Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.354 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | 0.0012 | 0.354 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.354 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.354 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1889 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.