Detailed information for compound 1406170

Basic information

Technical information
  • TDR Targets ID: 1406170
  • Name: 1-(4-tert-butylphenyl)sulfonyl-3-methylpyrazo le
  • MW: 278.37 | Formula: C14H18N2O2S
  • H donors: 0 H acceptors: 3 LogP: 3.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccn(n1)S(=O)(=O)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C14H18N2O2S/c1-11-9-10-16(15-11)19(17,18)13-7-5-12(6-8-13)14(2,3)4/h5-10H,1-4H3
  • InChiKey: XXMXXUSAMCNMJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-tert-butylphenyl)sulfonyl-3-methyl-pyrazole
  • ST5326259
  • ZINC00079742
  • SDCCGMLS-0032047.P002
  • 1-[(4-tert-butylphenyl)sulfonyl]-3-methyl-1H-pyrazole
  • MLS000049449
  • SMR000075426

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0041 0.0064
Giardia lamblia High cysteine membrane protein Group 2 0.2688 0.366 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Mycobacterium ulcerans oxidoreductase 0.0112 0.0132 0.2298
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.0034 0.0026 0.0025
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0112 0.0132 0.2605
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0048 0.0046 0.0045
Plasmodium vivax NAD-dependent deacetylase, putative 0.0048 0.0046 0.0878
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0324 0.0424 1
Brugia malayi serpin 0.0017 0.0003 0.0002
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0129 0.0157 0.0156
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0026 0.0545
Brugia malayi transcriptional regulator, Sir2 family protein 0.0327 0.0427 0.0425
Plasmodium vivax aspartyl protease, putative 0.0034 0.0026 0.0494
Brugia malayi proprotein convertase 2 0.463 0.6319 0.6319
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0016 0.0001 0.0001
Brugia malayi serpin 0.0017 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0158 0.0196 0.0195
Onchocerca volvulus 0.0161 0.0199 0.2474
Loa Loa (eye worm) serpin 0.0017 0.0003 0.0002
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.0073 0.169
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0043 0.0068
Echinococcus granulosus serine protease inhibitor 0.0017 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.0424 0.0691
Loa Loa (eye worm) hypothetical protein 0.0148 0.0182 0.0181
Onchocerca volvulus Huntingtin homolog 0.0148 0.0182 0.2256
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Brugia malayi BmSERPIN 0.0017 0.0003 0.0002
Echinococcus multilocularis Estrogen regulated protein EP45 0.0017 0.0003 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Echinococcus multilocularis protoporphyrinogen oxidase 0.0112 0.0132 0.0165
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0026 0.0545
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.0294 0.0294
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0324 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Echinococcus granulosus lysine specific histone demethylase 1A 0.0549 0.0732 0.0731
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0331 0.0432 1
Brugia malayi hypothetical protein 0.0017 0.0003 0.0002
Onchocerca volvulus Huntingtin homolog 0.0148 0.0182 0.2256
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0026 0.0026
Brugia malayi BmSERPIN, truncated 0.0017 0.0003 0.0002
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0026 0.0025
Brugia malayi serpin 0.0017 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0136 0.0166 0.0166
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0046 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0324 0.0424 0.0424
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0041 0.005
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.0744 0.0931
Plasmodium falciparum subtilisin-like protease 2 0.0324 0.0424 0.8395
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0046 0.0044
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0026 0.0026
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0112 0.0132 0.2605
Echinococcus multilocularis Estrogen regulated protein EP45 0.0017 0.0003 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0003 0.0002
Brugia malayi serpin (BmSERPIN) 0.0017 0.0003 0.0002
Mycobacterium leprae Possible secreted protease 0.0324 0.0424 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0048 0.0046 0.1039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0041 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0064
Plasmodium vivax subtilisin-like protease 2, putative 0.0324 0.0424 0.8395
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0041 0.005
Schistosoma mansoni site-1 peptidase (S08 family) 0.0324 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0596 0.0796 0.0794
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0327 0.0427 0.0533
Loa Loa (eye worm) proprotein convertase 2 0.1793 0.2434 0.2433
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0324 0.0424 0.053
