Detailed information for compound 1405981

Basic information

Technical information
  • TDR Targets ID: 1405981
  • Name: 1-(4,7-dimethoxy1H-indole-2-carbonyl)piperidi ne-4-carboxylic acid
  • MW: 332.351 | Formula: C17H20N2O5
  • H donors: 2 H acceptors: 3 LogP: 1.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1[nH]c(c2)C(=O)N1CCC(CC1)C(=O)O)OC
  • InChi: 1S/C17H20N2O5/c1-23-13-3-4-14(24-2)15-11(13)9-12(18-15)16(20)19-7-5-10(6-8-19)17(21)22/h3-4,9-10,18H,5-8H2,1-2H3,(H,21,22)
  • InChiKey: UQXHTYXPPDAISS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4,7-dimethoxy-1H-indol-2-yl)-oxomethyl]-4-piperidinecarboxylic acid
  • 1-(4,7-dimethoxy1H-indole-2-carbonyl)isonipecotic acid
  • 1-[(4,7-dimethoxy-1H-indol-2-yl)carbonyl]piperidine-4-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major S-adenosylmethionine decarboxylase 0.042 0.3047 0.8051
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0028 0.0049 0.0061
Toxoplasma gondii DNA methyltransferase 2, putative 0.0097 0.0575 0.6199
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0141 0.0911 1
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0052 0.0236 0.0188
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0052 0.0288
Schistosoma mansoni enhancer of zeste ezh 0.0192 0.1305 0.2589
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0542 0.1092
Toxoplasma gondii Purine nucleoside phosphorylase 0.0052 0.0236 0.237
Schistosoma mansoni uridine phosphorylase 0.0052 0.0236 0.0425
Echinococcus multilocularis purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Schistosoma mansoni hypothetical protein 0.0028 0.0049 0.0046
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0052 0.0236 0.0559
Echinococcus multilocularis hepatoma derived growth factor protein 0.0025 0.0026 0.0053
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0052 0.0288
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0028 0.0049 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0181 0.1218 0.2412
Plasmodium falciparum purine nucleoside phosphorylase 0.0052 0.0236 0.0494
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Loa Loa (eye worm) hypothetical protein 0.0166 0.1103 0.1206
Brugia malayi hypothetical protein 0.0166 0.1103 0.1181
Echinococcus granulosus DNA methyltransferase 2, putative 0.0097 0.0575 0.1158
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0052 0.0236 0.3824
Leishmania major hypothetical protein, conserved 0.0064 0.0325 0.0796
Leishmania major arginine N-methyltransferase, type I 0.0028 0.0049 0.0061
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0052 0.0236 0.3824
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0777 0.849
Schistosoma mansoni purine nucleoside phosphorylase 0.0052 0.0236 0.0425
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0283 0.1995 0.5247
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0869 0.6478 0.7082
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Brugia malayi hypothetical protein 0.0166 0.1103 0.1181
Schistosoma mansoni histone J3 methyltransferase 0.0504 0.3686 0.741
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0058 0.0276 0.0665
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0052 0.0236 0.3824
Loa Loa (eye worm) hypothetical protein 0.0037 0.0123 0.0134
Echinococcus multilocularis uridine phosphorylase 1 0.0052 0.0236 0.0476
Loa Loa (eye worm) hypothetical protein 0.0166 0.1103 0.1206
Echinococcus granulosus protein arginine N methyltransferase 7 0.0028 0.0049 0.0099
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0025 0.0027 0.0054
Treponema pallidum pfs protein (pfs) 0.0052 0.0236 0.5
Schistosoma mansoni uridine phosphorylase 0.0052 0.0236 0.0425
Onchocerca volvulus Alhambra homolog 0.0028 0.0052 0.0026
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.0465 0.111
Schistosoma mansoni purine nucleoside phosphorylase 0.0052 0.0236 0.0425
Trypanosoma cruzi spermidine synthase, putative 0.0516 0.3778 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Schistosoma mansoni SET domain protein 0.0038 0.0129 0.0207
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0054 0.0056
Onchocerca volvulus 0.0227 0.1574 0.1551
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0033 0.0087 0.0174
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0097 0.0575 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.1218 0.1331
Echinococcus granulosus protein arginine methyltransferase 0.003 0.0063 0.0127
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0283 0.1995 0.5247
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0181 0.1218 0.2452
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0064 0.0325 0.0796
Plasmodium vivax spermidine synthase, putative 0.0516 0.3778 1
Brugia malayi Bromodomain containing protein 0.0027 0.0042 0.0017
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0504 0.3686 0.4013
Loa Loa (eye worm) uridine phosphorylase 0.0052 0.0236 0.0258
