Detailed information for compound 1406165

Basic information

Technical information
  • TDR Targets ID: 1406165
  • Name: 2-[(2-acetamidoacetyl)-(1,3-benzodioxol-5-ylm ethyl)amino]-2-(4-chlorophenyl)-N-(3-ethoxypr opyl)acetamide
  • MW: 503.975 | Formula: C25H30ClN3O6
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOCCCNC(=O)C(N(C(=O)CNC(=O)C)Cc1ccc2c(c1)OCO2)c1ccc(cc1)Cl
  • InChi: 1S/C25H30ClN3O6/c1-3-33-12-4-11-27-25(32)24(19-6-8-20(26)9-7-19)29(23(31)14-28-17(2)30)15-18-5-10-21-22(13-18)35-16-34-21/h5-10,13,24H,3-4,11-12,14-16H2,1-2H3,(H,27,32)(H,28,30)
  • InChiKey: PJWCRDQQMFOPJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(2-acetamido-1-oxoethyl)-(1,3-benzodioxol-5-ylmethyl)amino]-2-(4-chlorophenyl)-N-(3-ethoxypropyl)acetamide
  • 2-(2-acetamidoethanoyl-(1,3-benzodioxol-5-ylmethyl)amino)-2-(4-chlorophenyl)-N-(3-ethoxypropyl)ethanamide
  • MLS000729800
  • N~2~-acetyl-N~1~-(1,3-benzodioxol-5-ylmethyl)-N~1~-{1-(4-chlorophenyl)-2-[(3-ethoxypropyl)amino]-2-oxoethyl}glycinamide
  • SMR000308077
  • STK149142

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0061 0.024
Onchocerca volvulus 0.1078 0.302 1
Loa Loa (eye worm) Smad1 0.0084 0.0196 0.0196
Echinococcus granulosus peroxisome assembly protein 26 0.261 0.7373 0.7372
Echinococcus multilocularis tubulin gamma 1 chain 0.1905 0.5369 0.5367
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0084 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Echinococcus multilocularis CREB binding protein 0.0072 0.0165 0.016
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0063 0.0138 0.0133
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0265 0.1129
Echinococcus multilocularis lamin 0.0027 0.0035 0.003
Loa Loa (eye worm) DR-78 0.0045 0.0088 0.0088
Echinococcus multilocularis CREB binding protein 0.0016 0.0006 0.0001
Mycobacterium tuberculosis Probable reductase 0.0107 0.0263 0.1119
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0061 0.0055
Schistosoma mansoni hypothetical protein 0.0068 0.0151 0.0146
Onchocerca volvulus 0.0036 0.0061 0.0149
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0118 0.0113
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Onchocerca volvulus 0.0165 0.0429 0.1375
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0247 0.0247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0101 0.0247 0.0242
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 0.003
Brugia malayi Probable isocitrate dehydrogenase 0.0024 0.0027 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Schistosoma mansoni CREB-binding protein 2 0.0104 0.0255 0.0249
Mycobacterium leprae cell division protein FtsZ 0.0827 0.2308 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.038 0.038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0362 0.0362
Mycobacterium ulcerans hypothetical protein 0.002 0.0016 0.0046
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0005 0.0005
Trypanosoma cruzi zeta tubulin, putative 0.0827 0.2308 0.2304
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0602 0.0597
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0057 0.012 0.0115
Onchocerca volvulus 0.0036 0.0061 0.0149
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Brugia malayi tailless protein 0.0045 0.0088 0.0088
Echinococcus granulosus TGF beta signal transducer SmadC 0.0084 0.0196 0.0191
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0265 0.1088
Brugia malayi intermediate filament protein 0.0027 0.0035 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.016 0.0413 0.0408
Onchocerca volvulus 0.0027 0.0035 0.0064
Echinococcus multilocularis ecdysone induced protein 78C 0.0101 0.0247 0.0242
Onchocerca volvulus 0.0065 0.0145 0.0429
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0088 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0024 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0012 0.003
Schistosoma mansoni alpha tubulin 0.261 0.7373 0.7372
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0195 0.0513 0.0508
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0061 0.024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0196 0.019
Echinococcus granulosus jun protein 0.0083 0.0196 0.019
Schistosoma mansoni alpha tubulin 0.261 0.7373 0.7372
Trichomonas vaginalis DNA topoisomerase II, putative 0.0063 0.0138 0.0137
Trypanosoma brucei DNA topoisomerase ii 0.005 0.01 0.0095
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0024 0.0024
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0092 0.0087
Leishmania major gamma-tubulin 0.1905 0.5369 0.5367
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0263 0.1119
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0024 0.0027 0.0021
Trichomonas vaginalis tubulin alpha chain, putative 0.1078 0.302 0.3019
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0069 0.0064
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0033 0.0033
Echinococcus multilocularis FTZ F1 alpha 0.0101 0.0247 0.0242
Schistosoma mansoni zinc finger protein 0.0045 0.0088 0.0083
Loa Loa (eye worm) steroid hormone receptor 0.0101 0.0247 0.0247
Brugia malayi nuclear receptor RXR 0.0045 0.0088 0.0088
Brugia malayi bZIP transcription factor family protein 0.0083 0.0196 0.0196
Leishmania major dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Brugia malayi hypothetical protein 0.0065 0.0145 0.0145
Plasmodium falciparum flap endonuclease 1 0.0026 0.0033 0.0027
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0107 0.0262 0.1072
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0103 0.0425
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0104 0.0255 0.0249
Giardia lamblia Epsilon tubulin 0.0827 0.2308 0.2304
Giardia lamblia Delta tubulin 0.0827 0.2308 0.2304
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0092 0.0092
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Schistosoma mansoni tubulin subunit gamma 0.1905 0.5369 0.5367
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0037 0.0065 0.0164
Trypanosoma cruzi zeta tubulin, putative 0.0827 0.2308 0.2304
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0024 0.0027 0.0027
