Detailed information for compound 1406192

Basic information

Technical information
  • TDR Targets ID: 1406192
  • Name: 2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-( 2-phenylsulfanylphenyl)acetamide
  • MW: 356.465 | Formula: C17H16N4OS2
  • H donors: 1 H acceptors: 3 LogP: 3.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1Sc1ccccc1)CSc1nncn1C
  • InChi: 1S/C17H16N4OS2/c1-21-12-18-20-17(21)23-11-16(22)19-14-9-5-6-10-15(14)24-13-7-3-2-4-8-13/h2-10,12H,11H2,1H3,(H,19,22)
  • InChiKey: YLJBQDGKULIRMG-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(4-methyl-1,2,4-triazol-3-yl)thio]-N-[2-(phenylthio)phenyl]acetamide
  • 2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylphenyl)ethanamide
  • SMR000066179
  • T0507-6979
  • Oprea1_367296
  • ZINC03225356
  • MLS000054416

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0559 0.0553
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0018 0.0009
Onchocerca volvulus Peroxidase homolog 0.0067 0.0559 0.096
Trypanosoma brucei alpha tubulin 0.0697 0.7931 0.7931
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0074 0.0241
Echinococcus multilocularis tubulin alpha chain 0.0697 0.7931 0.7928
Echinococcus granulosus Tubulin alpha 1 chain 0.0697 0.7931 0.7928
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.007 0.0598 0.0586
Loa Loa (eye worm) hypothetical protein 0.0083 0.0744 0.0738
Schistosoma mansoni flap endonuclease-1 0.0025 0.0075 0.0068
Toxoplasma gondii exonuclease III APE 0.0041 0.026 0.0253
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1057 0.1051
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0312 0.0306
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0255
Schistosoma mansoni Smad4 0.002 0.0013 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0262 0.0255
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0948 0.0942
Trypanosoma brucei protein kinase, putative 0.0052 0.0384 0.0384
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0074 0.0067
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0031 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0312 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0262 0.0255
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.007 0.0598 0.2497
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Leishmania major cytochrome p450-like protein 0.0061 0.0494 0.0488
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0262 0.0255
Echinococcus granulosus geminin 0.0752 0.8574 0.8572
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0262 0.025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0424 0.0412
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0064 0.0057
Loa Loa (eye worm) Smad1 0.0045 0.0303 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0262 0.0255
Echinococcus multilocularis GPCR, family 2 0.0035 0.0183 0.017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0262 0.0255
Plasmodium falciparum tubulin epsilon chain, putative 0.0505 0.5684 0.5681
Loa Loa (eye worm) hypothetical protein 0.0478 0.5367 0.5364
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0424 0.0412
Loa Loa (eye worm) hypothetical protein 0.0036 0.0198 0.0192
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0074 0.0286
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0074 0.0241
Mycobacterium leprae cell division protein FtsZ 0.0219 0.2343 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0045 0.0303 0.0291
Trichomonas vaginalis tubulin, putative 0.0286 0.312 0.3074
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.007 0.0598 0.0592
Echinococcus multilocularis tubulin alpha 3 chain 0.0697 0.7931 0.7928
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Echinococcus granulosus tubulin alpha 3 chain 0.0697 0.7931 0.7928
Echinococcus granulosus Tubulin alpha 1 chain 0.0697 0.7931 0.7928
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0007 0.0007
Brugia malayi MH1 domain containing protein 0.0045 0.0303 0.0296
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0074 0.0286
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.798 0.7978
Plasmodium vivax tubulin alpha chain, putative 0.0697 0.7931 0.793
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.007 0.0598 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.0494 0.0488
Treponema pallidum cell division protein FtsZ 0.0219 0.2343 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0697 0.7931 0.7928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0312 0.0248
Schistosoma mansoni tubulin subunit beta 0.0219 0.2343 0.2337
Echinococcus granulosus alpha tubulin 0.0697 0.7931 0.7928
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0286 0.312 0.3074
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0106 0.0041
Trichomonas vaginalis tubulin gamma chain, putative 0.0505 0.5684 0.5656
Echinococcus granulosus single minded 2 0.004 0.0246 0.0234
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0099 0.0086
Echinococcus multilocularis smad 0.0045 0.0303 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0384 0.032
Schistosoma mansoni alpha tubulin 0.0697 0.7931 0.793
Brugia malayi hypothetical protein 0.024 0.2589 0.2583
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Onchocerca volvulus 0.0049 0.0351 0.0595
Trichomonas vaginalis tubulin epsilon chain, putative 0.0697 0.7931 0.7917
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0217 0.021
Echinococcus granulosus tubulin alpha 1C chain 0.0697 0.7931 0.7928
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0262 0.0255
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0527 0.0521
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0697 0.7931 0.7917
Trichomonas vaginalis tubulin epsilon chain, putative 0.0697 0.7931 0.7917
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0384 0.0377
Echinococcus granulosus GPCR family 2 0.0035 0.0183 0.017
