Detailed information for compound 1405370

Basic information

Technical information
  • TDR Targets ID: 1405370
  • Name: N-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]e thyl]-3-nitrobenzenesulfonamide
  • MW: 343.382 | Formula: C11H13N5O4S2
  • H donors: 1 H acceptors: 6 LogP: 0.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc(c1)S(=O)(=O)NCCSc1nncn1C
  • InChi: 1S/C11H13N5O4S2/c1-15-8-12-14-11(15)21-6-5-13-22(19,20)10-4-2-3-9(7-10)16(17)18/h2-4,7-8,13H,5-6H2,1H3
  • InChiKey: CYHGOVXWKAFDDU-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-nitro-benzenesulfonamide
  • N-[2-[(4-methyl-1,2,4-triazol-3-yl)thio]ethyl]-3-nitrobenzenesulfonamide
  • N-[2-[(4-methyl-1,2,4-triazol-3-yl)thio]ethyl]-3-nitro-benzenesulfonamide
  • Benzenesulfonamide, N-[2-(4-methyl-4H-1,2,4-triazol-3-yl)ethyl]-3-nitro-
  • N-(2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethyl)-3-nitrobenzenesulfonamide
  • A2484/0105553

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 0.0045 0.0106 0.0099
Toxoplasma gondii LsmAD domain-containing protein 0.0157 0.0494 0.0488
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0106 0.0099
Plasmodium vivax tubulin alpha chain, putative 0.2156 0.7385 0.7383
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0049
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.0279 0.0273
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.046 0.046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0073 0.0288
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0106 0.0288
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0047
Entamoeba histolytica hypothetical protein 0.0257 0.0838 0.0826
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0279 0.0279
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0187 0.0187
Brugia malayi glutathione reductase 0.0046 0.0111 0.0111
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0099 0.0402
Brugia malayi Isocitrate dehydrogenase 0.0146 0.0456 0.0456
Trypanosoma cruzi alpha tubulin, putative 0.2156 0.7385 0.7383
Echinococcus multilocularis peroxisome assembly protein 26 0.2156 0.7385 0.7383
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0101 0.01
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0148 0.0462 0.0456
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0356 0.1497
Schistosoma mansoni hypothetical protein 0.0071 0.0195 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0124
Echinococcus multilocularis tubulin alpha chain 0.2156 0.7385 0.7383
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0015 0.0008
Loa Loa (eye worm) Smad1 0.0059 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0013
Echinococcus granulosus CREB binding protein 0.0065 0.0174 0.0168
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0146 0.0456 0.045
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0018 0.0013 0.0006
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0106 0.0099
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0071 0.0195 0.0188
Echinococcus granulosus TGF beta signal transducer SmadC 0.0059 0.0154 0.0147
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0124 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.0279 0.0279
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0018 0.0013 0.0006
Brugia malayi Pre-SET motif family protein 0.0204 0.0656 0.0656
Loa Loa (eye worm) alpha-tubulin 0.2156 0.7385 0.7385
Echinococcus granulosus lamin 0.0026 0.0042 0.0036
Brugia malayi Tubulin beta chain 0.0891 0.3023 0.3023
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0015 0.0036
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0083 0.0212
Echinococcus multilocularis geminin 0.157 0.5364 0.5361
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0019 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0111 0.0104
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.0279 0.0273
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0099 0.0402
Echinococcus multilocularis Smad4 0.0059 0.0154 0.0147
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.005 0.0044
Echinococcus granulosus Tubulin alpha 1 chain 0.2156 0.7385 0.7383
Brugia malayi hypothetical protein 0.016 0.0502 0.0502
Echinococcus granulosus tubulin alpha chain 0.2156 0.7385 0.7383
Chlamydia trachomatis endonuclease IV 0.0075 0.021 1
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0022 0.0015
Schistosoma mansoni lamin 0.0026 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Brugia malayi Tubulin beta chain 0.0684 0.2308 0.2308
Plasmodium vivax tubulin gamma chain, putative 0.1574 0.538 0.5377
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2156 0.7385 0.7385
Echinococcus granulosus tubulin alpha chain 0.2156 0.7385 0.7383
Loa Loa (eye worm) alpha-tubulin 0.2156 0.7385 0.7385
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0318 0.0318
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0048 0.0048
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.005 0.0044
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0105 0.0314 0.1314
Trypanosoma cruzi PAB1-binding protein , putative 0.0157 0.0494 0.0488
Loa Loa (eye worm) hypothetical protein 0.008 0.0227 0.0227
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0049
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Brugia malayi ecdysone receptor 0.0045 0.0106 0.0106
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.0279 0.0273
Onchocerca volvulus 0.0048 0.0118 0.0329
Brugia malayi conserved hypotetical protein 0.0045 0.0106 0.0106
Trypanosoma brucei epsilon tubulin 0.1574 0.538 0.5377
Toxoplasma gondii isocitrate dehydrogenase 0.0146 0.0456 0.045
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0106 0.0099
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0146 0.0456 0.1952
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0456 0.0449
Brugia malayi nuclear receptor NHR-67 0.0045 0.0106 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0318 0.0317
Giardia lamblia Alpha-tubulin 0.2156 0.7385 0.7383
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Onchocerca volvulus 0.0738 0.2495 0.8243
Mycobacterium leprae Probable lipase LipE 0.0035 0.0073 0.0263
Onchocerca volvulus 0.0035 0.0073 0.0178
Mycobacterium ulcerans epimerase 0.002 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Schistosoma mansoni tubulin subunit delta 0.0684 0.2308 0.2303
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0073 0.0288