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0041 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.008 0.091
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0324 0.0424 1
Schistosoma mansoni hypothetical protein 0.1468 0.199 0.199
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0327 0.0427 0.0426
Plasmodium vivax subtilisin-like serine protease, putative 0.0324 0.0424 0.8395
Leishmania major silent information regulator 2, putative 0.0327 0.0427 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0026 0.0025
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0327 0.0427 1
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0026 0.0494
Echinococcus granulosus neuropeptide s receptor 0.0558 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.2838 0.3865 0.3864
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0324 0.0424 1
Loa Loa (eye worm) serpin 0.0017 0.0003 0.0002
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0048 0.0046 0.0056
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0046 0.0046
Chlamydia trachomatis protoporphyrinogen oxidase 0.0112 0.0132 0.5
Onchocerca volvulus 0.0324 0.0424 0.5307
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0112 0.0132 0.2605
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0026 0.0494
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0163 0.0202 0.0201
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0046 0.0046
Loa Loa (eye worm) serpin protein 6 0.0017 0.0003 0.0002
Plasmodium falciparum plasmepsin III 0.0034 0.0026 0.0494
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0048 0.0046 0.0056
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0327 0.0427 0.0696
Echinococcus granulosus protein will die slowly 0.0136 0.0166 0.0165
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0324 0.0424 1
Plasmodium falciparum plasmepsin VII 0.0034 0.0026 0.0494
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0016 0.0001 0.0001
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0048 0.0046 0.0878
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0003 0.0003
Echinococcus granulosus serine:threonine protein kinase N2 0.0068 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0045 0.0041 0.0039
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0041 0.0102
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.0135 0.0134
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0112 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0167 0.0209 0.0207
Schistosoma mansoni chromatin regulatory protein sir2 0.0327 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Toxoplasma gondii subtilisin SUB1 0.0324 0.0424 0.9253
Leishmania major sir2-family protein-like protein 0.0048 0.0046 0.1039
Trypanosoma brucei SIR2-like protein 4, putative 0.0048 0.0046 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0327 0.0427 0.9854
Entamoeba histolytica SWIRM domain protein 0.0046 0.0043 0.0984
Schistosoma mansoni SWI/SNF complex-related 0.0046 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Trypanosoma cruzi UDP-galactopyranose mutase 0.0112 0.0132 0.2342
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0046 0.0044
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1793 0.2434 0.2434
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.0424 0.0691
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0327 0.0427 1
Toxoplasma gondii subtilisin SUB4 0.0324 0.0424 0.9253
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Echinococcus granulosus Protein kinase C brain isozyme 0.0016 0.0001 0.0001
Mycobacterium ulcerans dehydrogenase 0.0112 0.0132 0.2298
Brugia malayi serpin 0.0017 0.0003 0.0002
Brugia malayi Myb-like DNA-binding domain containing protein 0.0163 0.0202 0.0201
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0094 0.0094
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0112 0.0132 0.2871
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0023 0.0022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Schistosoma mansoni chromatin regulatory protein sir2 0.0327 0.0427 0.0427
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.008 0.008
Toxoplasma gondii subtilisin SUB12 0.0324 0.0424 0.9253
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0048 0.0046 0.0045
Loa Loa (eye worm) serpin 0.0017 0.0003 0.0002
Toxoplasma gondii subtilisin SUB10 0.0324 0.0424 0.9253
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1468 0.199 0.3253
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Giardia lamblia Transcriptional regulator, Sir2 family 0.0048 0.0046 0.0115
Loa Loa (eye worm) TK/EGFR protein kinase 0.0592 0.079 0.0789
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0017 0.0003 0.0045
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0549 0.0732 0.0732
Brugia malayi Subtilase family protein 0.0324 0.0424 0.0422
