Detailed information for compound 1405179

Basic information

Technical information
  • TDR Targets ID: 1405179
  • Name: 4-methoxy-N-[2-[1-(oxolane-3-carbonyl)piperid in-4-yl]pyrazol-3-yl]benzamide
  • MW: 398.456 | Formula: C21H26N4O4
  • H donors: 1 H acceptors: 3 LogP: 1.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)Nc1ccnn1C1CCN(CC1)C(=O)C1COCC1
  • InChi: 1S/C21H26N4O4/c1-28-18-4-2-15(3-5-18)20(26)23-19-6-10-22-25(19)17-7-11-24(12-8-17)21(27)16-9-13-29-14-16/h2-6,10,16-17H,7-9,11-14H2,1H3,(H,23,26)
  • InChiKey: QNWOYGNLPATUDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methoxy-N-[2-[1-(tetrahydrofuran-3-carbonyl)-4-piperidyl]pyrazol-3-yl]benzamide
  • 4-methoxy-N-[2-[1-[oxo-(3-tetrahydrofuranyl)methyl]-4-piperidinyl]-3-pyrazolyl]benzamide
  • 4-methoxy-N-[2-[1-(oxolan-3-ylcarbonyl)piperidin-4-yl]pyrazol-3-yl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.002 0.0062
Brugia malayi beta-lactamase family protein 0.007 0.0169 0.0203
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0184 0.0217
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0024 0.0024
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0053 0.0053
Echinococcus multilocularis zinc finger protein 0.0043 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0139
Giardia lamblia Kinase, CMGC GSK 0.005 0.0109 0.0106
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0105 0.0126
Echinococcus granulosus geminin 0.1877 0.5596 0.6703
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0083 0.0207 0.0223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0044 0.0053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0075 0.0223
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0035 0.0018
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0024 0.0281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0035 0.0064 0.0198
Echinococcus granulosus tar DNA binding protein 0.0192 0.0534 0.0639
Schistosoma mansoni hypothetical protein 0.1877 0.5596 0.6703
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0042 0.0042
Schistosoma mansoni nuclear receptor 0.0029 0.0044 0.0053
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.002 0.003
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0064 0.0076
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.002 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.014 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0084 0.01
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0106 0.0127
Brugia malayi Pre-SET motif family protein 0.0226 0.0637 0.0763
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0534 0.0639
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0095 0.0114
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.002 0.003
Brugia malayi MH2 domain containing protein 0.0049 0.0106 0.0127
Brugia malayi isocitrate dehydrogenase 0.0083 0.0207 0.0248
Schistosoma mansoni cpg binding protein 0.0063 0.0148 0.0178
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0074 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0327 0.0939 0.1124
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0169 0.0179
Schistosoma mansoni zinc finger protein 0.0029 0.0044 0.0053
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Brugia malayi Flap endonuclease-1 0.0026 0.0035 0.0041
Echinococcus multilocularis peregrin 0.0036 0.0067 0.0067
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0074 0.0074
Schistosoma mansoni ran 0.0021 0.0019 0.0023
Schistosoma mansoni smad1 5 8 and 0.0049 0.0106 0.0127
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0151 0.0151
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0268 0.0321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0075 0.0067
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0024 0.0029
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0106 0.0127
Trichomonas vaginalis esterase, putative 0.007 0.0169 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0153 0.0184
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.002 0.0024
Echinococcus granulosus muscleblind protein 0.1055 0.3127 0.3745
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.014 0.0168
Onchocerca volvulus 0.0029 0.0044 0.0511
Brugia malayi beta-NAC-like protein 0.0213 0.0599 0.0718
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0059 0.007
Loa Loa (eye worm) TAR-binding protein 0.0192 0.0534 0.0639
Brugia malayi AMP-binding enzyme family protein 0.007 0.0169 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.014 0.0168
Schistosoma mansoni hypothetical protein 0.0307 0.0881 0.1055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.014 0.0168
Brugia malayi beta-lactamase 0.007 0.0169 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0537 0.0635
Brugia malayi Calcitonin receptor-like protein seb-1 0.0971 0.2875 0.3444
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0971 0.2875 0.3444
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0169 0.0553
Trypanosoma brucei transcription factor BTF3, putative 0.0213 0.0599 0.0696
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.014 0.014
Leishmania major importin beta-1 subunit, putative 0.0023 0.0026 0.0008
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.025 0.0299
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.031 0.0888 0.2752
Loa Loa (eye worm) RNA binding protein 0.0192 0.0534 0.0639
Brugia malayi MH1 domain containing protein 0.0027 0.004 0.0048
Echinococcus granulosus Smad4 0.0049 0.0106 0.0127
Schistosoma mansoni smad1 5 8 and 0.0049 0.0106 0.0127
Trypanosoma brucei beta lactamase 0.0129 0.0344 0.039
Loa Loa (eye worm) hypothetical protein 0.0097 0.025 0.0299
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0207 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0169 0.0179
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0083 0.0207 0.0686
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0001