Echinococcus granulosus cpg binding protein 0.0069 0.0365 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0236 0.0188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0057
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.023 0.1595 0.5361
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0283 0.1995 0.4018
Schistosoma mansoni methylthioadenosine phosphorylase 0.0283 0.1995 0.3986
Leishmania major spermidine synthase 0.0516 0.3778 1
Echinococcus granulosus geminin 0.0164 0.1089 0.2193
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0542 0.1092
Toxoplasma gondii hypothetical protein 0.0064 0.0325 0.3377
Echinococcus granulosus spermidine synthase 0.0516 0.3778 0.7609
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0029
Onchocerca volvulus 0.0113 0.0698 0.0673
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0058 0.0276 0.0665
Trypanosoma cruzi spermidine synthase, putative 0.0516 0.3778 1
Onchocerca volvulus 0.0166 0.1103 0.108
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0042 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.4965 1
Brugia malayi jmjC domain containing protein 0.0036 0.0112 0.0094
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0033 0.0087 0.0174
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0052 0.0236 0.021
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0052 0.0236 0.0559
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0036 0.0114 0.0229
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0052 0.0105
Toxoplasma gondii phosphorylase family protein 0.0052 0.0236 0.237
Loa Loa (eye worm) SET domain-containing protein 0.0131 0.0834 0.0912
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.042 0.3047 0.6137
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.042 0.3047 0.8051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0777 0.1566
Echinococcus granulosus microtubule associated protein 2 0.0671 0.4965 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0112 0.0123
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0063 0.0074
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0494
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0063 0.0014
Leishmania major methylthioadenosine phosphorylase, putative 0.0283 0.1995 0.5247
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1219 0.9146 1
Brugia malayi Pre-SET motif family protein 0.0156 0.1027 0.1098
Leishmania major histone-lysine N-methyltransferase, putative 0.0064 0.0325 0.0796
Echinococcus multilocularis disco interacting protein 2 0.0037 0.0123 0.0247
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.042 0.3047 0.8051
Toxoplasma gondii hypothetical protein 0.0082 0.0465 0.4962
Entamoeba histolytica hypothetical protein 0.0052 0.0236 0.3824
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0028 0.0049 0.0099
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.035 0.0383
Toxoplasma gondii histone lysine methyltransferase SET1 0.0076 0.042 0.4448
Echinococcus multilocularis purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0028 0.0049 0.0061
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0131 0.0834 0.168
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0144 0.094 0.1893
Trypanosoma brucei histone-lysine n-methyltransferase 0.0064 0.0325 0.0796
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0068 0.0358 0.0722
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0192 0.1305 0.2629
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0141 0.0911 0.1835
Echinococcus multilocularis spermidine synthase 0.0516 0.3778 0.7609
Toxoplasma gondii phosphorylase family protein 0.0052 0.0236 0.237
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0136 0.0274
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0064 0.0325 0.0796
Toxoplasma gondii bicoid-interacting protein BIN3 0.0028 0.0049 0.0258
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0052 0.0052
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.003 0.0063 0.0415
Echinococcus granulosus PWWP domain containing protein 2A 0.0025 0.0026 0.0053
Echinococcus granulosus hepatoma derived growth factor protein 0.0025 0.0026 0.0053
Echinococcus granulosus protein arginine N methyltransferase 8 0.003 0.0063 0.0127
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0052 0.0236 0.023
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0052 0.0236 0.3824
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0283 0.1995 0.6938
Brugia malayi uridine phosphorylase family protein 0.0052 0.0236 0.023
Echinococcus granulosus methyltransferase protein 5 0.0028 0.0049 0.0099
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.042 0.3047 0.8051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0029
Loa Loa (eye worm) hypothetical protein 0.0058 0.0276 0.0302
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0058 0.0276 0.4551
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0097 0.0575 0.6199
