TDR Targets

Basic information

Technical information

TDR Targets ID: 1407614
Name: 2,6-bis(furan-2-yl)-3,5-dimethylpiperidin-4-o ne; hydron; chloride
MW: 295.761 | Formula: C15H18ClNO3
H donors: 1 H acceptors: 1 LogP: 2.45 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(C)C(NC(C1C)c1ccco1)c1ccco1.Cl
InChi: 1S/C15H17NO3.ClH/c1-9-13(11-5-3-7-18-11)16-14(10(2)15(9)17)12-6-4-8-19-12;/h3-10,13-14,16H,1-2H3;1H
InChiKey: CRPWMVLIRHIUFA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,6-bis(furan-2-yl)-3,5-dimethylpiperidin-4-one hydrochloride
2,6-bis(2-furyl)-3,5-dimethyl-piperidin-4-one hydrochloride
2,6-bis(2-furyl)-3,5-dimethyl-piperidin-4-one; hydron; chloride
2,6-bis(2-furyl)-3,5-dimethyl-4-piperidinone hydrochloride
2,6-bis(2-furyl)-3,5-dimethyl-4-piperidinone; hydron; chloride
2,6-bis(2-furyl)-3,5-dimethyl-4-piperidone hydrochloride
2,6-bis(2-furyl)-3,5-dimethyl-4-piperidone; hydron; chloride
2,6-bis(furan-2-yl)-3,5-dimethyl-piperidin-4-one hydrochloride
2,6-bis(furan-2-yl)-3,5-dimethyl-piperidin-4-one; hydron; chloride
2,6-Di-furan-2-yl-3,5-dimethyl-piperidin-4-one
MLS000070285
SMR000011000