Brugia malayi hypothetical protein 0.0032 0.0054 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0139
Brugia malayi nuclear receptor NHR-88 0.0061 0.014 0.0168
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0207 0.0223
Trypanosoma brucei ISWI complex protein 0.0031 0.0051 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0054 0.0065
Echinococcus multilocularis muscleblind protein 1 0.1055 0.3127 0.3127
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.0109 0.013
Onchocerca volvulus 0.0021 0.002 0.0232
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0169 0.0203
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0026 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0116 0.0114
Schistosoma mansoni ran 0.0021 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Loa Loa (eye worm) hypothetical protein 0.0158 0.0431 0.0517
Loa Loa (eye worm) oxidoreductase 0.0021 0.002 0.0024
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0106 0.0127
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0054 0.0065
Mycobacterium ulcerans beta-lactamase 0.007 0.0169 0.0179
Echinococcus multilocularis smad 0.0049 0.0106 0.0106
Entamoeba histolytica transcription factor BTF3, putative 0.0213 0.0599 0.1856
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0795 0.094
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.014 0.0168
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Brugia malayi jmjC domain containing protein 0.0103 0.0268 0.0321
Echinococcus granulosus smad 0.0049 0.0106 0.0127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0034 0.0041
Echinococcus granulosus zinc finger protein 0.0043 0.0087 0.0104
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Schistosoma mansoni hypothetical protein 0.0042 0.0086 0.0102
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0129 0.0344 1
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0169 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Schistosoma mansoni Smad4 0.0022 0.0024 0.0029
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0074 0.0074
Brugia malayi nuclear receptor RXR 0.0029 0.0044 0.0053
Schistosoma mansoni transient receptor potential channel 0.0097 0.025 0.0299
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.002 0.003
Onchocerca volvulus 0.007 0.0169 0.1965
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0107 0.0336
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0102
Brugia malayi intracellular kinase 0.005 0.0109 0.013
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0044 0.0053
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0075 0.009
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0731 0.0864
Echinococcus granulosus FTZ F1 alpha 0.0061 0.014 0.0168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0971 0.2875 0.3444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0169 0.0553
Brugia malayi MH2 domain containing protein 0.0725 0.2136 0.2559
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.014 0.0168
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.2829 0.8454 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.014 0.0168
Brugia malayi hypothetical protein 0.0038 0.0073 0.0088
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0035 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0051 0.0061
Schistosoma mansoni ap endonuclease 0.0039 0.0075 0.009
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0053 0.0039
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0075 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0044 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0044 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0033 0.0039
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0169 0.0179
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0657 0.193 0.2312
Schistosoma mansoni importin beta-1 0.0028 0.0042 0.005
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0094 0.0112
Loa Loa (eye worm) hypothetical protein 0.1055 0.3127 0.3745
Loa Loa (eye worm) hypothetical protein 0.0054 0.012 0.0144
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0141 0.0169
Onchocerca volvulus 0.0033 0.0057 0.0663
Echinococcus granulosus flap endonuclease 1 0.0026 0.0035 0.0041
Echinococcus granulosus tumor protein p63 0.0353 0.1018 0.122
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0024 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0054 0.0054
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.014 0.0168
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Onchocerca volvulus 0.0029 0.0044 0.0511
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.0332 0.0332
Echinococcus multilocularis solute carrier family 5 0.0039 0.0074 0.0074
Toxoplasma gondii exonuclease III APE 0.0039 0.0075 0.0066
Brugia malayi MH1 domain containing protein 0.0027 0.004 0.0048
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.2794 0.8348 0.8348
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0327 0.0939 0.1124
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0109 0.0129
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0075 0.0075
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0035 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0169 0.02
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0024 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.014 0.0168
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0084 0.01
Echinococcus multilocularis geminin 0.1877 0.5596 0.5596
Echinococcus granulosus peregrin 0.0036 0.0067 0.008
Schistosoma mansoni cpg binding protein 0.0056 0.0127 0.0152
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0086 0.0102
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0074 0.0089
Echinococcus multilocularis high affinity choline transporter 1 0.0351 0.1013 0.1013
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0086 0.0102
