Detailed information for compound 1405378

Basic information

Technical information
  • TDR Targets ID: 1405378
  • Name: N-[[5-[2-[(5-chloro-2-methylphenyl)amino]-2-o xoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]m ethyl]thiophene-2-carboxamide
  • MW: 449.977 | Formula: C19H20ClN5O2S2
  • H donors: 2 H acceptors: 4 LogP: 3.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(SCC(=O)Nc2cc(Cl)ccc2C)nnc1CNC(=O)c1cccs1
  • InChi: 1S/C19H20ClN5O2S2/c1-3-25-16(10-21-18(27)15-5-4-8-28-15)23-24-19(25)29-11-17(26)22-14-9-13(20)7-6-12(14)2/h4-9H,3,10-11H2,1-2H3,(H,21,27)(H,22,26)
  • InChiKey: XBEMLJPKVTUDRT-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[[5-[2-[(5-chloro-2-methyl-phenyl)amino]-2-oxo-ethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]methyl]thiophene-2-carboxamide
  • N-[[5-[[2-[(5-chloro-2-methylphenyl)amino]-2-oxoethyl]thio]-4-ethyl-1,2,4-triazol-3-yl]methyl]-2-thiophenecarboxamide
  • N-[[5-[[2-[(5-chloro-2-methyl-phenyl)amino]-2-keto-ethyl]thio]-4-ethyl-1,2,4-triazol-3-yl]methyl]thiophene-2-carboxamide
  • ZINC02861002
  • MLS000537765
  • N-{[5-({2-[(5-chloro-2-methylphenyl)amino]-2-oxoethyl}thio)-4-ethyl-4H-1,2,4-triazol-3-yl]methyl}-2-thiophenecarboxamide
  • SMR000144003

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum 3D7 M1-family aminopeptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Toxoplasma gondii aminopeptidase N protein Get druggable targets OG5_130542 All targets in OG5_130542
Cryptosporidium parvum zincin/aminopeptidase N like metalloprotease Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium berghei M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Toxoplasma gondii aminopeptidase n, putative Get druggable targets OG5_130542 All targets in OG5_130542
Neospora caninum Aminopeptidase N (EC 3.4.11.2), related Get druggable targets OG5_130542 All targets in OG5_130542
Toxoplasma gondii aminopeptidase N, putative Get druggable targets OG5_130542 All targets in OG5_130542
Babesia bovis aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Theileria parva alpha-aminoacylpeptide hydrolase, putative Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium falciparum M1-family alanyl aminopeptidase Get druggable targets OG5_130542 All targets in OG5_130542
Cryptosporidium hominis aminopeptidase N Get druggable targets OG5_130542 All targets in OG5_130542
Neospora caninum hypothetical protein Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium yoelii m1-family aminopeptidase Get druggable targets OG5_130542 All targets in OG5_130542
Plasmodium vivax M1-family alanyl aminopeptidase, putative Get druggable targets OG5_130542 All targets in OG5_130542

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Leishmania major isocitrate dehydrogenase, putative 0.003 0.003 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0109 0.0229 0.0229
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0109 0.0229 0.0229
Trypanosoma cruzi tubulin delta chain 0.093 0.2287 0.2287
Trichomonas vaginalis tubulin beta chain, putative 0.2922 0.7283 0.7283
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0544 0.1319 0.1319
Trichomonas vaginalis tubulin, putative 0.1212 0.2994 0.2993
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor 0.0047 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0089 0.0089
Entamoeba histolytica tartrate dehydrogenase, putative 0.003 0.003 0.0028
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0246 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0033 0.0038 0.0038
Plasmodium falciparum thioredoxin reductase 0.0048 0.0076 0.0067
Brugia malayi Thioredoxin reductase 0.0048 0.0076 0.0076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0109 0.0229 0.0229
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0075 0.0144 0.0144
Trichomonas vaginalis tubulin beta chain, putative 0.2922 0.7283 0.7283
Brugia malayi nuclear receptor NHR-88 0.0109 0.0229 0.0229
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0133 0.0132
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0016 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0029 0.0029
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0016 0.0016
Schistosoma mansoni histone deacetylase hda2 0.0189 0.0429 0.0429
Plasmodium falciparum tubulin gamma chain 0.2141 0.5326 0.5322
Schistosoma mansoni alpha tubulin 0.2922 0.7283 0.7283
Plasmodium falciparum tubulin epsilon chain, putative 0.2141 0.5326 0.5322
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0106 0.0222 0.0222
Plasmodium falciparum histone deacetylase, putative 0.0299 0.0704 0.0696
Entamoeba histolytica histone deacetylase, putative 0.0544 0.1319 0.1317
Loa Loa (eye worm) tubulin gamma chain 0.2141 0.5326 0.5326
Schistosoma mansoni tubulin subunit beta 0.093 0.2287 0.2287
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0016 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0109 0.0229 0.0229
Echinococcus granulosus smad 0.0101 0.021 0.021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0109 0.0229 0.0229
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0016 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0033 0.0033
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1212 0.2994 0.2993
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0001 0.0001
Echinococcus multilocularis histone deacetylase 6 0.0323 0.0765 0.0765
Trichomonas vaginalis tubulin beta chain, putative 0.2922 0.7283 0.7283
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Trypanosoma brucei alpha tubulin 0.2922 0.7283 0.7283
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0446 0.1074 0.1073
Loa Loa (eye worm) hypothetical protein 0.0063 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0016 0.0015
Echinococcus granulosus cpg binding protein 0.0031 0.0033 0.0033
Brugia malayi 6-phosphofructokinase 0.011 0.0232 0.0232
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0024 0.0016 0.0007
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0022 0.0022
Giardia lamblia Hypothetical protein 0.0024 0.0016 0.0014
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.1144 0.1144
Echinococcus granulosus histone deacetylase 6 0.0299 0.0704 0.0704
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0151 0.0142
Echinococcus granulosus histone deacetylase 6 0.0299 0.0704 0.0704
Brugia malayi nuclear receptor RXR 0.0063 0.0112 0.0112
Loa Loa (eye worm) alpha-tubulin 0.2922 0.7283 0.7283
Plasmodium falciparum tubulin delta chain, putative 0.093 0.2287 0.2281
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.003 0.003
Echinococcus multilocularis musashi 0.0053 0.0089 0.0089
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0069 0.0069
Loa Loa (eye worm) DR-78 0.0047 0.0072 0.0072
Trypanosoma cruzi histone deacetylase, putative 0.0299 0.0704 0.0704
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0047 0.0206
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0001 0.0001
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0154 0.0341 0.0341
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0276 0.0276
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0069 0.0069
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0001 0.0001
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0047 0.0047
Echinococcus granulosus tubulin delta chain 0.093 0.2287 0.2287
Trypanosoma cruzi alpha tubulin, putative 0.2922 0.7283 0.7283
Brugia malayi tubulin alpha chain - mouse 0.2922 0.7283 0.7283
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0246 0.0572 0.0572
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.023 0.1007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0072 0.0236
Echinococcus granulosus alpha tubulin 0.2922 0.7283 0.7283
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0112 0.0112
Brugia malayi Tubulin gamma chain 0.2141 0.5326 0.5326
Brugia malayi hypothetical protein 0.0316 0.0747 0.0747
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0065 0.0117 0.0117
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.003 0.003 0.003
Schistosoma mansoni flap endonuclease-1 0.0024 0.0015 0.0015
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0147 0.0323 0.0323