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0046 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.0744 0.0931
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0549 0.0732 0.0731
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Entamoeba histolytica hypothetical protein 0.0046 0.0043 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0001 0.0001
Plasmodium falciparum plasmepsin IX 0.0034 0.0026 0.0494
Echinococcus granulosus serine protease inhibitor 0.0017 0.0003 0.0003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0041 0.0913
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.008 0.091
Echinococcus multilocularis neuroendocrine convertase 2 0.463 0.6319 0.7909
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.008 0.1722
Echinococcus granulosus neuroendocrine convertase 2 0.463 0.6319 0.6319
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4481 0.6115 0.7653
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0324 0.0424 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0034 0.0026 0.0026
Plasmodium vivax aspartyl protease, putative 0.0034 0.0026 0.0494
Trypanosoma brucei subtilisin peptidase 0.0324 0.0424 0.9799
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0026 0.0545
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0026 0.0025
Plasmodium falciparum plasmepsin II 0.0034 0.0026 0.0494
Loa Loa (eye worm) sirtuin 4 0.0048 0.0046 0.0044
Brugia malayi hypothetical protein 0.0034 0.0026 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Schistosoma mansoni protein kinase 0.0129 0.0157 0.0157
Plasmodium vivax aspartyl protease, putative 0.0034 0.0026 0.0494
Echinococcus granulosus plasminogen activator inhibitor 2 0.0017 0.0003 0.0003
Plasmodium falciparum plasmepsin IV 0.0034 0.0026 0.0494
Trypanosoma cruzi subtilisin peptidase 0.0324 0.0424 0.9778
Loa Loa (eye worm) subtilase 0.0324 0.0424 0.0422
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1793 0.2434 0.3979
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0042
Leishmania major UDP-galactopyranose mutase 0.0112 0.0132 0.3082
Loa Loa (eye worm) transcriptional regulator 0.0327 0.0427 0.0425
Onchocerca volvulus 0.0136 0.0166 0.2048
Toxoplasma gondii subtilisin SUB9 0.0324 0.0424 0.9253
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Loa Loa (eye worm) hypothetical protein 0.0112 0.0132 0.0131
Plasmodium vivax plasmepsin V, putative 0.0383 0.0505 1
Plasmodium falciparum plasmepsin I 0.0034 0.0026 0.0494
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0003 0.0003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1793 0.2434 0.3979
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0041 0.0925
Echinococcus granulosus serine protease inhibitor 0.0017 0.0003 0.0003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Brugia malayi SWIRM domain containing protein 0.0046 0.0043 0.0042
Plasmodium falciparum plasmepsin V 0.0383 0.0505 1
Plasmodium vivax plasmepsin IV, putative 0.0034 0.0026 0.0494
Trichomonas vaginalis hypothetical protein 0.1468 0.199 0.3253
Schistosoma mansoni amine oxidase 0.0112 0.0132 0.0132
Brugia malayi neuroendocrine convertase 1 precursor 0.463 0.6319 0.6319
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0026 0.0494
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0048 0.0046 0.1039
Echinococcus granulosus Estrogen regulated protein EP45 0.0017 0.0003 0.0003
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0041 0.0041
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.008 0.0079
Echinococcus multilocularis epidermal growth factor receptor 0.0592 0.079 0.0988
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0046 0.0043 0.0043
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0046 0.0878
Toxoplasma gondii subtilisin SUB11 0.0324 0.0424 0.9253
Toxoplasma gondii SWIRM domain-containing protein 0.0046 0.0043 0.0917
Brugia malayi serpin precursor 0.0017 0.0003 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.008 0.091
Toxoplasma gondii histone lysine-specific demethylase 0.0112 0.0132 0.2871
Onchocerca volvulus 0.0034 0.0026 0.0288
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0026 0.0025
Echinococcus multilocularis serine:threonine protein kinase N2 0.0077 0.0085 0.0105
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Brugia malayi serpin (BmSERPIN) 0.0017 0.0003 0.0002
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0331 0.0432 1
Schistosoma mansoni amine oxidase 0.0112 0.0132 0.0132
Schistosoma mansoni site-1 peptidase (S08 family) 0.0324 0.0424 0.0424
Brugia malayi Serpin protein 6 0.0017 0.0003 0.0002
Schistosoma mansoni serpin 0.0017 0.0003 0.0003
Schistosoma mansoni serpin 0.0017 0.0003 0.0003
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0026 0.0032
Brugia malayi SWIRM domain containing protein 0.0596 0.0796 0.0794
Brugia malayi Pepsin A precursor 0.0034 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Schistosoma mansoni furin-1 (S08 family) 0.3162 0.4309 0.4309