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0062 0.0074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0075 0.009
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0066 0.0079
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0035 0.0064 0.0054
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.0332 0.0398
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0116 0.0366
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Giardia lamblia PHD finger protein 15 0.0032 0.0053 0.0039
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.0016 0.0019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0044 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Mycobacterium tuberculosis Conserved protein 0.007 0.0169 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.014 0.0168
Leishmania major hypothetical protein, conserved 0.007 0.0169 0.018
Echinococcus multilocularis 6 phosphogluconolactonase 0.0035 0.0064 0.0064
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0054 0.0065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0068
Schistosoma mansoni smad 0.0022 0.0024 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.014 0.0168
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0035 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0033 0.0039
Leishmania major hypothetical protein, conserved 0.0158 0.0431 0.0495
Brugia malayi PHD-finger family protein 0.0032 0.0053 0.0063
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0169 0.0203
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0024
Brugia malayi PHD-finger family protein 0.0017 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0599 0.0708
Echinococcus multilocularis protein kinase shaggy 0.005 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0599 0.0708
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0169 0.0169
Echinococcus granulosus transcription factor eb 0.066 0.194 0.2323
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0054 0.0065
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.014 0.0168
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0169 0.0179
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0268 0.0762 0.0892
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0044 0.0044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0169 0.4606
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0033 0.0039
Schistosoma mansoni cpg binding protein 0.0063 0.0148 0.0178
Brugia malayi TAR-binding protein 0.0192 0.0534 0.0639
Loa Loa (eye worm) Smad1 0.0049 0.0106 0.0127
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.0534 0.0639
Leishmania major hypothetical protein, conserved 0.0031 0.0051 0.0038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Brugia malayi steroid hormone receptor 0.0061 0.014 0.0168
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0056 0.0067
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.014 0.014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0169 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.014 0.014
Schistosoma mansoni sodium/solute symporter 0.0039 0.0074 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0054 0.0065
Echinococcus multilocularis tar DNA binding protein 0.0192 0.0534 0.0534
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0015 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0327 0.0939 0.0939
Mycobacterium tuberculosis Conserved protein 0.007 0.0169 0.0553
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0033 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0062 0.0074
Schistosoma mansoni transient receptor potential channel 0.0064 0.0151 0.0181
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0177 0.0177
Onchocerca volvulus 0.0056 0.0127 0.1477
Loa Loa (eye worm) hypothetical protein 0.0144 0.039 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0047 0.0056
Loa Loa (eye worm) transcription factor SMAD2 0.0725 0.2136 0.2559
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0207 0.0223
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.2829 0.8454 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0075 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0163 0.0195
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.002 0.0024
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0044 0.0044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0033 0.0039
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Brugia malayi GH02984p 0.0351 0.1013 0.1214
Mycobacterium leprae conserved hypothetical protein 0.007 0.0169 0.4605
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0066 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0059 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0065
Brugia malayi AMP-binding enzyme family protein 0.007 0.0169 0.0203
Entamoeba histolytica hypothetical protein 0.0035 0.0064 0.0198
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0035 0.0064 0.0054
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0042 0.0026
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.014 0.0168
Echinococcus granulosus high affinity choline transporter 1 0.0351 0.1013 0.1214
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0062 0.0062
Echinococcus multilocularis chromobox protein 1 0.0075 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0035 0.0064 0.0076
Plasmodium vivax ataxin-2 like protein, putative 0.0158 0.0431 0.0488
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Onchocerca volvulus 0.0233 0.0656 0.7622
Echinococcus granulosus 6 phosphogluconolactonase 0.0035 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Brugia malayi MH1 domain containing protein 0.0049 0.0106 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0207 0.0207
Giardia lamblia DNA repair protein RAD52 0.1089 0.3228 0.3804
Brugia malayi hypothetical protein 0.0032 0.0054 0.0065
Loa Loa (eye worm) hypothetical protein 0.1055 0.3127 0.3745
