TDR Targets

Basic information

Technical information

TDR Targets ID: 1407138
Name: 2-(1-morpholin-4-yl-1-oxopropan-2-yl)isoindol e-1,3-dione
MW: 288.299 | Formula: C15H16N2O4
H donors: 0 H acceptors: 3 LogP: 0.46 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(N1C(=O)c2c(C1=O)cccc2)C(=O)N1CCOCC1
InChi: 1S/C15H16N2O4/c1-10(13(18)16-6-8-21-9-7-16)17-14(19)11-4-2-3-5-12(11)15(17)20/h2-5,10H,6-9H2,1H3
InChiKey: SYABYJUMIQCIRA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(1-methyl-2-morpholino-2-oxo-ethyl)isoindoline-1,3-dione
2-(1-methyl-2-morpholino-2-oxoethyl)isoindoline-1,3-dione
2-(2-keto-1-methyl-2-morpholino-ethyl)isoindoline-1,3-quinone
2-(1-morpholin-4-yl-1-oxo-propan-2-yl)isoindole-1,3-dione
STOCK2S-95723
SMR000041309
MLS000078190
Oprea1_381610

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	allatostatin A receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1974	0.1825
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.1294	0.1207
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0085	0.3944	0.3831
Schistosoma mansoni	alpha glucosidase	0.0044	0.1673	0.1669
Brugia malayi	putative neuropeptide receptor	0.0037	0.1294	0.1294
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0029	0.0887	0.0489
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.1294	0.0913
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Schistosoma mansoni	cpg binding protein	0.0035	0.1185	0.1074
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	neuropeptide receptor	0.0037	0.1294	0.1207
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.1294	0.1207
Schistosoma mansoni	amine GPCR	0.0037	0.1294	0.1207
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1673	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.1294	0.0913
Schistosoma mansoni	zinc finger protein	0.0026	0.0692	0.0473
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.1294	0.0913
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.1673	1
Schistosoma mansoni	myosin xvIII	0.0037	0.1294	0.1207
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	hypothetical protein	0.0037	0.1294	0.1207
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.1294	0.1207
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1673	1
Echinococcus granulosus	hypothetical protein	0.0037	0.1294	0.0913
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.1294	0.1207
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	somatostatin receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.046	0.0191
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.1294	0.0913
Trypanosoma brucei	ISWI complex protein	0.0018	0.0303	0.0808
Brugia malayi	Dopamine receptor protein 2	0.0037	0.1294	0.1294
Echinococcus multilocularis	cpg binding protein	0.0039	0.1418	0.1043
Brugia malayi	Serotonin receptor	0.0037	0.1294	0.1294
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.1294	0.0913
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	zinc finger protein	0.0026	0.0692	0.0285
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Schistosoma mansoni	cpg binding protein	0.0039	0.1418	0.1358
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Onchocerca volvulus		0.0037	0.1294	0.2094
Onchocerca volvulus		0.0037	0.1294	0.2094
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.1185	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0418	0.014
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.1294	0.1207
Echinococcus multilocularis	sex peptide receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.1294	0.1207
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	g protein coupled receptor	0.0037	0.1294	0.0913
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.046	0.0043
Brugia malayi	sulfakinin receptor protein	0.0037	0.1294	0.1294
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.1294	0.0913
Onchocerca volvulus		0.0037	0.1294	0.2094
Brugia malayi	neuropeptide F receptor	0.0037	0.1294	0.1294
Echinococcus granulosus	g protein coupled receptor	0.0037	0.1294	0.0913
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.1294	0.0913
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.1294	0.0913
Brugia malayi	G-protein coupled receptor	0.0037	0.1294	0.1294
Echinococcus multilocularis	zinc finger protein	0.0026	0.0692	0.0285
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.1294	0.1294
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.1673	1
Schistosoma mansoni	cpg binding protein	0.0039	0.1418	0.1358
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Onchocerca volvulus		0.0035	0.1185	0.1889
Brugia malayi	CXXC zinc finger family protein	0.0035	0.1185	0.1185
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.1294	0.0913
Trypanosoma brucei	glucosidase, putative	0.0044	0.1673	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1819	0.1666
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	alpha-glucosidase	0.0169	0.851	1
Brugia malayi	G protein-coupled receptor	0.0037	0.1294	0.1294
Brugia malayi	neuropeptide F receptor	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	serotonin receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.1673	0.1518
Echinococcus granulosus	fetal alzheimer antigen falz	0.0029	0.0887	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.1294	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Brugia malayi	RE15519p	0.0037	0.1294	0.1294
Schistosoma mansoni	biogenic amine receptor	0.0037	0.1294	0.1207
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	g protein coupled receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.1294	0.0913
Brugia malayi	ORL1-like opioid receptor	0.0037	0.1294	0.1294
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.1294	0.1131
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.1294	0.1294
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Onchocerca volvulus		0.0037	0.1294	0.2094
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	adenoreceptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0069	0.3028	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.1294	0.1294
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Brugia malayi	larval opioid receptor	0.0037	0.1294	0.1294
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.1294	0.1207
Schistosoma mansoni	hypothetical protein	0.0025	0.0654	0.0427
Schistosoma mansoni	histamine h1 receptor	0.0037	0.1294	0.1207
Schistosoma mansoni	hypothetical protein	0.0037	0.1294	0.1207
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0074	0.3327	0.3036
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.1294	0.0913
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.046	0.0191
Schistosoma mansoni	opsin-like receptor	0.0037	0.1294	0.1207
Onchocerca volvulus		0.0037	0.1294	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	sex peptide receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Brugia malayi	PHD-finger family protein	0.0032	0.1042	0.1042
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1673	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.1294	0.2094
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.1294	0.0913
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.1673	1
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.1659	0.1294