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.005 0.019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0279 0.0273
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0146 0.0456 0.045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0018 0.0013 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.0279 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.0279 0.0279
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0048 0.0042
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0106 0.0099
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0318 0.0312
Toxoplasma gondii alpha-tubulin I, putative 0.2156 0.7385 0.7383
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0063
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0318 0.0312
Plasmodium vivax delta tubulin, putative 0.0684 0.2308 0.2303
Plasmodium vivax ataxin-2 like protein, putative 0.0157 0.0494 0.0488
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0106 0.0099
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0018 0.0013 0.0026
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0106 0.0316 0.0316
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0015 0.0008
Onchocerca volvulus 0.0095 0.0279 0.0864
Brugia malayi hypothetical protein 0.005 0.0124 0.0124
Loa Loa (eye worm) acetyltransferase 0.0144 0.0447 0.0447
Echinococcus multilocularis tubulin subunit TubB 0.2156 0.7385 0.7383
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0007 0.0153
Trypanosoma brucei PAB1-binding protein , putative 0.0157 0.0494 0.0488
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0059 0.0154 0.0147
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0447 0.044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0447 0.044
Onchocerca volvulus 0.0233 0.0753 0.2444
Echinococcus multilocularis mothers against decapentaplegic 6 0.0026 0.0042 0.0035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.0279 0.0864
Echinococcus multilocularis tumor protein p63 0.0331 0.1092 0.1087
Echinococcus granulosus geminin 0.157 0.5364 0.5361
Giardia lamblia Epsilon tubulin 0.0684 0.2308 0.2303
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.0279 0.0273
Echinococcus granulosus CREB binding protein 0.0103 0.0306 0.0299
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0054 0.0048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0015 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0015 0.0013
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.021 0.086
Loa Loa (eye worm) tubulin alpha 2 0.0581 0.1956 0.1956
Loa Loa (eye worm) CBP-B 0.0072 0.0201 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0279 0.0279
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.012 0.0113
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.002 0.0022 0.0066
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0124 0.0117
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0187 0.0185
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0148 0.0462 0.0456
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0015 0.0008
Brugia malayi MH2 domain containing protein 0.0862 0.2924 0.2924
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0049
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0146 0.0456 0.045
Echinococcus granulosus alpha tubulin 0.2156 0.7385 0.7383
Onchocerca volvulus 0.0163 0.0514 0.1649
Onchocerca volvulus 0.0028 0.0048 0.0096
Echinococcus granulosus tubulin alpha chain 0.2156 0.7385 0.7383
Schistosoma mansoni smad1 5 8 and 0.0059 0.0154 0.0147
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0318 0.0312
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.001
Toxoplasma gondii exonuclease III APE 0.0018 0.0015 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Brugia malayi Smad1 0.0059 0.0154 0.0154
Mycobacterium ulcerans thymidylate synthase 0.0105 0.0314 0.1336
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0045 0.0107 0.0291
Loa Loa (eye worm) tubulin alpha-2 chain 0.2156 0.7385 0.7385
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.269 0.2685
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0042 0.0042
Mycobacterium ulcerans endonuclease IV 0.0075 0.021 0.0884
Loa Loa (eye worm) MH1 domain-containing protein 0.0059 0.0154 0.0154
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.0008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0106 0.0288
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0049
Schistosoma mansoni zinc finger protein 0.0045 0.0106 0.0099
Brugia malayi p25-alpha family protein 0.0358 0.1187 0.1187
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0103 0.0306 0.0299
Brugia malayi Tubulin gamma chain 0.1574 0.538 0.538
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0124 0.0118
Trypanosoma cruzi tubulin gamma chain 0.1574 0.538 0.5377
Plasmodium vivax DNA topoisomerase II, putative 0.0062 0.0166 0.0159
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Echinococcus multilocularis lamin dm0 0.0026 0.0042 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0128 0.0128
Brugia malayi Flap endonuclease-1 0.0026 0.0039 0.0039
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Toxoplasma gondii DNA topoisomerase 2, putative 0.0062 0.0166 0.0159
Trypanosoma cruzi DNA topoisomerase II, putative 0.0056 0.0144 0.0138
Schistosoma mansoni single-minded 0.0048 0.0116 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0045 0.0043
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0318 0.0318
Echinococcus granulosus chromobox protein 1 0.0068 0.0187 0.018
Mycobacterium leprae cell division protein FtsZ 0.0684 0.2308 1
Plasmodium falciparum alpha tubulin 2 0.2156 0.7385 0.7383
Plasmodium falciparum DNA topoisomerase 2 0.0062 0.0166 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.0279 0.0273
Trichomonas vaginalis tubulin alpha chain, putative 0.0891 0.3023 0.3022
Loa Loa (eye worm) hypothetical protein 0.0163 0.0514 0.0514
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0054 0.0048
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.005 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.0279 0.0279
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0093 0.0246
Brugia malayi MH1 domain containing protein 0.0032 0.0063 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0279 0.0273
Echinococcus multilocularis tubulin gamma 1 chain 0.1574 0.538 0.5377
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0356 0.1519