Echinococcus multilocularis lamin dm0 0.0027 0.0035 0.003
Brugia malayi MH2 domain containing protein 0.0084 0.0196 0.0196
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.1273 0.1268
Brugia malayi thymidylate synthase 0.0107 0.0262 0.0262
Loa Loa (eye worm) isocitrate dehydrogenase 0.0195 0.0513 0.0513
Plasmodium falciparum ataxin-2 like protein, putative 0.016 0.0413 0.0408
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Leishmania major cytochrome p450-like protein 0.0023 0.0024 0.0018
Entamoeba histolytica tubulin alpha chain, putative 0.261 0.7373 0.737
Echinococcus multilocularis isocitrate dehydrogenase 0.0195 0.0513 0.0508
Plasmodium vivax tubulin alpha chain, putative 0.261 0.7373 0.7372
Trichomonas vaginalis tubulin gamma chain, putative 0.1905 0.5369 0.5369
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.0007
Giardia lamblia Alpha-tubulin 0.261 0.7373 0.7372
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0061 0.0061
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0362 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0362 0.0357
Schistosoma mansoni hypothetical protein 0.0125 0.0314 0.0309
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0084 0.0079
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0297 0.1266
Brugia malayi glutathione reductase 0.0047 0.0092 0.0092
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0088 0.0088
Mycobacterium tuberculosis Conserved protein 0.0036 0.0061 0.024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0088 0.0083
Onchocerca volvulus 0.0028 0.004 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0037 0.0065 0.0065
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0265 0.026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0101 0.0247 0.0242
Loa Loa (eye worm) alpha-tubulin 0.261 0.7373 0.7373
Onchocerca volvulus 0.003 0.0046 0.0098
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0061 0.024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0247 0.0247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0007
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0088 0.0088
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0265 0.026
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0103 0.0098
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0078 0.0205
Echinococcus multilocularis tumor protein p63 0.0335 0.0911 0.0906
Echinococcus multilocularis tubulin alpha 1C chain 0.261 0.7373 0.7372
Mycobacterium tuberculosis Cell division protein FtsZ 0.0827 0.2308 1
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0024 0.0027 0.0021
Loa Loa (eye worm) transcription factor SMAD2 0.1226 0.344 0.344
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0088 0.0088
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0118 0.0118
Echinococcus granulosus cpg binding protein 0.003 0.0045 0.0039
Echinococcus multilocularis peroxisome assembly protein 26 0.261 0.7373 0.7372
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0143 0.0366 0.0361
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0362 0.0357
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0156 0.0154
Trichomonas vaginalis tubulin, putative 0.0827 0.2308 0.2307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0101 0.0247 0.0247
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0024 0.0018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0088 0.0083
Schistosoma mansoni hypothetical protein 0.0367 0.1001 0.0996
Chlamydia trachomatis DNA gyrase subunit B 0.0021 0.0018 0.0893
Brugia malayi Probable isocitrate dehydrogenase 0.0024 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0069 0.0068
Schistosoma mansoni transcription factor LCR-F1 0.0367 0.1001 0.0996
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1905 0.5369 0.5367
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0175 0.0175
Echinococcus granulosus tumor protein p63 0.0335 0.0911 0.0906
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.001 0.0008
Echinococcus granulosus Tubulin alpha 1 chain 0.261 0.7373 0.7372
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0061 0.0061
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0092 0.0087
Brugia malayi hypothetical protein 0.0045 0.0088 0.0088
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0101 0.0247 0.0247
Schistosoma mansoni smad 0.0037 0.0065 0.006
Treponema pallidum cell division protein FtsZ 0.0827 0.2308 1
Brugia malayi Tubulin gamma chain 0.1905 0.5369 0.5369
Schistosoma mansoni smad1 5 8 and 0.0084 0.0196 0.0191
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0195 0.0513 0.0508
Loa Loa (eye worm) tubulin alpha chain 0.261 0.7373 0.7373
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0033 0.002
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0033 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0011
Brugia malayi hypothetical protein 0.0165 0.0429 0.0429
Loa Loa (eye worm) tubulin alpha 2 0.1783 0.5024 0.5024
Brugia malayi Cytochrome P450 family protein 0.0023 0.0024 0.0024
Brugia malayi conserved hypotetical protein 0.0045 0.0088 0.0088
Brugia malayi nuclear receptor NHR-88 0.0045 0.0088 0.0088
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.2274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0045 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) tubulin beta chain 0.0827 0.2308 0.2308
Echinococcus multilocularis thymidylate synthase 0.0107 0.0262 0.0257
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0362 0.0357
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0046 0.0089 0.0243
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0165 0.0429 0.0429
Brugia malayi nuclear receptor NHR-88 0.0101 0.0247 0.0247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0088 0.0083
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.0027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0263 0.1119
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0007
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0083 0.0335
Chlamydia trachomatis endonuclease IV 0.0076 0.0175 1