Schistosoma mansoni cpg binding protein 0.0031 0.0033 0.0033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0001 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.1489 0.369 0.369
Schistosoma mansoni cpg binding protein 0.0031 0.0033 0.0033
Trichomonas vaginalis brca1-associated protein, putative 0.0024 0.0016 0.0015
Echinococcus multilocularis histone deacetylase 8 0.0189 0.0429 0.0429
Schistosoma mansoni cpg binding protein 0.0029 0.0029 0.0029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0109 0.0229 0.0229
Echinococcus multilocularis nuclear receptor nhr 48 0.0047 0.0072 0.0072
Echinococcus granulosus neuropeptide s receptor 0.0474 0.1144 0.1144
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0049 0.0049
Brugia malayi Probable DNA topoisomerase II 0.0065 0.0117 0.0117
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.1144 0.1144
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0022 0.0013
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0154 0.0341 0.0341
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0375 0.0897 0.0889
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0083 0.0083
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0072 0.0072
Toxoplasma gondii histone deacetylase HDAC3 0.0544 0.1319 0.1319
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0232 0.023
Brugia malayi Steroid receptor seven-up type 2 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0083 0.0164 0.0164
Leishmania major DNA topoisomerase ii 0.0058 0.0101 0.0101
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Toxoplasma gondii aminopeptidase N protein 0.0375 0.0897 0.0897
Brugia malayi Tubulin alpha-2 chain 0.2922 0.7283 0.7283
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0291 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0109 0.0229 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0109 0.0229 0.0229
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0024 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0109 0.0229 0.0229
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0001 0.0001
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.023 0.1007
Brugia malayi hypothetical protein 0.0047 0.0072 0.0072
Trichomonas vaginalis tubulin, putative 0.093 0.2287 0.2286
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0002
Onchocerca volvulus 0.0098 0.0201 0.0668
Echinococcus multilocularis tumor protein p63 0.067 0.1635 0.1635
Schistosoma mansoni thyroid hormone receptor 0.0237 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.003 0.0028
Brugia malayi TAZ zinc finger family protein 0.011 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0001 0.0001
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0024 0.0016 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.0109 0.0229 0.0761
Echinococcus granulosus muscleblind protein 0.0296 0.0698 0.0698
Echinococcus granulosus dna polymerase eta 0.0019 0.0002 0.0002
Echinococcus granulosus tubulin alpha 1C chain 0.2922 0.7283 0.7283
Trypanosoma brucei histone deacetylase 1 0.0544 0.1319 0.1319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0109 0.0229 0.0229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0109 0.0229 0.0229
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0022 0.0022
Brugia malayi jmjC domain containing protein 0.0058 0.0102 0.0102
Trichomonas vaginalis esterase, putative 0.0037 0.0047 0.0046
Echinococcus granulosus thyroid hormone receptor alpha 0.0047 0.0072 0.0072
Brugia malayi Tubulin beta chain 0.093 0.2287 0.2287
Trypanosoma brucei alpha tubulin, putative 0.1212 0.2994 0.2994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.032 0.032
Schistosoma mansoni unc-13 (munc13) 0.003 0.003 0.003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0001 0.0001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.1516
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0065 0.0117 0.0117
Trichomonas vaginalis DNA topoisomerase II, putative 0.0065 0.0117 0.0116
Loa Loa (eye worm) acetyltransferase 0.0291 0.0685 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.032 0.032
Mycobacterium ulcerans thymidylate synthase 0.0109 0.0229 0.1002
Echinococcus multilocularis tubulin alpha chain 0.2922 0.7283 0.7283
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0069 0.0129 0.0129
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0047 0.0072 0.0072
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0024 0.0016 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0033 0.0033
Brugia malayi nuclear hormone receptor family member odr-7 0.0047 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0072 0.0072
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.003 0.003 0.0132
Brugia malayi nuclear hormone receptor 0.0047 0.0072 0.0072
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0022
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0076 0.0076
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0065 0.0117 0.0117
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0201 0.0201
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0098 0.0098
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0232 0.0982
Brugia malayi nuclear hormone receptor family member nhr-6 0.0047 0.0072 0.0072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0173 0.0172
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0101 0.0101
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.0067 0.4108
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Schistosoma mansoni histone deacetylase 0.0544 0.1319 0.1319
Echinococcus granulosus isocitrate dehydrogenase NAD 0.003 0.003 0.003
Schistosoma mansoni smad 0.0101 0.021 0.021
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0054
Giardia lamblia Gamma tubulin 0.2141 0.5326 0.5325
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0542 0.2369
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.011 0.0232 0.0232
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0246 0.0572 0.0572
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0109 0.0229 0.0229
Loa Loa (eye worm) alpha-tubulin 0.2922 0.7283 0.7283
Echinococcus multilocularis muscleblind protein 0.0296 0.0698 0.0698
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0098 0.0098
Giardia lamblia DNA topoisomerase II 0.0062 0.011 0.0108
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0119 0.0119
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.003 0.003 0.0095
Echinococcus granulosus histone deacetylase 7 0.0299 0.0704 0.0704
Trichomonas vaginalis tubulin gamma chain, putative 0.2141 0.5326 0.5326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.0229 0.0229
Trypanosoma brucei epsilon tubulin 0.2141 0.5326 0.5326
Brugia malayi hypothetical protein 0.0153 0.0339 0.0339
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0089 0.0089
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0016 0.0016
Schistosoma mansoni lamin 0.0053 0.0089 0.0089
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Echinococcus multilocularis thymidylate synthase 0.0109 0.0229 0.0229
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0001 0.0001
Toxoplasma gondii alpha-tubulin I, putative 0.2922 0.7283 0.7283
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0033 0.0038 0.0038
Echinococcus granulosus FTZ F1 alpha 0.0109 0.0229 0.0229
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0031 0.0033 0.0107
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Schistosoma mansoni histone deacetylase 1 2 3 0.0189 0.0429 0.0429
Echinococcus multilocularis Tubulin alpha 1 chain 0.2922 0.7283 0.7283
Echinococcus granulosus tubulin alpha chain 0.2922 0.7283 0.7283
Leishmania major mitochondrial DNA topoisomerase II 0.0051 0.0083 0.0083
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.0067 0.0293
Trypanosoma brucei zeta tubulin, putative 0.093 0.2287 0.2287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0102 0.0102
Schistosoma mansoni single-minded 0.0049 0.0079 0.0079
Loa Loa (eye worm) tubulin alpha-3 chain 0.171 0.4244 0.4244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0109 0.0229 0.0229
Schistosoma mansoni zinc finger protein 0.0047 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0056 0.0096 0.0096