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0039 0.0039
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0146 0.0456 0.045
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0106 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0157 0.0494 0.0488
Schistosoma mansoni smad1 5 8 and 0.0059 0.0154 0.0147
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0029 0.0029
Brugia malayi nuclear receptor RXR 0.0045 0.0106 0.0106
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0073 0.0073
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0105 0.0314 0.0308
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0029 0.0029
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0106 0.0099
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0318 0.0312
Trichomonas vaginalis tubulin gamma chain, putative 0.1574 0.538 0.5379
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.005 0.0044
Echinococcus granulosus Tubulin alpha 1 chain 0.2156 0.7385 0.7383
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0356 0.1519
Trypanosoma brucei alpha tubulin 0.2156 0.7385 0.7383
Loa Loa (eye worm) hypothetical protein 0.0042 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Schistosoma mansoni alpha tubulin 0.2156 0.7385 0.7383
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0157 0.0494 0.0494
Brugia malayi Heterochromatin protein 1 0.0068 0.0187 0.0187
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.005 0.0044
Leishmania major cytochrome p450-like protein 0.0022 0.0029 0.0022
Echinococcus granulosus CREB binding protein 0.0016 0.0007 0.0001
Brugia malayi MH2 domain containing protein 0.0059 0.0154 0.0154
Schistosoma mansoni cpg binding protein 0.0028 0.0048 0.0042
Trypanosoma cruzi zeta tubulin, putative 0.0684 0.2308 0.2303
Echinococcus granulosus Smad4 0.0059 0.0154 0.0147
Echinococcus multilocularis tubulin delta chain 0.0684 0.2308 0.2303
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0427 0.0421
Loa Loa (eye worm) thymidylate synthase 0.0105 0.0314 0.0314
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Echinococcus multilocularis CREB binding protein 0.0016 0.0007 0.0001
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0099 0.4635
Brugia malayi nuclear receptor RXR 0.005 0.0124 0.0124
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.021 0.0884
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0106 0.0106
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0073 0.0288
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0093 0.0086
Trichomonas vaginalis tubulin alpha chain, putative 0.0891 0.3023 0.3022
Loa Loa (eye worm) hypothetical protein 0.1265 0.4313 0.4313
Loa Loa (eye worm) hypothetical protein 0.0075 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Brugia malayi mothers against decapentaplegic homolog 3 0.0026 0.0042 0.0042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0101 0.01
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Brugia malayi MH2 domain containing protein 0.0059 0.0154 0.0154
Trypanosoma brucei alpha tubulin 0.2156 0.7385 0.7383
Trypanosoma cruzi tubulin delta chain 0.0684 0.2308 0.2303
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0684 0.2308 0.2303
Echinococcus granulosus cpg binding protein 0.003 0.0054 0.0047
Onchocerca volvulus 0.0041 0.0093 0.0244
Loa Loa (eye worm) tubulin gamma chain 0.1574 0.538 0.538
Echinococcus multilocularis tubulin alpha chain 0.2156 0.7385 0.7383
Brugia malayi Tubulin alpha-2 chain 0.2156 0.7385 0.7385
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0018 0.0013 0.0013
Echinococcus granulosus lamin dm0 0.0026 0.0042 0.0036
Brugia malayi hypothetical protein 0.005 0.0124 0.0124
Trichomonas vaginalis tubulin beta chain, putative 0.2156 0.7385 0.7385
Echinococcus multilocularis tubulin alpha 3 chain 0.2156 0.7385 0.7383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0435 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.0279 0.0279
Onchocerca volvulus 0.0035 0.0073 0.0178
Brugia malayi Tubulin alpha chain 0.0684 0.2308 0.2308
Brugia malayi tubulin alpha-2 chain 0.2156 0.7385 0.7385
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0083 0.0077
Echinococcus granulosus peroxisome assembly protein 26 0.2156 0.7385 0.7383
Trichomonas vaginalis tubulin beta chain, putative 0.2156 0.7385 0.7385
Trypanosoma brucei alpha tubulin 0.2156 0.7385 0.7383
Brugia malayi tailless protein 0.0045 0.0106 0.0106
Brugia malayi Pre-SET motif family protein 0.003 0.0054 0.0054
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.0279 0.0864
Echinococcus multilocularis chromobox protein 1 0.0068 0.0187 0.018
Schistosoma mansoni smad 0.0059 0.0154 0.0147
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0018 0.0013 0.0006
Treponema pallidum cell division protein FtsZ 0.0684 0.2308 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0279 0.0279
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0062 0.0166 0.0159
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0007 0.0007
Echinococcus granulosus smad 0.0059 0.0154 0.0147
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0013 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0015 0.0008
Schistosoma mansoni CREB-binding protein 2 0.0103 0.0306 0.0299
Echinococcus granulosus FTZ F1 alpha 0.0095 0.0279 0.0273
Echinococcus granulosus tubulin alpha 3 chain 0.2156 0.7385 0.7383
Trichomonas vaginalis tubulin epsilon chain, putative 0.2156 0.7385 0.7385
Brugia malayi 6-phosphofructokinase 0.0106 0.0318 0.0318
Schistosoma mansoni chromobox protein 0.0068 0.0187 0.018
Echinococcus multilocularis tubulin alpha 1C chain 0.2156 0.7385 0.7383
Mycobacterium ulcerans beta-lactamase 0.0035 0.0073 0.0288
Loa Loa (eye worm) p25-alpha family protein 0.0358 0.1187 0.1187
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0073 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0435 0.0428
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0099 0.0378
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0101 0.0095
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1265 0.4313 0.4312
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0124
Brugia malayi 6-phosphofructokinase 0.0106 0.0318 0.0318
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0106 0.0099
Plasmodium falciparum flap endonuclease 1 0.0026 0.0039 0.0033
Trypanosoma brucei epsilon tubulin 0.1574 0.538 0.5377
Brugia malayi hypothetical protein 0.005 0.0124 0.0124