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0003 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0207 0.0207
Schistosoma mansoni nuclear receptor 0.0029 0.0044 0.0053
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0083 0.0207 0.0226
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0094 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0321 0.0384
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0169 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.014 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.014 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0053 0.0039
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.0109 0.0106
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0169 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0018
Brugia malayi RNA binding protein 0.0192 0.0534 0.0639
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0044 0.0053
Onchocerca volvulus 0.0257 0.0731 0.8488
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.014 0.014
Toxoplasma gondii propionate-CoA ligase 0.0021 0.002 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0061 0.014 0.0168
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0035 0.0064 0.0054
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.0109 0.0109
Schistosoma mansoni high-affinity choline transporter 0.0351 0.1013 0.1214
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0066 0.0066
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0074 0.0089
Brugia malayi chromobox protein homolog 3 0.0042 0.0084 0.0101
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0003 0.0004
Brugia malayi Importin beta-1 subunit 0.0028 0.0042 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0107 0.0336
Schistosoma mansoni hypothetical protein 0.0664 0.1952 0.2339
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0169 0.0524
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0169 0.0553
Mycobacterium ulcerans lipase LipD 0.007 0.0169 0.0179
Schistosoma mansoni hypothetical protein 0.0307 0.0881 0.1055
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0279 0.0795 0.0952
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.0664 0.1952 0.2339
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0169 0.0179
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0024
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.0507 0.5889
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.0247
Echinococcus granulosus cpg binding protein 0.0063 0.0148 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0075 0.0067
Echinococcus granulosus jumonji domain containing protein 0.0044 0.009 0.0107
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.014 0.0168
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.2794 0.8348 1
Brugia malayi Bromodomain containing protein 0.0036 0.0067 0.008
Brugia malayi nuclear receptor NHR-67 0.0029 0.0044 0.0053
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0279 0.0795 0.0952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.014 0.0168
Trypanosoma brucei PAB1-binding protein , putative 0.0158 0.0431 0.0495
Brugia malayi hypothetical protein 0.0158 0.0431 0.0517
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.002 0.002
Schistosoma mansoni chromobox protein 0.0075 0.0184 0.022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.014 0.0168
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0169 0.0524
Onchocerca volvulus 0.007 0.0169 0.1965
Trypanosoma cruzi PAB1-binding protein , putative 0.0158 0.0431 0.0495
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0169 0.0203
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0075 0.0067
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.1825 0.5438 0.6505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0163 0.0163
Onchocerca volvulus 0.0021 0.002 0.0232
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0053 0.0063
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0926 0.2738 0.3264
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0044 0.0044
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0094 0.0111
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0044 0.0511
Giardia lamblia Kinase, CMGC GSK 0.005 0.0109 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0534 0.0639
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.2794 0.8348 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0063
Brugia malayi hypothetical protein 0.0035 0.0064 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0169 0.0179
Loa Loa (eye worm) hypothetical protein 0.0042 0.0084 0.0101
Brugia malayi MH1 domain containing protein 0.0049 0.0106 0.0127
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0637 0.0763
Brugia malayi SET domain containing protein 0.0015 0.0002 0.0003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0059 0.0059
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0071 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0351 0.1013 0.1214
Brugia malayi jmjC domain containing protein 0.0045 0.0094 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.014 0.0168
Schistosoma mansoni transient receptor potential channel 0.0064 0.0151 0.0181
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0169 0.02
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.003
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.003
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0109 0.013
Echinococcus granulosus solute carrier family 5 0.0039 0.0074 0.0089
Brugia malayi RNA, U transporter 1 0.0079 0.0196 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0207 0.0226
Plasmodium falciparum importin beta, putative 0.0028 0.0042 0.0026
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0035 0.0064 0.0053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.014 0.0168
Loa Loa (eye worm) DR-78 0.0029 0.0044 0.0053