Brugia malayi tubulin alpha chain - mouse 0.0697 0.7931 0.793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0312 0.0248
Trypanosoma brucei epsilon tubulin 0.0505 0.5684 0.5684
Brugia malayi MH2 domain containing protein 0.0045 0.0303 0.0296
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0559 0.0553
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0183 0.0176
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0219 0.2343 0.2292
Echinococcus multilocularis isocitrate dehydrogenase 0.007 0.0598 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0262 0.0255
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0366 0.0359
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0064 0.0051
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0217 0.0204
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0074 0.0286
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0257 0.025
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0689 0.0683
Trypanosoma brucei unspecified product 0.0043 0.0287 0.0287
Trypanosoma brucei epsilon tubulin 0.0505 0.5684 0.5684
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0384 0.0372
Schistosoma mansoni hypothetical protein 0.0053 0.0393 0.0386
Loa Loa (eye worm) tubulin alpha chain 0.0697 0.7931 0.793
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0515 0.2177
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.026 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0125 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0262 0.025
Trypanosoma brucei zeta tubulin 0.0219 0.2343 0.2343
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0262 0.0438
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Onchocerca volvulus 0.005 0.0366 0.0621
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0262 0.0255
Brugia malayi nuclear hormone receptor 0.0041 0.0262 0.0255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0262 0.025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0262 0.0255
Echinococcus granulosus lamin 0.0057 0.0442 0.043
Onchocerca volvulus 0.0067 0.0559 0.096
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0494 0.0488
Trypanosoma cruzi zeta tubulin, putative 0.0219 0.2343 0.2337
Trichomonas vaginalis set domain proteins, putative 0.0241 0.2593 0.2544
Trichomonas vaginalis tubulin gamma chain, putative 0.0505 0.5684 0.5656
Toxoplasma gondii isocitrate dehydrogenase 0.007 0.0598 0.0592
Trypanosoma brucei alpha tubulin 0.0697 0.7931 0.7931
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0384 0.032
Echinococcus granulosus lamin dm0 0.0057 0.0442 0.043
Trypanosoma brucei zeta tubulin, putative 0.0219 0.2343 0.2343
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0074 0.0286
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0505 0.5684 0.5681
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0262 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0126
Schistosoma mansoni hypothetical protein 0.0025 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.005 0.0366 0.0359
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0203 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.05 0.0493
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0074 0.0286
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0134 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0203 0.0138
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.028 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0203 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0126
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0106 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0653 0.0646
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0074 0.0241
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0133 0.0126
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0099 0.0086
Trichomonas vaginalis tubulin alpha chain, putative 0.0286 0.312 0.3074
Loa Loa (eye worm) hypothetical protein 0.0411 0.4589 0.4586
Echinococcus multilocularis mothers against decapentaplegic 5 0.0045 0.0303 0.0291
Echinococcus multilocularis Tubulin alpha 1 chain 0.0697 0.7931 0.7928
Trypanosoma brucei tubulin delta chain 0.0219 0.2343 0.2343
Trypanosoma brucei isocitrate dehydrogenase, putative 0.007 0.0598 0.0598
Echinococcus granulosus mothers against decapentaplegic 5 0.0045 0.0303 0.0291
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0384 0.0372
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0262 0.025
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0206 0.0853
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0262 0.0255
Toxoplasma gondii isocitrate dehydrogenase 0.007 0.0598 0.0592
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0559 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0312 0.0312
Trichomonas vaginalis tubulin beta chain, putative 0.0697 0.7931 0.7917
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0515 0.0515
Schistosoma mansoni alpha tubulin 0.0697 0.7931 0.793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0094 0.0028
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0262 0.025
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Plasmodium vivax delta tubulin, putative 0.0219 0.2343 0.2337
Brugia malayi hypothetical protein 0.0067 0.0559 0.0553
Schistosoma mansoni Smad4 0.0045 0.0303 0.0296
Mycobacterium tuberculosis Cell division protein FtsZ 0.0219 0.2343 1
Schistosoma mansoni ap endonuclease 0.0041 0.026 0.0253
Schistosoma mansoni tubulin subunit alpha 0.0219 0.2343 0.2337
Loa Loa (eye worm) hypothetical protein 0.0075 0.0653 0.0646
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.05 0.211
Schistosoma mansoni tubulin subunit epsilon 0.0505 0.5684 0.5681
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0424 0.0417
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0106 0.01
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0384 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0312 0.0248