Trichomonas vaginalis tubulin, putative 0.1078 0.302 0.3019
Brugia malayi Tubulin beta chain 0.1078 0.302 0.302
Loa Loa (eye worm) MH1 domain-containing protein 0.0037 0.0065 0.0065
Brugia malayi phosphofructokinase 0.0108 0.0265 0.0265
Plasmodium vivax SET domain protein, putative 0.003 0.0045 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0162 0.0419 0.0419
Trypanosoma brucei epsilon tubulin 0.1905 0.5369 0.5367
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0107 0.0262 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0005 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0101 0.0247 0.0247
Brugia malayi nuclear receptor RXR 0.0056 0.0118 0.0118
Onchocerca volvulus Protein ultraspiracle homolog 0.0101 0.0247 0.0769
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0042 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0061 0.0059
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0061 0.0059
Brugia malayi MH1 domain containing protein 0.0084 0.0196 0.0196
Echinococcus granulosus alpha tubulin 0.261 0.7373 0.7372
Onchocerca volvulus 0.0036 0.0062 0.0153
Echinococcus granulosus ecdysone induced protein 78C 0.0101 0.0247 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0362 0.0357
Schistosoma mansoni tubulin subunit beta 0.0827 0.2308 0.2304
Schistosoma mansoni single-minded 0.0048 0.0096 0.0091
Trypanosoma brucei trypanothione reductase 0.0047 0.0092 0.0087
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0061 0.024
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0005 0.0004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0088 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0101 0.0247 0.0242
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Echinococcus granulosus FTZ F1 alpha 0.0101 0.0247 0.0242
Echinococcus multilocularis tubulin alpha 3 chain 0.261 0.7373 0.7372
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0083 0.0077
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0061 0.024
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0024 0.0027 0.0046
Mycobacterium leprae Probable lipase LipE 0.0036 0.0061 0.0195
Echinococcus granulosus neuropeptide s receptor 0.0462 0.1273 0.1268
Schistosoma mansoni cpg binding protein 0.0028 0.004 0.0035
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0084 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0247 0.0242
Plasmodium vivax DNA gyrase subunit B, putative 0.0021 0.0018 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.016 0.0413 0.0408
Trichomonas vaginalis tubulin gamma chain, putative 0.0827 0.2308 0.2307
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.01 0.0095
Toxoplasma gondii thioredoxin reductase 0.0047 0.0092 0.0087
Trypanosoma cruzi tubulin delta chain 0.0827 0.2308 0.2304
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0101 0.0247 0.0247
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0088 0.024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0101 0.0247 0.0247
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0092 0.0087
Entamoeba histolytica DNA topoisomerase II, putative 0.0063 0.0138 0.0126
Echinococcus multilocularis CREB binding protein 0.0016 0.0006 0.0001
Echinococcus granulosus Tubulin alpha 1 chain 0.261 0.7373 0.7372
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0107 0.0107
Schistosoma mansoni DNA topoisomerase II 0.0063 0.0138 0.0133
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0057 0.012 0.0115
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Brugia malayi nuclear hormone receptor 0.0045 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0101 0.0247 0.0247
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Brugia malayi ecdysteroid receptor 0.0101 0.0247 0.0247
Leishmania major delta tubulin, putative 0.0827 0.2308 0.2304
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Brugia malayi Tubulin alpha-2 chain 0.261 0.7373 0.7373
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.012 0.0115
Echinococcus multilocularis musashi 0.0027 0.0035 0.003
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0383 0.0383
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0012 0.003
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0175 0.017
Echinococcus granulosus tubulin gamma 1 chain 0.1905 0.5369 0.5367
Brugia malayi hypothetical protein 0.0056 0.0118 0.0118
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0061 0.0195
Brugia malayi TAZ zinc finger family protein 0.0104 0.0255 0.0255
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0084 0.0196 0.0191
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0118 0.0118
Echinococcus granulosus mothers against decapentaplegic 6 0.0037 0.0065 0.006
Plasmodium vivax delta tubulin, putative 0.0827 0.2308 0.2304
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.2243 0.2239
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0827 0.2308 0.2304
Schistosoma mansoni hypothetical protein 0.0072 0.0163 0.0157
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0046
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0063 0.0138 0.0133
Mycobacterium ulcerans epimerase 0.002 0.0016 0.0046
Echinococcus granulosus muscleblind protein 0.0148 0.038 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0101 0.0247 0.0247
Brugia malayi Tubulin alpha chain 0.0827 0.2308 0.2308
Plasmodium vivax DNA topoisomerase II, putative 0.0063 0.0138 0.0133
Brugia malayi beta-lactamase family protein 0.0036 0.0061 0.0061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0061 0.024
Trichomonas vaginalis tubulin epsilon chain, putative 0.261 0.7373 0.7373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0061 0.024
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0156 0.0156
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0265 0.026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0045 0.004
Loa Loa (eye worm) alpha-tubulin 0.261 0.7373 0.7373
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0042 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0247 0.0247
Brugia malayi PAS domain containing protein 0.0048 0.0096 0.0096