Plasmodium falciparum flap endonuclease 1 0.0026 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.2922 0.7283 0.7283
Loa Loa (eye worm) tubulin alpha chain 0.2922 0.7283 0.7283
Schistosoma mansoni Smad4 0.0101 0.021 0.021
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Trichomonas vaginalis tubulin beta-1 chain, putative 0.093 0.2287 0.2286
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0246 0.0572 0.2501
Echinococcus multilocularis nAChR subunit 0.0018 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Brugia malayi hypothetical protein 0.0063 0.0112 0.0112
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0048 0.0076 0.0076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0488 0.0488
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0047 0.0206
Echinococcus granulosus chromobox protein 1 0.0071 0.0133 0.0133
Trichomonas vaginalis BRCA1-associated protein, putative 0.0024 0.0016 0.0015
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.032 0.032
Schistosoma mansoni jun-related protein 0.0069 0.0129 0.0129
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0002 0.0002
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0001 0.0001
Brugia malayi MH1 domain containing protein 0.0056 0.0096 0.0096
Trypanosoma brucei alpha tubulin 0.2922 0.7283 0.7283
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0151 0.0149
Onchocerca volvulus 0.0067 0.0123 0.0408
Entamoeba histolytica hypothetical protein 0.0446 0.1074 0.1073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0072 0.0072
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0109 0.0229 0.0229
Treponema pallidum cell division protein FtsZ 0.093 0.2287 1
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0047 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0102 0.0102
Trichomonas vaginalis tubulin alpha chain, putative 0.1212 0.2994 0.2993
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0001 0.0001
Schistosoma mansoni tubulin subunit gamma 0.2141 0.5326 0.5326
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0024 0.0016 0.0016
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.0067 0.0067
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0047 0.0072 0.0072
Brugia malayi acetyltransferase, GNAT family protein 0.0291 0.0685 0.0685
Toxoplasma gondii aminopeptidase N, putative 0.0375 0.0897 0.0897
Echinococcus multilocularis thyroid hormone receptor alpha 0.0237 0.055 0.055
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0047 0.0038
Trichomonas vaginalis tubulin beta chain, putative 0.2922 0.7283 0.7283
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0049 0.0047
Brugia malayi bZIP transcription factor family protein 0.0085 0.0169 0.0169
Mycobacterium ulcerans epimerase 0.002 0.0007 0.0029
Loa Loa (eye worm) p25-alpha family protein 0.0372 0.0888 0.0888
Echinococcus multilocularis BRCA1 associated protein 0.0024 0.0016 0.0016
Echinococcus multilocularis jun protein 0.0085 0.0169 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0232 0.0231
Loa Loa (eye worm) hypothetical protein 0.0045 0.0069 0.0069
Trichomonas vaginalis histone deacetylase, putative 0.0544 0.1319 0.1318
Brugia malayi hypothetical protein 0.0063 0.0112 0.0112
Schistosoma mansoni histone deacetylase 4 5 0.0299 0.0704 0.0704
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0154 0.0341 0.0341
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.002 0.002
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0016 0.0016
Plasmodium vivax histone deacetylase, putative 0.0189 0.0429 0.0421
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Brugia malayi nuclear receptor RXR 0.0047 0.0072 0.0072
Brugia malayi hypoxia-induced factor 1 0.0153 0.0339 0.0339
Schistosoma mansoni tubulin subunit alpha 0.2922 0.7283 0.7283
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Schistosoma mansoni tubulin subunit epsilon 0.2141 0.5326 0.5326
Brugia malayi Probable isocitrate dehydrogenase 0.003 0.003 0.003
Echinococcus granulosus tubulin alpha chain 0.2922 0.7283 0.7283
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.2922 0.7283 0.7283
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0154 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) nuclear receptor NHR-67 0.0047 0.0072 0.0072
Echinococcus multilocularis tubulin alpha 1C chain 0.2922 0.7283 0.7283
Schistosoma mansoni DNA topoisomerase II 0.0065 0.0117 0.0117
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0232 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Onchocerca volvulus Protein ultraspiracle homolog 0.0109 0.0229 0.0761
Brugia malayi beta-lactamase 0.0037 0.0047 0.0047
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0016 0.0016
Echinococcus multilocularis CREB binding protein 0.0078 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0134 0.0291 0.0291
Trypanosoma cruzi histone deacetylase, putative 0.0299 0.0704 0.0704
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0102 0.0102
Loa Loa (eye worm) isocitrate dehydrogenase 0.0246 0.0572 0.0572
Toxoplasma gondii thioredoxin reductase 0.0048 0.0076 0.0076
Loa Loa (eye worm) tubulin alpha 2 0.1992 0.4951 0.4951
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1992 0.4951 0.4951
Onchocerca volvulus 0.0037 0.0048 0.0157
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0058 0.0101 0.0101
Brugia malayi Cation transporter family protein 0.0018 0.0001 0.0001
Brugia malayi Histone deacetylase family protein 0.0299 0.0704 0.0704
Leishmania major cytochrome p450-like protein 0.0027 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0047 0.0206
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0022 0.0022
Loa Loa (eye worm) phosphofructokinase 0.011 0.0232 0.0232
Echinococcus multilocularis tubulin alpha 1C chain 0.2922 0.7283 0.7283
Trypanosoma brucei zeta tubulin 0.093 0.2287 0.2287
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0016 0.0016
Echinococcus granulosus lamin 0.0053 0.0089 0.0089
Echinococcus multilocularis histone deacetylase 7 0.0299 0.0704 0.0704
Trypanosoma cruzi PAB1-binding protein , putative 0.0237 0.055 0.055
Mycobacterium leprae cell division protein FtsZ 0.093 0.2287 1
Trypanosoma brucei epsilon tubulin 0.2141 0.5326 0.5326
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0027 0.0027
Brugia malayi Tubulin alpha-2 chain 0.2922 0.7283 0.7283
Schistosoma mansoni hypothetical protein 0.0106 0.0222 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0109 0.0229 0.0229
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0109 0.0229 0.0229
Schistosoma mansoni isocitrate dehydrogenase 0.003 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0237 0.055 0.055
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1608 0.3987 0.3987
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0246 0.0572 0.0572
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0065 0.0117 0.0117
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0024 0.0016 0.0016
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0544 0.1319 0.1318
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0001 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0109 0.0229 0.0229
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0072 0.0236
Plasmodium falciparum glutathione reductase 0.0048 0.0076 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.093 0.2287 0.2286
Trypanosoma cruzi epsilon tubulin, putative 0.2141 0.5326 0.5326
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Onchocerca volvulus 0.0037 0.0047 0.0153
Brugia malayi intermediate filament protein 0.0053 0.0089 0.0089
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0109 0.0229 0.1002
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Leishmania major epsilon tubulin, putative 0.2141 0.5326 0.5326
Echinococcus granulosus dihydrofolate reductase 0.0045 0.0067 0.0067
Leishmania major hypothetical protein, conserved 0.0037 0.0047 0.0047
Trichomonas vaginalis tubulin epsilon chain, putative 0.2922 0.7283 0.7283
Loa Loa (eye worm) hypothetical protein 0.0296 0.0698 0.0698
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0024 0.0016 0.0016
