Detailed information for compound 1406165

Basic information

Technical information
  • TDR Targets ID: 1406165
  • Name: 2-[(2-acetamidoacetyl)-(1,3-benzodioxol-5-ylm ethyl)amino]-2-(4-chlorophenyl)-N-(3-ethoxypr opyl)acetamide
  • MW: 503.975 | Formula: C25H30ClN3O6
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOCCCNC(=O)C(N(C(=O)CNC(=O)C)Cc1ccc2c(c1)OCO2)c1ccc(cc1)Cl
  • InChi: 1S/C25H30ClN3O6/c1-3-33-12-4-11-27-25(32)24(19-6-8-20(26)9-7-19)29(23(31)14-28-17(2)30)15-18-5-10-21-22(13-18)35-16-34-21/h5-10,13,24H,3-4,11-12,14-16H2,1-2H3,(H,27,32)(H,28,30)
  • InChiKey: PJWCRDQQMFOPJT-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(2-acetamido-1-oxoethyl)-(1,3-benzodioxol-5-ylmethyl)amino]-2-(4-chlorophenyl)-N-(3-ethoxypropyl)acetamide
  • 2-(2-acetamidoethanoyl-(1,3-benzodioxol-5-ylmethyl)amino)-2-(4-chlorophenyl)-N-(3-ethoxypropyl)ethanamide
  • MLS000729800
  • N~2~-acetyl-N~1~-(1,3-benzodioxol-5-ylmethyl)-N~1~-{1-(4-chlorophenyl)-2-[(3-ethoxypropyl)amino]-2-oxoethyl}glycinamide
  • SMR000308077
  • STK149142

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0007
Loa Loa (eye worm) Smad1 0.0084 0.0196 0.0196
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.012 0.0115
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0297 0.1266
Loa Loa (eye worm) hypothetical protein 0.0076 0.0175 0.0175
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0021 0.0018 0.0055
Schistosoma mansoni hypothetical protein 0.0072 0.0163 0.0157
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0101 0.0247 0.0247
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0069 0.0064
Brugia malayi glutathione reductase 0.0047 0.0092 0.0092
Onchocerca volvulus 0.0165 0.0429 0.1375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0088 0.0088
Trypanosoma cruzi alpha tubulin, putative 0.261 0.7373 0.7372
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0088 0.0088
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Toxoplasma gondii alpha-tubulin I, putative 0.261 0.7373 0.7372
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0088 0.0083
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Loa Loa (eye worm) isocitrate dehydrogenase 0.0195 0.0513 0.0513
Echinococcus granulosus muscleblind protein 0.0148 0.038 0.0375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0196 0.019
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0092 0.0087
Trypanosoma brucei beta tubulin 0.1905 0.5369 0.5367
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0024 0.0027 0.0021
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0098 0.0092
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0012
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0083 0.0077
Echinococcus granulosus intermediate filament protein 0.0027 0.0035 0.003
Trichomonas vaginalis tubulin beta chain, putative 0.1078 0.302 0.3019
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus granulosus smad 0.0084 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0027
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0195 0.0513 0.0508
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Plasmodium falciparum DNA topoisomerase 2 0.0063 0.0138 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0045 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0101 0.0247 0.0247
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Schistosoma mansoni Smad4 0.0084 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Echinococcus granulosus CREB binding protein 0.0065 0.0145 0.014
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0016 0.0046
Schistosoma mansoni nuclear receptor 0.0045 0.0088 0.0083
Brugia malayi hypothetical protein 0.0162 0.0419 0.0419
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0012 0.003
Brugia malayi Pre-SET motif family protein 0.0207 0.0547 0.0547
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0101 0.0247 0.0247
Brugia malayi Tubulin alpha chain 0.261 0.7373 0.7373
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0045 0.004
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0088 0.0088
Brugia malayi MH1 domain containing protein 0.0084 0.0196 0.0196
Mycobacterium ulcerans thymidylate synthase 0.0107 0.0262 0.1114
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0195 0.0513 0.0508
Trypanosoma brucei PAB1-binding protein , putative 0.016 0.0413 0.0408
Giardia lamblia Gamma tubulin 0.1905 0.5369 0.5367
Brugia malayi tailless protein 0.0045 0.0088 0.0088
Brugia malayi hypothetical protein 0.016 0.0413 0.0413
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0088 0.0088
Brugia malayi hypothetical protein 0.0051 0.0103 0.0103
Brugia malayi nuclear receptor NHR-88 0.0101 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0827 0.2308 0.2307
Echinococcus granulosus flap endonuclease 1 0.0026 0.0033 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0046
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0005 0.0004
Echinococcus granulosus Tubulin alpha 1 chain 0.261 0.7373 0.7372
Echinococcus granulosus tubulin epsilon chain 0.1905 0.5369 0.5367
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Mycobacterium ulcerans epimerase 0.002 0.0016 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0101 0.0247 0.0247
Brugia malayi beta-lactamase family protein 0.0036 0.0061 0.0061
Plasmodium vivax SET domain protein, putative 0.003 0.0045 0.004
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Brugia malayi ecdysteroid receptor 0.0101 0.0247 0.0247
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0042 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0061 0.0055
Trypanosoma brucei DNA topoisomerase ii 0.005 0.01 0.0095
Echinococcus granulosus CREB binding protein 0.0016 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0037
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Echinococcus multilocularis Tubulin alpha 1 chain 0.261 0.7373 0.7372
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0265 0.026
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0088 0.0083
Brugia malayi Muscleblind-like protein 0.0148 0.038 0.038
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0046 0.0089 0.0243