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0078 0.0076
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0061 0.024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0051 0.0105 0.01
Brugia malayi nuclear hormone receptor 0.0101 0.0247 0.0247
Loa Loa (eye worm) glutathione reductase 0.0047 0.0092 0.0092
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0039
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0083 0.0335
Loa Loa (eye worm) pax transcription factor protein 2 0.0747 0.208 0.208
Mycobacterium ulcerans cell division protein FtsZ 0.0827 0.2308 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0367 0.1001 0.0996
Trichomonas vaginalis tubulin beta chain, putative 0.1078 0.302 0.3019
Brugia malayi Steroid receptor seven-up type 2 0.0101 0.0247 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0045 0.004
Plasmodium falciparum alpha tubulin 2 0.261 0.7373 0.7372
Brugia malayi Pax transcription factor protein 2 0.0747 0.208 0.208
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0168 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0061 0.0059
Echinococcus multilocularis chromobox protein 1 0.0069 0.0156 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0101 0.0247 0.0247
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0314 0.0309
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0101 0.0247 0.0242
Echinococcus granulosus tubulin alpha 3 chain 0.261 0.7373 0.7372
Trypanosoma cruzi PAB1-binding protein , putative 0.016 0.0413 0.0408
Echinococcus granulosus tubulin epsilon chain 0.1905 0.5369 0.5367
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1533 0.4312 0.4312
Loa Loa (eye worm) hypothetical protein 0.261 0.7373 0.7373
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0088 0.0088
Loa Loa (eye worm) tubulin alpha 2 0.1783 0.5024 0.5024
Loa Loa (eye worm) beta-lactamase 0.0036 0.0061 0.0061
Brugia malayi MH2 domain containing protein 0.1226 0.344 0.344
Trypanosoma cruzi alpha tubulin, putative 0.261 0.7373 0.7372
Schistosoma mansoni intermediate filament proteins 0.0027 0.0035 0.003
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 0.0253
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0314 0.0309
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0175 0.0694
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0265 0.1129
Brugia malayi Heterochromatin protein 1 0.0069 0.0156 0.0156
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0084 0.0079
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0107 0.0263 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0037 0.0036
Plasmodium vivax tubulin epsilon chain, putative 0.1905 0.5369 0.5367
Trichomonas vaginalis tubulin alpha chain, putative 0.1905 0.5369 0.5369
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0024 0.0027 0.0092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.004 0.0035
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0372 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0827 0.2308 0.2307
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0083 0.4635
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Loa Loa (eye worm) p25-alpha family protein 0.0363 0.099 0.099
Echinococcus multilocularis cpg binding protein 0.003 0.0045 0.0039
Schistosoma mansoni RAR-like nuclear receptor 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0035
Loa Loa (eye worm) MH1 domain-containing protein 0.0084 0.0196 0.0196
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0195 0.0513 0.0508
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0625 0.0625
Brugia malayi CXXC zinc finger family protein 0.0028 0.004 0.004
Echinococcus multilocularis tubulin delta chain 0.0827 0.2308 0.2304
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0021 0.0018 0.0055
Toxoplasma gondii isocitrate dehydrogenase 0.0195 0.0513 0.0508
Echinococcus multilocularis CREB binding protein 0.0016 0.0006 0.0001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0263 0.1119
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0101 0.0247 0.0242
Brugia malayi ecdysone receptor 0.0045 0.0088 0.0088
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0107 0.0262 0.1114
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0072 0.0163 0.0157
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.0012
Leishmania major DNA topoisomerase ii 0.0057 0.012 0.0115
Trichomonas vaginalis tubulin, putative 0.1078 0.302 0.3019
Echinococcus granulosus chromobox protein 1 0.0069 0.0156 0.015
Trypanosoma brucei epsilon tubulin 0.1905 0.5369 0.5367
Onchocerca volvulus 0.0042 0.0077 0.0204
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0061 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0247 0.0247
Echinococcus granulosus intermediate filament protein 0.0027 0.0035 0.003
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.0027
Schistosoma mansoni nuclear receptor 0.0045 0.0088 0.0083
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Onchocerca volvulus TPPP family protein homolog 0.0363 0.099 0.3241
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0247 0.0247
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0168 0.0704
Plasmodium falciparum DNA topoisomerase 2 0.0063 0.0138 0.0133
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0088 0.0083
Echinococcus granulosus smad 0.0084 0.0196 0.0191
Trypanosoma brucei alpha tubulin, putative 0.1078 0.302 0.3017
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Brugia malayi MH1 domain containing protein 0.0046 0.009 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0024 0.0027 0.0092
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0195 0.0513 0.0508
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0265 0.0265
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0098 0.0092
Leishmania major zeta tubulin, putative 0.0827 0.2308 0.2304
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0024 0.0027 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0168 0.0162
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0168 0.0704
Brugia malayi hypoxia-induced factor 1 0.0149 0.0383 0.0383