Trypanosoma brucei cytochrome P450, putative 0.0061 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0262 0.025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0384 0.0377
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Brugia malayi steroid hormone receptor 0.0041 0.0262 0.0255
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0424 0.0417
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0074 0.0241
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0312 0.03
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0384 0.0384
Schistosoma mansoni ap endonuclease 0.0041 0.026 0.0253
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0262 0.025
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0689 0.0683
Schistosoma mansoni tubulin subunit alpha 0.0697 0.7931 0.793
Plasmodium vivax tubulin alpha chain, putative 0.0697 0.7931 0.793
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0255
Loa Loa (eye worm) hypothetical protein 0.0093 0.0861 0.0855
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0262 0.0255
Brugia malayi hypothetical protein 0.0124 0.1225 0.1219
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0262 0.025
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0074 0.0241
Echinococcus granulosus dna polymerase kappa 0.0063 0.0515 0.0503
Trypanosoma cruzi DNA polymerase eta, putative 0.0093 0.0861 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0262 0.0255
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0188 0.0122
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0106 0.01
Brugia malayi Tubulin alpha chain 0.0219 0.2343 0.2337
Schistosoma mansoni intermediate filament proteins 0.0057 0.0442 0.0435
Echinococcus multilocularis protein dispatched 1 0.0049 0.0351 0.0339
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0384 0.0377
Brugia malayi Isocitrate dehydrogenase 0.007 0.0598 0.0592
Echinococcus granulosus Smad4 0.0045 0.0303 0.0291
Loa Loa (eye worm) hypothetical protein 0.0053 0.0393 0.0387
Echinococcus multilocularis tubulin alpha chain 0.0697 0.7931 0.7928
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.0515 0.0509
Entamoeba histolytica hypothetical protein 0.0156 0.1606 0.1516
Leishmania major DNA polymerase eta, putative 0.0093 0.0861 0.0855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0262 0.0255
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0384 0.0372
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0312 0.0208
Echinococcus granulosus smad 0.0045 0.0303 0.0291
Giardia lamblia DINP protein human, muc B family 0.0063 0.0515 0.0509
Brugia malayi nuclear receptor NHR-88 0.0041 0.0262 0.0255
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0074 0.0241
Giardia lamblia GTOR 0.0046 0.0312 0.0306
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.145 0.1439
Trichomonas vaginalis tubulin beta chain, putative 0.0697 0.7931 0.7917
Echinococcus granulosus Tubulin alpha 1 chain 0.0697 0.7931 0.7928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0424 0.0417
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0018 0.0011
Brugia malayi tubulin alpha-2 chain 0.0697 0.7931 0.793
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0074 0.0286
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0478 0.5367 0.5364
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0217 0.021
Trypanosoma brucei beta tubulin 0.0505 0.5684 0.5684
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0013 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0262 0.0255
Loa Loa (eye worm) tubulin gamma chain 0.0505 0.5684 0.5681
Toxoplasma gondii alpha-tubulin I, putative 0.0697 0.7931 0.793
Giardia lamblia Alpha-tubulin 0.0697 0.7931 0.793
Loa Loa (eye worm) tubulin alpha-2 chain 0.0697 0.7931 0.793
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.007 0.0598 0.0586
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0074 0.0067
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0074 0.0061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0064 0.0057
Echinococcus multilocularis lamin 0.0057 0.0442 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2343 0.2292
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0061 0.0494 0.2086
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.026 0.0247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0262 0.025
Trypanosoma cruzi epsilon tubulin, putative 0.0505 0.5684 0.5681
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0744 0.0738
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Echinococcus granulosus jun protein 0.0085 0.0776 0.0764
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0966 0.096
Loa Loa (eye worm) hypothetical protein 0.0056 0.043 0.0423
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0074 0.0241
Echinococcus multilocularis hypothetical protein 0.0697 0.7931 0.7928
Brugia malayi ecdysteroid receptor 0.0041 0.0262 0.0255
Echinococcus granulosus tumor protein p63 0.0343 0.3794 0.3786
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.026 0.1082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0133 0.0126
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0203 0.0203
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0262 0.0438
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0018 0.0046
Loa Loa (eye worm) hypothetical protein 0.024 0.2589 0.2583
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0689 0.2888
Schistosoma mansoni peroxidasin 0.0067 0.0559 0.0553
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0262 0.025
Giardia lamblia Alpha-tubulin 0.0697 0.7931 0.793
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0515 0.214
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0074 0.0241
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.026 0.0253
Leishmania major cytochrome p450-like protein 0.0025 0.0074 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0257 0.025
