Detailed information for compound 1407029

Basic information

Technical information
  • TDR Targets ID: 1407029
  • Name: 1-(3,4-dimethoxyphenyl)-3-[(2,5-dimethoxyphen yl)amino]prop-2-en-1-one
  • MW: 343.374 | Formula: C19H21NO5
  • H donors: 1 H acceptors: 1 LogP: 3.82 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)N/C=C/C(=O)c1ccc(c(c1)OC)OC)OC
  • InChi: 1S/C19H21NO5/c1-22-14-6-8-17(23-2)15(12-14)20-10-9-16(21)13-5-7-18(24-3)19(11-13)25-4/h5-12,20H,1-4H3/b10-9+
  • InChiKey: SWDYEVXRGXVNCT-MDZDMXLPSA-N  


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Synonyms

  • (E)-1-(3,4-dimethoxyphenyl)-3-[(2,5-dimethoxyphenyl)amino]prop-2-en-1-one
  • 1-(3,4-Dimethoxy-phenyl)-3-(2,5-dimethoxy-phenylamino)-propenone
  • BAS 02377515
  • MLS001209424
  • SMR000517645
  • ZINC00352466

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0277 0.0775
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0469 0.7848
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0588 0.1281
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0125 0.0125
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.002 0.0277 0.0277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000018326
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0047 0.0054
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0281 0.5
Schistosoma mansoni cpg binding protein 0.0037 0.0626 0.0626
Schistosoma mansoni hypothetical protein 0.0019 0.0265 0.0265
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0462 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0047 0.0452
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0462 0.4153
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0281 0.2296
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0588 0.0581
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.012 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0125 0.0331
Mycobacterium ulcerans lipase LipD 0.0035 0.0588 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0586 0.164
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0044
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0317
Loa Loa (eye worm) hypothetical protein 0.0012 0.012 0.0337
Mycobacterium tuberculosis Conserved protein 0.0035 0.0588 0.1281
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0047 0.0452
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0281 0.2337
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0781 0.2185
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0499 0.4525
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0095 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0047 0.0113
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0281 0.2337
Plasmodium vivax glutathione reductase, putative 0.0057 0.1045 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0499 0.4772
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0125 0.035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0125 0.0118
Brugia malayi Matrixin family protein 0.002 0.0277 0.0756
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.1045 0.1039
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0281 0.4315
Loa Loa (eye worm) RecQ helicase 0.0029 0.0469 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0125 0.035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0125 0.0118
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0344 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0125 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0125 0.0331
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0192 0.2834
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0125 0.0331
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.1045 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0047 0.0054
Plasmodium falciparum thioredoxin reductase 0.002 0.0281 0.2337
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0281 0.4315
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0125 0.0118
Schistosoma mansoni hypothetical protein 0.0019 0.0265 0.0265
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0588 0.1281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0052 0.0052
Loa Loa (eye worm) matrix metalloproteinase 0.002 0.0277 0.0775
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1109 0.3104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000018326
Schistosoma mansoni hypothetical protein 0.0019 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.1646
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0781 0.217
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2337
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0462 0.1483
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0092 0.0238
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.012 0.0113
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0313 0.4923
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0125 0.0331
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2545 0.5722
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.1045 0.2319
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0125 0.0118
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0265 0.0258
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0462 0.7667
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0588 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0043 0.0766 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0047 0.004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0588 0.1281
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0095 0.0266
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0281 0.2684
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0047 0.0387
Schistosoma mansoni hypothetical protein 0.0028 0.0445 0.0445
Plasmodium falciparum thioredoxin reductase 0.0057 0.1045 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0277 0.0775
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2843 0.6398
Mycobacterium tuberculosis Probable reductase 0.013 0.2545 0.5722
Loa Loa (eye worm) hypothetical protein 0.018 0.3573 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0462 0.1293
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0469 0.1296
Schistosoma mansoni hypothetical protein 0.0041 0.0719 0.0719
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0125 0.1083
Brugia malayi hypothetical protein 0.002 0.0278 0.0759
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0125 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0125 0.035
Loa Loa (eye worm) hypothetical protein 0.0146 0.2866 0.8022
Mycobacterium ulcerans hypothetical protein 0.0035 0.0588 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0125 0.035
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0462 0.4153
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0462 0.4153
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0281 0.4431
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0125 0.0118
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0462 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0125 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.029 0.0604
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0125 0.0118
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0265 0.0258
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0047 0.0204
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0281 0.2337
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0588 0.1629
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0588 0.1281
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0047 0.0387
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.1646
Brugia malayi Matrixin family protein 0.0047 0.0846 0.2354
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0281 0.0584
Loa Loa (eye worm) matrixin family protein 0.0047 0.0846 0.2369
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2843 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0125 0.0118
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.012 0.0337
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0499 0.4772
Mycobacterium leprae Probable lipase LipE 0.0035 0.0588 0.1934
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0125 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0021 0.0313 0.0877
