Detailed information for compound 1407443

Basic information

Technical information
  • TDR Targets ID: 1407443
  • Name: N-cyclohexyl-5-furan-2-yl-N-methyl-7-(trifluo romethyl)pyrazolo[1,5-a]pyrimidine-2-carboxam ide
  • MW: 392.375 | Formula: C19H19F3N4O2
  • H donors: 0 H acceptors: 3 LogP: 3.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)c1nn2c(c1)nc(cc2C(F)(F)F)c1ccco1)C1CCCCC1
  • InChi: 1S/C19H19F3N4O2/c1-25(12-6-3-2-4-7-12)18(27)14-11-17-23-13(15-8-5-9-28-15)10-16(19(20,21)22)26(17)24-14/h5,8-12H,2-4,6-7H2,1H3
  • InChiKey: ZAVJWZNODOBKPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclohexyl-5-(2-furyl)-N-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
  • N-cyclohexyl-5-(2-furyl)-N-methyl-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide
  • IDI1_025041
  • MLS000107799
  • SMR000103763
  • STK342774
  • BAS 00435222
  • ZINC00827101
  • ChemDiv3_007131

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Pyruvate kinase 0.0643 0.6504 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.007 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.0981 0.1508
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.007 0.0107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0007 0.001
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0269 0.2606 0.4
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0195 0.183 0.2814
Trichomonas vaginalis pyruvate kinase, putative 0.0643 0.6504 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0097 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0542 0.0834
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0542 0.0542
Entamoeba histolytica hypothetical protein 0.0028 0.0097 0.0201
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0176 0.0207
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0051 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0542 0.064
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Leishmania major pyruvate phosphate dikinase, putative 0.0269 0.2606 0.4006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0269 0.2606 0.4
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0036 0.0176 0.0207
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0294 0.0452
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0051 0.0051
Schistosoma mansoni pyruvate kinase 0.0643 0.6504 0.7669
Trichomonas vaginalis pyruvate kinase, putative 0.0643 0.6504 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0165 0.0195
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0294 0.0452
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.007 0.007
Echinococcus granulosus snurportin 1 0.0372 0.3674 0.4332
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0497 0.0497
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0007 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0542 0.064
Brugia malayi Doublecortin family protein 0.0024 0.0051 0.0078
Brugia malayi jmjC domain containing protein 0.0071 0.0542 0.0834
Schistosoma mansoni hypothetical protein 0.0036 0.0176 0.0207
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0497 0.0586
Schistosoma mansoni hypothetical protein 0.0047 0.0294 0.0347
Schistosoma mansoni pyruvate kinase 0.033 0.3242 0.3823
Loa Loa (eye worm) hypothetical protein 0.0077 0.0608 0.0935
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0449 0.4476 0.6882
Trypanosoma brucei pyruvate kinase 1, putative 0.0643 0.6504 1
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0542 0.064
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8481 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0339 0.0521
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0051 0.006
Trypanosoma brucei pyruvate kinase 1 0.0643 0.6504 1
Loa Loa (eye worm) hypothetical protein 0.0643 0.6504 1
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0608 0.0935
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0107 0.0164
Schistosoma mansoni loxhd1 0.0024 0.0051 0.006
Entamoeba histolytica pyruvate phosphate dikinase 0.0269 0.2606 0.5815
Schistosoma mansoni rab6-interacting 0.0024 0.0051 0.006
Onchocerca volvulus Pyruvate kinase homolog 0.0643 0.6504 1
Plasmodium falciparum pyruvate kinase 0.0643 0.6504 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0107 0.0126
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0007 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0007 0.001
Echinococcus granulosus pyruvate kinase 0.033 0.3242 0.3823
Echinococcus granulosus pyruvate kinase 0.033 0.3242 0.3823
Schistosoma mansoni hypothetical protein 0.0024 0.0051 0.006
Brugia malayi Pre-SET motif family protein 0.0204 0.1923 0.2957
Schistosoma mansoni pyruvate kinase 0.0643 0.6504 0.7669
Toxoplasma gondii exonuclease III APE 0.002 0.0007 0.001