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0024 0.0027 0.0025
Trypanosoma cruzi tubulin delta chain 0.0827 0.2308 0.2304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0077 0.0072
Mycobacterium ulcerans beta-lactamase 0.0036 0.0061 0.024
Leishmania major delta tubulin, putative 0.0827 0.2308 0.2304
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Echinococcus multilocularis CREB binding protein 0.0016 0.0006 0.0001
Brugia malayi hypothetical protein 0.0065 0.0145 0.0145
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0372 0.0367
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0092 0.0087
Echinococcus granulosus tubulin alpha 3 chain 0.261 0.7373 0.7372
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0195 0.0513 0.0508
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Brugia malayi nuclear receptor RXR 0.0056 0.0118 0.0118
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0372 0.0372
Echinococcus multilocularis FTZ F1 alpha 0.0101 0.0247 0.0242
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Onchocerca volvulus 0.0036 0.0061 0.0149
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0265 0.0265
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0007
Brugia malayi phosphofructokinase 0.0108 0.0265 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0024 0.0024
Plasmodium vivax delta tubulin, putative 0.0827 0.2308 0.2304
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 0.0253
Echinococcus multilocularis isocitrate dehydrogenase 0.0195 0.0513 0.0508
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0088 0.0088
Trichomonas vaginalis tubulin alpha chain, putative 0.1078 0.302 0.3019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0007
Brugia malayi hypothetical protein 0.0165 0.0429 0.0429
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Echinococcus multilocularis peroxisome assembly protein 26 0.261 0.7373 0.7372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0045 0.004
Brugia malayi Isocitrate dehydrogenase 0.0195 0.0513 0.0513
Mycobacterium tuberculosis Conserved protein 0.0036 0.0061 0.024
Plasmodium vivax ataxin-2 like protein, putative 0.016 0.0413 0.0408
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0024 0.0018
Onchocerca volvulus 0.0036 0.0061 0.0149
Schistosoma mansoni flap endonuclease-1 0.0023 0.0026 0.002
Echinococcus granulosus CREB binding protein 0.0104 0.0255 0.0249
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0247 0.0242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0367 0.1001 0.0996
Echinococcus granulosus tubulin delta chain 0.0827 0.2308 0.2304
Echinococcus multilocularis tubulin epsilon chain 0.1905 0.5369 0.5367
Schistosoma mansoni steroid hormone receptor ad4bp 0.0101 0.0247 0.0242
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0372 0.0367
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.004 0.004
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0628 0.0627
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0118 0.0118
Echinococcus granulosus jun protein 0.0083 0.0196 0.019
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0024 0.0027 0.0027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Echinococcus multilocularis Smad4 0.0084 0.0196 0.0191
Loa Loa (eye worm) tubulin alpha 2 0.0706 0.1963 0.1963
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0084 0.0196 0.0191
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0045 0.004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0018 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0168 0.0704
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.012 0.0115
Plasmodium falciparum tubulin gamma chain 0.1905 0.5369 0.5367
Trypanosoma cruzi tubulin gamma chain 0.1905 0.5369 0.5367
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Brugia malayi TAZ zinc finger family protein 0.0104 0.0255 0.0255
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0072 0.0163 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0037 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0021 0.0018 0.0055
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0265 0.026
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0012 0.003
Onchocerca volvulus 0.0065 0.0145 0.0429
Brugia malayi CXXC zinc finger family protein 0.0028 0.004 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0196 0.0196
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0072 0.0163 0.0157
Echinococcus multilocularis tubulin delta chain 0.0827 0.2308 0.2304
Echinococcus granulosus alpha tubulin 0.261 0.7373 0.7372
Brugia malayi MH1 domain containing protein 0.0046 0.009 0.009
Echinococcus granulosus transcription factor eb 0.0107 0.0263 0.0258
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0101 0.0247 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0061 0.0059
Leishmania major hypothetical protein, conserved 0.0036 0.0061 0.0055
Leishmania major cytochrome p450-like protein 0.0023 0.0024 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0195 0.0513 0.2203
Trichomonas vaginalis tubulin, putative 0.1078 0.302 0.3019
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0061 0.024
Brugia malayi Dihydrofolate reductase 0.0043 0.0083 0.0083
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0063 0.0138 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0051 0.0105 0.01
Toxoplasma gondii endonuclease IV APN 0.0076 0.0175 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.001 0.0008
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0042 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0134 0.0129
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0088 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0061 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0168 0.0704
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0107 0.0262 0.1114
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0175 0.017
Schistosoma mansoni tubulin subunit delta 0.0827 0.2308 0.2304
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0084 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0247 0.0247
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0092 0.0092