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0016 0.0046
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0037
Mycobacterium ulcerans lipase LipD 0.0036 0.0061 0.024
Schistosoma mansoni lamin 0.0027 0.0035 0.003
Echinococcus granulosus tubulin subunit TubB 0.261 0.7373 0.7372
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 0.0253
Brugia malayi Thioredoxin reductase 0.0047 0.0092 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0061 0.0055
Brugia malayi Cytochrome P450 family protein 0.0052 0.0107 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.001 0.0008
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Schistosoma mansoni chromobox protein 0.0069 0.0156 0.015
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0118 0.0118
Echinococcus multilocularis transcription factor eb 0.0107 0.0263 0.0258
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0035 0.0035
Schistosoma mansoni unc-13 (munc13) 0.0024 0.0027 0.0021
Entamoeba histolytica tartrate dehydrogenase, putative 0.0024 0.0027 0.0014
Onchocerca volvulus 0.0235 0.0628 0.2037
Plasmodium falciparum glutathione reductase 0.0047 0.0092 0.0087
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1783 0.5024 0.5024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Brugia malayi beta-lactamase 0.0036 0.0061 0.0061
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0265 0.1129
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0084 0.0196 0.0191
Echinococcus multilocularis tubulin alpha 1C chain 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0049 0.0099 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Brugia malayi steroid hormone receptor 0.0101 0.0247 0.0247
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0088 0.0088
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0045 0.0045
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0035 0.0035
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0088 0.0088
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0018 0.0055
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0024 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Schistosoma mansoni smad1 5 8 and 0.0084 0.0196 0.0191
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0061 0.0061
Mycobacterium tuberculosis Conserved protein 0.0036 0.0061 0.024
Leishmania major trypanothione reductase 0.0047 0.0092 0.0087
Brugia malayi Cytochrome P450 family protein 0.0023 0.0024 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Brugia malayi MH1 domain containing protein 0.0084 0.0196 0.0196
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0024 0.0027 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0061 0.024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0016 0.0046
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0018 0.0055
Plasmodium falciparum alpha tubulin 1 0.261 0.7373 0.7372
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0101 0.0247 0.0247
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Echinococcus granulosus tubulin alpha 3 chain 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0101 0.0247 0.0242
Toxoplasma gondii alpha tubulin TUBA1 0.261 0.7373 0.7372
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0081 0.0189 0.0189
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0045 0.004
Echinococcus multilocularis jun protein 0.0083 0.0196 0.019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0101 0.0247 0.0242
Plasmodium falciparum thioredoxin reductase 0.0047 0.0092 0.0087
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0088 0.0083
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0092 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Schistosoma mansoni chromobox protein 0.0069 0.0156 0.015
Brugia malayi Probable DNA topoisomerase II 0.0063 0.0138 0.0138
Plasmodium falciparum tubulin gamma chain 0.1905 0.5369 0.5367
Echinococcus multilocularis thyroid hormone receptor alpha 0.0226 0.0602 0.0597
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Leishmania major isocitrate dehydrogenase, putative 0.0024 0.0027 0.0021
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0168 0.0162
Echinococcus granulosus tubulin alpha 1C chain 0.261 0.7373 0.7372
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0265 0.026
Brugia malayi hypothetical protein 0.0051 0.0103 0.0103
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0099 0.0093
Loa Loa (eye worm) hypothetical protein 0.1533 0.4312 0.4312
Trichomonas vaginalis tubulin epsilon chain, putative 0.0827 0.2308 0.2307
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0065
Toxoplasma gondii isocitrate dehydrogenase 0.0195 0.0513 0.0508
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0088 0.0088
Echinococcus granulosus tubulin alpha 0.1905 0.5369 0.5367
Onchocerca volvulus 0.0045 0.0088 0.024
Brugia malayi Isocitrate dehydrogenase 0.0195 0.0513 0.0513
Brugia malayi Dihydrofolate reductase 0.0043 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.1783 0.5024 0.5024
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0037
Schistosoma mansoni hypothetical protein 0.209 0.5895 0.5893
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0196 0.019
Brugia malayi beta-lactamase family protein 0.0036 0.0061 0.0061
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0297 0.1266
Toxoplasma gondii ABC1 family protein 0.0036 0.0061 0.0055
Trypanosoma cruzi epsilon tubulin, putative 0.1905 0.5369 0.5367
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0072 0.0163 0.0157
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0607 0.2613
Brugia malayi mothers against decapentaplegic homolog 3 0.0037 0.0065 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0367 0.1001 0.0996
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0297 0.1225
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0007
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0265 0.0265
Toxoplasma gondii endonuclease IV APN 0.0076 0.0175 0.017
Mycobacterium ulcerans beta-lactamase 0.0036 0.0061 0.024
