Detailed information for compound 1406724

Basic information

Technical information
  • TDR Targets ID: 1406724
  • Name: (2-oxo-4-phenylchromen-7-yl) cyclohexanecarbo xylate
  • MW: 348.392 | Formula: C22H20O4
  • H donors: 0 H acceptors: 2 LogP: 4.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCCC1)Oc1ccc2c(c1)oc(=O)cc2c1ccccc1
  • InChi: 1S/C22H20O4/c23-21-14-19(15-7-3-1-4-8-15)18-12-11-17(13-20(18)26-21)25-22(24)16-9-5-2-6-10-16/h1,3-4,7-8,11-14,16H,2,5-6,9-10H2
  • InChiKey: ZEZFNHJAXJEXGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2-oxo-4-phenyl-chromen-7-yl) cyclohexanecarboxylate
  • cyclohexanecarboxylic acid (2-oxo-4-phenyl-7-chromenyl) ester
  • cyclohexanecarboxylic acid (2-keto-4-phenyl-chromen-7-yl) ester
  • ST5108527
  • Oprea1_601739
  • MLS000574367
  • 2-oxo-4-phenyl-2H-chromen-7-yl cyclohexanecarboxylate
  • ZINC00045143
  • SMR000195030

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.8641 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0645 0.0611
Brugia malayi PHD-finger family protein 0.0036 0.1446 0.1421
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.3581 0.3558
Echinococcus granulosus casein kinase i 0.008 0.368 0.3657
Trypanosoma cruzi casein kinase, delta isoform, putative 0.008 0.368 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.3326 0.3301
Echinococcus multilocularis casein kinase I delta 0.008 0.368 0.3657
Trypanosoma cruzi casein kinase, putative 0.008 0.368 1
Schistosoma mansoni zinc finger protein 0.0018 0.0537 0.0503
Loa Loa (eye worm) hypothetical protein 0.0046 0.1954 0.213
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0901 0.0891
Trypanosoma cruzi casein kinase, putative 0.008 0.368 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0179 0.0042
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.3326 0.5
Brugia malayi CXXC zinc finger family protein 0.0035 0.1361 0.132
Schistosoma mansoni hypothetical protein 0.0018 0.0537 0.0503
Echinococcus granulosus casein kinase I delta 0.008 0.368 0.3657
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0645 0.0611
Trypanosoma cruzi casein kinase, putative 0.008 0.368 1
Brugia malayi Bromodomain containing protein 0.0051 0.2167 0.2281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0684 0.065
Schistosoma mansoni protein kinase 0.008 0.368 0.3657
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.3326 0.8871
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.3326 0.3301
Loa Loa (eye worm) casein kinase 0.0063 0.2787 0.311
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.1083 0.105
Schistosoma mansoni bromodomain containing protein 0.0011 0.0179 0.0144
Onchocerca volvulus Huntingtin homolog 0.0148 0.7119 1
Echinococcus granulosus casein kinase I alpha 0.008 0.368 0.3657
Echinococcus multilocularis casein kinase I alpha 0.008 0.368 0.3657
Onchocerca volvulus Huntingtin homolog 0.0148 0.7119 1
Echinococcus multilocularis casein kinase I alpha 0.008 0.368 0.3657
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.8641 0.8636
Brugia malayi casein kinase 1, delta 0.008 0.368 0.4085
Schistosoma mansoni zinc finger protein 0.003 0.1118 0.1086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0684 0.0635
Loa Loa (eye worm) hypothetical protein 0.0053 0.2317 0.2558
Schistosoma mansoni cpg binding protein 0.0039 0.1579 0.1548
Echinococcus multilocularis casein kinase I delta 0.008 0.368 0.3657
Echinococcus multilocularis casein kinase I gamma 0.0064 0.2852 0.2826
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.2852 0.2826
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1361 0.1433
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0684 0.065
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0865 0.0849
Echinococcus multilocularis casein kinase i 0.008 0.368 0.3657
Echinococcus granulosus casein kinase I delta 0.008 0.368 0.3657
Toxoplasma gondii histone lysine methyltransferase SET1 0.0073 0.3301 0.7131
Trypanosoma cruzi casein kinase, putative 0.008 0.368 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3326 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.1083 0.105
Echinococcus granulosus casein kinase I gamma 0.0064 0.2852 0.2826
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0645 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3326 0.5
Brugia malayi Protein kinase domain containing protein 0.0064 0.2852 0.3098
Loa Loa (eye worm) protein kinase domain-containing protein 0.0064 0.2852 0.3188
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.236 0.6412
Brugia malayi hypothetical protein 0.0148 0.7119 0.8185
Loa Loa (eye worm) acetyltransferase 0.0178 0.8641 1
Trichomonas vaginalis CK1 family protein kinase 0.008 0.368 1
Schistosoma mansoni cpg binding protein 0.0039 0.1579 0.1548
Onchocerca volvulus 0.008 0.368 0.4028
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0645 0.0611
Schistosoma mansoni bromodomain containing protein 0.0083 0.3801 0.3779
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.008 0.368 0.4162
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0079 0.3615 0.9791
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.3326 0.3301
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.3326 0.7313
Echinococcus multilocularis cpg binding protein 0.0039 0.1579 0.1548
Echinococcus granulosus cpg binding protein 0.0039 0.1579 0.1548
Plasmodium vivax casein kinase 1, putative 0.008 0.368 1
Trichomonas vaginalis CK1 family protein kinase 0.008 0.368 1
Trypanosoma cruzi casein kinase, putative 0.008 0.368 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.8246 0.824
Entamoeba histolytica casein kinase 1, putative 0.008 0.368 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.3939 0.4467
Leishmania major casein kinase, putative 0.008 0.368 1
Brugia malayi casein kinase I 0.008 0.368 0.4085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0144 0.0108
Giardia lamblia Kinase, CK1 Casein kinase 0.008 0.368 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1804 0.1774
Schistosoma mansoni serine/threonine protein kinase 0.008 0.368 0.3657
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.008 0.368 0.4162
Echinococcus granulosus zinc finger protein 0.003 0.1118 0.1086
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1804 0.1774
Trypanosoma brucei casein kinase I, isoform 2 0.008 0.368 1
Schistosoma mansoni hypothetical protein 0.0025 0.0865 0.0832
Echinococcus multilocularis casein kinase I alpha 0.008 0.368 0.3657
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.3326 0.3301
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0144 0.0108
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.1083 0.105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0684 0.065
Echinococcus granulosus casein kinase I alpha 0.008 0.368 0.3657
Echinococcus granulosus casein kinase I alpha 0.008 0.368 0.3657
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3326 0.5
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.8641 0.8636
Echinococcus multilocularis zinc finger protein 0.003 0.1118 0.1086
Toxoplasma gondii casein kinase I 0.008 0.368 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2535 0.2814
Schistosoma mansoni cpg binding protein 0.0035 0.1361 0.133
Loa Loa (eye worm) hypothetical protein 0.0148 0.7119 0.8209
Onchocerca volvulus 0.0079 0.3615 0.3914
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.3581 0.3558
Trichomonas vaginalis CK1 family protein kinase 0.008 0.368 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3338 0.3313
Entamoeba histolytica casein kinase, putative 0.008 0.368 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0684 0.065
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.008 0.368 0.4162
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.236 0.2332
Loa Loa (eye worm) hypothetical protein 0.0148 0.7119 0.8209
Plasmodium falciparum casein kinase 1 0.008 0.368 1
Brugia malayi Bromodomain containing protein 0.0097 0.4521 0.5087

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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