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.001 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0169 0.02
Mycobacterium leprae Probable lipase LipE 0.007 0.0169 0.4605
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0044 0.0053
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0044 0.0053
Toxoplasma gondii NAC domain-containing protein 0.0213 0.0599 0.0687
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0024
Plasmodium falciparum basic transcription factor 3b, putative 0.0213 0.0599 0.0687
Schistosoma mansoni zinc finger protein 0.0043 0.0087 0.0104
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0014 0.0017
Echinococcus multilocularis Smad4 0.0049 0.0106 0.0106
Echinococcus multilocularis muscleblind protein 0.1055 0.3127 0.3127
Plasmodium vivax SET domain protein, putative 0.0034 0.0059 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.002 0.003
Loa Loa (eye worm) ICD-1 protein 0.0213 0.0599 0.0718
Loa Loa (eye worm) isocitrate dehydrogenase 0.0083 0.0207 0.0248
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.2829 0.8454 1
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.014 0.0168
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0035 0.0064 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0169 0.02
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0113 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0534 0.0639
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0169 0.0553
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0033 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0169 0.0203
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.002 0.003
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0083 0.0207 0.0248
Onchocerca volvulus 0.0061 0.014 0.1632
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0033 0.0039
Mycobacterium ulcerans hypothetical protein 0.007 0.0169 0.0179
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.025 0.0299
Loa Loa (eye worm) hypothetical protein 0.0971 0.2875 0.3444
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.009 0.009
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0035 0.0064 0.0053
Echinococcus multilocularis transcription factor btf3 0.0213 0.0599 0.0599
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0044 0.0053
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0127 0.0152
Brugia malayi Muscleblind-like protein 0.1055 0.3127 0.3745
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0086 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0084 0.01
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0169 0.0553
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0169 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.014 0.0168
Schistosoma mansoni hypothetical protein 0.0307 0.0881 0.1055
Brugia malayi PHD-finger family protein 0.0054 0.012 0.0143
Brugia malayi hypothetical protein 0.0029 0.0044 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0534 0.0639
Schistosoma mansoni Smad4 0.0049 0.0106 0.0127
Leishmania major basic transcription factor 3a, putative 0.0213 0.0599 0.0696
Schistosoma mansoni hypothetical protein 0.0032 0.0053 0.0063
Loa Loa (eye worm) nuclear factor I 0.0027 0.004 0.0048
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.0534 0.0639
Echinococcus granulosus GPCR family 2 0.0307 0.0881 0.1055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0327 0.0939 0.1124
Loa Loa (eye worm) latrophilin receptor protein 2 0.0307 0.0881 0.1055
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0169 0.018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0054 0.0065
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0035 0.0064 0.1364
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0107 0.0336
Schistosoma mansoni hypothetical protein 0.0071 0.017 0.0204
Schistosoma mansoni hypothetical protein 0.0042 0.0084 0.01
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0268 0.0268
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0042 0.0086 0.0078
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.2829 0.8454 1
Brugia malayi hypothetical protein 0.0102 0.0264 0.0316
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0075 0.0089
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.014 0.014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0116 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0795 0.094
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0079
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.024 0.0287
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0169 0.4606
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0116 0.0114
Echinococcus multilocularis isocitrate dehydrogenase 0.0083 0.0207 0.0207
Onchocerca volvulus 0.0021 0.002 0.0232
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.002 0.0001
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.2829 0.8454 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0014 0.0014
Echinococcus multilocularis GPCR, family 2 0.0307 0.0881 0.0881
Mycobacterium tuberculosis Possible penicillin-binding protein 0.045 0.1308 0.4538
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.2794 0.8348 1
Schistosoma mansoni flap endonuclease-1 0.0023 0.0027 0.0033
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0083 0.0207 0.0248
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0307 0.0881 0.0881
Entamoeba histolytica hypothetical protein 0.0023 0.0026 0.008
Schistosoma mansoni bromodomain containing protein 0.0132 0.0354 0.0424
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0016 0.0019
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.2794 0.8348 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0106 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0042 0.0027
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0074 0.0089
Brugia malayi Bromodomain containing protein 0.0156 0.0425 0.0509
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1825 0.5438 0.6424