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0151 0.0149
Schistosoma mansoni tubulin subunit alpha 0.2922 0.7283 0.7283
Brugia malayi beta-lactamase family protein 0.0037 0.0047 0.0047
Schistosoma mansoni smad 0.0045 0.0069 0.0069
Echinococcus multilocularis histone deacetylase 0.0299 0.0704 0.0704
Trichomonas vaginalis histone deacetylase, putative 0.0544 0.1319 0.1318
Loa Loa (eye worm) hypothetical protein 0.0316 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0009 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Echinococcus granulosus tubulin alpha 3 chain 0.2922 0.7283 0.7283
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0001 0.0001
Echinococcus multilocularis tubulin subunit TubB 0.2922 0.7283 0.7283
Echinococcus multilocularis histone deacetylase 3 0.0544 0.1319 0.1319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0047 0.0047
Echinococcus granulosus tubulin alpha chain 0.2922 0.7283 0.7283
Schistosoma mansoni nuclear receptor 0.0047 0.0072 0.0072
Schistosoma mansoni histone deacetylase hda2 0.0323 0.0765 0.0765
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0047 0.0072 0.0072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0047 0.0206
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0029 0.0029
Brugia malayi follicle stimulating hormone receptor 0.024 0.0558 0.0558
Chlamydia trachomatis DNA gyrase subunit B 0.0035 0.0043 0.2437
Brugia malayi conserved hypotetical protein 0.0047 0.0072 0.0072
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0558 0.0558
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.0109 0.0229 0.0229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0049 0.0049
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.032 0.032
Brugia malayi ecdysone receptor 0.0047 0.0072 0.0072
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0016 0.0016
Brugia malayi isocitrate dehydrogenase 0.0246 0.0572 0.0572
Echinococcus granulosus Smad4 0.0101 0.021 0.021
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0072 0.0072
Toxoplasma gondii endonuclease IV APN 0.0078 0.0151 0.0151
Leishmania major gamma-tubulin 0.2141 0.5326 0.5326
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0002 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.0112 0.0112
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0001 0.0001
Trichomonas vaginalis tubulin gamma chain, putative 0.093 0.2287 0.2286
Mycobacterium ulcerans hypothetical protein 0.0037 0.0047 0.0206
Plasmodium vivax histone deacetylase, putative 0.0299 0.0704 0.0696
Echinococcus granulosus histone deacetylase 0.0299 0.0704 0.0704
Loa Loa (eye worm) histone deacetylase 1 0.0544 0.1319 0.1319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0047 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0375 0.0897 0.0889
Brugia malayi tailless protein 0.0047 0.0072 0.0072
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0232 0.0232
Onchocerca volvulus 0.0316 0.0747 0.2491
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.171 0.4244 0.4244
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0055 0.0179
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0009 0.0038
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0033 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0049 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0112 0.0112
Trichomonas vaginalis tubulin beta chain, putative 0.2922 0.7283 0.7283
Brugia malayi Histone deacetylase 1 0.0544 0.1319 0.1319
Toxoplasma gondii exonuclease III APE 0.0037 0.0049 0.0049
Loa Loa (eye worm) pax transcription factor protein 2 0.0766 0.1875 0.1875
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0106 0.0222 0.0222
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0063 0.0112 0.0112
Trypanosoma cruzi zeta tubulin, putative 0.093 0.2287 0.2287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0033 0.0033
Brugia malayi chromobox protein homolog 3 0.004 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0063 0.0112 0.0112
Entamoeba histolytica tubulin alpha chain, putative 0.2922 0.7283 0.7283
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.003 0.003 0.0029
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0173 0.0173
Trichomonas vaginalis tubulin, putative 0.1212 0.2994 0.2993
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0002 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0007 0.0029
Echinococcus multilocularis histone deacetylase 6 0.0299 0.0704 0.0704
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0073 0.0239
Echinococcus granulosus Tubulin alpha 1 chain 0.2922 0.7283 0.7283
Toxoplasma gondii 6-phosphofructokinase 0.003 0.003 0.003
Echinococcus multilocularis ecdysone induced protein 78C 0.0109 0.0229 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0063 0.0112 0.0112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0246 0.0572 0.0572
Echinococcus multilocularis isocitrate dehydrogenase 0.0246 0.0572 0.0572
Toxoplasma gondii DNA topoisomerase 2, putative 0.0065 0.0117 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0246 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Plasmodium vivax tubulin gamma chain, putative 0.2141 0.5326 0.5322
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi glutathione reductase 0.0048 0.0076 0.0076
Leishmania major histone deacetylase, putative 0.0299 0.0704 0.0704
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1992 0.4951 0.4951
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0069 0.0069
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0001 0.0001
Trypanosoma cruzi epsilon tubulin, putative 0.2141 0.5326 0.5326
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0001 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0024 0.0016 0.0016
Schistosoma mansoni tubulin subunit alpha 0.2922 0.7283 0.7283
Loa Loa (eye worm) histone deacetylase 11 0.0189 0.0429 0.0429
Brugia malayi tubulin alpha-2 chain 0.2922 0.7283 0.7283
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.011 0.0231 0.0231
Echinococcus granulosus tubulin alpha chain 0.2922 0.7283 0.7283
Loa Loa (eye worm) CBP-B 0.0079 0.0153 0.0153
Brugia malayi hypothetical protein 0.0052 0.0086 0.0086
Toxoplasma gondii histone deacetylase HDAC5 0.0189 0.0429 0.0429
Schistosoma mansoni tubulin subunit alpha 0.093 0.2287 0.2287
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0024 0.0016 0.0016
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0154 0.0341 0.0333
Loa Loa (eye worm) hypothetical protein 0.0296 0.0698 0.0698
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0261 0.1141
Toxoplasma gondii ABC1 family protein 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Entamoeba histolytica tubulin alpha-1 chain 0.2922 0.7283 0.7283
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0232 0.0232
Brugia malayi PAS domain containing protein 0.0049 0.0079 0.0079
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0001 0.0001
Trypanosoma brucei histone deacetylase 4 0.0299 0.0704 0.0704
Echinococcus granulosus CREB binding protein 0.0071 0.0132 0.0132
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.093 0.2287 0.2287
Trypanosoma cruzi zeta tubulin, putative 0.093 0.2287 0.2287
Echinococcus granulosus tumor protein p63 0.067 0.1635 0.1635
Brugia malayi hypothetical protein 0.0166 0.0371 0.0371
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0047 0.0047
Mycobacterium tuberculosis Hypothetical protein 0.0052 0.0086 0.0374
Echinococcus granulosus CREB binding protein 0.011 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0016 0.0007
Echinococcus granulosus nuclear receptor nhr 48 0.0047 0.0072 0.0072
Schistosoma mansoni lamin 0.0053 0.0089 0.0089
Plasmodium vivax histone deacetylase 2, putative 0.0299 0.0704 0.0696
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0544 0.1319 0.1318
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.1144 0.1144
Toxoplasma gondii histone deacetylase HDAC1 0.0299 0.0704 0.0704
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.003 0.003 0.003
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0002 0.0002
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0001 0.0001
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0001 0.0001