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.1294	0.0913
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.1294	0.1207
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.1294	0.0913
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.1294	0.0913
Onchocerca volvulus		0.0114	0.5488	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.1294	0.1207
Echinococcus multilocularis	somatostatin receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Schistosoma mansoni	amine GPCR	0.0037	0.1294	0.1207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Brugia malayi	Bromodomain containing protein	0.0046	0.1814	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0021	0.046	0.0282
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0418	0.014
Schistosoma mansoni	neuropeptide receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.1294	0.1131
Schistosoma mansoni	biogenic amine receptor	0.0037	0.1294	0.1207
Brugia malayi	Dopamine receptor	0.0037	0.1294	0.1294
Schistosoma mansoni	bromodomain containing protein	0.0078	0.3562	0.3972
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Brugia malayi	Melatonin receptor type 1A	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.1294	0.0913
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.1673	1
Schistosoma mansoni	biogenic amine receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0053	0.2207	0.2062
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.1673	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.1294	0.0913
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.1294	0.0913
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.1294	0.0913
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.1294	0.2094
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.1294	0.0913
Leishmania major	hypothetical protein, conserved	0.0018	0.0303	0.0808
Schistosoma mansoni	amine GPCR	0.0037	0.1294	0.1207
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.1294	0.1294
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.1294	0.0913
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.1294	0.0913
Onchocerca volvulus		0.0037	0.1294	0.2094
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1673	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.1294	0.0913
Schistosoma mansoni	opsin-like receptor	0.0037	0.1294	0.1207
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1673	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.1294	0.1207
Brugia malayi	AKH receptor	0.0037	0.1294	0.1294
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.1294	0.0913
Schistosoma mansoni	alpha-glucosidase	0.0169	0.851	1
Echinococcus granulosus	fmrfamide receptor	0.0037	0.1294	0.0913
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.1673	0.1309
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.1294	0.0913
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0303	0.0808
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.1294	0.1207
Echinococcus multilocularis	serotonin receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0459	0.0281
Schistosoma mansoni	hypothetical protein	0.0037	0.1294	0.1207
Echinococcus multilocularis	serotonin receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	neuropeptide receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.1294	0.0913
Onchocerca volvulus		0.0037	0.1294	0.2094
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.1294	0.1207
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.1673	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.046	0.0043
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.1294	0.0913
Brugia malayi	GnHR receptor homolog	0.0037	0.1294	0.1294
Brugia malayi	Serotonin receptor	0.0037	0.1294	0.1294
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.1673	0.1673
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.1294	0.0913
Schistosoma mansoni	hypothetical protein	0.0037	0.1294	0.1207
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.1294	0.0913
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0029	0.0887	0.0711
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.1294	0.1131
Onchocerca volvulus		0.0037	0.1294	0.2094
Echinococcus granulosus	neuropeptide receptor	0.0037	0.1294	0.0913
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.1294	0.1131
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.1673	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.1294	0.1131
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.1294	0.1294
Schistosoma mansoni	amine GPCR	0.0037	0.1294	0.1207
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.33	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.1294	0.1131
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.1294	0.0913
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.1294	0.0913
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	orexin receptor type 2	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0074	0.3327	0.3036
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.1673	1
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.1294	0.0913
Brugia malayi	hypothetical protein	0.0037	0.1294	0.1294
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.1294	0.1131
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.1294	0.0913
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.1294	0.0913
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.1673	0.1309
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.1294	0.0913
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.1294	0.1294
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.1294	0.0913
Schistosoma mansoni	neuropeptide receptor	0.0037	0.1294	0.1207
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.1294	0.1207
Schistosoma mansoni	opsin-like receptor	0.0037	0.1294	0.1207
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.1294	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.1294	0.1131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.1294	0.0913
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.1294	0.1207
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	cpg binding protein	0.0039	0.1418	0.1043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Schistosoma mansoni	amine GPCR	0.0037	0.1294	0.1207
Brugia malayi	Dopamine receptor protein 1	0.0037	0.1294	0.1294
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.1659	0.1294
Brugia malayi	Bromodomain containing protein	0.0093	0.4332	0.4332
Brugia malayi	G-protein coupled receptor	0.0037	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0654	0.048
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.1294	0.1131
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.1294	0.0913
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.1294	0.0913
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.1294	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.1294	0.0913
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.1673	1
Onchocerca volvulus		0.0037	0.1294	0.2094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.1294	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1294	0.1131
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0303	0.0808

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1544588

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1407138