Toxoplasma gondii isocitrate dehydrogenase 0.0146 0.0456 0.045
Trichomonas vaginalis DNA topoisomerase II, putative 0.0062 0.0166 0.0164
Echinococcus multilocularis CREB binding protein 0.0072 0.0198 0.0192
Loa Loa (eye worm) hypothetical protein 0.0042 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0279 0.0279
Echinococcus multilocularis tubulin epsilon chain 0.1574 0.538 0.5377
Echinococcus multilocularis CREB binding protein 0.0016 0.0007 0.0001
Schistosoma mansoni Smad4 0.0026 0.0042 0.0035
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0062 0.0166 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0083 0.0082
Toxoplasma gondii ABC1 family protein 0.0035 0.0073 0.0066
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0106 0.0099
Brugia malayi PAS domain containing protein 0.0048 0.0116 0.0116
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0106 0.0106
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0101 0.0095
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0073 0.0288
Loa Loa (eye worm) glutathione reductase 0.0046 0.0111 0.0111
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0029 0.0029
Schistosoma mansoni transcription factor LCR-F1 0.0257 0.0838 0.0832
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0106 0.0099
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0101 0.0095
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0062 0.0166 0.0166
Echinococcus granulosus tubulin alpha 3 chain 0.2156 0.7385 0.7383
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0257 0.0838 0.0826
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0105 0.0314 0.1336
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0124
Echinococcus granulosus flap endonuclease 1 0.0026 0.0039 0.0033
Plasmodium falciparum tubulin gamma chain 0.1574 0.538 0.5377
Echinococcus granulosus thymidylate synthase 0.0105 0.0314 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.0279 0.0279
Trypanosoma brucei zeta tubulin 0.0684 0.2308 0.2303
Trichomonas vaginalis conserved hypothetical protein 0.0684 0.2308 0.2307
Plasmodium falciparum tubulin epsilon chain, putative 0.1574 0.538 0.5377
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0318 0.0312
Brugia malayi hypothetical protein 0.0065 0.0174 0.0174
Echinococcus granulosus tubulin subunit TubB 0.2156 0.7385 0.7383
Onchocerca volvulus Bile acid receptor homolog 0.0095 0.0279 0.0864
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0012 0.001
Schistosoma mansoni DNA topoisomerase II 0.0062 0.0166 0.0159
Mycobacterium ulcerans hypothetical protein 0.0035 0.0073 0.0288
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0042 0.0042
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0015 0.0015
Brugia malayi beta-lactamase family protein 0.0035 0.0073 0.0073
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0106 0.0099
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0039 0.0033
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0018 0.0013 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0073 0.0071
Trichomonas vaginalis esterase, putative 0.0035 0.0073 0.0071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0054 0.0048
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0439 0.0432
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.005 0.2274
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Leishmania major mitochondrial DNA topoisomerase II 0.0049 0.012 0.0113
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0007 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0124 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0435 0.0428
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Leishmania major DNA topoisomerase ii 0.0056 0.0144 0.0138
Echinococcus granulosus neuropeptide s receptor 0.0457 0.1526 0.1521
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0071 0.0195 0.0188
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0099 0.0093
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0015 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0054 0.0048
Schistosoma mansoni tubulin subunit beta 0.0684 0.2308 0.2303
Loa Loa (eye worm) transcription factor SMAD2 0.0862 0.2924 0.2924
Brugia malayi photoreceptor-specific nuclear receptor 0.0095 0.0279 0.0279
Trichomonas vaginalis tubulin beta chain, putative 0.2156 0.7385 0.7385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Mycobacterium tuberculosis Probable reductase 0.0106 0.0315 0.1342
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0376 0.037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.0279 0.0273
Echinococcus granulosus mothers against decapentaplegic 5 0.0059 0.0154 0.0147
Trichomonas vaginalis tubulin epsilon chain, putative 0.2156 0.7385 0.7385
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0447 0.0447
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.0279 0.0273
Echinococcus granulosus tubulin epsilon chain 0.1574 0.538 0.5377
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.021 0.0204
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Schistosoma mansoni jun-related protein 0.0067 0.0182 0.0175
Plasmodium falciparum tubulin delta chain, putative 0.0684 0.2308 0.2303
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0318 0.0317
Leishmania major zeta tubulin, putative 0.0684 0.2308 0.2303
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0056 0.0144 0.0138
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.1526 0.1521
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0111 0.0111
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0062 0.0166 0.0159
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0318 0.0312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.021 0.021
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0049
Brugia malayi MH1 domain containing protein 0.0059 0.0154 0.0154
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.0279 0.0273
Echinococcus multilocularis smad 0.0059 0.0154 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0073 0.0071
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0015 0.0036
Trypanosoma brucei trypanothione reductase 0.0046 0.0111 0.0104
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0018 0.0013 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0093 0.0092
Brugia malayi Cytochrome P450 family protein 0.0051 0.0128 0.0128
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0015 0.0015