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0016 0.0016
Onchocerca volvulus 0.0043 0.0062 0.0203
Loa Loa (eye worm) tubulin alpha 2 0.078 0.1912 0.1912
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0232 0.023
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0047 0.0206
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0001 0.0001
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0133 0.0133
Schistosoma mansoni intermediate filament proteins 0.0053 0.0089 0.0089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0446 0.1074 0.1074
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0001 0.0001
Trypanosoma brucei trypanothione reductase 0.0048 0.0076 0.0076
Echinococcus granulosus ecdysone induced protein 78C 0.0109 0.0229 0.0229
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0173 0.0173
Giardia lamblia Delta tubulin 0.093 0.2287 0.2286
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0246 0.0572 0.0564
Mycobacterium tuberculosis Probable reductase 0.011 0.023 0.1007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0109 0.0229 0.0761
Schistosoma mansoni Smad4 0.0045 0.0069 0.0069
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0069 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0113 0.0113
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0109 0.0229 0.0229
Schistosoma mansoni brca1-associated protein (brap2) 0.0024 0.0016 0.0016
Echinococcus multilocularis mothers against decapentaplegic 5 0.0101 0.021 0.021
Brugia malayi Dihydrofolate reductase 0.0045 0.0067 0.0067
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0027 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0237 0.055 0.0542
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0261 0.1141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0047 0.0047
Mycobacterium ulcerans hypothetical protein 0.002 0.0007 0.0029
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0154 0.0341 0.0333
Schistosoma mansoni nuclear receptor 0.0047 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.032 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0109 0.0229 0.0229
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Mycobacterium ulcerans beta-lactamase 0.0037 0.0047 0.0206
Brugia malayi Pre-SET motif family protein 0.0212 0.0488 0.0488
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0022 0.0022
Onchocerca volvulus 0.1212 0.2994 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0047 0.0206
Echinococcus granulosus chromobox protein 1 0.0071 0.0133 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0072 0.0072
Trypanosoma cruzi histone deacetylase 1, putative 0.0544 0.1319 0.1319
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0001 0.0001
Trypanosoma brucei alpha tubulin 0.2922 0.7283 0.7283
Echinococcus granulosus thymidylate synthase 0.0109 0.0229 0.0229
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0024 0.0016 0.0014
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0069 0.0226
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0232 0.0232
Trypanosoma cruzi histone deacetylase 1, putative 0.0544 0.1319 0.1319
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.023 0.1007
Onchocerca volvulus 0.0029 0.0029 0.0091
Toxoplasma gondii histone deacetylase HDAC4 0.0189 0.0429 0.0429
Loa Loa (eye worm) beta-lactamase 0.0037 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0072 0.0072
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0016 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0109 0.0229 0.0229
Onchocerca volvulus 0.0766 0.1875 0.6262
Loa Loa (eye worm) hypothetical protein 0.0166 0.0371 0.0371
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0016 0.0016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0049 0.004
Brugia malayi MH2 domain containing protein 0.0101 0.021 0.021
Toxoplasma gondii aminopeptidase n, putative 0.0375 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Echinococcus multilocularis histone deacetylase 1 0.0544 0.1319 0.1319
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0073 0.0239
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.003 0.003 0.003
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0241 0.0561 0.1869
Schistosoma mansoni alpha tubulin 0.2922 0.7283 0.7283
Schistosoma mansoni nuclear receptor nhr-48 0.0047 0.0072 0.0072
Echinococcus granulosus flap endonuclease 1 0.0026 0.0022 0.0022
Trypanosoma brucei tubulin delta chain 0.093 0.2287 0.2287
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0246 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Toxoplasma gondii isocitrate dehydrogenase 0.0246 0.0572 0.0572
Brugia malayi MH1 domain containing protein 0.0101 0.021 0.021
Loa Loa (eye worm) histone deacetylase 0.0299 0.0704 0.0704
Echinococcus multilocularis tubulin alpha chain 0.2922 0.7283 0.7283
Echinococcus multilocularis cpg binding protein 0.0031 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0001 0.0001
Schistosoma mansoni nAChR subunit 0.0018 0.0001 0.0001
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0024 0.0016 0.0014
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0001 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0246 0.0572 0.0572
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0133 0.0132
Echinococcus granulosus dna polymerase kappa 0.0019 0.0002 0.0002
Brugia malayi nuclear receptor NHR-88 0.0047 0.0072 0.0072
Brugia malayi Cytochrome P450 family protein 0.0027 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Schistosoma mansoni ap endonuclease 0.0037 0.0049 0.0049
Schistosoma mansoni chromobox protein 0.0071 0.0133 0.0133
Plasmodium vivax delta tubulin, putative 0.093 0.2287 0.2281
Loa Loa (eye worm) hypothetical protein 0.0098 0.0201 0.0201
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0076 0.0076
Leishmania major DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0232 0.1016
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.023 0.1007
Brugia malayi hypothetical protein 0.0047 0.0072 0.0072
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Entamoeba histolytica DNA topoisomerase II, putative 0.0065 0.0117 0.0115
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0024 0.0016 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0232 0.0231
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0016 0.0016
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0022 0.0022
Entamoeba histolytica tubulin gamma chain 0.2141 0.5326 0.5325
Echinococcus multilocularis hypothetical protein 0.2922 0.7283 0.7283
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.003 0.003 0.003
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0047 0.0073 0.0239
Brugia malayi dihydrofolate reductase family protein 0.0045 0.0067 0.0067
Trypanosoma cruzi histone deacetylase, putative 0.0189 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.0446 0.1074 0.1074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0016 0.0016
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0024 0.0016 0.0048
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0063 0.0112 0.0112
Brugia malayi 6-phosphofructokinase 0.011 0.0232 0.0232
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0101 0.021 0.021
Echinococcus multilocularis chromobox protein 1 0.0071 0.0133 0.0133
Plasmodium falciparum histone deacetylase 2 0.0299 0.0704 0.0696
Onchocerca volvulus TPPP family protein homolog 0.0372 0.0888 0.2963
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Brugia malayi MH2 domain containing protein 0.0101 0.021 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0002
Trichomonas vaginalis histone deacetylase, putative 0.0544 0.1319 0.1318
Giardia lamblia Alpha-tubulin 0.2922 0.7283 0.7283
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0206
Schistosoma mansoni hypothetical protein 0.0053 0.0087 0.0087
Echinococcus multilocularis tubulin alpha 0.2141 0.5326 0.5326
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0173 0.0165
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0049 0.0047
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0058 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.2922 0.7283 0.7283