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Brugia malayi protein kinase C II. 0.0084 0.0094 0.0093
Schistosoma mansoni chromatin regulatory protein sir2 0.0327 0.0427 0.0427
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0324 0.0424 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0324 0.0424 0.0423
Loa Loa (eye worm) hypothetical protein 0.0324 0.0424 0.0422
Toxoplasma gondii subtilisin SUB2 0.0324 0.0424 0.9253
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Echinococcus multilocularis Furin 1 0.1793 0.2434 0.3046
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.008 0.008
Brugia malayi Will die slowly protein 0.0136 0.0166 0.0164
Giardia lamblia hypothetical protein 0.0046 0.0043 0.0109
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.008 0.1848
Schistosoma mansoni protein kinase 0.0129 0.0157 0.0157
Plasmodium falciparum plasmepsin VI 0.0034 0.0026 0.0494
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0041 0.004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0001 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.008 0.0099
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0324 0.0424 0.0423
Plasmodium falciparum plasmepsin X 0.0034 0.0026 0.0494
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4481 0.6115 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Brugia malayi celfurPC protein 0.585 0.799 0.7989
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0003 0.0003
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0112 0.0132 0.0131
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Possible oxidoreductase 0.0112 0.0132 0.2298
Echinococcus granulosus chromatin regulatory protein sir2 0.0327 0.0427 0.0426
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0327 0.0427 0.9854
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0048 0.0046 0.1039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0041 0.005
Echinococcus multilocularis serine protease inhibitor 0.0017 0.0003 0.0003
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0026 0.0545
Toxoplasma gondii aspartyl protease ASP5 0.0349 0.0458 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0158 0.0196 0.0195
Onchocerca volvulus 0.0034 0.0026 0.0288
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0041 0.0925
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0324 0.0424 0.0424
Echinococcus multilocularis membrane bound transcription factor site 1 0.0324 0.0424 0.053
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0324 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.0424 0.0691
Echinococcus granulosus epidermal growth factor receptor 0.0592 0.079 0.0789
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0048 0.0046 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.0424 0.0691
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1793 0.2434 0.3979
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0026 0.0026
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0112 0.0132 0.2298
Loa Loa (eye worm) hypothetical protein 0.0549 0.0732 0.0731
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0549 0.0732 0.0915
Giardia lamblia Sirtuin type 2 0.0048 0.0046 0.0115
Entamoeba histolytica protein kinase, putative 0.0017 0.0003 0.004
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0324 0.0424 1
Echinococcus granulosus Furin 1 0.1793 0.2434 0.2434
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0041 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0046 0.0968
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0132 0.2298
Loa Loa (eye worm) hypothetical protein 0.0048 0.0046 0.0044
Toxoplasma gondii aspartyl protease 0.0034 0.0026 0.0545
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0048 0.0046 0.1025
Echinococcus multilocularis 0.0112 0.0132 0.0165
Mycobacterium ulcerans monoamine oxidase 0.0112 0.0132 0.2298
Echinococcus multilocularis serine protease inhibitor 0.0017 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1793 0.2434 0.3979
Loa Loa (eye worm) WD40 repeat protein 0.0136 0.0166 0.0164
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0331 0.0432 1
Toxoplasma gondii subtilisin SUB6 0.0324 0.0424 0.9253
Echinococcus multilocularis chromatin regulatory protein sir2 0.0327 0.0427 0.0533
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1264 0.1711 0.1711
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0327 0.0427 0.0696
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0129 0.0157 0.0195
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0324 0.0424 0.0422
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0046 0.0044
Brugia malayi serpin 0.0017 0.0003 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0148 0.0182 0.0181
Trichomonas vaginalis WD repeat domain, putative 0.0136 0.0166 0.0269