Onchocerca volvulus Matrilysin homolog 0.0043 0.0766 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0462 0.7667
Leishmania major hypothetical protein, conserved 0.0035 0.0588 0.5417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2684
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0125 0.0118
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0499 0.4083
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0047 0.0387
Onchocerca volvulus 0.0035 0.0588 0.7522
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0281 0.2337
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0008 0.0047 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.1646
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0588 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0173 0.0465
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0588 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0047 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0781 0.0774
Brugia malayi Matrixin family protein 0.002 0.0277 0.0756
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0462 0.7667
Onchocerca volvulus Matrilysin homolog 0.002 0.0277 0.3192
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.012 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.1646
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0265 0.0724
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.2545 0.8934
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0047 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0047 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000018326
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0047 0.0054
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0281 0.2296
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0588 0.1281
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0719 0.1995
Echinococcus granulosus muscleblind protein 0.018 0.3573 0.3568
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0281 0.2337
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0462 0.0995
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2545 0.5722
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2337
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0499 0.4525
Brugia malayi nuclear receptor NHR-88 0.0012 0.0125 0.0331
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0071 0.1336 0.133
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0588 0.0581
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0125 0.0125
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0984
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.1045 0.1039
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0125 0.0125
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0588 0.0588
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0281 0.2337
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0052 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1109 0.309
Loa Loa (eye worm) oxidoreductase 0.0008 0.0047 0.0132
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0000000018326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0125 0.035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2684
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.012 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Brugia malayi Matrixin family protein 0.002 0.0277 0.0756
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0469 0.0462
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.1841
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0317
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0313 0.0877
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.1646
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.1454
Echinococcus granulosus cpg binding protein 0.0037 0.0626 0.062
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0047 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0125 0.0331
Schistosoma mansoni cpg binding protein 0.0035 0.0586 0.0586
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0047 0.0452
Onchocerca volvulus 0.0029 0.0462 0.5767
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0281 0.0274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.029 0.0604
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0155 0.0148
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1109 0.309
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0000000018326
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0984
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0125 0.0331
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0281 0.0767
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0313 0.2667
Plasmodium falciparum glutathione reductase 0.0057 0.1045 1
Onchocerca volvulus 0.0035 0.0588 0.7522
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0462 0.7667
Echinococcus granulosus GPCR family 2 0.0019 0.0265 0.0258
Brugia malayi nuclear hormone receptor 0.0012 0.0125 0.0331
Onchocerca volvulus 0.002 0.0277 0.3192
Onchocerca volvulus 0.0035 0.0588 0.7522
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0125 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0462 0.7667
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0125 0.0331
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2545 0.5722
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0125 0.0118
Echinococcus multilocularis GPCR, family 2 0.0019 0.0265 0.0258
Mycobacterium ulcerans beta-lactamase 0.0035 0.0588 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0281 0.2337
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.1454
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.443 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0265 0.0258
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0125 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0047 0.0113
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0125 0.0331
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000018326
Plasmodium falciparum glutathione reductase 0.002 0.0281 0.2337
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1383 0.1383
Brugia malayi beta-lactamase 0.0035 0.0588 0.1629
Brugia malayi hypothetical protein 0.003 0.0499 0.1379
Brugia malayi Thioredoxin reductase 0.0057 0.1045 0.2912
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0462 0.1275
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0125 0.0331
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.012 0.0113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0281 0.2684
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0265 0.0724
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0125 0.0118
Brugia malayi CXXC zinc finger family protein 0.0035 0.0586 0.1623
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0588 0.1281
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0588 0.5624
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0125 0.0331
Onchocerca volvulus 0.0012 0.0125 0.1083
Echinococcus granulosus bloom syndrome protein 0.0029 0.0469 0.0462
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0397 0.3504
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0281 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0588 1
Brugia malayi Hemopexin family protein 0.0028 0.0445 0.1227
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2843 0.6398
Toxoplasma gondii thioredoxin reductase 0.0057 0.1045 0.8556
Onchocerca volvulus 0.0028 0.0445 0.5528
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1222 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0281 0.2337
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0047 0.0452
Loa Loa (eye worm) hypothetical protein 0.002 0.0277 0.0775
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0469 0.7848
Echinococcus multilocularis muscleblind protein 1 0.018 0.3573 0.3568
Brugia malayi Matrixin family protein 0.002 0.0277 0.0756
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0588 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0281 0.2684
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0781 0.0781
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0125 0.0125
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2545 0.5722
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0047 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0125 0.0125