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0297 0.1266
Giardia lamblia Alpha-tubulin 0.261 0.7373 0.7372
Echinococcus granulosus ecdysone induced protein 78C 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0045 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Toxoplasma gondii isocitrate dehydrogenase 0.0195 0.0513 0.0508
Loa Loa (eye worm) MH1 domain-containing protein 0.0084 0.0196 0.0196
Brugia malayi nuclear hormone receptor 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.0027
Plasmodium falciparum thioredoxin reductase 0.0047 0.0092 0.0087
Toxoplasma gondii isocitrate dehydrogenase 0.0195 0.0513 0.0508
Schistosoma mansoni jun-related protein 0.0068 0.0151 0.0146
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.015 0.0385 0.038
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0042 0.0037
Schistosoma mansoni hypothetical protein 0.209 0.5895 0.5893
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0297 0.1225
Echinococcus granulosus Tubulin alpha 1 chain 0.261 0.7373 0.7372
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0045 0.004
Schistosoma mansoni hypothetical protein 0.209 0.5895 0.5893
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Echinococcus granulosus thymidylate synthase 0.0107 0.0262 0.0257
Loa Loa (eye worm) beta-lactamase 0.0036 0.0061 0.0061
Schistosoma mansoni nuclear receptor 0.0045 0.0088 0.0083
Brugia malayi Flap endonuclease-1 0.0026 0.0033 0.0033
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0084 0.0079
Echinococcus multilocularis tubulin gamma 1 chain 0.1905 0.5369 0.5367
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0061 0.024
Schistosoma mansoni alpha tubulin 0.261 0.7373 0.7372
Schistosoma mansoni tubulin subunit beta 0.0827 0.2308 0.2304
Trichomonas vaginalis tubulin gamma chain, putative 0.0827 0.2308 0.2307
Echinococcus granulosus chromobox protein 1 0.0069 0.0156 0.015
Brugia malayi Tubulin alpha-2 chain 0.261 0.7373 0.7373
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0827 0.2308 0.2304
Echinococcus multilocularis lamin dm0 0.0027 0.0035 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0118 0.0113
Echinococcus multilocularis Tubulin alpha 1 chain 0.261 0.7373 0.7372
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0362 0.0357
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0024 0.0027 0.0092
Plasmodium falciparum alpha tubulin 2 0.261 0.7373 0.7372
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0356 0.0351
Loa Loa (eye worm) hypothetical protein 0.261 0.7373 0.7373
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0107 0.0263 0.0263
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0827 0.2308 0.2307
Brugia malayi Pre-SET motif family protein 0.003 0.0045 0.0045
Schistosoma mansoni tubulin subunit alpha 0.0827 0.2308 0.2304
Plasmodium vivax DNA topoisomerase II, putative 0.0063 0.0138 0.0133
Schistosoma mansoni cpg binding protein 0.0028 0.004 0.0035
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0069 0.0177
Echinococcus multilocularis mothers against decapentaplegic 5 0.0084 0.0196 0.0191
Trypanosoma brucei alpha tubulin, putative 0.1078 0.302 0.3017
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1533 0.4312 0.4312
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0092 0.0087
Echinococcus multilocularis mothers against decapentaplegic 6 0.0037 0.0065 0.006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0084 0.0079
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0088 0.0083
Echinococcus granulosus lamin dm0 0.0027 0.0035 0.003
Echinococcus multilocularis smad 0.0084 0.0196 0.0191
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0057 0.012 0.0115
Mycobacterium ulcerans hypothetical protein 0.002 0.0016 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0156 0.0154
Trichomonas vaginalis tubulin epsilon chain, putative 0.261 0.7373 0.7373
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0069 0.0057
Echinococcus multilocularis tubulin alpha 3 chain 0.261 0.7373 0.7372
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0265 0.0265
Echinococcus multilocularis jun protein 0.0083 0.0196 0.019
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Schistosoma mansoni CREB-binding protein 2 0.0104 0.0255 0.0249
Echinococcus granulosus tubulin subunit TubB 0.261 0.7373 0.7372
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0088 0.024
Schistosoma mansoni alpha tubulin 0.261 0.7373 0.7372
Loa Loa (eye worm) tubulin alpha chain 0.261 0.7373 0.7373
Echinococcus granulosus peroxisome assembly protein 26 0.261 0.7373 0.7372
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0083 0.0291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0168 0.0704
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.0007
Mycobacterium tuberculosis Cell division protein FtsZ 0.0827 0.2308 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0061 0.0059
Schistosoma mansoni DNA topoisomerase II 0.0063 0.0138 0.0133
Echinococcus multilocularis ecdysone induced protein 78C 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0081 0.0189 0.0189
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0168 0.0162
Brugia malayi MH1 domain containing protein 0.0084 0.0196 0.0196
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0084 0.0079
Echinococcus multilocularis tubulin alpha 0.1905 0.5369 0.5367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0101 0.0247 0.0247
Trypanosoma cruzi epsilon tubulin, putative 0.1905 0.5369 0.5367
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Echinococcus granulosus CREB binding protein 0.0016 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0148 0.038 0.038
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.2274
Brugia malayi hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) CBP-B 0.0073 0.0168 0.0168
Echinococcus granulosus lamin 0.0027 0.0035 0.003
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0083 0.0077
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.0007
Brugia malayi ecdysone receptor 0.0045 0.0088 0.0088
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0084 0.0083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0362 0.0362