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0045 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0101 0.0247 0.0242
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0035 0.0035
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0024 0.0027 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0101 0.0247 0.0247
Echinococcus multilocularis Tubulin alpha 1 chain 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Entamoeba histolytica tubulin alpha-1 chain 0.261 0.7373 0.737
Schistosoma mansoni nuclear receptor 0.0045 0.0088 0.0083
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0033 0.0027
Echinococcus granulosus mothers against decapentaplegic 5 0.0084 0.0196 0.0191
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0827 0.2308 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus multilocularis mothers against decapentaplegic 2 0.0037 0.0065 0.006
Brugia malayi Tubulin alpha-2 chain 0.261 0.7373 0.7373
Brugia malayi MH2 domain containing protein 0.0084 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0083 0.0291
Loa Loa (eye worm) hypothetical protein 0.016 0.0413 0.0413
Brugia malayi Tubulin beta chain 0.0827 0.2308 0.2308
Schistosoma mansoni smad1 5 8 and 0.0084 0.0196 0.0191
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0088 0.0083
Loa Loa (eye worm) tubulin gamma chain 0.1905 0.5369 0.5369
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0018 0.0013
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0175 0.0737
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0602 0.0597
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Echinococcus multilocularis Tubulin alpha 1 chain 0.261 0.7373 0.7372
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0046 0.0089 0.0243
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0827 0.2308 0.2307
Echinococcus multilocularis mothers against decapentaplegic 6 0.0037 0.0065 0.006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0168 0.0704
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) acetyltransferase 0.0145 0.0372 0.0372
Leishmania major hypothetical protein, conserved 0.0036 0.0061 0.0055
Echinococcus multilocularis muscleblind protein 0.0148 0.038 0.0375
Plasmodium vivax glutathione reductase, putative 0.0047 0.0092 0.0087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0101 0.0247 0.0242
Brugia malayi hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0024 0.0024
Mycobacterium ulcerans thymidylate synthase 0.0107 0.0262 0.1114
Plasmodium falciparum ataxin-2 like protein, putative 0.016 0.0413 0.0408
Echinococcus granulosus CREB binding protein 0.0016 0.0006 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0069 0.0068
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.015 0.0385 0.038
Echinococcus multilocularis geminin 0.209 0.5895 0.5893
Brugia malayi Smad1 0.0084 0.0196 0.0196
Echinococcus granulosus mothers against decapentaplegic 2 0.0037 0.0065 0.006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0042 0.0159
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0265 0.026
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0042 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0101 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Echinococcus granulosus lamin 0.0027 0.0035 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Brugia malayi hypothetical protein 0.0103 0.0252 0.0252
Echinococcus granulosus CREB binding protein 0.0016 0.0006 0.0001
Trypanosoma brucei beta tubulin 0.1905 0.5369 0.5367
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0056 0.3111
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.261 0.7373 0.7373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0118 0.0113
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Loa Loa (eye worm) thymidylate synthase 0.0107 0.0262 0.0262
Brugia malayi Tubulin alpha chain 0.261 0.7373 0.7373
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.1273 0.1268
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0195 0.0513 0.0508
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.0027
Brugia malayi hypothetical protein 0.0056 0.0118 0.0118
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0083 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0263 0.1119
Brugia malayi Flap endonuclease-1 0.0026 0.0033 0.0033
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0827 0.2308 0.2304
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0042 0.0037
Echinococcus multilocularis tubulin epsilon chain 0.1905 0.5369 0.5367
Brugia malayi p25-alpha family protein 0.0363 0.099 0.099
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.01 0.0095
Schistosoma mansoni tubulin subunit alpha 0.261 0.7373 0.7372
Brugia malayi MH1 domain containing protein 0.0046 0.009 0.009
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0061 0.0055
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0088 0.0083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0199 0.0525 0.052
Echinococcus granulosus chromobox protein 1 0.0069 0.0156 0.015
Echinococcus granulosus lamin dm0 0.0027 0.0035 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0247 0.0247
Brugia malayi hypothetical protein 0.016 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0103 0.0102
Echinococcus granulosus geminin 0.209 0.5895 0.5893
Schistosoma mansoni alpha tubulin 0.261 0.7373 0.7372
Onchocerca volvulus 0.0049 0.0099 0.0275
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0101 0.0247 0.0242
Schistosoma mansoni jun-related protein 0.0068 0.0151 0.0146
Mycobacterium tuberculosis Conserved protein 0.0036 0.0061 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0101 0.0247 0.0247
Brugia malayi 6-phosphofructokinase 0.0108 0.0265 0.0265
Trypanosoma brucei zeta tubulin 0.0827 0.2308 0.2304
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0088 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0101 0.0247 0.0247
Echinococcus granulosus Tubulin alpha 1 chain 0.261 0.7373 0.7372
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0069 0.0177
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0092 0.0378