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0039 0.0033
Brugia malayi Probable isocitrate dehydrogenase 0.0018 0.0013 0.0013
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0073 0.0073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.0279 0.0273
Brugia malayi tubulin alpha chain - mouse 0.2156 0.7385 0.7385
Schistosoma mansoni thyroid hormone receptor 0.0218 0.0704 0.0698
Echinococcus granulosus single minded 2 0.0035 0.0073 0.0066
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0073 0.0288
Leishmania major epsilon tubulin, putative 0.1574 0.538 0.5377
Echinococcus granulosus tubulin alpha chain 0.2156 0.7385 0.7383
Schistosoma mansoni intermediate filament proteins 0.0026 0.0042 0.0036
Schistosoma mansoni smad 0.0026 0.0042 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0435 0.0428
Echinococcus multilocularis Tubulin alpha 1 chain 0.2156 0.7385 0.7383
Brugia malayi Tubulin alpha-2 chain 0.2156 0.7385 0.7385
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0257 0.0838 0.0832
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0059 0.0154 0.0147
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0039 0.0033
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0029 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0435 0.0428
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0376 0.037
Mycobacterium tuberculosis Conserved protein 0.0035 0.0073 0.0288
Onchocerca volvulus 0.0045 0.0106 0.0288
Onchocerca volvulus 0.0065 0.0174 0.0515
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0015 0.0002
Brugia malayi ecdysteroid receptor 0.0095 0.0279 0.0279
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.021 0.0204
Entamoeba histolytica DNA topoisomerase II, putative 0.0062 0.0166 0.0154
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0117 0.0111
Plasmodium falciparum thioredoxin reductase 0.0046 0.0111 0.0104
Brugia malayi phosphofructokinase 0.0106 0.0318 0.0318
Onchocerca volvulus 0.0891 0.3023 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0318 0.1332
Echinococcus granulosus CREB binding protein 0.0016 0.0007 0.0001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0106 0.0106
Brugia malayi hypothetical protein 0.0257 0.0838 0.0838
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0728 0.3135
Plasmodium falciparum ataxin-2 like protein, putative 0.0157 0.0494 0.0488
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0015 0.0013
Trypanosoma cruzi DNA topoisomerase II, putative 0.0056 0.0144 0.0138
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0073 0.0288
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.005 0.0044
Trypanosoma brucei zeta tubulin, putative 0.0684 0.2308 0.2303
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0012 0.001
Entamoeba histolytica tubulin alpha-1 chain 0.2156 0.7385 0.7382
Leishmania major gamma-tubulin 0.1574 0.538 0.5377
Echinococcus granulosus tubulin alpha 1C chain 0.2156 0.7385 0.7383
Brugia malayi hypothetical protein 0.0102 0.0302 0.0302
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0039 0.0033
Brugia malayi steroid hormone receptor 0.0095 0.0279 0.0279
Schistosoma mansoni Smad4 0.0026 0.0042 0.0035
Leishmania major hypothetical protein, conserved 0.0035 0.0073 0.0066
Echinococcus granulosus jun protein 0.0082 0.0235 0.0228
Schistosoma mansoni alpha tubulin 0.2156 0.7385 0.7383
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0054 0.0048
Loa Loa (eye worm) pax transcription factor protein 2 0.0738 0.2495 0.2495
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0015 0.0036
Brugia malayi chromobox protein homolog 3 0.0038 0.0083 0.0083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0435 0.0435
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.1526 0.1521
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0279 0.0279
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0318 0.1354
Echinococcus multilocularis tubulin alpha 0.1574 0.538 0.5377
Mycobacterium ulcerans cell division protein FtsZ 0.0684 0.2308 1
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0124 0.0122
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0029 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0124 0.0124
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0029 0.0022
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0106 0.0106
Schistosoma mansoni tubulin subunit alpha 0.2156 0.7385 0.7383
Trypanosoma brucei DNA topoisomerase ii 0.0049 0.012 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0279 0.0279
Echinococcus granulosus muscleblind protein 0.0146 0.0456 0.0449
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0099 0.0099
Echinococcus multilocularis tubulin alpha 1C chain 0.2156 0.7385 0.7383
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0684 0.2308 1
Schistosoma mansoni hypothetical protein 0.0051 0.0126 0.0119
Onchocerca volvulus 0.0035 0.0073 0.0178
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0315 0.1342
Onchocerca volvulus 0.0026 0.0042 0.0077
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0073 0.0073
Loa Loa (eye worm) tubulin alpha 2 0.1472 0.5028 0.5028
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1472 0.5028 0.5028
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0008
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0099 0.0093
Brugia malayi hypothetical protein 0.0157 0.0494 0.0494
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0146 0.0456 0.045
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0099 0.0099
Brugia malayi MH2 domain containing protein 0.0026 0.0042 0.0042
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0318 0.0312
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0045 0.0107 0.0291
Schistosoma mansoni hypothetical protein 0.157 0.5364 0.5361
Loa Loa (eye worm) hypothetical protein 0.0048 0.0118 0.0118
Brugia malayi hypoxia-induced factor 1 0.0147 0.046 0.046
Plasmodium vivax SET domain protein, putative 0.003 0.0054 0.0048
Brugia malayi beta-lactamase family protein 0.0035 0.0073 0.0073
Brugia malayi alpha-tubulin 0.2156 0.7385 0.7385
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0106 0.0099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.0279 0.0273
Mycobacterium ulcerans hypothetical protein 0.002 0.0019 0.0055
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0356 0.1519
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Brugia malayi MH1 domain containing protein 0.0059 0.0154 0.0154