Brugia malayi mothers against decapentaplegic homolog 3 0.0037 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0005 0.0153
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0118 0.0113
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0265 0.026
Loa Loa (eye worm) hypothetical protein 0.1533 0.4312 0.4312
Plasmodium vivax tubulin gamma chain, putative 0.1905 0.5369 0.5367
Onchocerca volvulus 0.0027 0.0035 0.0064
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0263 0.1119
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0118 0.0113
Loa Loa (eye worm) p25-alpha family protein 0.0363 0.099 0.099
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0175 0.0737
Echinococcus multilocularis hypothetical protein 0.261 0.7373 0.7372
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0247 0.0247
Giardia lamblia Epsilon tubulin 0.0827 0.2308 0.2304
Plasmodium vivax tubulin epsilon chain, putative 0.1905 0.5369 0.5367
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0265 0.026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0101 0.0247 0.0247
Trypanosoma brucei zeta tubulin, putative 0.0827 0.2308 0.2304
Echinococcus multilocularis thymidylate synthase 0.0107 0.0262 0.0257
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0084 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0247 0.0247
Brugia malayi nuclear receptor NHR-88 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0103 0.0425
Mycobacterium leprae Probable lipase LipE 0.0036 0.0061 0.0195
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0168 0.0162
Echinococcus granulosus tubulin alpha 1C chain 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0037
Schistosoma mansoni zinc finger protein 0.0045 0.0088 0.0083
Onchocerca volvulus TPPP family protein homolog 0.0363 0.099 0.3241
Brugia malayi beta-lactamase family protein 0.0036 0.0061 0.0061
Onchocerca volvulus 0.0049 0.0099 0.0275
Leishmania major isocitrate dehydrogenase, putative 0.0024 0.0027 0.0021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0143 0.0366 0.0361
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0061 0.0061
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0056 0.3111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0069 0.0068
Mycobacterium tuberculosis Conserved protein 0.0036 0.0061 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0061 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Brugia malayi Cytochrome P450 family protein 0.0052 0.0107 0.0107
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0078 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0061 0.0055
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0247 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0037 0.0036
Onchocerca volvulus 0.0042 0.0077 0.0204
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0168 0.0162
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0024 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0007
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0088 0.0083
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0061 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0101 0.0247 0.0242
Echinococcus granulosus tubulin alpha 1C chain 0.261 0.7373 0.7372
Echinococcus granulosus Tubulin alpha 1 chain 0.261 0.7373 0.7372
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0263 0.1119
Schistosoma mansoni hypothetical protein 0.0125 0.0314 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0101 0.0247 0.0247
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0063 0.0138 0.0133
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0088 0.0083
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0078 0.0205
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0088 0.024
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0024 0.008
Brugia malayi MH2 domain containing protein 0.0084 0.0196 0.0196
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.1273 0.1268
Brugia malayi alpha-tubulin 0.261 0.7373 0.7373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0362 0.0357
Trichomonas vaginalis DNA topoisomerase II, putative 0.0063 0.0138 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0131 0.0125
Mycobacterium leprae cell division protein FtsZ 0.0827 0.2308 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1078 0.302 0.3019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0061 0.024
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0039
Schistosoma mansoni chromobox protein 0.0069 0.0156 0.015
Echinococcus granulosus mothers against decapentaplegic 5 0.0084 0.0196 0.0191
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0263 0.1119
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0168 0.0162
Loa Loa (eye worm) nuclear factor I 0.0046 0.009 0.009
Trypanosoma brucei trypanothione reductase 0.0047 0.0092 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0101 0.0247 0.0247
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0156 0.0154
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0069 0.0064
Brugia malayi Cytochrome P450 family protein 0.0023 0.0024 0.0024
Onchocerca volvulus 0.0036 0.0062 0.0153
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0175 0.0694
Schistosoma mansoni smad1 5 8 and 0.0084 0.0196 0.0191
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1905 0.5369 0.5367
Loa Loa (eye worm) acetyltransferase 0.0145 0.0372 0.0372
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0247 0.0247
Leishmania major zeta tubulin, putative 0.0827 0.2308 0.2304
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0063 0.0138 0.0138
Echinococcus granulosus neuropeptide s receptor 0.0462 0.1273 0.1268
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.01 0.0095
Echinococcus multilocularis CREB binding protein 0.0016 0.0006 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0265 0.0265
Brugia malayi Cell division protein ftsZ 0.0827 0.2308 0.2308
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0092 0.0087
Plasmodium vivax tubulin alpha chain, putative 0.261 0.7373 0.7372
Loa Loa (eye worm) alpha-tubulin 0.261 0.7373 0.7373
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0362 0.0362
