Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.8362 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.2535 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2535 | 0.2535 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.8362 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.