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0074 0.0241
Loa Loa (eye worm) hypothetical protein 0.0083 0.0749 0.0742
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.05 0.0493
Trypanosoma brucei unspecified product 0.0063 0.0515 0.0515
Onchocerca volvulus 0.003 0.0133 0.0211
Trichomonas vaginalis tubulin, putative 0.0286 0.312 0.3074
Onchocerca volvulus Peroxidasin homolog 0.0067 0.0559 0.096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.026 0.0253
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0948 0.0937
Onchocerca volvulus Peroxidase homolog 0.0067 0.0559 0.096
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.798 0.7977
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Echinococcus multilocularis peroxisome assembly protein 26 0.0697 0.7931 0.7928
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0106 0.01
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.05 0.0493
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0045 0.0303 0.0291
Schistosoma mansoni hypothetical protein 0.0075 0.0653 0.0646
Trichomonas vaginalis tubulin beta chain, putative 0.0697 0.7931 0.7917
Loa Loa (eye worm) hypothetical protein 0.0109 0.1057 0.1051
Loa Loa (eye worm) hypothetical protein 0.0078 0.0689 0.0683
Schistosoma mansoni coup transcription factor 0.0041 0.0262 0.0255
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0312 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0424 0.0412
Brugia malayi hypothetical protein 0.0053 0.0402 0.0395
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0219 0.2343 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.028 0.0274
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.0515 0.0503
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0007 0.0007
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0384 0.0377
Brugia malayi MH1 domain containing protein 0.0045 0.0303 0.0296
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0689 0.0683
Brugia malayi Pre-SET motif family protein 0.0212 0.2252 0.2246
Loa Loa (eye worm) nuclear factor I 0.0025 0.0068 0.0061
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.05 0.0488
Brugia malayi follicle stimulating hormone receptor 0.0238 0.2559 0.2554
Giardia lamblia Gamma tubulin 0.0505 0.5684 0.5681
Loa Loa (eye worm) tubulin beta chain 0.0219 0.2343 0.2337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.05 0.211
Brugia malayi hypothetical protein 0.0067 0.0562 0.0555
Brugia malayi Flap endonuclease-1 0.0028 0.0106 0.01
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0074 0.0241
Brugia malayi bZIP transcription factor family protein 0.0085 0.0776 0.077
Trypanosoma brucei alpha tubulin 0.0697 0.7931 0.7931
Brugia malayi hypoxia-induced factor 1 0.0153 0.1568 0.1562
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0074 0.0241
Loa Loa (eye worm) alpha-tubulin 0.0697 0.7931 0.793
Trypanosoma brucei DNA polymerase eta, putative 0.0093 0.0861 0.0861
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0411 0.4589 0.4553
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0262 0.0255
Loa Loa (eye worm) tubulin alpha-3 chain 0.0411 0.4589 0.4586
Schistosoma mansoni alpha tubulin 0.0697 0.7931 0.793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0424 0.0417
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0074 0.0286
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0353 0.0346
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0069 0.0589 0.0583
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0183 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Leishmania major DNA polymerase eta, putative 0.0049 0.0353 0.0346
Brugia malayi Cytochrome P450 family protein 0.0064 0.0527 0.0521
Trichomonas vaginalis tubulin beta chain, putative 0.0697 0.7931 0.7917
Echinococcus multilocularis tubulin subunit TubB 0.0697 0.7931 0.7928
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0303 0.0296
Trichomonas vaginalis tubulin beta chain, putative 0.0697 0.7931 0.7917
Schistosoma mansoni hypothetical protein 0.0752 0.8574 0.8573
Schistosoma mansoni hypothetical protein 0.0049 0.0351 0.0345
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.026 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0074 0.0241
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.026 0.0195
Plasmodium falciparum tubulin delta chain, putative 0.0219 0.2343 0.2337
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0384 0.0377
Brugia malayi Tubulin beta chain 0.0286 0.312 0.3115
Schistosoma mansoni tubulin subunit alpha 0.0697 0.7931 0.793
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0356 0.035
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0074 0.0286
Brugia malayi Smad1 0.0045 0.0303 0.0296
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0074 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0074 0.0241
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0255
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0384 0.0377
Echinococcus multilocularis Smad4 0.0045 0.0303 0.0291
Brugia malayi MH1 domain containing protein 0.0025 0.0068 0.0061
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0262 0.0255
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0106 0.01
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0212 0.0199
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0515 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Entamoeba histolytica hypothetical protein 0.0156 0.1606 0.1516
Loa Loa (eye worm) tubulin alpha 2 0.0478 0.5367 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0097 0.0031
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0074 0.0241
Leishmania major DNA polymerase kappa, putative 0.0063 0.0515 0.0509
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.9416 0.9415
Mycobacterium ulcerans cell division protein FtsZ 0.0219 0.2343 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0074 0.0286