Schistosoma mansoni tubulin subunit alpha 0.261 0.7373 0.7372
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0037
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0033 0.0027
Trypanosoma cruzi epsilon tubulin, putative 0.1905 0.5369 0.5367
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0061 0.0061
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0314 0.0309
Schistosoma mansoni Smad4 0.0037 0.0065 0.006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0093 0.0093
Plasmodium falciparum flap endonuclease 1 0.0026 0.0033 0.0027
Echinococcus granulosus tumor protein p63 0.0335 0.0911 0.0906
Echinococcus multilocularis chromobox protein 1 0.0069 0.0156 0.015
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0362 0.0357
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0033 0.002
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0024 0.0027 0.0021
Loa Loa (eye worm) TOPoisomerase family member 0.0063 0.0138 0.0138
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0011
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0083 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0061 0.0055
Echinococcus multilocularis thyroid hormone receptor alpha 0.0226 0.0602 0.0597
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0101 0.0247 0.0242
Plasmodium falciparum alpha tubulin 1 0.261 0.7373 0.7372
Schistosoma mansoni smad 0.0037 0.0065 0.006
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0016 0.0046
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0063 0.0138 0.0133
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0018 0.0055
Brugia malayi isocitrate dehydrogenase 0.0195 0.0513 0.0513
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0607 0.2613
Entamoeba histolytica tubulin alpha-1 chain 0.261 0.7373 0.737
Trichomonas vaginalis tubulin gamma chain, putative 0.1905 0.5369 0.5369
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Chlamydia trachomatis DNA gyrase subunit B 0.0021 0.0018 0.0893
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0827 0.2308 1
Onchocerca volvulus 0.003 0.0046 0.0098
Schistosoma mansoni Smad4 0.0037 0.0065 0.006
Chlamydia trachomatis endonuclease IV 0.0076 0.0175 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0084 0.0196 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0101 0.0247 0.0247
Schistosoma mansoni unc-13 (munc13) 0.0024 0.0027 0.0021
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0175 0.017
Brugia malayi p25-alpha family protein 0.0363 0.099 0.099
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0265 0.1129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.001 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.1226 0.344 0.344
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0088 0.0083
Loa Loa (eye worm) thymidylate synthase 0.0107 0.0262 0.0262
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0099 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0103 0.0102
Trypanosoma brucei zeta tubulin 0.0827 0.2308 0.2304
Trichomonas vaginalis tubulin alpha chain, putative 0.1905 0.5369 0.5369
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0263 0.1077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0362 0.0357
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.1273 0.1268
Brugia malayi photoreceptor-specific nuclear receptor 0.0101 0.0247 0.0247
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0083 0.0083
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0057 0.012 0.0115
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0079
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0033 0.0027
Echinococcus granulosus mothers against decapentaplegic 2 0.0037 0.0065 0.006
Schistosoma mansoni lamin 0.0027 0.0035 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0101 0.0247 0.0242
Brugia malayi hypothetical protein 0.0103 0.0252 0.0252
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0012 0.003
Trypanosoma cruzi zeta tubulin, putative 0.0827 0.2308 0.2304
Onchocerca volvulus 0.0036 0.0061 0.0149
Brugia malayi MH2 domain containing protein 0.0084 0.0196 0.0196
Echinococcus multilocularis tubulin alpha 1C chain 0.261 0.7373 0.7372
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0061 0.024
Loa Loa (eye worm) tubulin alpha 2 0.1783 0.5024 0.5024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0007
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1783 0.5024 0.5024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.004 0.0035
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 0.0253
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0088 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0035 0.0035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0195 0.0513 0.0508
Leishmania major dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0088 0.0083
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Schistosoma mansoni tubulin subunit alpha 0.261 0.7373 0.7372
Loa Loa (eye worm) steroid hormone receptor 0.0101 0.0247 0.0247
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0118 0.0118
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0033 0.0031
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0046 0.0089 0.0243
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.0027
Giardia lamblia DNA topoisomerase II 0.006 0.013 0.0125
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0061 0.0055
Entamoeba histolytica DNA topoisomerase II, putative 0.0063 0.0138 0.0126
Echinococcus multilocularis Tubulin alpha 1 chain 0.261 0.7373 0.7372
Loa Loa (eye worm) pax transcription factor protein 2 0.0747 0.208 0.208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0088 0.0083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0101 0.0247 0.0242
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0297 0.1266
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0024 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0101 0.0247 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0101 0.0247 0.0242
Mycobacterium tuberculosis Conserved protein 0.0036 0.0061 0.024
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0602 0.0597
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0168 0.0704
