 2A 0.0063 0.0281 0.0332
Schistosoma mansoni hypothetical protein 0.0028 0.0023 0.0027
Loa Loa (eye worm) PWWP domain-containing protein 0.0063 0.0281 0.0307
Brugia malayi beta-lactamase family protein 0.0205 0.1351 0.1466
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Plasmodium vivax hypothetical protein, conserved 0.0205 0.1351 0.1719
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1245 0.9145 1
Mycobacterium tuberculosis Probable esterase LipL 0.0205 0.1351 0.0935
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0091 0.0494 0.0611
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0104 0.0589 0.0565
Loa Loa (eye worm) spermidine synthase 0.1057 0.7735 0.8458
Schistosoma mansoni hypothetical protein 0.0063 0.0281 0.0332
Trypanosoma cruzi spermidine synthase, putative 0.1057 0.7735 1
Echinococcus multilocularis protein arginine methyltransferase 0.003 0.0037 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0205 0.1351 0.1594
Onchocerca volvulus 0.0357 0.2484 0.2465
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0091 0.0494 0.0611
Onchocerca volvulus 0.0205 0.1351 0.1329
Brugia malayi Bromodomain containing protein 0.0029 0.0025 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0091 0.0494 0.0472
Brugia malayi hypothetical protein 0.0357 0.2484 0.2706
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0083 0.0098
Trypanosoma cruzi glyoxalase II 0.0091 0.0494 0.0611
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0205 0.1351 0.0935
Echinococcus multilocularis SET and MYND domain containing protein 3 0.007 0.0332 0.0392
Schistosoma mansoni cpg binding protein 0.0162 0.1022 0.1206
Chlamydia trachomatis AMP nucleosidase 0.0104 0.0589 1
Echinococcus granulosus uridine phosphorylase 1 0.0104 0.0589 0.0695
Treponema pallidum pfs protein (pfs) 0.0104 0.0589 1
Leishmania major spermidine synthase 0.1057 0.7735 1
Brugia malayi jmjC domain containing protein 0.0036 0.0083 0.0077
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0083 0.043 0.0525
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0833 0.6055 0.607
Echinococcus granulosus protein arginine methyltransferase 0.003 0.0037 0.0043
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0091 0.0494 0.0583
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0012 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0205 0.1351 0.1541
Trichomonas vaginalis penicillin-binding protein, putative 0.0205 0.1351 0.1331
Brugia malayi Pre-SET motif family protein 0.1245 0.9145 1
Schistosoma mansoni hypothetical protein 0.0029 0.0025 0.003
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0147 0.091 0.115
Brugia malayi WGR domain containing protein 0.0095 0.0525 0.0561
Brugia malayi NNMT/PNMT/TEMT family protein 0.0887 0.6462 0.7062
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0589 0.0567
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.018 0.1162 0.5003
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0589 0.0695
Trichomonas vaginalis D-aminoacylase, putative 0.0205 0.1351 0.1331
Loa Loa (eye worm) hypothetical protein 0.0205 0.1351 0.1477

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 42.9 nM Inhibition of GST-tagged recombinant human PARP-1 expressed in Escherichia coli after 30 mins by fluorescence-based assay ChEMBL. 24388690
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.