Loa Loa (eye worm) hypothetical protein 0.0057 0.0442 0.0435
Trypanosoma cruzi tubulin delta chain 0.0219 0.2343 0.2337
Schistosoma mansoni lamin 0.0057 0.0442 0.0435
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0074 0.0286
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0206 0.0194
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0126
Schistosoma mansoni tubulin subunit gamma 0.0505 0.5684 0.5681
Echinococcus multilocularis expressed conserved protein 0.0094 0.0877 0.0866
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0262 0.0255
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0353 0.0346
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.026 0.026
Trichomonas vaginalis tubulin epsilon chain, putative 0.0219 0.2343 0.2292
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.05 0.0488
Echinococcus granulosus tubulin alpha 0.0505 0.5684 0.5679
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0384 0.0372
Brugia malayi MH2 domain containing protein 0.002 0.0013 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0262 0.0255
Echinococcus multilocularis tubulin alpha 1C chain 0.0697 0.7931 0.7928
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0217 0.0204
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0948 0.0937
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0176
Entamoeba histolytica hypothetical protein 0.0156 0.1606 0.1516
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Trichomonas vaginalis tubulin, putative 0.0219 0.2343 0.2292
Leishmania major zeta tubulin, putative 0.0219 0.2343 0.2337
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.0515 0.0503
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0744 0.0738
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0262 0.0255
Onchocerca volvulus 0.0037 0.0206 0.034
Loa Loa (eye worm) tubulin alpha 2 0.0192 0.2025 0.2019
Onchocerca volvulus 0.0286 0.312 0.546
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2589 0.2579
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0133 0.012
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0106 0.0094
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0206 0.0199
Chlamydia trachomatis endonuclease IV 0.0078 0.0689 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.028 0.0274
Echinococcus multilocularis tumor protein p63 0.0343 0.3794 0.3786
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0183 0.017
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0212 0.0199
Brugia malayi hypothetical protein 0.0156 0.1606 0.16
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1057 0.1051
Leishmania major hypothetical protein, conserved 0.0083 0.0744 0.0738
Brugia malayi nuclear receptor RXR 0.0024 0.0064 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0183 0.0176
Brugia malayi hypothetical protein 0.0083 0.0744 0.0738
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Echinococcus multilocularis lamin dm0 0.0057 0.0442 0.043
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0351 0.0345
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0442 0.0435
Trypanosoma cruzi zeta tubulin, putative 0.0219 0.2343 0.2337
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0074 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0203 0.0138
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.2559 0.2554
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.008
Schistosoma mansoni patched 1 0.0043 0.028 0.0274
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0092
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Echinococcus granulosus microtubule associated protein 2 0.0701 0.798 0.7977
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0442 0.0435
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0697 0.7931 0.793
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.026 0.0253
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0203 0.0197
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0559 0.0553
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0156 0.1606 0.1595
Onchocerca volvulus 0.0057 0.0442 0.0754
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.007 0.0598 0.0592
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0183 0.017
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0515 0.0509
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.007 0.0598 0.0586
Trypanosoma brucei PAB1-binding protein , putative 0.0083 0.0744 0.0744
Brugia malayi Tubulin gamma chain 0.0505 0.5684 0.5681
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0744 0.0738
Schistosoma mansoni Smad4 0.002 0.0013 0.0006
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0312 0.0306
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0515 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0097 0.0031
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0074 0.0286
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0312 0.0306
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.026 0.104
Echinococcus granulosus tubulin epsilon chain 0.0505 0.5684 0.5679
Brugia malayi Blistered cuticle protein 3 0.0067 0.0559 0.0553
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0559 0.0553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.026 0.0253
Plasmodium vivax tubulin epsilon chain, putative 0.0505 0.5684 0.5681
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0442 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0074 0.0286
Onchocerca volvulus 0.0507 0.5703 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0262 0.0255
Echinococcus multilocularis Tubulin alpha 1 chain 0.0697 0.7931 0.7928
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0074 0.0241
Loa Loa (eye worm) blistered cuticle protein 3 0.0067 0.0559 0.0553
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0515 0.2177
Echinococcus multilocularis Tubulin alpha 1 chain 0.0697 0.7931 0.7928