Loa Loa (eye worm) TOPoisomerase family member 0.0062 0.0166 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0218 0.0704 0.0698
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.0279 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0055
Brugia malayi hypothetical protein 0.0045 0.0106 0.0106
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0157 0.015
Trypanosoma brucei alpha tubulin 0.2156 0.7385 0.7383
Brugia malayi TAZ zinc finger family protein 0.0103 0.0306 0.0306
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.005 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0279 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0073 0.0071
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0039 0.0033
Entamoeba histolytica tubulin alpha chain, putative 0.2156 0.7385 0.7382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0279 0.0273
Brugia malayi nuclear hormone receptor 0.0045 0.0106 0.0106
Schistosoma mansoni tubulin subunit epsilon 0.1574 0.538 0.5377
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.005 0.2274
Giardia lamblia Alpha-tubulin 0.2156 0.7385 0.7383
Toxoplasma gondii alpha tubulin TUBA1 0.2156 0.7385 0.7383
Schistosoma mansoni alpha tubulin 0.2156 0.7385 0.7383
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.0279 0.0273
Trichomonas vaginalis tubulin gamma chain, putative 0.1574 0.538 0.5379
Echinococcus multilocularis chromobox protein 1 0.0068 0.0187 0.018
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0022 0.0015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0111 0.0453
Loa Loa (eye worm) hypothetical protein 0.0146 0.0456 0.0456
Schistosoma mansoni tubulin subunit gamma 0.1574 0.538 0.5377
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0111 0.0104
Echinococcus multilocularis musashi 0.0026 0.0042 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.0279 0.0279
Echinococcus granulosus tumor protein p63 0.0331 0.1092 0.1087
Loa Loa (eye worm) MH2 domain-containing protein 0.0862 0.2924 0.2924
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0042 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0656 0.0656
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0106 0.0106
Brugia malayi isocitrate dehydrogenase 0.0146 0.0456 0.0456
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0315 0.1342
Trichomonas vaginalis tubulin alpha chain, putative 0.0891 0.3023 0.3022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0315 0.1342
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.0279 0.0279
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0257 0.0838 0.0832
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0106 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0318 0.0317
Brugia malayi hypothetical protein 0.0045 0.0106 0.0106
Echinococcus multilocularis Tubulin alpha 1 chain 0.2156 0.7385 0.7383
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0161 0.0154
Trypanosoma cruzi tubulin delta chain 0.0684 0.2308 0.2303
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0106 0.0106
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0101 0.0095
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.0279 0.0273
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0106 0.0099
Trichomonas vaginalis tubulin, putative 0.0891 0.3023 0.3022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.0279 0.0279
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1472 0.5028 0.5027
Echinococcus multilocularis cpg binding protein 0.003 0.0054 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.0279 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.0279 0.0279
Toxoplasma gondii endonuclease IV APN 0.0075 0.021 0.0204
Trypanosoma brucei tubulin gamma chain 0.1574 0.538 0.5377
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0042
Brugia malayi MH1 domain containing protein 0.0032 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0123 0.0376 0.037
Onchocerca volvulus 0.0105 0.0314 0.0981
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0148 0.0462 0.0456
Plasmodium falciparum glutathione reductase 0.0046 0.0111 0.0104
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.002 0.0022 0.0066
Trichomonas vaginalis tubulin beta chain, putative 0.2156 0.7385 0.7385
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.0008
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.005 0.0044
Trichomonas vaginalis tubulin gamma chain, putative 0.0684 0.2308 0.2307
Echinococcus multilocularis hypothetical protein 0.2156 0.7385 0.7383
Brugia malayi Thioredoxin reductase 0.0046 0.0111 0.0111
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0749 0.0749
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0039 0.0038
Trypanosoma cruzi epsilon tubulin, putative 0.1574 0.538 0.5377
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0148 0.0462 0.0456
Echinococcus multilocularis tubulin alpha 3 chain 0.2156 0.7385 0.7383
Onchocerca volvulus TPPP family protein homolog 0.0358 0.1187 0.3888
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0039 0.0027
Echinococcus multilocularis jun protein 0.0082 0.0235 0.0228
Loa Loa (eye worm) tubulin beta chain 0.0684 0.2308 0.2308
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Echinococcus multilocularis lamin 0.0026 0.0042 0.0036
Schistosoma mansoni isocitrate dehydrogenase 0.0018 0.0013 0.0006
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0083 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0073 0.0071
Schistosoma mansoni chromobox protein 0.0068 0.0187 0.018
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.002 0.0022 0.0066
Schistosoma mansoni nuclear receptor 0.0045 0.0106 0.0099
Brugia malayi Tubulin alpha chain 0.2156 0.7385 0.7385
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0093 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0157 0.0494 0.0488
Chlamydia trachomatis DNA gyrase subunit B 0.002 0.0022 0.0892
Mycobacterium ulcerans lipase LipD 0.0035 0.0073 0.0288
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0099 0.0093
Brugia malayi Probable DNA topoisomerase II 0.0062 0.0166 0.0166
Plasmodium vivax glutathione reductase, putative 0.0046 0.0111 0.0104
Trypanosoma brucei tubulin delta chain 0.0684 0.2308 0.2303
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0318 0.0318
Plasmodium vivax tubulin epsilon chain, putative 0.1574 0.538 0.5377
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.0279 0.0273