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0046 0.009 0.009
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.1273 0.1268
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0195 0.0513 0.2203
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0101 0.0247 0.0247
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0024 0.0018
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0088 0.024
Onchocerca volvulus 0.0036 0.0061 0.0149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0061 0.0055
Schistosoma mansoni flap endonuclease-1 0.0023 0.0026 0.002
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0061 0.0055
Schistosoma mansoni coup transcription factor 0.0101 0.0247 0.0242
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0156 0.0154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Giardia lamblia Alpha-tubulin 0.261 0.7373 0.7372
Leishmania major epsilon tubulin, putative 0.1905 0.5369 0.5367
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0372 0.0367
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0195 0.0513 0.0508
Trichomonas vaginalis tubulin alpha chain, putative 0.1078 0.302 0.3019
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0079
Giardia lamblia Gamma tubulin 0.1905 0.5369 0.5367
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus multilocularis chromobox protein 1 0.0069 0.0156 0.015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0101 0.0247 0.0242
Giardia lamblia DNA topoisomerase II 0.006 0.013 0.0125
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0356 0.0351
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0168 0.0162
Echinococcus multilocularis smad 0.0084 0.0196 0.0191
Echinococcus multilocularis tubulin alpha 0.1905 0.5369 0.5367
Schistosoma mansoni retinoic acid receptor RXR 0.0199 0.0525 0.052
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0007
Echinococcus multilocularis Tubulin alpha 1 chain 0.261 0.7373 0.7372
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0175 0.017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0077 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0078 0.0076
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0024 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0362 0.0357
Brugia malayi 6-phosphofructokinase 0.0108 0.0265 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0827 0.2308 0.2307
Schistosoma mansoni tubulin subunit delta 0.0827 0.2308 0.2304
Echinococcus granulosus tubulin alpha 1C chain 0.261 0.7373 0.7372
Brugia malayi MH2 domain containing protein 0.0037 0.0065 0.0065
Brugia malayi Pre-SET motif family protein 0.0207 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0038
Echinococcus multilocularis mothers against decapentaplegic 5 0.0084 0.0196 0.0191
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0195 0.0513 0.0508
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Trypanosoma cruzi epsilon tubulin, putative 0.1905 0.5369 0.5367
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0265 0.026
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0083 0.0077
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0628 0.0627
Schistosoma mansoni hypothetical protein 0.209 0.5895 0.5893
Trypanosoma brucei tubulin delta chain 0.0827 0.2308 0.2304
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Echinococcus granulosus single minded 2 0.0036 0.0061 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0247 0.0247
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0046 0.0089 0.0243
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Echinococcus multilocularis tubulin subunit TubB 0.261 0.7373 0.7372
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0263 0.1119
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0297 0.1266
Echinococcus granulosus thymidylate synthase 0.0107 0.0262 0.0257
Echinococcus granulosus Smad4 0.0084 0.0196 0.0191
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0084 0.0083
Loa Loa (eye worm) tubulin alpha-3 chain 0.1533 0.4312 0.4312
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0083 0.0077
Loa Loa (eye worm) hypothetical protein 0.0106 0.0262 0.0262
Brugia malayi photoreceptor-specific nuclear receptor 0.0101 0.0247 0.0247
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0024 0.0027 0.0027
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0088 0.0083
Brugia malayi Muscleblind-like protein 0.0148 0.038 0.038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0168 0.0162
Leishmania major mitochondrial DNA topoisomerase II 0.005 0.01 0.0095
Echinococcus multilocularis hypothetical protein 0.261 0.7373 0.7372
Brugia malayi alpha-tubulin 0.261 0.7373 0.7373
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0247 0.0242
Schistosoma mansoni isocitrate dehydrogenase 0.0024 0.0027 0.0021
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0372 0.0372
Plasmodium falciparum tubulin epsilon chain, putative 0.1905 0.5369 0.5367
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0061 0.024
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0148 0.038 0.038
Trypanosoma cruzi tubulin gamma chain 0.1905 0.5369 0.5367
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0263 0.1077
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0083 0.0083
Brugia malayi hypothetical protein 0.0162 0.0419 0.0419
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0033 0.0027
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0195 0.0513 0.0508
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0196 0.0196
Schistosoma mansoni Smad4 0.0084 0.0196 0.0191
Onchocerca volvulus Bile acid receptor homolog 0.0101 0.0247 0.0769
Loa Loa (eye worm) hypothetical protein 0.0047 0.0093 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Onchocerca volvulus 0.0747 0.208 0.6871
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Schistosoma mansoni tubulin subunit alpha 0.0827 0.2308 0.2304
Echinococcus granulosus CREB binding protein 0.0104 0.0255 0.0249
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0118 0.0113
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.012 0.0115