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0086 0.0102
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0024 0.0029
Schistosoma mansoni smad 0.0049 0.0106 0.0127
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0129 0.0344 0.1165
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0044 0.0053
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0109 0.013
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0035 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0795 0.094
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0001
Brugia malayi tailless protein 0.0029 0.0044 0.0053
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0019 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0327 0.0939 0.0939
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.014 0.014
Schistosoma mansoni inositol transporter 0.0039 0.0074 0.0089
Mycobacterium ulcerans hypothetical protein 0.007 0.0169 0.0179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0044 0.0511
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0062 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.014 0.0168
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0307 0.0881 0.1055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0083 0.0207 0.0207
Plasmodium falciparum ataxin-2 like protein, putative 0.0158 0.0431 0.0488
Brugia malayi hypothetical protein 0.0301 0.0861 0.1031
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0795 0.094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0163 0.0195
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0089
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Trypanosoma brucei protein kinase, putative 0.005 0.0109 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0169 0.018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0075 0.5
Trypanosoma cruzi ISWI complex protein 0.0031 0.0051 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0024
Echinococcus multilocularis chromobox protein 1 0.0075 0.0184 0.0184
Echinococcus multilocularis snurportin 1 0.0297 0.0851 0.0851
Echinococcus multilocularis cpg binding protein 0.0063 0.0148 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0169 0.0179
Schistosoma mansoni zinc finger protein 0.0031 0.0051 0.0061
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.0109 0.013
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0109 0.0337
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0795 0.094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.0939 0.1124
Brugia malayi latrophilin 2 splice variant baaae 0.0664 0.1952 0.2339
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.014 0.014
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.0016 0.0019
Onchocerca volvulus 0.0301 0.0861 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.002 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0169 0.018
Plasmodium vivax importin-beta 2, putative 0.0028 0.0042 0.0026
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.0016 0.0016
Schistosoma mansoni ap endonuclease 0.0039 0.0075 0.009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0068
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0169 0.0553
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0106 0.0127
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.0109 0.0106
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.014 0.1632
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.014 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.014 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0047 0.0056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0065
Schistosoma mansoni transcription factor btf3 0.0213 0.0599 0.0718
Entamoeba histolytica hypothetical protein 0.0213 0.0599 0.1856
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.002 0.0024
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.066 0.194 0.2323
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0169 0.0553
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0094 0.0112
Schistosoma mansoni chromobox protein 0.0075 0.0184 0.022
Brugia malayi Pre-SET motif family protein 0.0034 0.0059 0.007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0177 0.0212
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1089 0.3228 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Echinococcus granulosus importin subunit beta 1 0.0028 0.0042 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0013 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.005
Schistosoma mansoni 6-phosphogluconolactonase 0.0035 0.0064 0.0077
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0083 0.0207 0.0226
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0307 0.0881 0.0881
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0072 0.0072
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0053 0.0039
Brugia malayi CXXC zinc finger family protein 0.0056 0.0127 0.0152
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.001 0.001
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0184 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0158 0.0431 0.0495
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0035 0.0064 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0307 0.0881 0.1055
Schistosoma mansoni coup transcription factor 0.0061 0.014 0.0168
Toxoplasma gondii LsmAD domain-containing protein 0.0158 0.0431 0.0488
Loa Loa (eye worm) hypothetical protein 0.0657 0.193 0.2312
Brugia malayi beta-lactamase family protein 0.007 0.0169 0.0203
Mycobacterium ulcerans lipoprotein LpqF 0.0129 0.0344 0.0389
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0044 0.0053
Brugia malayi Heterochromatin protein 1 0.0075 0.0184 0.022
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.2829 0.8454 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Loa Loa (eye worm) beta-lactamase 0.007 0.0169 0.0203