Echinococcus multilocularis chromobox protein 1 0.0069 0.0156 0.015
Schistosoma mansoni tubulin subunit epsilon 0.1905 0.5369 0.5367
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0103 0.0098
Toxoplasma gondii thioredoxin reductase 0.0047 0.0092 0.0087
Brugia malayi 6-phosphofructokinase 0.0108 0.0265 0.0265
Onchocerca volvulus 0.0045 0.0088 0.024
Mycobacterium ulcerans lipase LipD 0.0036 0.0061 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0165 0.0429 0.0429
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Brugia malayi tubulin alpha chain - mouse 0.261 0.7373 0.7373
Loa Loa (eye worm) alpha-tubulin 0.261 0.7373 0.7373
Schistosoma mansoni coup transcription factor 0.0101 0.0247 0.0242
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0005 0.0004
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Echinococcus granulosus tubulin alpha 0.1905 0.5369 0.5367
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0061 0.024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Schistosoma mansoni smad1 5 8 and 0.0084 0.0196 0.0191
Schistosoma mansoni tubulin subunit gamma 0.1905 0.5369 0.5367
Echinococcus multilocularis CREB binding protein 0.0072 0.0165 0.016
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0088 0.0088
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Onchocerca volvulus 0.0028 0.004 0.008
Brugia malayi steroid hormone receptor 0.0101 0.0247 0.0247
Echinococcus granulosus single minded 2 0.0036 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0061 0.0059
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0104 0.0255 0.0249
Echinococcus granulosus tubulin alpha 3 chain 0.261 0.7373 0.7372
Plasmodium falciparum glutathione reductase 0.0047 0.0092 0.0087
Echinococcus multilocularis tumor protein p63 0.0335 0.0911 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0101 0.0247 0.0247
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0024 0.0024
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0092 0.0378
Echinococcus multilocularis CREB binding protein 0.0016 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0107 0.0262 0.0257
Loa Loa (eye worm) hypothetical protein 0.0148 0.038 0.038
Brugia malayi MH2 domain containing protein 0.1226 0.344 0.344
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0265 0.1129
Trichomonas vaginalis tubulin alpha chain, putative 0.1078 0.302 0.3019
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0042 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0547 0.0547
Onchocerca volvulus Bile acid receptor homolog 0.0101 0.0247 0.0769
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Entamoeba histolytica hypothetical protein 0.0367 0.1001 0.0989
Schistosoma mansoni single-minded 0.0048 0.0096 0.0091
Schistosoma mansoni isocitrate dehydrogenase 0.0024 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.0162 0.0419 0.0419
Trypanosoma brucei epsilon tubulin 0.1905 0.5369 0.5367
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0263 0.1119
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0195 0.0513 0.0508
Loa Loa (eye worm) hypothetical protein 0.0049 0.0099 0.0099
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0024 0.0027 0.0092
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0314 0.0309
Trichomonas vaginalis esterase, putative 0.0036 0.0061 0.0059
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0101 0.0247 0.0242
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0042 0.0159
Echinococcus granulosus TGF beta signal transducer SmadC 0.0084 0.0196 0.0191
Loa Loa (eye worm) tubulin gamma chain 0.1905 0.5369 0.5369
Schistosoma mansoni lamin 0.0027 0.0035 0.003
Trypanosoma brucei tubulin delta chain 0.0827 0.2308 0.2304
Toxoplasma gondii alpha tubulin TUBA1 0.261 0.7373 0.7372
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0625 0.0625
Loa Loa (eye worm) glutathione reductase 0.0047 0.0092 0.0092
Schistosoma mansoni alpha tubulin 0.261 0.7373 0.7372
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0045 0.004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0101 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Brugia malayi Tubulin alpha chain 0.0827 0.2308 0.2308
Brugia malayi conserved hypotetical protein 0.0045 0.0088 0.0088
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0168 0.0162
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0265 0.026
Brugia malayi hypothetical protein 0.0045 0.0088 0.0088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0101 0.0247 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0101 0.0247 0.0247
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1783 0.5024 0.5024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Trichomonas vaginalis tubulin alpha chain, putative 0.1078 0.302 0.3019
Brugia malayi nuclear hormone receptor 0.0101 0.0247 0.0247
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0088 0.0083
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0195 0.0513 0.0508
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0083 0.0335
Brugia malayi MH2 domain containing protein 0.0037 0.0065 0.0065
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0024 0.0027 0.0027
Echinococcus multilocularis tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0024 0.0027 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0088 0.0083
Brugia malayi bZIP transcription factor family protein 0.0083 0.0196 0.0196
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0101 0.0247 0.0242
Echinococcus granulosus tubulin gamma 1 chain 0.1905 0.5369 0.5367
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Leishmania major mitochondrial DNA topoisomerase II 0.005 0.01 0.0095
Mycobacterium ulcerans cell division protein FtsZ 0.0827 0.2308 1
Brugia malayi nuclear receptor RXR 0.0045 0.0088 0.0088
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0168 0.0162
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0195 0.0513 0.0508
Trypanosoma brucei epsilon tubulin 0.1905 0.5369 0.5367
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0083 0.4635
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0061 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0101 0.0247 0.0242