Trypanosoma cruzi spermidine synthase, putative 0.0516 0.3778 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Loa Loa (eye worm) PWWP domain-containing protein 0.0025 0.0026 0.0029
Brugia malayi SET domain containing protein 0.0192 0.1305 0.1402
Loa Loa (eye worm) SET domain-containing protein 0.0192 0.1305 0.1427
Loa Loa (eye worm) hypothetical protein 0.0107 0.0656 0.0718
Brugia malayi SET domain containing protein 0.0116 0.072 0.076
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0136 0.0274
Loa Loa (eye worm) hypothetical protein 0.0067 0.0345 0.0377
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0052 0.0236 0.3824
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.003 0.0063 0.003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0206 0.0225
Brugia malayi Spermidine synthase 0.0516 0.3778 0.4113
Trypanosoma brucei spermidine synthase 0.0516 0.3778 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.0283 0.1995 0.4018
Schistosoma mansoni hypothetical protein 0.005 0.0221 0.0394
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0028 0.0049 0.0258
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.042 0.3047 0.8051
Loa Loa (eye worm) hypothetical protein 0.0869 0.6478 0.7082
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0052 0.0105
Echinococcus granulosus histone lysine methyltransferase setb 0.0181 0.1218 0.2452
Echinococcus multilocularis purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Echinococcus granulosus uridine phosphorylase 1 0.0052 0.0236 0.0476
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0112 0.0174
Treponema pallidum uridine phosphorylase (udp) 0.0052 0.0236 0.5
Schistosoma mansoni methylthioadenosine phosphorylase 0.0283 0.1995 0.3986
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0064 0.0325 0.0796
Giardia lamblia UPL-1 0.0052 0.0236 1
Brugia malayi Protein arginine N-methyltransferase 0.0028 0.0049 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0397 0.075
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0097 0.0575 0.1403
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0205 0.14 0.3618
Plasmodium falciparum spermidine synthase 0.0516 0.3778 1
Mycobacterium ulcerans spermidine synthase 0.0384 0.2771 1
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0028 0.0049 0.0061
Onchocerca volvulus 0.0037 0.0123 0.0097
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0504 0.3686 0.403
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0384 0.2771 1
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0205 0.14 0.3618
Brugia malayi NNMT/PNMT/TEMT family protein 0.0869 0.6478 0.7074
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0097 0.0575 0.1461
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Schistosoma mansoni cpg binding protein 0.0069 0.0365 0.0686
Brugia malayi hypothetical protein 0.0058 0.0276 0.0274
Brugia malayi Pre-SET motif family protein 0.1219 0.9146 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Loa Loa (eye worm) Carm1-pending protein 0.0141 0.0911 0.0996
Echinococcus multilocularis peregrin 0.0053 0.0242 0.0487
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0064 0.0325 0.0796
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0227 0.1574 0.3133
Brugia malayi PHD-finger family protein 0.0028 0.0052 0.0028
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0028 0.0049 0.0061
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0028 0.0049 0.0061
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.042 0.3047 0.6137
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0028 0.0049 0.0061
Leishmania major arginine N-methyltransferase-like protein 0.003 0.0063 0.0098
Leishmania major hypothetical protein, conserved 0.0064 0.0325 0.0796
Plasmodium falciparum protein arginine N-methyltransferase 1 0.003 0.0063 0.003
Schistosoma mansoni cpg binding protein 0.0067 0.035 0.0656
Loa Loa (eye worm) spermidine synthase 0.0516 0.3778 0.413
Echinococcus granulosus SET and MYND domain containing protein 3 0.0068 0.0358 0.0722
Leishmania major nucleoside phosphorylase-like protein 0.0052 0.0236 0.0559
Echinococcus granulosus histone h3 methyltransferase 0.0504 0.3686 0.7424
Loa Loa (eye worm) hypothetical protein 0.0869 0.6478 0.7082
Echinococcus multilocularis cpg binding protein 0.0069 0.0365 0.0736
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0097 0.0575 0.1158
Echinococcus multilocularis PWWP domain containing protein 2A 0.0025 0.0026 0.0053
Schistosoma mansoni hypothetical protein 0.0028 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0777 0.1521
Brugia malayi SET domain containing protein 0.0131 0.0834 0.0886
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0052 0.0236 0.5
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0131 0.0834 0.168
Echinococcus multilocularis histone h3 methyltransferase 0.0504 0.3686 0.7424
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0112 0.0174