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0744 0.0738
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0183 0.017
Trypanosoma brucei tubulin gamma chain 0.0505 0.5684 0.5684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0074 0.0241
Trichomonas vaginalis tubulin alpha chain, putative 0.0286 0.312 0.3074
Trypanosoma cruzi tubulin gamma chain 0.0505 0.5684 0.5681
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0074 0.0286
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0074 0.0286
Brugia malayi cytochrome P450 0.0025 0.0074 0.0067
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.026 0.0155
Echinococcus multilocularis musashi 0.0057 0.0442 0.043
Loa Loa (eye worm) alpha-tubulin 0.0697 0.7931 0.793
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0007 0.0007
Brugia malayi Cell division protein ftsZ 0.0219 0.2343 0.2337
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0045 0.0303 0.0296
Trypanosoma cruzi alpha tubulin, putative 0.0697 0.7931 0.793
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0287 0.0287
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0262 0.0255
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0074 0.0241
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0312 0.0208
Echinococcus granulosus Protein patched homolog 1 0.0043 0.028 0.0268
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0262 0.0255
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0515 0.0509
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0262 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0384 0.0377
Loa Loa (eye worm) tubulin alpha 2 0.0478 0.5367 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0203 0.0138
Entamoeba histolytica tubulin alpha chain, putative 0.0697 0.7931 0.7909
Brugia malayi isocitrate dehydrogenase 0.007 0.0598 0.0592
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0219 0.2343 0.2337
Brugia malayi MH1 domain containing protein 0.0025 0.0068 0.0061
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.5293 0.5287
Entamoeba histolytica tubulin gamma chain 0.0505 0.5684 0.5638
Schistosoma mansoni smad 0.0045 0.0303 0.0296
Brugia malayi mothers against decapentaplegic homolog 3 0.002 0.0013 0.0006
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0948 0.0851
Echinococcus granulosus tubulin alpha chain 0.0697 0.7931 0.7928
Echinococcus multilocularis tubulin alpha chain 0.0697 0.7931 0.7928
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.012 0.0107
Trypanosoma cruzi tubulin delta chain 0.0219 0.2343 0.2337
Echinococcus granulosus expressed conserved protein 0.0094 0.0877 0.0866
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.1568 0.1562
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0384 0.032
Mycobacterium ulcerans epimerase 0.002 0.0018 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0287 0.0287
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.026 0.0195
Plasmodium falciparum alpha tubulin 2 0.0697 0.7931 0.793
Trichomonas vaginalis tubulin gamma chain, putative 0.0219 0.2343 0.2292
Echinococcus multilocularis jun protein 0.0085 0.0776 0.0764
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.05 0.2074
Trypanosoma cruzi epsilon tubulin, putative 0.0505 0.5684 0.5681
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0262 0.025
Echinococcus multilocularis 0.0025 0.0074 0.0061
Trypanosoma brucei unspecified product 0.0043 0.0287 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0262 0.0255
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0057
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0064 0.0051
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.0515 0.0509
Brugia malayi Pre-SET motif family protein 0.003 0.0133 0.0126
Echinococcus multilocularis peroxidasin 0.0067 0.0559 0.0547
Echinococcus multilocularis protein patched 0.0043 0.028 0.0268
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0312 0.0306
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0074 0.0241
Trichomonas vaginalis tubulin beta chain, putative 0.0286 0.312 0.3074
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.05 0.0493
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0064 0.0057
Schistosoma mansoni peroxidasin 0.0067 0.0559 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0262 0.025
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0176
Giardia lamblia Delta tubulin 0.0219 0.2343 0.2337
Echinococcus multilocularis tubulin alpha 0.0505 0.5684 0.5679
Mycobacterium ulcerans endonuclease IV 0.0078 0.0689 0.2921
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0689 0.2888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0262 0.0255
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0384 0.032
Plasmodium falciparum flap endonuclease 1 0.0028 0.0106 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0659 0.7481 0.7479
Onchocerca volvulus 0.0067 0.0562 0.0965
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Echinococcus multilocularis tubulin gamma 1 chain 0.0505 0.5684 0.5679
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0013 0.0006
Echinococcus multilocularis tubulin alpha chain 0.0697 0.7931 0.7928
Plasmodium vivax SET domain protein, putative 0.003 0.0133 0.0126
Trypanosoma brucei alpha tubulin 0.0697 0.7931 0.7931
Leishmania major delta tubulin, putative 0.0219 0.2343 0.2337
Loa Loa (eye worm) hypothetical protein 0.0166 0.1718 0.1712
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0776 0.0764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0515 0.0509
Brugia malayi Tubulin alpha-2 chain 0.0697 0.7931 0.793
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0262 0.0255
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0133 0.012
Trichomonas vaginalis tubulin alpha chain, putative 0.0505 0.5684 0.5656
Echinococcus granulosus peroxidasin 0.0067 0.0559 0.0547
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0776 0.0764