Echinococcus multilocularis tubulin alpha 3 chain 0.2922 0.7283 0.7283
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0109 0.0229 0.0229
Plasmodium falciparum DNA topoisomerase 2 0.0065 0.0117 0.0109
Plasmodium vivax tubulin alpha chain, putative 0.2922 0.7283 0.7281
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0047 0.0072 0.0072
Echinococcus granulosus BRCA1 associated protein 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0078 0.0151 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0016 0.0007
Schistosoma mansoni histone deacetylase 4 5 0.0299 0.0704 0.0704
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0016 0.0015
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0001 0.0001
Plasmodium vivax tubulin alpha chain, putative 0.2922 0.7283 0.7281
Onchocerca volvulus 0.0037 0.0047 0.0153
Echinococcus granulosus nAChR subunit 0.0018 0.0001 0.0001
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.003 0.003 0.003
Mycobacterium ulcerans lipase LipD 0.0037 0.0047 0.0206
Schistosoma mansoni RAR-like nuclear receptor 0.0109 0.0229 0.0229
Trypanosoma brucei histone deacetylase, putative 0.0299 0.0704 0.0704
Trypanosoma brucei epsilon tubulin 0.2141 0.5326 0.5326
Brugia malayi nuclear hormone receptor 0.0109 0.0229 0.0229
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.003
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0002 0.0001
Brugia malayi Probable isocitrate dehydrogenase 0.003 0.003 0.003
Brugia malayi Isocitrate dehydrogenase 0.0246 0.0572 0.0572
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0109 0.0229 0.0229
Trichomonas vaginalis tubulin epsilon chain, putative 0.093 0.2287 0.2286
Schistosoma mansoni coup transcription factor 0.0109 0.0229 0.0229
Brugia malayi Heterochromatin protein 1 0.0071 0.0133 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0109 0.0229 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0109 0.0229 0.0229
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Trypanosoma brucei DNA topoisomerase ii 0.0051 0.0083 0.0083
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0169 0.0169
Brugia malayi BRCA1-associated protein 2 containing protein 0.0024 0.0016 0.0016
Brugia malayi Flap endonuclease-1 0.0026 0.0022 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0022 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Echinococcus multilocularis peroxisome assembly protein 26 0.2922 0.7283 0.7283
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0001 0.0001
Brugia malayi Tubulin alpha chain 0.2922 0.7283 0.7283
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0237 0.055 0.055
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0109 0.0229 0.0229
Echinococcus multilocularis lamin dm0 0.0053 0.0089 0.0089
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0047 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0026 0.0025
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0038 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0022 0.0098
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0086 0.0085
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0047 0.0072 0.0072
Loa Loa (eye worm) histone deacetylase 7A 0.0299 0.0704 0.0704
Onchocerca volvulus 0.0053 0.0089 0.0294
Loa Loa (eye worm) Smad1 0.0101 0.021 0.021
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0112 0.0112
Brugia malayi Cation transporter family protein 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0037 0.0047 0.0153
Brugia malayi CXXC zinc finger family protein 0.0029 0.0029 0.0029
Mycobacterium leprae Probable lipase LipE 0.0037 0.0047 0.0206
Plasmodium vivax histone deacetylase 1, putative 0.0544 0.1319 0.1311
Plasmodium vivax DNA topoisomerase II, putative 0.0065 0.0117 0.0109
Echinococcus granulosus peroxisome assembly protein 26 0.2922 0.7283 0.7283
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0109 0.0229 0.0229
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0024 0.0016 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0209 0.048 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0001 0.0001
Mycobacterium ulcerans cell division protein FtsZ 0.093 0.2287 1
Brugia malayi Cell division protein ftsZ 0.093 0.2287 0.2287
Trichomonas vaginalis tubulin gamma chain, putative 0.2141 0.5326 0.5326
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0232 0.023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0076 0.0332
Leishmania major histone deacetylase, putative 0.0544 0.1319 0.1319
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.171 0.4244 0.4244
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0101 0.021 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0237 0.055 0.0542
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.003 0.003 0.0132
Schistosoma mansoni dihydrofolate reductase 0.0045 0.0067 0.0067
Schistosoma mansoni smad1 5 8 and 0.0101 0.021 0.021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0109 0.0229 0.0229
Brugia malayi MH1 domain containing protein 0.0056 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0033
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.003 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0047 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0109 0.0229 0.0229
Echinococcus multilocularis tubulin alpha chain 0.2922 0.7283 0.7283
Trichomonas vaginalis tubulin epsilon chain, putative 0.2922 0.7283 0.7283
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Loa Loa (eye worm) TOPoisomerase family member 0.0065 0.0117 0.0117
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.023 0.1007
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0109 0.0229 0.1002
Schistosoma mansoni tubulin subunit delta 0.093 0.2287 0.2287
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0276 0.0276
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.032 0.032
Loa Loa (eye worm) tubulin alpha chain 0.2922 0.7283 0.7283
Toxoplasma gondii isocitrate dehydrogenase 0.0246 0.0572 0.0572
Brugia malayi thymidylate synthase 0.0109 0.0229 0.0229
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0007 0.0018
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0109 0.0229 0.0229
Leishmania major delta tubulin, putative 0.093 0.2287 0.2287
Echinococcus multilocularis muscleblind protein 1 0.0296 0.0698 0.0698
Schistosoma mansoni retinoic acid receptor RXR 0.0209 0.048 0.048
Echinococcus granulosus tubulin subunit TubB 0.2922 0.7283 0.7283
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.0229 0.0229
Brugia malayi Smad1 0.0101 0.021 0.021
Mycobacterium ulcerans endonuclease IV 0.0078 0.0151 0.0659
Loa Loa (eye worm) nuclear factor I 0.0056 0.0096 0.0096
Brugia malayi Tubulin beta chain 0.1212 0.2994 0.2994
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0109 0.0229 0.0229
Brugia malayi jmjC domain containing protein 0.0057 0.0098 0.0098
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0052 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.0064
Echinococcus granulosus tubulin alpha 3 chain 0.2922 0.7283 0.7283
Echinococcus multilocularis Tubulin alpha 1 chain 0.2922 0.7283 0.7283
Giardia lamblia Epsilon tubulin 0.093 0.2287 0.2286
Leishmania major zeta tubulin, putative 0.093 0.2287 0.2287
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0002 0.0009
Echinococcus granulosus tubulin alpha 0.2141 0.5326 0.5326
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0046
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0049 0.004
Brugia malayi alpha-tubulin 0.2922 0.7283 0.7283
Brugia malayi Muscleblind-like protein 0.0296 0.0698 0.0698
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0076 0.0067
Schistosoma mansoni CREB-binding protein 2 0.011 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.2638 0.6571 0.6571
Trypanosoma brucei histone deacetylase 3 0.0299 0.0704 0.0704
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0151 0.0659
Brugia malayi hypothetical protein 0.0446 0.1074 0.1074
Brugia malayi beta-lactamase family protein 0.0037 0.0047 0.0047
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0237 0.055 0.055
Echinococcus granulosus geminin 0.2638 0.6571 0.6571
Giardia lamblia Alpha-tubulin 0.2922 0.7283 0.7283