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0052 0.0236 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Echinococcus multilocularis protein arginine N methyltransferase 8 0.003 0.0063 0.0127
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0052 0.0236 1
Echinococcus multilocularis geminin 0.0164 0.1089 0.2193
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0042 0.0084
Echinococcus multilocularis PWWP domain containing protein 2A 0.0025 0.0026 0.0053
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0052 0.0236 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0052 0.0236 0.0559
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0281 0.0308
Brugia malayi CXXC zinc finger family protein 0.0067 0.035 0.0355
Echinococcus granulosus PWWP domain containing protein 2A 0.0025 0.0026 0.0053
Entamoeba histolytica hypothetical protein 0.0058 0.0276 0.4551
Schistosoma mansoni protein arginine n-methyltransferase 0.0141 0.0911 0.1791
Brugia malayi Carm1-pending protein 0.0141 0.0911 0.097
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0063 0.0074
Echinococcus granulosus purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0052 0.0236 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0052 0.0057
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0037 0.0123 0.0195
Trypanosoma cruzi spermidine synthase, putative 0.0516 0.3778 1
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.042 0.3047 0.8051
Loa Loa (eye worm) hypothetical protein 0.0104 0.0633 0.0692
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0069 0.0047
Schistosoma mansoni cpg binding protein 0.0069 0.0365 0.0686
Plasmodium vivax SET domain protein, putative 0.0123 0.0777 0.1947
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0084 0.048 0.0918
Schistosoma mansoni suppressor of variegation 4-20-related 0.0131 0.0834 0.1636
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0097 0.0196
Schistosoma mansoni methylthioadenosine phosphorylase 0.0052 0.0236 0.0425
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0283 0.1995 0.5247
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0063 0.0014
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0036 0.0114 0.0229
Brugia malayi jmjC domain containing protein 0.0092 0.0542 0.0565
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0063 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0236 0.0188
Echinococcus granulosus disco interacting protein 2 0.0037 0.0123 0.0247
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0192 0.1305 0.2629
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0097 0.0575 0.1403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0181 0.1218 0.2412
Leishmania major modification methylase-like protein 0.0097 0.0575 0.1461
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.008 0.0446 0.1057
Echinococcus multilocularis protein arginine methyltransferase 0.003 0.0063 0.0127
Loa Loa (eye worm) hypothetical protein 0.0166 0.1103 0.1206
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0141 0.0911 0.1835
Trypanosoma brucei uridine phosphorylase 0.0052 0.0236 0.0559
Chlamydia trachomatis AMP nucleosidase 0.0052 0.0236 0.5
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0283 0.1995 0.2181
Schistosoma mansoni hypothetical protein 0.0164 0.1089 0.2151
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.042 0.3047 0.3331
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.042 0.3047 0.3312
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.008 0.0446 0.1057
Brugia malayi Bromodomain containing protein 0.0028 0.0052 0.0028
Mycobacterium leprae probable uridine phosphorylase 0.0052 0.0236 0.5
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0052 0.0236 0.3824
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0064 0.0325 0.0796
Echinococcus granulosus methyl CpG binding domain protein 2 0.0025 0.0027 0.0054
Echinococcus granulosus peregrin 0.0053 0.0242 0.0487
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0028 0.0049 0.0054
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0064 0.0325 0.0796
Schistosoma mansoni hypothetical protein 0.0164 0.1089 0.2151
Echinococcus multilocularis purine nucleoside phosphorylase 0.0052 0.0236 0.0476
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0112 0.0226
Loa Loa (eye worm) hypothetical protein 0.0033 0.0087 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.4965 1
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0097 0.0575 0.111
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0052 0.0236 0.0188
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0058 0.0276 0.0665
Brugia malayi Disco-interacting protein 2 homolog 0.0037 0.0123 0.0106
Onchocerca volvulus 0.0067 0.035 0.0325
Brugia malayi MTAP 0.0283 0.1995 0.2158

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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