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Toxoplasma gondii protease inhibitor PI1 0.0017 0.0003 0.0045
Brugia malayi serpin 0.0017 0.0003 0.0002
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0003 0.0003
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0324 0.0424 0.9778
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1793 0.2434 0.3979
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1468 0.199 0.3253
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Trypanosoma cruzi UDP-galactopyranose mutase 0.0112 0.0132 0.2342
Schistosoma mansoni protein kinase 0.0129 0.0157 0.0157
Plasmodium falciparum subtilisin-like protease 3 0.0324 0.0424 0.8395
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0113 0.0135 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0043 0.0068
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0026 0.0026
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1468 0.199 0.3253
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0112 0.0132 0.2298
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0041 0.004
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0046 0.0968
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0327 0.0427 0.9867
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.0148 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Echinococcus granulosus lysine specific histone demethylase 1A 0.0112 0.0132 0.0132
Echinococcus multilocularis protein will die slowly 0.0136 0.0166 0.0206
Plasmodium vivax subtilisin-like protease 1 0.0324 0.0424 0.8395
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1793 0.2434 0.3979
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4481 0.6115 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Toxoplasma gondii subtilisin SUB5 0.0324 0.0424 0.9253
Entamoeba histolytica serine protease inhibitor, putative 0.0017 0.0003 0.0048
Brugia malayi NAD-dependent deacetylase SIRT1 0.0048 0.0046 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.008 0.091
Echinococcus granulosus Estrogen regulated protein EP45 0.0017 0.0003 0.0003
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0046 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.0424 0.0691
Plasmodium falciparum protoporphyrinogen oxidase 0.0112 0.0132 0.2605
Loa Loa (eye worm) hypothetical protein 0.0034 0.0026 0.0025
Entamoeba histolytica SWIRM domain protein 0.0046 0.0043 0.0984
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0046 0.0123
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0046 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.1468 0.199 0.3253
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Schistosoma mansoni tyrosine kinase 0.0592 0.079 0.079
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0132 0.2605
Echinococcus multilocularis protein kinase c epsilon type 0.0084 0.0094 0.0117
Onchocerca volvulus CoRest homolog 0.0167 0.0209 0.2591
Echinococcus multilocularis 0.585 0.799 1
Brugia malayi Furin-like cysteine rich region family protein 0.0592 0.079 0.0789
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0112 0.0132 0.2298
Plasmodium falciparum subtilisin-like protease 1 0.0324 0.0424 0.8395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0112 0.0132 0.2605
Loa Loa (eye worm) serpin 0.0017 0.0003 0.0002
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0324 0.0424 0.0422
Giardia lamblia Hypothetical protein 0.0327 0.0427 0.1158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0026 0.0025
Giardia lamblia Furin precursor putative serine protease 0.1468 0.199 0.5432
Toxoplasma gondii subtilisin SUB8 0.0324 0.0424 0.9253
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0041 0.004
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0026 0.0041
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0084 0.0094 0.0093
Toxoplasma gondii subtilisin SUB7 0.0324 0.0424 0.9253
Onchocerca volvulus 0.0596 0.0796 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4481 0.6115 0.6115
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0048 0.0046 0.0045
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0048 0.0046 0.0115
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0048 0.0046 0.0878
Brugia malayi hypothetical protein 0.0112 0.0132 0.0131
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0026 0.0026
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0046 0.1039
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0132 0.2605
Leishmania major subtilisin-like serine peptidase 0.0324 0.0424 0.9931
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0046 0.0043 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0324 0.0424 0.0691
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0026 0.0025
Echinococcus granulosus protein kinase c epsilon type 0.0084 0.0094 0.0094

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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