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0072 0.0072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0281 0.066 0.066
Echinococcus granulosus tubulin alpha 1C chain 0.2922 0.7283 0.7283
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0232 0.1016
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0109 0.0229 0.0229
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.003 0.003 0.0132
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0246 0.0572 0.0572
Brugia malayi hypothetical protein 0.0067 0.0123 0.0123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0109 0.0229 0.0229
Trypanosoma brucei alpha tubulin 0.2922 0.7283 0.7283
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0063 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0232 0.0231
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0063 0.0112 0.0112
Brugia malayi phosphofructokinase 0.011 0.0232 0.0232
Loa Loa (eye worm) tubulin alpha 2 0.1992 0.4951 0.4951
Loa Loa (eye worm) hypothetical protein 0.0189 0.0429 0.0429
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0232 0.0232
Brugia malayi ecdysteroid receptor 0.0109 0.0229 0.0229
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0232 0.0232
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0024 0.0016 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0173 0.0172
Brugia malayi Pre-SET motif family protein 0.0031 0.0033 0.0033
Onchocerca volvulus 0.0047 0.0072 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.093 0.2287 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0151 0.0142
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0544 0.1319 0.1318
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0024 0.0016 0.0016
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.003 0.0029
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0037 0.0047 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0001 0.0001
Trypanosoma cruzi tubulin gamma chain 0.2141 0.5326 0.5326
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0001 0.0001
Schistosoma mansoni Smad4 0.0045 0.0069 0.0069
Brugia malayi histone deacetylase 3 (HD3) 0.0544 0.1319 0.1319
Trichomonas vaginalis tubulin alpha chain, putative 0.1212 0.2994 0.2993
Toxoplasma gondii LsmAD domain-containing protein 0.0237 0.055 0.055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0246 0.0572 0.0572
Loa Loa (eye worm) MH2 domain-containing protein 0.1489 0.369 0.369
Echinococcus granulosus histone deacetylase 3 0.0544 0.1319 0.1319
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0151 0.0142
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0047
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.003 0.003 0.003
Echinococcus multilocularis chromobox protein 1 0.0071 0.0133 0.0133
Loa Loa (eye worm) thymidylate synthase 0.0109 0.0229 0.0229
Echinococcus multilocularis tubulin alpha chain 0.2922 0.7283 0.7283
Mycobacterium leprae conserved hypothetical protein 0.002 0.0007 0.0029
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0024 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0016 0.0015
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.0067 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0232 0.0231
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0063 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Schistosoma mansoni alpha tubulin 0.2922 0.7283 0.7283
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0022 0.0021
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0022 0.002
Brugia malayi steroid hormone receptor 0.0109 0.0229 0.0229
Trypanosoma brucei tubulin gamma chain 0.2141 0.5326 0.5326
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0024 0.0016 0.0007
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0246 0.0572 0.0572
Chlamydia trachomatis endonuclease IV 0.0078 0.0151 1
Echinococcus multilocularis tubulin epsilon chain 0.2141 0.5326 0.5326
Echinococcus multilocularis Smad4 0.0101 0.021 0.021
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0024 0.0016 0.0014
Brugia malayi orphan nuclear receptor NR2E1 0.0047 0.0072 0.0072
Brugia malayi p25-alpha family protein 0.0372 0.0888 0.0888
Schistosoma mansoni DNA polymerase eta 0.0019 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0026 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.023 0.1007
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0049 0.0048
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0246 0.0572 0.0564
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0109 0.0229 0.0229
Trichomonas vaginalis histone deacetylase, putative 0.0544 0.1319 0.1318
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0002 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0049 0.0176
Echinococcus multilocularis Tubulin alpha 1 chain 0.2922 0.7283 0.7283
Echinococcus granulosus mothers against decapentaplegic 5 0.0101 0.021 0.021
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Brugia malayi Pax transcription factor protein 2 0.0766 0.1875 0.1875
Brugia malayi Cation transporter family protein 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0109 0.0229 0.0761
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0022 0.002
Loa Loa (eye worm) glutathione reductase 0.0048 0.0076 0.0076
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.0067 0.0293
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0446 0.1074 0.1073
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0098 0.0098
Echinococcus granulosus histone deacetylase 8 0.0189 0.0429 0.0429
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0062 0.0204
Schistosoma mansoni hypothetical protein 0.0128 0.0276 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0047 0.0047
Leishmania major trypanothione reductase 0.0048 0.0076 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0072 0.0072
Plasmodium vivax SET domain protein, putative 0.0031 0.0033 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0261 0.1141
Plasmodium falciparum histone deacetylase 1 0.0544 0.1319 0.1311
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0001 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0053 0.0089 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0109 0.0229 0.0229
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Echinococcus granulosus transcription factor eb 0.011 0.0231 0.0231
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0024 0.0016 0.0016
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0024 0.0016 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0173 0.0173
Echinococcus multilocularis smad 0.0101 0.021 0.021
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0022
Schistosoma mansoni histone deacetylase 0.0544 0.1319 0.1319
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0022 0.0022
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.003 0.003 0.003
Schistosoma mansoni transcription factor LCR-F1 0.0446 0.1074 0.1074
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0047 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.002 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0016 0.0015
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0047 0.0206
Plasmodium falciparum alpha tubulin 1 0.2922 0.7283 0.7281
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0049 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0047 0.0206
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0261 0.1141
Trichomonas vaginalis histone deacetylase, putative 0.0544 0.1319 0.1318
Loa Loa (eye worm) tubulin alpha-2 chain 0.2922 0.7283 0.7283
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0024 0.0016 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0076 0.0076
Echinococcus multilocularis tubulin alpha 3 chain 0.2922 0.7283 0.7283
Loa Loa (eye worm) hypothetical protein 0.0109 0.0229 0.0229
Echinococcus granulosus histone deacetylase 1 0.0544 0.1319 0.1319
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0083 0.0083
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0291 0.0685 0.0685
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0001 0.0001
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0151 0.0151
Toxoplasma gondii histone deacetylase HDAC2 0.0544 0.1319 0.1319