Brugia malayi Smad1 0.0049 0.0106 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0107 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0795 0.094
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0184 0.0217
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0268 0.0762 0.2629
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0094 0.0112
Brugia malayi glucose-6-phosphate dehydrogenase 0.2794 0.8348 1
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0534 0.0639
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0044 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0086 0.0078
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0065
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0086 0.0086
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0074 0.0074
Trichomonas vaginalis ran, putative 0.0021 0.0019 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.014 0.0168
Onchocerca volvulus Alhambra homolog 0.0032 0.0053 0.061
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0169 0.0179
Loa Loa (eye worm) hypothetical protein 0.009 0.0228 0.0273
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0899 0.2657 0.3167
Schistosoma mansoni thyroid hormone receptor 0.0061 0.014 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.014 0.0168
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0075 0.0066
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0969 0.2868 1
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0151 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.014 0.0168
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0035 0.0018
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0035 0.0064 0.0077
Trypanosoma cruzi transcription factor btf3, putative 0.0213 0.0599 0.0696
Loa Loa (eye worm) hypothetical protein 0.0068 0.0163 0.0195
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0094 0.0111
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0035 0.0018
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.0168
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0074 0.0089
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.014 0.014
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.0851 0.1019
Schistosoma mansoni hypothetical protein 0.0307 0.0881 0.1055
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0075 0.0066
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0044 0.0053
Echinococcus granulosus chromobox protein 1 0.0075 0.0184 0.022
Trypanosoma brucei 6-phosphogluconolactonase 0.0035 0.0064 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0327 0.0939 0.1124
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0035 0.0064 0.0077
Onchocerca volvulus 0.007 0.0169 0.1966
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.014 0.0168
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0094 0.1092
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0023
Brugia malayi Isocitrate dehydrogenase 0.0083 0.0207 0.0248
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.002 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0599 0.0708
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0074 0.0089
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0106 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0507 0.06
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0044 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0026 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.014 0.0168
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0105 0.0126
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.2794 0.8348 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.2794 0.8348 1
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0035 0.0064 0.0053
Loa Loa (eye worm) hypothetical protein 0.0078 0.0192 0.023
Trypanosoma cruzi ISWI complex protein 0.0031 0.0051 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0169 0.0553
Plasmodium falciparum ataxin-2 like protein, putative 0.0158 0.0431 0.0488
Entamoeba histolytica hypothetical protein 0.031 0.0888 0.2752
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0044 0.0053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0075 0.0066
Echinococcus granulosus protein kinase shaggy 0.005 0.0109 0.013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0053 0.0063
Brugia malayi Pax transcription factor protein 2 0.0233 0.0656 0.0786
Brugia malayi hypothetical protein 0.0029 0.0044 0.0053
Brugia malayi MH2 domain containing protein 0.0022 0.0024 0.0029
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0297 0.0329
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.2794 0.8348 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0139
Leishmania major 6-phosphogluconolactonase 0.0035 0.0064 0.0054
Loa Loa (eye worm) MH2 domain-containing protein 0.0725 0.2136 0.2559
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0044 0.0053
Onchocerca volvulus 0.0052 0.0113 0.1314
Loa Loa (eye worm) hypothetical protein 0.0301 0.0861 0.1031
Onchocerca volvulus 0.007 0.0169 0.1965
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.014 0.0168
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0048
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0024 0.0029
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0151 0.0151
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.014 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0169 0.018
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0044 0.0053
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.014 0.0168
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0035 0.0064 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0075 0.0089
Entamoeba histolytica hypothetical protein 0.0035 0.0064 0.0198
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0169 0.018
Mycobacterium tuberculosis Conserved protein 0.007 0.0169 0.0553
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0035 0.0107