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.2274
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0016 0.0016
Echinococcus granulosus Smad4 0.0084 0.0196 0.0191
Brugia malayi Pax transcription factor protein 2 0.0747 0.208 0.208
Plasmodium vivax tubulin alpha chain, putative 0.261 0.7373 0.7372
Schistosoma mansoni intermediate filament proteins 0.0027 0.0035 0.003
Brugia malayi hypothetical protein 0.0367 0.1001 0.1001
Trichomonas vaginalis tubulin epsilon chain, putative 0.0827 0.2308 0.2307
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0101 0.0247 0.0247
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0101 0.0247 0.0769
Brugia malayi Smad1 0.0084 0.0196 0.0196
Schistosoma mansoni chromobox protein 0.0069 0.0156 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0069 0.0068
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0033 0.0033
Echinococcus granulosus mothers against decapentaplegic 6 0.0037 0.0065 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.016 0.0413 0.0408
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0199 0.0525 0.052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0383 0.0383
Trypanosoma cruzi zeta tubulin, putative 0.0827 0.2308 0.2304
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0065
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0083 0.0077
Brugia malayi hypoxia-induced factor 1 0.0149 0.0383 0.0383
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0118 0.0118
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0083 0.0335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0061 0.0055
Treponema pallidum cell division protein FtsZ 0.0827 0.2308 1
Loa Loa (eye worm) tubulin beta chain 0.0827 0.2308 0.2308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0061 0.024
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0042 0.0079 0.0079
Onchocerca volvulus 0.0235 0.0628 0.2037
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.016 0.0413 0.0413
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0101 0.0247 0.0242
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.1273 0.1268
Trichomonas vaginalis tubulin epsilon chain, putative 0.261 0.7373 0.7373
Schistosoma mansoni retinoic acid receptor RXR 0.0199 0.0525 0.052
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.2243 0.2239
Brugia malayi Tubulin gamma chain 0.1905 0.5369 0.5369
Brugia malayi Heterochromatin protein 1 0.0069 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0101 0.0247 0.0247
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0024 0.0027 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0362 0.0357
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.0385 0.038
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Loa Loa (eye worm) MH1 domain-containing protein 0.0037 0.0065 0.0065
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0024 0.0027 0.0021
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0024 0.0027 0.0021
Schistosoma mansoni smad1 5 8 and 0.0084 0.0196 0.0191
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0602 0.0597
Plasmodium vivax DNA gyrase subunit B, putative 0.0021 0.0018 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0362 0.0357
Loa Loa (eye worm) tubulin alpha-2 chain 0.261 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.0262 0.0262
Giardia lamblia Alpha-tubulin 0.261 0.7373 0.7372
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0033 0.0027
Leishmania major trypanothione reductase 0.0047 0.0092 0.0087
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0042 0.0041
Onchocerca volvulus 0.0101 0.0247 0.0769
Trichomonas vaginalis tubulin beta chain, putative 0.261 0.7373 0.7373
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Toxoplasma gondii ABC1 family protein 0.0036 0.0061 0.0055
Brugia malayi Probable isocitrate dehydrogenase 0.0024 0.0027 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0078 0.0076
Echinococcus multilocularis lamin 0.0027 0.0035 0.003
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0061 0.024
Plasmodium falciparum tubulin delta chain, putative 0.0827 0.2308 0.2304
Mycobacterium ulcerans hypothetical protein 0.0036 0.0061 0.024
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0042 0.0037
Loa Loa (eye worm) tubulin alpha 2 0.1783 0.5024 0.5024
Echinococcus multilocularis transcription factor eb 0.0107 0.0263 0.0258
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0037 0.0065 0.0164
Trypanosoma cruzi PAB1-binding protein , putative 0.016 0.0413 0.0408
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Brugia malayi tubulin alpha-2 chain 0.261 0.7373 0.7373
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0107 0.0262 0.1072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0101 0.0247 0.0247
Plasmodium falciparum tubulin epsilon chain, putative 0.1905 0.5369 0.5367
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0101 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0088 0.0088
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0265 0.1129
Onchocerca volvulus Protein ultraspiracle homolog 0.0101 0.0247 0.0769
Entamoeba histolytica tubulin gamma chain 0.1905 0.5369 0.5364
Brugia malayi 6-phosphofructokinase 0.0108 0.0265 0.0265
Plasmodium falciparum DNA gyrase subunit B 0.0021 0.0018 0.0013
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0265 0.026
Loa Loa (eye worm) hypothetical protein 0.0046 0.009 0.009
Leishmania major gamma-tubulin 0.1905 0.5369 0.5367
Schistosoma mansoni hypothetical protein 0.0068 0.0151 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0362 0.0357
Trypanosoma brucei alpha tubulin 0.261 0.7373 0.7372
Brugia malayi chromobox protein homolog 3 0.0039 0.0069 0.0069
Trichomonas vaginalis tubulin, putative 0.1078 0.302 0.3019
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0175 0.0175
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.01 0.0095
Brugia malayi nuclear receptor NHR-67 0.0045 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0107 0.0107
Toxoplasma gondii DNA topoisomerase 2, putative 0.0063 0.0138 0.0133
Loa Loa (eye worm) hypothetical protein 0.003 0.0045 0.0045