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trypanosoma cruzi	solanesyl-diphosphate synthase	0.0433	0.267	0.2596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.1717	0.1706
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Leishmania major	hypothetical protein, conserved	0.0043	0.0148	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0233	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0185	0.018
Echinococcus granulosus	zinc finger protein	0.0024	0.002	0.002
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0148	0.0087
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.01	0.01
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0043	0.0043
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0036	0.01	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0148	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.01	0.01
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0147	0.0147
Brugia malayi	beta-lactamase family protein	0.0043	0.0148	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0333	0.0333
Trypanosoma cruzi	polyprenyl synthase, putative	0.059	0.3682	0.3619
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.01	0.0038
Entamoeba histolytica	geranylgeranyl pyrophosphate synthase, putative	0.0433	0.267	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0013	0.0008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0091	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0148	0.0135
Brugia malayi	Pre-SET motif family protein	0.0251	0.1492	0.144
Brugia malayi	beta-lactamase family protein	0.0043	0.0148	0.0087
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0148	0.0143
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.01	0.0095
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0148	0.0135
Leishmania major	hypothetical protein, conserved	0.0188	0.108	0.0991
Trypanosoma cruzi	hypothetical protein, conserved	0.0181	0.1035	0.0945
Trypanosoma cruzi	polyprenyl synthase, putative	0.059	0.3682	0.3619
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0517	0.3208	0.3208
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0148	0.0049
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.01	0.0095
Echinococcus granulosus	prenyl decaprenyl diphosphate synthase	0.0433	0.267	0.267
Toxoplasma gondii	ABC1 family protein	0.0043	0.0148	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Mycobacterium leprae	PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	0.0433	0.267	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Treponema pallidum	octaprenyl-diphosphate synthase	0.059	0.3682	0.5
Trichomonas vaginalis	esterase, putative	0.0043	0.0148	0.0135
Onchocerca volvulus		0.0043	0.0148	0.0297
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0433	0.267	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0148	0.0143
Mycobacterium tuberculosis	Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate	0.0433	0.267	0.256
Echinococcus multilocularis	prenyl (decaprenyl) diphosphate synthase	0.0433	0.267	0.267
Brugia malayi	Bromodomain containing protein	0.0091	0.0453	0.0394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Echinococcus granulosus	histone lysine methyltransferase setb	0.0057	0.0233	0.0233
Echinococcus granulosus	decaprenyl diphosphate synthase subunit 1	0.0433	0.267	0.267
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0036	0.01	0.0087
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0036	0.01	0.01
Onchocerca volvulus		0.0043	0.0148	0.0297
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0419	0.0415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0148	0.0049
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0148	0.0049
Schistosoma mansoni	trans-prenyltransferase	0.0433	0.267	0.267
Echinococcus multilocularis	geranylgeranyl pyrophosphate synthase	0.059	0.3682	0.3682
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0433	0.267	0.266
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0233	0.0233
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0028	0.0023
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0147	0.0147
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0333	0.0333
Schistosoma mansoni	geranylgeranyl pyrophosphate synthase	0.059	0.3682	0.3682
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0166	0.0162
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0036	0.01	0.0087
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0361	0.0361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Loa Loa (eye worm)	polyprenyl synthetase	0.0433	0.267	0.2666
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0433	0.267	0.5
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0036	0.01	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Leishmania major	polyprenyl synthase, putative	0.059	0.3682	0.3619
Chlamydia trachomatis	geranylgeranyl pyrophosphate synthase	0.0433	0.267	0.5
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.01	0.0087
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.01	0.01
Onchocerca volvulus		0.0286	0.1717	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trypanosoma brucei	solanesyl-diphosphate synthase, putative	0.0433	0.267	0.266
Schistosoma mansoni	hypothetical protein	0.0025	0.0028	0.0028
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.01	0.0038
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0036	0.01	0.0087
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0148	0.0143
Onchocerca volvulus		0.0043	0.0148	0.0297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0036	0.01	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Mycobacterium tuberculosis	Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)	0.0433	0.267	0.256
Brugia malayi	beta-lactamase	0.0043	0.0148	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0148	0.0143
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0433	0.267	0.2596
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0036	0.01	0.01
Schistosoma mansoni	glutathione synthetase	0.0433	0.267	0.267
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.1663	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0148	0.0143
Brugia malayi	geranylgeranyl pyrophosphate synthetase	0.059	0.3682	0.3643
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0036	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0148	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0052	0.02	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0148	0.0148
Brugia malayi	Polyprenyl synthetase family protein	0.0433	0.267	0.2625
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.1492	0.1488
Leishmania major	solanesyl-diphosphate synthase, putative	0.0433	0.267	0.2596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Plasmodium vivax	octaprenyl pyrophosphate synthase, putative	0.0433	0.267	0.2596
Loa Loa (eye worm)	geranylgeranyl pyrophosphate synthetase	0.059	0.3682	0.3679
Mycobacterium tuberculosis	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)	0.0433	0.267	0.256
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0036	0.01	0.0087
Entamoeba histolytica	bifunctional short chain isoprenyl diphosphate synthase, putative	0.0433	0.267	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0043	0.0043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Brugia malayi	Bromodomain containing protein	0.0046	0.0166	0.0105
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0148	0.0148
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0148	0.0135
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0148	0.0148
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0036	0.01	0.0087
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0148	0.0143
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.01	0.0087
Echinococcus multilocularis	decaprenyl diphosphate synthase subunit 1	0.0433	0.267	0.267
Schistosoma mansoni	zinc finger protein	0.0024	0.002	0.002
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0148	0.0135
Brugia malayi	Pre-SET motif family protein	0.0036	0.01	0.0039
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0517	0.3208	0.3208
Entamoeba histolytica	geranylgeranyl pyrophosphate synthetase, putative	0.0433	0.267	1
Mycobacterium ulcerans	polyprenyl synthetase IdsB	0.0433	0.267	0.256
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0433	0.267	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.01	0.0087
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0148	0.0135
Echinococcus granulosus	geranylgeranyl pyrophosphate synthase	0.059	0.3682	0.3682
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0148	0.0143
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0057	0.0233	0.0233
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0233	0.0233
Mycobacterium ulcerans	polyprenyl diphosphate synthetase, GrcC1	0.0433	0.267	0.256
Echinococcus multilocularis	zinc finger protein	0.0024	0.002	0.002

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 195 um	PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	1 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (binding)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1542304

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1407614