Echinococcus granulosus neuropeptide s receptor 0.0472 0.5293 0.5287
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.145 0.1439
Echinococcus granulosus tubulin alpha chain 0.0697 0.7931 0.7928
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) tubulin alpha chain 0.0697 0.7931 0.793
Echinococcus granulosus flap endonuclease 1 0.0028 0.0106 0.0094
Schistosoma mansoni DNA polymerase eta 0.0093 0.0861 0.0855
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2589 0.2579
Leishmania major cytochrome p450-like protein 0.0025 0.0074 0.0067
Brugia malayi Cytochrome P450 family protein 0.0025 0.0074 0.0067
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0559 0.0553
Onchocerca volvulus Peroxidasin homolog 0.0067 0.0559 0.096
Loa Loa (eye worm) hypothetical protein 0.0067 0.0559 0.0553
Trichomonas vaginalis tubulin alpha chain, putative 0.0286 0.312 0.3074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Echinococcus granulosus tubulin subunit TubB 0.0697 0.7931 0.7928
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0156 0.1606 0.1595
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0515 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0136 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0234 0.0169
Schistosoma mansoni smad1 5 8 and 0.0045 0.0303 0.0296
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0057
Brugia malayi hypothetical protein 0.0024 0.0064 0.0057
Giardia lamblia Epsilon tubulin 0.0219 0.2343 0.2337
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0074 0.0286
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0312 0.0306
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.007 0.0598 0.0586
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0188 0.0122
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.007 0.0598 0.0598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0262 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0175 0.011
Loa Loa (eye worm) MH2 domain-containing protein 0.0659 0.7481 0.7479
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0074 0.0286
Brugia malayi hypothetical protein 0.0024 0.0064 0.0057
Schistosoma mansoni tubulin subunit alpha 0.0697 0.7931 0.793
Loa Loa (eye worm) isocitrate dehydrogenase 0.007 0.0598 0.0592
Loa Loa (eye worm) hypothetical protein 0.0041 0.0262 0.0255
Echinococcus granulosus tubulin alpha 3 chain 0.0697 0.7931 0.7928
Leishmania major alpha tubulin 0.0697 0.7931 0.793
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0262 0.025
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.028 0.0268
Onchocerca volvulus Chorion peroxidase homolog 0.0067 0.0559 0.096
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.007 0.0598 0.0586
Plasmodium falciparum tubulin gamma chain 0.0505 0.5684 0.5681
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0262 0.025
Schistosoma mansoni tubulin subunit delta 0.0219 0.2343 0.2337
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0384 0.0377
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.0494 0.0488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0424 0.0417
Brugia malayi MAP kinase sur-1 0.0052 0.0384 0.0377
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0176
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0074 0.0074
Brugia malayi Tubulin beta chain 0.0219 0.2343 0.2337
Echinococcus multilocularis geminin 0.0752 0.8574 0.8572
Echinococcus granulosus tubulin alpha 1C chain 0.0697 0.7931 0.7928
Brugia malayi Pax transcription factor protein 2 0.0507 0.5703 0.57
Schistosoma mansoni hypothetical protein 0.0156 0.1606 0.16
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1057 0.1051
Schistosoma mansoni smad1 5 8 and 0.0045 0.0303 0.0296
Brugia malayi intermediate filament protein 0.0057 0.0442 0.0435
Echinococcus granulosus tubulin alpha chain 0.0697 0.7931 0.7928
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0322 0.3549 0.3544
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0515 0.0515
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0074 0.0286
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.0515 0.0509
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0183 0.0176
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0064 0.0057
Toxoplasma gondii alpha tubulin TUBA1 0.0697 0.7931 0.793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0203 0.0138
Brugia malayi MH2 domain containing protein 0.0045 0.0303 0.0296
Schistosoma mansoni hypothetical protein 0.0037 0.0212 0.0205
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.007 0.0598 0.0592
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0515 0.0515
Echinococcus granulosus tubulin delta chain 0.0219 0.2343 0.2333
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0559 0.0553
Onchocerca volvulus 0.0241 0.2593 0.4535
Echinococcus granulosus tubulin alpha chain 0.0697 0.7931 0.7928
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0262 0.0255
Brugia malayi Tubulin alpha chain 0.0697 0.7931 0.793
Echinococcus multilocularis tubulin delta chain 0.0219 0.2343 0.2333
Schistosoma mansoni smad1 5 8 and 0.0045 0.0303 0.0296
Loa Loa (eye worm) hypothetical protein 0.0033 0.0159 0.0152
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0057
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0303 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0262 0.0255
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0064 0.0057
Brugia malayi CHE-14 protein 0.0043 0.028 0.0274
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0515 0.0452
Trichomonas vaginalis tubulin beta chain, putative 0.0697 0.7931 0.7917
Plasmodium vivax ataxin-2 like protein, putative 0.0083 0.0744 0.0738
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0262 0.0255
Loa Loa (eye worm) hypothetical protein 0.01 0.0948 0.0942
Toxoplasma gondii LsmAD domain-containing protein 0.0083 0.0744 0.0738