Entamoeba histolytica tubulin alpha chain, putative 0.261 0.7373 0.737
Brugia malayi hypothetical protein 0.0056 0.0118 0.0118
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0088 0.0083
Brugia malayi Tubulin alpha-2 chain 0.261 0.7373 0.7373
Onchocerca volvulus 0.0747 0.208 0.6871
Leishmania major DNA topoisomerase ii 0.0057 0.012 0.0115
Brugia malayi Probable isocitrate dehydrogenase 0.0024 0.0027 0.0027
Schistosoma mansoni smad 0.0084 0.0196 0.0191
Echinococcus multilocularis tubulin alpha 3 chain 0.261 0.7373 0.7372
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0035 0.0035
Brugia malayi intermediate filament protein 0.0027 0.0035 0.0035
Loa Loa (eye worm) DR-78 0.0045 0.0088 0.0088
Echinococcus multilocularis musashi 0.0027 0.0035 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0827 0.2308 0.2307
Trypanosoma brucei epsilon tubulin 0.1905 0.5369 0.5367
Brugia malayi PAS domain containing protein 0.0048 0.0096 0.0096
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0033 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0035
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0118 0.0113
Onchocerca volvulus 0.0027 0.0035 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0101 0.0247 0.0247
Leishmania major hypothetical protein, conserved 0.016 0.0413 0.0408
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0046 0.0089 0.0243
Loa Loa (eye worm) tubulin alpha-3 chain 0.1533 0.4312 0.4312
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0367 0.1001 0.0996
Echinococcus multilocularis tubulin subunit TubB 0.261 0.7373 0.7372
Onchocerca volvulus 0.0045 0.0088 0.024
Brugia malayi hypothetical protein 0.0056 0.0118 0.0118
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0024 0.0027 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0196 0.019
Echinococcus multilocularis geminin 0.209 0.5895 0.5893
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0195 0.0513 0.0508
Trypanosoma cruzi tubulin delta chain 0.0827 0.2308 0.2304
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.261 0.7373 0.7373
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0061 0.024
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.0027
Brugia malayi Probable DNA topoisomerase II 0.0063 0.0138 0.0138
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0195 0.0513 0.0508
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0367 0.1001 0.0996
Leishmania major epsilon tubulin, putative 0.1905 0.5369 0.5367
Brugia malayi Tubulin beta chain 0.1078 0.302 0.302
Loa Loa (eye worm) hypothetical protein 0.1783 0.5024 0.5024
Brugia malayi MH1 domain containing protein 0.0046 0.009 0.009
Brugia malayi thymidylate synthase 0.0107 0.0262 0.0262
Mycobacterium ulcerans endonuclease IV 0.0076 0.0175 0.0737
Brugia malayi Thioredoxin reductase 0.0047 0.0092 0.0092
Brugia malayi beta-lactamase 0.0036 0.0061 0.0061
Trichomonas vaginalis tubulin gamma chain, putative 0.1905 0.5369 0.5369
Loa Loa (eye worm) hypothetical protein 0.0106 0.0262 0.0262
Echinococcus multilocularis muscleblind protein 0.0148 0.038 0.0375
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0018 0.0055
Echinococcus multilocularis muscleblind protein 1 0.0148 0.038 0.0375
Trichomonas vaginalis tubulin, putative 0.0827 0.2308 0.2307
Loa Loa (eye worm) transcription factor SMAD2 0.1226 0.344 0.344
Echinococcus granulosus tubulin alpha chain 0.261 0.7373 0.7372
Echinococcus multilocularis mothers against decapentaplegic 2 0.0037 0.0065 0.006
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0088 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0101 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0037 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0263 0.1119
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0827 0.2308 0.2304
Brugia malayi Cytochrome P450 family protein 0.0023 0.0024 0.0024
Echinococcus granulosus chromobox protein 1 0.0069 0.0156 0.015
Echinococcus multilocularis cpg binding protein 0.003 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.0264
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0247 0.0242
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0061 0.0195
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 0.0253
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0265 0.026
Mycobacterium tuberculosis Probable reductase 0.0107 0.0263 0.1119
Giardia lamblia Delta tubulin 0.0827 0.2308 0.2304
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.016 0.0413 0.0408
Brugia malayi Tubulin beta chain 0.0827 0.2308 0.2308
Echinococcus granulosus cpg binding protein 0.003 0.0045 0.0039
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0035 0.0035
Loa Loa (eye worm) tubulin alpha chain 0.261 0.7373 0.7373
Entamoeba histolytica tartrate dehydrogenase, putative 0.0024 0.0027 0.0014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0061 0.0061
Schistosoma mansoni tubulin subunit alpha 0.261 0.7373 0.7372
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0195 0.0513 0.0508
Onchocerca volvulus 0.1078 0.302 1
Trypanosoma cruzi PAB1-binding protein , putative 0.016 0.0413 0.0408
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0061 0.024
Trypanosoma brucei tubulin gamma chain 0.1905 0.5369 0.5367
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0265 0.1088
Onchocerca volvulus 0.0107 0.0262 0.0818
Leishmania major alpha tubulin 0.261 0.7373 0.7372
Plasmodium vivax glutathione reductase, putative 0.0047 0.0092 0.0087
Loa Loa (eye worm) hypothetical protein 0.0101 0.0247 0.0247
Schistosoma mansoni transcription factor LCR-F1 0.0367 0.1001 0.0996
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0625 0.0625
Toxoplasma gondii LsmAD domain-containing protein 0.016 0.0413 0.0408
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0061 0.024
Echinococcus granulosus geminin 0.209 0.5895 0.5893
Echinococcus multilocularis tubulin alpha 1C chain 0.261 0.7373 0.7372
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0024 0.0024
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0024 0.0027 0.0046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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