Brugia malayi Cell division protein ftsZ 0.0827 0.2308 0.2308
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0131 0.0125
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0033 0.0031
Trichomonas vaginalis tubulin gamma chain, putative 0.1905 0.5369 0.5369
Onchocerca volvulus 0.0101 0.0247 0.0769
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0084 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0088 0.0083
Echinococcus multilocularis Smad4 0.0084 0.0196 0.0191
Brugia malayi isocitrate dehydrogenase 0.0195 0.0513 0.0513
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0088 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Plasmodium falciparum DNA gyrase subunit B 0.0021 0.0018 0.0013
Echinococcus multilocularis tubulin alpha 3 chain 0.261 0.7373 0.7372
Schistosoma mansoni tubulin subunit alpha 0.261 0.7373 0.7372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0362 0.0357
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Loa Loa (eye worm) MH2 domain-containing protein 0.1226 0.344 0.344
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0061 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0039
Mycobacterium ulcerans endonuclease IV 0.0076 0.0175 0.0737
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0069 0.0064
Echinococcus granulosus flap endonuclease 1 0.0026 0.0033 0.0027
Trypanosoma brucei epsilon tubulin 0.1905 0.5369 0.5367
Schistosoma mansoni lamin 0.0027 0.0035 0.003
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.2274
Schistosoma mansoni Smad4 0.0037 0.0065 0.006
Echinococcus granulosus tubulin delta chain 0.0827 0.2308 0.2304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0168 0.0704
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0168 0.0162
Trichomonas vaginalis esterase, putative 0.0036 0.0061 0.0059
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0024 0.0027 0.0092
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0021 0.0018 0.0055
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0037
Plasmodium falciparum tubulin delta chain, putative 0.0827 0.2308 0.2304
Loa Loa (eye worm) TOPoisomerase family member 0.0063 0.0138 0.0138
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0118 0.0113
Trypanosoma cruzi tubulin delta chain 0.0827 0.2308 0.2304
Toxoplasma gondii alpha-tubulin I, putative 0.261 0.7373 0.7372
Loa Loa (eye worm) tubulin alpha-2 chain 0.261 0.7373 0.7373
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0024 0.0027 0.0021
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Brugia malayi Pre-SET motif family protein 0.003 0.0045 0.0045
Loa Loa (eye worm) tubulin alpha chain 0.261 0.7373 0.7373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0045 0.004
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0265 0.026
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1078 0.302 0.3019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0045 0.004
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0265 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.004 0.004
Brugia malayi hypothetical protein 0.0367 0.1001 0.1001
Onchocerca volvulus 0.0107 0.0262 0.0818
Onchocerca volvulus 0.0027 0.0035 0.0064
Echinococcus granulosus transcription factor eb 0.0107 0.0263 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.016 0.0413 0.0408
Onchocerca volvulus 0.0045 0.0088 0.024
Schistosoma mansoni smad 0.0084 0.0196 0.0191
Schistosoma mansoni tubulin subunit epsilon 0.1905 0.5369 0.5367
Plasmodium vivax tubulin alpha chain, putative 0.261 0.7373 0.7372
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0625 0.0625
Leishmania major hypothetical protein, conserved 0.016 0.0413 0.0408
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Schistosoma mansoni Smad4 0.0037 0.0065 0.006
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 0.0253
Loa Loa (eye worm) hypothetical protein 0.0076 0.0175 0.0175
Toxoplasma gondii DNA topoisomerase 2, putative 0.0063 0.0138 0.0133
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0024 0.0027 0.0021
Brugia malayi tubulin alpha chain - mouse 0.261 0.7373 0.7373
Trypanosoma brucei tubulin gamma chain 0.1905 0.5369 0.5367
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0033 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1783 0.5024 0.5024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0101 0.0247 0.0242
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.016 0.0413 0.0408
Brugia malayi chromobox protein homolog 3 0.0039 0.0069 0.0069
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0024 0.008
Loa Loa (eye worm) CBP-B 0.0073 0.0168 0.0168
Brugia malayi nuclear receptor NHR-67 0.0045 0.0088 0.0088
Plasmodium vivax tubulin gamma chain, putative 0.1905 0.5369 0.5367
Schistosoma mansoni tubulin subunit alpha 0.261 0.7373 0.7372
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0101 0.0247 0.0769
Schistosoma mansoni steroid hormone receptor ad4bp 0.0101 0.0247 0.0242
Trichomonas vaginalis tubulin alpha chain, putative 0.1078 0.302 0.3019
Mycobacterium ulcerans hypothetical protein 0.0036 0.0061 0.024
Trichomonas vaginalis tubulin epsilon chain, putative 0.261 0.7373 0.7373
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0101 0.0247 0.0242
Echinococcus multilocularis muscleblind protein 1 0.0148 0.038 0.0375
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0134 0.0129
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0063 0.0138 0.0138
Loa Loa (eye worm) tubulin alpha 2 0.0706 0.1963 0.1963
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0362 0.0357
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0195 0.0513 0.0508
Trypanosoma brucei zeta tubulin, putative 0.0827 0.2308 0.2304
Brugia malayi tubulin alpha-2 chain 0.261 0.7373 0.7373
Echinococcus granulosus CREB binding protein 0.0065 0.0145 0.014
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0042 0.0037
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0061 0.0055
Entamoeba histolytica tubulin gamma chain 0.1905 0.5369 0.5364
Loa Loa (eye worm) nuclear factor I 0.0046 0.009 0.009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.