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0018 0.0013 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0146 0.0456 0.045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Onchocerca volvulus 0.0036 0.0075 0.0184
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0753 0.0752
Echinococcus granulosus tubulin delta chain 0.0684 0.2308 0.2303
Trichomonas vaginalis conserved hypothetical protein 0.0684 0.2308 0.2307
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0073 0.0263
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0192 0.0612 0.0606
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Trypanosoma cruzi zeta tubulin, putative 0.0684 0.2308 0.2303
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.1526 0.1521
Schistosoma mansoni coup transcription factor 0.0095 0.0279 0.0273
Brugia malayi Cytochrome P450 family protein 0.0022 0.0029 0.0029
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0073 0.0288
Echinococcus multilocularis isocitrate dehydrogenase 0.0146 0.0456 0.045
Brugia malayi beta-lactamase 0.0035 0.0073 0.0073
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.0279 0.0273
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.0279 0.0273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0235 0.0228
Echinococcus multilocularis mothers against decapentaplegic 5 0.0059 0.0154 0.0147
Trichomonas vaginalis tubulin, putative 0.0684 0.2308 0.2307
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0083
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0146 0.0456 0.0456
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0124 0.0118
Brugia malayi Pax transcription factor protein 2 0.0738 0.2495 0.2495
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0083 0.0071
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0073 0.0066
Schistosoma mansoni retinoic acid receptor RXR 0.0192 0.0612 0.0606
Leishmania major hypothetical protein, conserved 0.0157 0.0494 0.0488
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0146 0.0456 0.045
Schistosoma mansoni tubulin subunit alpha 0.2156 0.7385 0.7383
Plasmodium falciparum alpha tubulin 1 0.2156 0.7385 0.7383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0046
Schistosoma mansoni flap endonuclease-1 0.0023 0.0031 0.0024
Loa Loa (eye worm) tubulin alpha chain 0.2156 0.7385 0.7385
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0111 0.0104
Mycobacterium tuberculosis Conserved protein 0.0035 0.0073 0.0288
Brugia malayi thymidylate synthase 0.0105 0.0314 0.0314
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0073 0.0066
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0054
Trichomonas vaginalis tubulin epsilon chain, putative 0.0684 0.2308 0.2307
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.012 0.0113
Mycobacterium leprae conserved hypothetical protein 0.002 0.0019 0.003
Onchocerca volvulus 0.003 0.0055 0.0118
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.0279 0.0273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0435 0.0428
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0146 0.0456 0.045
Giardia lamblia Gamma tubulin 0.1574 0.538 0.5377
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0146 0.0456 0.045
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0059 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.0279 0.0279
Echinococcus granulosus tubulin alpha 1C chain 0.2156 0.7385 0.7383
Echinococcus multilocularis thyroid hormone receptor alpha 0.0218 0.0704 0.0698
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0235 0.0228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0435 0.0435
Leishmania major isocitrate dehydrogenase, putative 0.0018 0.0013 0.0006
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0022 0.0015
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0073 0.0288
Echinococcus multilocularis transcription factor eb 0.0106 0.0316 0.0309
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0018 0.0013 0.0013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0315 0.1342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0279 0.0273
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0106 0.0099
Echinococcus granulosus tubulin alpha 0.1574 0.538 0.5377
Echinococcus granulosus transcription factor eb 0.0106 0.0316 0.0309
Brugia malayi nuclear hormone receptor 0.0095 0.0279 0.0279
Brugia malayi intermediate filament protein 0.0026 0.0042 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0054 0.0048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0042 0.0042
Schistosoma mansoni Smad4 0.0059 0.0154 0.0147
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Echinococcus granulosus tubulin gamma 1 chain 0.1574 0.538 0.5377
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0315 0.1342
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0073 0.0066
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0146 0.0456 0.045
Loa Loa (eye worm) tubulin alpha 2 0.1472 0.5028 0.5028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0073 0.0066
Echinococcus multilocularis mothers against decapentaplegic 2 0.0026 0.0042 0.0035
Trypanosoma brucei epsilon tubulin 0.1574 0.538 0.5377
Brugia malayi Dihydrofolate reductase 0.0043 0.0099 0.0099
Plasmodium vivax tubulin alpha chain, putative 0.2156 0.7385 0.7383
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0318 0.0306
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.005 0.0044
Brugia malayi nuclear receptor NHR-88 0.0095 0.0279 0.0279
Schistosoma mansoni tubulin subunit alpha 0.2156 0.7385 0.7383
Mycobacterium ulcerans DNA gyrase subunit B 0.002 0.0022 0.0066
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0684 0.2308 0.2307
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.2156 0.7385 0.7385
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0124 0.0118
Brugia malayi nuclear receptor NHR-88 0.0045 0.0106 0.0106
Giardia lamblia Delta tubulin 0.0684 0.2308 0.2303
Trypanosoma brucei beta tubulin 0.1574 0.538 0.5377
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0018 0.0013 0.0026
Echinococcus granulosus mothers against decapentaplegic 2 0.0026 0.0042 0.0035
Echinococcus granulosus mothers against decapentaplegic 6 0.0026 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0045 0.0106 0.0106
Brugia malayi bZIP transcription factor family protein 0.0082 0.0235 0.0235
Echinococcus multilocularis Tubulin alpha 1 chain 0.2156 0.7385 0.7383