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Leishmania major GTP-binding protein, putative 0.0026 0.007 0.0107
Schistosoma mansoni hypothetical protein 0.0036 0.0176 0.0207
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.007 0.0082
Loa Loa (eye worm) pyruvate kinase 0.0643 0.6504 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0165 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0126
Loa Loa (eye worm) hypothetical protein 0.0113 0.0981 0.1508
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0542 0.0542
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1625 0.1917
Leishmania major pyruvate kinase 0.0643 0.6504 1
Schistosoma mansoni ran 0.0026 0.007 0.0082
Plasmodium vivax SET domain protein, putative 0.0029 0.0107 0.0164
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0165 0.0254
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.007 0.0107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0007 0.0008
Onchocerca volvulus 0.0232 0.2216 0.3355
Brugia malayi jmjC domain containing protein 0.0071 0.0542 0.0834
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0024 0.0051 0.0078
Entamoeba histolytica pyruvate kinase, putative 0.0449 0.4476 1
Mycobacterium ulcerans pyruvate kinase 0.0643 0.6504 1
Loa Loa (eye worm) pyruvate kinase 0.0643 0.6504 1
Onchocerca volvulus Pyruvate kinase homolog 0.0643 0.6504 1
Onchocerca volvulus 0.0029 0.0107 0.0087
Echinococcus multilocularis snurportin 1 0.0372 0.3674 0.3674
Echinococcus granulosus RUN 0.0024 0.0051 0.006
Leishmania major pyruvate kinase 0.0643 0.6504 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0339 0.0399
Onchocerca volvulus 0.0047 0.0294 0.0377
Echinococcus granulosus GPCR family 2 0.0036 0.0176 0.0207
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0294 0.0643
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0339 0.0511
Echinococcus multilocularis pyruvate kinase 0.0643 0.6504 0.6504
Wolbachia endosymbiont of Brugia malayi pyruvate phosphate dikinase 0.0269 0.2606 1
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2216 0.34
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2212 0.2212
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0294 0.0442
Mycobacterium tuberculosis Probable pyruvate, phosphate dikinase PpdK 0.0269 0.2606 0.4
Loa Loa (eye worm) pyruvate kinase 0.0643 0.6504 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.007 0.0107
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0164
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.007 0.0107
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3674 0.5649
Schistosoma mansoni ran 0.0026 0.007 0.0082
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Leishmania major importin beta-1 subunit, putative 0.0028 0.0097 0.0149
Schistosoma mansoni survival motor neuron protein 0.0047 0.0294 0.0347
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8481 0.8481
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0096 0.0113
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0165 0.0254
Mycobacterium ulcerans pyruvate phosphate dikinase 0.0269 0.2606 0.4
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0126
Brugia malayi pyruvate kinase 0.0136 0.1215 0.1868
Brugia malayi RNA, U transporter 1 0.0099 0.0834 0.1282
Plasmodium falciparum pyruvate kinase 2 0.033 0.3242 0.4985
Echinococcus granulosus geminin 0.0365 0.3601 0.4246
Giardia lamblia Pyruvate, phosphate dikinase 0.0269 0.2606 0.4
Brugia malayi pyruvate kinase, muscle isozyme 0.0136 0.1215 0.1868
Mycobacterium ulcerans hypothetical protein 0.0269 0.2606 0.4
Schistosoma mansoni hypothetical protein 0.0365 0.3601 0.4246
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.0981 0.1508
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0269 0.2606 0.4
Brugia malayi hypothetical protein 0.0231 0.2212 0.3401
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1625 0.2499
Echinococcus multilocularis RUN 0.0024 0.0051 0.0051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0643 0.6504 1
Echinococcus multilocularis geminin 0.0365 0.3601 0.3601
Trypanosoma cruzi pyruvate kinase 2, putative 0.0643 0.6504 1
Toxoplasma gondii pyruvate kinase PyKII 0.033 0.3242 0.4985
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0051 0.0051
Plasmodium vivax importin-beta 2, putative 0.0035 0.0165 0.0254
Plasmodium falciparum importin beta, putative 0.0035 0.0165 0.0254
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0339 0.0521
Mycobacterium leprae Probable pyruvate kinase PykA 0.0643 0.6504 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1574 0.1856
Echinococcus multilocularis pyruvate kinase 0.0643 0.6504 0.6504
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0176 0.027
Entamoeba histolytica Ran family GTPase 0.0026 0.007 0.0141