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0281 0.4315
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0281 0.0274
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0125 0.0118
Mycobacterium leprae PROBABLE HYDROLASE 0.0024 0.0364 0.1134
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0313 0.2667
Loa Loa (eye worm) hypothetical protein 0.0008 0.0047 0.0132
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0281 0.4431
Loa Loa (eye worm) hypothetical protein 0.0021 0.0313 0.0877
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0047 0.0113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0588 0.1646
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0313 1
Echinococcus multilocularis muscleblind protein 0.018 0.3573 0.3568
Loa Loa (eye worm) hypothetical protein 0.0021 0.0313 0.0877
Mycobacterium ulcerans hypothetical protein 0.0029 0.0462 0.7667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.002
Mycobacterium tuberculosis Conserved protein 0.0035 0.0588 0.1281
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0125 0.0118
Toxoplasma gondii ABC1 family protein 0.0035 0.0588 0.4812
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0095 0.0088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Loa Loa (eye worm) glutathione reductase 0.0057 0.1045 0.2926
Loa Loa (eye worm) hypothetical protein 0.003 0.0499 0.1396
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.1045 0.2926
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0265 0.0743
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2684
Onchocerca volvulus 0.0035 0.0586 0.7493
Trypanosoma brucei trypanothione reductase 0.0057 0.1045 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0125 0.035
Schistosoma mansoni DNA helicase recq1 0.0012 0.012 0.012
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0499 0.4525
Loa Loa (eye worm) hypothetical protein 0.0029 0.0462 0.1293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0462 0.0995
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0588 0.1934
Schistosoma mansoni cpg binding protein 0.0037 0.0626 0.0626
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0125 0.0331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0588 0.0588
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0125 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0781 0.0774
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0125 0.0125
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0047 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0125 0.0331
Leishmania major trypanothione reductase 0.0057 0.1045 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000018326
Leishmania major hypothetical protein, conserved 0.003 0.0499 0.4525
Schistosoma mansoni hypothetical protein 0.0014 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.035
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0588 0.1281
Loa Loa (eye worm) beta-lactamase 0.0035 0.0588 0.1646
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0047 0.0829 0.0829
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0047 0.0113
Trichomonas vaginalis esterase, putative 0.0035 0.0588 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0155 0.0148
Loa Loa (eye worm) hypothetical protein 0.018 0.3573 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2684
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0047 0.0054
Brugia malayi beta-lactamase family protein 0.0035 0.0588 0.1629
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0125 0.035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0265 0.0743
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0588 0.5417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0125 0.0331
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0281 0.2337
Brugia malayi glutathione reductase 0.0057 0.1045 0.2912
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.1045 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0462 0.7667
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0265 0.0258
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0047 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0173 0.0465
Treponema pallidum NADH oxidase 0.002 0.0281 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0462 0.1275
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0588 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0588 0.1646
Schistosoma mansoni DNA helicase recq5 0.0012 0.012 0.012
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0047 0.1024
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0462 0.1275
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0588 0.5417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0313 0.0877
Echinococcus multilocularis cpg binding protein 0.0037 0.0626 0.062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0125 0.0125
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0313 0.0658
Mycobacterium ulcerans hydrolase 0.0024 0.0364 0.5864
Brugia malayi ecdysteroid receptor 0.0012 0.0125 0.0331
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0047 0.004
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0192 0.4167
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0588 0.5624
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2545 0.5722
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.029 0.0604
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0462 0.7667
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0047 0.0054
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0462 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0047 0.0132
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0272 0.2226
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0125 0.1083
Mycobacterium tuberculosis Conserved protein 0.0035 0.0588 0.1281
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0281 0.5
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0024 0.0364 0.1002
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0047 0.0204
Brugia malayi Muscleblind-like protein 0.018 0.3573 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0071 0.1336 0.133
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0047 0.0047
Brugia malayi steroid hormone receptor 0.0012 0.0125 0.0331
Loa Loa (eye worm) matrixin family protein 0.0043 0.0766 0.2144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0462 0.1293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0781 0.0781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0364 0.102
Schistosoma mansoni coup transcription factor 0.0012 0.0125 0.0125
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0277 0.2299
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0462 0.1483
Brugia malayi beta-lactamase family protein 0.0035 0.0588 0.1629
Schistosoma mansoni hypothetical protein 0.0019 0.0265 0.0265
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0125 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.029 0.0604
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2843 0.6398
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0588 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0719 0.2011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0000000018326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2684
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0052 0.0044
Loa Loa (eye worm) hypothetical protein 0.006 0.1109 0.3104
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0125 0.1083
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0125 0.0118
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0024 0.0364 0.0774
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0499 0.4525
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0781 0.0774
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0125 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0125 0.035
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0281 0.2337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0781 0.0774
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0281 0.2684
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0047 0.0113

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5221 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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