Toxoplasma gondii ABC1 family protein 0.007 0.0169 0.0178
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0044 0.0053
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.0109 0.0106
Schistosoma mansoni Smad4 0.0022 0.0024 0.0029
Schistosoma mansoni hypothetical protein 0.0297 0.0851 0.1019
Plasmodium falciparum flap endonuclease 1 0.0026 0.0035 0.0018
Plasmodium vivax basic transcription factor 3b, putative 0.0213 0.0599 0.0687
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0071 0.017 0.0204
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0053 0.0063
Echinococcus granulosus transcription factor btf3 0.0213 0.0599 0.0718
Brugia malayi 6-phosphogluconolactonase family protein 0.0035 0.0064 0.0077
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.0656 0.0786
Echinococcus granulosus chromobox protein 1 0.0075 0.0184 0.022
Echinococcus multilocularis tumor protein p63 0.0353 0.1018 0.1018
Brugia malayi conserved hypotetical protein 0.0029 0.0044 0.0053
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.025 0.025
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.002 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0537 0.0635
Onchocerca volvulus 0.0039 0.0074 0.0863
Schistosoma mansoni smad1 5 8 and 0.0049 0.0106 0.0127
Loa Loa (eye worm) hypothetical protein 0.0307 0.0881 0.1055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0075 0.0066
Brugia malayi AMP-binding enzyme family protein 0.007 0.0169 0.0203
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0064 0.0076
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.2794 0.8348 1
Entamoeba histolytica protein kinase, putative 0.005 0.0109 0.0337
Onchocerca volvulus 0.0021 0.002 0.0232
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.002 0.003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.014 0.0168
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.002 0.0024
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0035 0.0064 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.014 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.0939 0.1124
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0169 0.02
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0207 0.0226
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0024 0.0029
Brugia malayi MH2 domain containing protein 0.0049 0.0106 0.0127
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0033 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0044 0.0053
Plasmodium vivax hypothetical protein, conserved 0.007 0.0169 0.0178
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0204 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0106 0.0127
Brugia malayi nuclear hormone receptor 0.0029 0.0044 0.0053
Brugia malayi nuclear receptor RXR 0.0032 0.0054 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0012
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0151 0.0181
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.007 0.0169 0.0203
Onchocerca volvulus 0.005 0.0109 0.1263
Brugia malayi CHD4 protein 0.0019 0.0016 0.0019
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0052 0.0113 0.0135
Brugia malayi hypothetical protein 0.0038 0.0073 0.0088
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0035 0.0041
Brugia malayi nuclear hormone receptor 0.0061 0.014 0.0168
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0026 0.0008
Schistosoma mansoni inositol transporter 0.0039 0.0074 0.0089
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0139
Entamoeba histolytica hypothetical protein 0.0035 0.0064 0.0198
Schistosoma mansoni 6-phosphogluconolactonase 0.0035 0.0064 0.0077
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0163 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0109 0.0129
Brugia malayi Latrophilin receptor protein 2 0.0307 0.0881 0.1055
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0014 0.0017
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0083 0.0207 0.0223
Entamoeba histolytica Ran family GTPase 0.0021 0.0019 0.006
Trypanosoma cruzi transcription factor btf3, putative 0.0213 0.0599 0.0696
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0042 0.0027
Schistosoma mansoni hypothetical protein 0.1877 0.5596 0.6703
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0053
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0075 0.0067
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0084 0.0981
Echinococcus granulosus snurportin 1 0.0297 0.0851 0.1019
Brugia malayi Bromodomain containing protein 0.0078 0.0192 0.023
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.2829 0.8454 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.0109 0.0107
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0026 0.003
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0109 0.0337
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0075 0.009
Onchocerca volvulus 0.0046 0.0095 0.1109
Brugia malayi ecdysteroid receptor 0.0061 0.014 0.0168
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0116 0.0062
Plasmodium falciparum phd finger protein, putative 0.0032 0.0053 0.0039
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0066 0.0079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0307 0.0881 0.1055
Brugia malayi ecdysone receptor 0.0029 0.0044 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0061 0.014 0.0168
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.014 0.1632
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.2794 0.8348 1
Brugia malayi nuclear receptor NHR-88 0.0029 0.0044 0.0053
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0035 0.0064 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.0939 0.1124
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.014 0.1632
Echinococcus multilocularis transcription factor eb 0.066 0.194 0.194

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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