Leishmania major DNA polymerase eta, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0001 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.032 0.032
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0047 0.0046
Trypanosoma brucei unspecified product 0.0019 0.0002 0.0002
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0076 0.0076
Echinococcus multilocularis geminin 0.2638 0.6571 0.6571
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.093 0.2287 0.2287
Trichomonas vaginalis set domain proteins, putative 0.0241 0.0561 0.056
Trypanosoma cruzi histone deacetylase, putative 0.0189 0.0429 0.0429
Brugia malayi Tubulin alpha chain 0.093 0.2287 0.2287
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0001 0.0001
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0169 0.0169
Echinococcus granulosus tubulin gamma 1 chain 0.2141 0.5326 0.5326
Plasmodium vivax ataxin-2 like protein, putative 0.0237 0.055 0.0542
Echinococcus granulosus histone deacetylase 6 0.0323 0.0765 0.0765
Trichomonas vaginalis tubulin beta chain, putative 0.1212 0.2994 0.2993
Onchocerca volvulus 0.0047 0.0072 0.0236
Trypanosoma cruzi tubulin delta chain 0.093 0.2287 0.2287
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.0231 0.0231
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0047 0.0206
Trypanosoma brucei histone deacetylase 2 0.0189 0.0429 0.0429
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0033 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0033 0.0033
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0109 0.0229 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.0237 0.055 0.055
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0144 0.0144
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.1992 0.4951 0.4951
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0002
Brugia malayi MH2 domain containing protein 0.1489 0.369 0.369
Brugia malayi histone deacetylase 11 0.0189 0.0429 0.0429
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0022 0.0022
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0045 0.0067 0.0293
Brugia malayi histone deacetylase 1 (HD1) 0.0544 0.1319 0.1319
Trichomonas vaginalis tubulin alpha chain, putative 0.1212 0.2994 0.2993
Echinococcus multilocularis tubulin gamma 1 chain 0.2141 0.5326 0.5326
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0109 0.0229 0.0229
Entamoeba histolytica hypothetical protein 0.0446 0.1074 0.1073
Schistosoma mansoni hypothetical protein 0.2638 0.6571 0.6571
Trichomonas vaginalis conserved hypothetical protein 0.093 0.2287 0.2286
Echinococcus granulosus tubulin alpha chain 0.2922 0.7283 0.7283
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0151 0.0659
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0022 0.0022
Schistosoma mansoni smad1 5 8 and 0.0101 0.021 0.021
Echinococcus granulosus jun protein 0.0085 0.0169 0.0169
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0049 0.0049
Schistosoma mansoni smad1 5 8 and 0.0101 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus Tubulin alpha 1 chain 0.2922 0.7283 0.7283
Echinococcus granulosus TGF beta signal transducer SmadC 0.0101 0.021 0.021
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.2141 0.5326 0.5326
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0055
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0232 0.0232
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0109 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.0087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0001 0.0001
Echinococcus multilocularis tubulin alpha chain 0.2922 0.7283 0.7283
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0024 0.0016 0.0015
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0339 0.0339
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0049 0.0049
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0232 0.0232
Trypanosoma brucei beta tubulin 0.2141 0.5326 0.5326
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.032 0.032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0062 0.0062
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0047 0.0072 0.0072
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.003 0.003 0.003
Brugia malayi Cytochrome P450 family protein 0.0027 0.0022 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0062 0.0061
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0001 0.0001
Schistosoma mansoni chromobox protein 0.0071 0.0133 0.0133
Brugia malayi hypothetical protein 0.0237 0.055 0.055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0024 0.0016 0.0016
Plasmodium vivax glutathione reductase, putative 0.0048 0.0076 0.0067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Schistosoma mansoni thyroid hormone receptor 0.0237 0.055 0.055
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Echinococcus granulosus Tubulin alpha 1 chain 0.2922 0.7283 0.7283
Brugia malayi MH2 domain containing protein 0.0045 0.0069 0.0069
Echinococcus multilocularis dna polymerase eta 0.0019 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.0064
Echinococcus multilocularis lamin 0.0053 0.0089 0.0089
Loa Loa (eye worm) MH1 domain-containing protein 0.0101 0.021 0.021
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.0072
Trypanosoma cruzi histone deacetylase, putative 0.0299 0.0704 0.0704
Trichomonas vaginalis tubulin alpha chain, putative 0.2141 0.5326 0.5326
Brugia malayi Histone deacetylase family protein 0.0299 0.0704 0.0704
Trichomonas vaginalis histone deacetylase, putative 0.0544 0.1319 0.1318
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0049 0.0214
Echinococcus multilocularis histone deacetylase 6 0.0299 0.0704 0.0704
Echinococcus granulosus single minded 2 0.0037 0.0047 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0053 0.0089 0.0089
Giardia lamblia Histone deacetylase 0.0544 0.1319 0.1317
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0024 0.0016 0.0016
Brugia malayi nuclear receptor NHR-67 0.0047 0.0072 0.0072
Toxoplasma gondii alpha tubulin TUBA1 0.2922 0.7283 0.7283
Loa Loa (eye worm) histone deacetylase 3 0.0544 0.1319 0.1319
Echinococcus multilocularis tubulin delta chain 0.093 0.2287 0.2287
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.003 0.1516
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0076 0.0076
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0001 0.0001
Leishmania major histone deacetylase, putative 0.0299 0.0704 0.0704
Onchocerca volvulus Histone deacetylase 10 homolog 0.0189 0.0429 0.1429
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0232 0.1016
Loa Loa (eye worm) tubulin beta chain 0.093 0.2287 0.2287
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0101 0.021 0.021
Mycobacterium tuberculosis Cell division protein FtsZ 0.093 0.2287 1
Echinococcus granulosus intermediate filament protein 0.0053 0.0089 0.0089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0076 0.0076
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0002 0.0002
Echinococcus granulosus tubulin epsilon chain 0.2141 0.5326 0.5326
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0446 0.1074 0.1074
Plasmodium falciparum alpha tubulin 2 0.2922 0.7283 0.7281
Leishmania major histone deacetylase, putative 0.0544 0.1319 0.1319
Echinococcus multilocularis transcription factor eb 0.011 0.0231 0.0231
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0069 0.0069
Echinococcus granulosus lamin dm0 0.0053 0.0089 0.0089
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0109 0.0229 0.0229
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0049 0.0176
Leishmania major alpha tubulin 0.2922 0.7283 0.7283
Schistosoma mansoni ap endonuclease 0.0037 0.0049 0.0049
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0001 0.0001
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0001 0.0001
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0001 0.0001
Plasmodium vivax tubulin epsilon chain, putative 0.2141 0.5326 0.5322

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.86 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1312 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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