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0111 0.0104
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0891 0.3023 0.3022
Schistosoma mansoni hypothetical protein 0.0067 0.0182 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0073 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0435 0.0428
Echinococcus multilocularis tubulin alpha chain 0.2156 0.7385 0.7383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0046
Echinococcus multilocularis tubulin alpha chain 0.2156 0.7385 0.7383
Schistosoma mansoni smad1 5 8 and 0.0059 0.0154 0.0147
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0118 0.0112
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0106 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.0279 0.0273
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0187 0.0185
Brugia malayi hypothetical protein 0.0163 0.0514 0.0514
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0019 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0045 0.0043
Entamoeba histolytica hypothetical protein 0.0257 0.0838 0.0826
Trichomonas vaginalis tubulin beta chain, putative 0.0891 0.3023 0.3022
Schistosoma mansoni hypothetical protein 0.157 0.5364 0.5361
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0029 0.0096
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0056 0.0144 0.0138
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0148 0.0462 0.0456
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1574 0.538 0.5377
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0148 0.0462 0.0456
Mycobacterium tuberculosis Cell division protein FtsZ 0.0684 0.2308 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0073 0.0288
Leishmania major alpha tubulin 0.2156 0.7385 0.7383
Brugia malayi Muscleblind-like protein 0.0146 0.0456 0.0456
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.0279 0.0273
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0045 0.0107 0.0291
Loa Loa (eye worm) tubulin alpha-3 chain 0.1265 0.4313 0.4313
Echinococcus granulosus intermediate filament protein 0.0026 0.0042 0.0036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0124 0.0118
Leishmania major trypanothione reductase 0.0046 0.0111 0.0104
Echinococcus multilocularis CREB binding protein 0.0016 0.0007 0.0001
Brugia malayi Cytochrome P450 family protein 0.0022 0.0029 0.0029
Onchocerca volvulus 0.0026 0.0042 0.0077
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0124 0.0124
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0106 0.0106
Echinococcus granulosus tubulin alpha chain 0.2156 0.7385 0.7383
Entamoeba histolytica hypothetical protein 0.0257 0.0838 0.0826
Giardia lamblia DNA topoisomerase II 0.0059 0.0156 0.015
Brugia malayi CXXC zinc finger family protein 0.0028 0.0048 0.0048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0015 0.0008
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0684 0.2308 0.2303
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0026 0.0042 0.0075
Loa Loa (eye worm) hypothetical protein 0.0095 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0105 0.0314 0.0314
Loa Loa (eye worm) beta-lactamase 0.0035 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.0279 0.0279
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0318 0.1354
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0018 0.0013 0.0013
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0124
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0068 0.3111
Echinococcus granulosus chromobox protein 1 0.0068 0.0187 0.018
Loa Loa (eye worm) DR-78 0.0045 0.0106 0.0106
Trypanosoma cruzi epsilon tubulin, putative 0.1574 0.538 0.5377
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0315 0.132
Onchocerca volvulus 0.0045 0.0106 0.0288
Loa Loa (eye worm) hypothetical protein 0.1472 0.5028 0.5028
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0106 0.0099
Echinococcus multilocularis tubulin alpha chain 0.2156 0.7385 0.7383
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0073 0.0288
Trichomonas vaginalis tubulin, putative 0.0891 0.3023 0.3022
Leishmania major delta tubulin, putative 0.0684 0.2308 0.2303
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0105 0.0314 0.0314
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0146 0.0456 0.045
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0018 0.0013 0.0011
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0146 0.0456 0.045
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0749 0.0749
Schistosoma mansoni hypothetical protein 0.0257 0.0838 0.0832
Echinococcus multilocularis muscleblind protein 0.0146 0.0456 0.0449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.0279 0.0279
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0012 0.001
Loa Loa (eye worm) tubulin alpha chain 0.2156 0.7385 0.7385
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0073 0.0066
Trichomonas vaginalis tubulin alpha chain, putative 0.1574 0.538 0.5379
Loa Loa (eye worm) hypothetical protein 0.016 0.0502 0.0502
Echinococcus granulosus Tubulin alpha 1 chain 0.2156 0.7385 0.7383
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0019 0.0055
Trichomonas vaginalis tubulin beta chain, putative 0.2156 0.7385 0.7385
Loa Loa (eye worm) nuclear factor I 0.0032 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0146 0.0456 0.0456
Schistosoma mansoni lamin 0.0026 0.0042 0.0036
Schistosoma mansoni tubulin subunit alpha 0.0684 0.2308 0.2303
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0049
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0318 0.0306
Echinococcus multilocularis thymidylate synthase 0.0105 0.0314 0.0308
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0318 0.0306
Brugia malayi Probable isocitrate dehydrogenase 0.0018 0.0013 0.0013
Brugia malayi Cell division protein ftsZ 0.0684 0.2308 0.2308
Trichomonas vaginalis tubulin beta chain, putative 0.2156 0.7385 0.7385
Toxoplasma gondii thioredoxin reductase 0.0046 0.0111 0.0104
Entamoeba histolytica tubulin gamma chain 0.1574 0.538 0.5374
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0073 0.0288
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0318 0.0317
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0318 0.1354
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0146 0.0456 0.045
Trypanosoma brucei alpha tubulin, putative 0.0891 0.3023 0.3018

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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