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.007 0.0107
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.01 0.0841 0.1294
Echinococcus multilocularis GPCR, family 2 0.0036 0.0176 0.0176
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0176 0.027
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0051 0.0051
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0841 0.1867
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0097 0.0139
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0339 0.0511
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1923 0.2957
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0097 0.0149
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Brugia malayi Pre-SET motif family protein 0.0029 0.0107 0.0164
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0542 0.064
Echinococcus multilocularis pyruvate kinase 0.0508 0.5092 0.5092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.001
Loa Loa (eye worm) pyruvate kinase 0.0136 0.1215 0.1868
Treponema pallidum pyruvate phosphate dikinase 0.0269 0.2606 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0176 0.0176
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0339 0.0521
Schistosoma mansoni hypothetical protein 0.0372 0.3674 0.4332
Echinococcus multilocularis pyruvate kinase 0.033 0.3242 0.3242
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0097 0.0139
Schistosoma mansoni lipoxygenase 0.0024 0.0051 0.006
Echinococcus multilocularis pyruvate kinase 0.033 0.3242 0.3242
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0841 0.1867
Loa Loa (eye worm) hypothetical protein 0.0231 0.2212 0.3401
Brugia malayi Importin beta-1 subunit 0.0035 0.0165 0.0254
Echinococcus granulosus pyruvate kinase 0.0643 0.6504 0.7669
Trypanosoma cruzi pyruvate kinase 2, putative 0.0643 0.6504 1
Echinococcus multilocularis pyruvate kinase 0.033 0.3242 0.3242
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0107 0.0107
Plasmodium vivax pyruvate kinase 2, putative 0.033 0.3242 0.4985
Loa Loa (eye worm) acetyltransferase 0.0175 0.1625 0.2499
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0051 0.0078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0254
Schistosoma mansoni polycystin 1-related 0.0024 0.0051 0.006
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8481 1
Trypanosoma brucei pyruvate phosphate dikinase 0.0269 0.2606 0.4006
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0036 0.0176 0.0207
Toxoplasma gondii pyruvate kinase PyK1 0.0643 0.6504 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.0981 0.1508
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.007 0.0107
Trichomonas vaginalis ran, putative 0.0026 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0078
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0176 0.027
Giardia lamblia Pyruvate kinase 0.033 0.3242 0.498
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0176 0.0207
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0269 0.2606 0.4006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1625 0.1625
Brugia malayi Pyruvate kinase, M2 isozyme 0.0643 0.6504 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0126
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0051 0.0078
Echinococcus granulosus pyruvate kinase 0.0643 0.6504 0.7669
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0643 0.6504 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0107 0.0126
Brugia malayi hypothetical protein 0.0024 0.0051 0.0078
Schistosoma mansoni rab6-interacting 0.0024 0.0051 0.006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0542 0.064
Schistosoma mansoni hypothetical protein 0.0365 0.3601 0.4246
Schistosoma mansoni importin beta-1 0.0035 0.0165 0.0195
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0007 0.001
Echinococcus granulosus pyruvate kinase 0.033 0.3242 0.3823
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0165 0.0254
Plasmodium vivax pyruvate kinase, putative 0.0643 0.6504 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0176 0.027
Schistosoma mansoni hypothetical protein 0.0077 0.0608 0.0717
Onchocerca volvulus Pyruvate kinase homolog 0.0643 0.6504 1
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2212 0.2608
Schistosoma mansoni lipoxygenase 0.0067 0.0497 0.0586
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0269 0.2606 0.4
Chlamydia trachomatis pyruvate kinase 0.0643 0.6504 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.007 0.0107
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0269 0.2606 0.4
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0051 0.0078
Loa Loa (eye worm) pyruvate kinase-PB 0.0449 0.4476 0.6882
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0269 0.2606 0.4006

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.