Onchocerca volvulus 0.0041 0.0262 0.0438
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0074 0.0067
Onchocerca volvulus 0.0067 0.0559 0.096
Loa Loa (eye worm) cytochrome P450 0.0025 0.0074 0.0067
Leishmania major epsilon tubulin, putative 0.0505 0.5684 0.5681
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0175 0.0169
Leishmania major gamma-tubulin 0.0505 0.5684 0.5681
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0133 0.012
Brugia malayi ImpB/MucB/SamB family protein 0.0093 0.0861 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0097 0.0031
Echinococcus granulosus tubulin alpha chain 0.0697 0.7931 0.7928
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0262 0.0255
Schistosoma mansoni jun-related protein 0.0069 0.0589 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0262 0.0255
Plasmodium vivax tubulin gamma chain, putative 0.0505 0.5684 0.5681
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.028 0.0216
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0312 0.03
Schistosoma mansoni single-minded 0.0049 0.0356 0.035
Entamoeba histolytica hypothetical protein 0.0156 0.1606 0.1516
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.008
Loa Loa (eye worm) CYP4Cod1 0.0061 0.0494 0.0488
Schistosoma mansoni smad 0.002 0.0013 0.0006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.007 0.0598 0.0592
Brugia malayi Cytochrome P450 family protein 0.0061 0.0494 0.0488
Echinococcus granulosus peroxisome assembly protein 26 0.0697 0.7931 0.7928
Onchocerca volvulus 0.0067 0.0559 0.096
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0074 0.0241
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0515 0.0509
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0134 0.0127
Echinococcus multilocularis tubulin alpha 1C chain 0.0697 0.7931 0.7928
Mycobacterium leprae putative cytochrome p450 0.0025 0.0074 0.0241
Schistosoma mansoni lamin 0.0057 0.0442 0.0435
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0262 0.0255
Brugia malayi PAS domain containing protein 0.0049 0.0356 0.035
Brugia malayi MH2 domain containing protein 0.0659 0.7481 0.7479
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0384 0.0377
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0262 0.0438
Echinococcus granulosus tubulin gamma 1 chain 0.0505 0.5684 0.5679
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0074 0.0241
Echinococcus multilocularis tubulin alpha chain 0.0697 0.7931 0.7928
Entamoeba histolytica tubulin alpha-1 chain 0.0697 0.7931 0.7909
Brugia malayi alpha-tubulin 0.0697 0.7931 0.793
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0515 0.214
Echinococcus multilocularis dna polymerase eta 0.0093 0.0861 0.085
Loa Loa (eye worm) pax transcription factor protein 2 0.0507 0.5703 0.57
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.026 0.0253
Echinococcus granulosus intermediate filament protein 0.0057 0.0442 0.043
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0074 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2343 0.2292
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0074 0.0286
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.5293 0.5287
Schistosoma mansoni transcription factor LCR-F1 0.0156 0.1606 0.16
Onchocerca volvulus Dual oxidase homolog 0.0067 0.0559 0.096
Toxoplasma gondii endonuclease IV APN 0.0078 0.0689 0.0683
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0262 0.025
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0478 0.5367 0.5336
Brugia malayi Peroxidasin 0.0067 0.0559 0.0553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0515 0.0509
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.026 0.0247
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2252 0.2246
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.026 0.0253
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0262 0.0255
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.5293 0.5287
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.05 0.211
Trypanosoma brucei epsilon tubulin 0.0505 0.5684 0.5684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0094 0.0028
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.0515 0.0413
Brugia malayi Cytochrome P450 family protein 0.0061 0.0494 0.0488
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0559 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0262 0.0255
Schistosoma mansoni survival motor neuron protein 0.0049 0.0351 0.0345
Schistosoma mansoni hypothetical protein 0.0752 0.8574 0.8573
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0255
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0219 0.2343 0.2337
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0262 0.025
Onchocerca volvulus 0.0057 0.0442 0.0754
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0074 0.0241
Plasmodium falciparum alpha tubulin 1 0.0697 0.7931 0.793
Trypanosoma brucei alpha tubulin, putative 0.0286 0.312 0.312
Brugia malayi Tubulin alpha-2 chain 0.0697 0.7931 0.793
Brugia malayi hypothetical protein 0.0166 0.1718 0.1712
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0262 0.0255
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0424 0.0412
Echinococcus multilocularis tubulin epsilon chain 0.0505 0.5684 0.5679
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0494 0.0488
Schistosoma mansoni cytochrome P450 0.0025 0.0074 0.0067
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0106 0.01
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.007 0.0598 0.0592
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0559 0.0553
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0262 0.025
Echinococcus granulosus dna polymerase eta 0.0093 0.0861 0.085
Mycobacterium ulcerans hypothetical protein 0.002 0.0018 0.0046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2079 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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