Detailed information for compound 1407708

Basic information

Technical information
  • TDR Targets ID: 1407708
  • Name: 1-[1-[(4-chlorophenyl)methyl]-3,7-dimethyl-2, 6-dioxopurin-8-yl]piperidine-4-carboxamide
  • MW: 430.888 | Formula: C20H23ClN6O3
  • H donors: 1 H acceptors: 4 LogP: 1.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cn1c(=O)c2n(C)c(nc2n(c1=O)C)N1CCC(CC1)C(=O)N
  • InChi: 1S/C20H23ClN6O3/c1-24-15-17(23-19(24)26-9-7-13(8-10-26)16(22)28)25(2)20(30)27(18(15)29)11-12-3-5-14(21)6-4-12/h3-6,13H,7-11H2,1-2H3,(H2,22,28)
  • InChiKey: SHCDMMPFJOFMLL-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-[1-[(4-chlorophenyl)methyl]-3,7-dimethyl-2,6-dioxo-purin-8-yl]piperidine-4-carboxamide
  • 1-[1-[(4-chlorophenyl)methyl]-3,7-dimethyl-2,6-dioxo-8-purinyl]-4-piperidinecarboxamide
  • 1-[1-(4-chlorobenzyl)-2,6-diketo-3,7-dimethyl-purin-8-yl]isonipecotamide
  • MLS000082094
  • STOCK4S-26755
  • SMR000043961

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Trypanosoma brucei beta tubulin 0.0293 0.3596 1
Schistosoma mansoni ap endonuclease 0.0037 0.0255 0.0283
Brugia malayi intermediate filament protein 0.0054 0.0474 0.1036
Brugia malayi Tubulin alpha-2 chain 0.024 0.2905 0.6532
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0341 0.0909
Trypanosoma brucei tubulin delta chain 0.0077 0.0771 0.2129
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0286 0.0611
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.038 0.0825
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0415 0.0934
Loa Loa (eye worm) tubulin beta chain 0.0293 0.3596 0.8099
Schistosoma mansoni Smad4 0.0024 0.009 0.0088
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0286 0.0611
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0396 0.5035
Leishmania major beta tubulin 0.0293 0.3596 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0396 0.0381
Loa Loa (eye worm) tubulin alpha chain 0.024 0.2905 0.6544
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Giardia lamblia Beta tubulin 0.0293 0.3596 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0538 0.1289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0286 0.0611
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0075 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0169
Giardia lamblia Alpha-tubulin 0.024 0.2905 0.8071
Loa Loa (eye worm) alpha-tubulin 0.024 0.2905 0.6544
Brugia malayi nuclear receptor RXR 0.0023 0.0075 0.0135
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0063 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0341 0.0909
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0396 0.0885
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0075 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0339 0.0797
Echinococcus granulosus tubulin alpha 3 chain 0.024 0.2905 0.3415
Schistosoma mansoni alpha-glucosidase 0.0169 0.1979 0.2321
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0077 0.0771 0.1954
Loa Loa (eye worm) hypothetical protein 0.0229 0.2755 0.6205
Trichomonas vaginalis tubulin beta chain, putative 0.0293 0.3596 0.882
Brugia malayi nuclear hormone receptor 0.0039 0.0286 0.0611
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0396 0.0892
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0022
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0474 0.1036
Giardia lamblia Gamma tubulin 0.0177 0.2074 0.5749
Leishmania major beta tubulin 0.0293 0.3596 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.024 0.2905 0.2894
Entamoeba histolytica tubulin gamma chain 0.0177 0.2074 0.5749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Echinococcus multilocularis beta tubulin 0.0293 0.3596 0.3586
Plasmodium vivax tubulin epsilon chain, putative 0.0177 0.2074 0.5664
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0026 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0396 0.0381
Echinococcus granulosus tubulin alpha chain 0.024 0.2905 0.3415
Schistosoma mansoni alpha tubulin 0.024 0.2905 0.3415
Brugia malayi hypothetical protein 0.0229 0.2755 0.6192
Echinococcus granulosus Smad4 0.0024 0.009 0.0088
Echinococcus granulosus tubulin alpha 1C chain 0.024 0.2905 0.3415
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0339 0.0903
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.01 0.1074 0.2608
Toxoplasma gondii beta tubulin 0.0293 0.3596 1
Echinococcus granulosus lamin 0.0054 0.0474 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0339 0.0763
Brugia malayi hypothetical protein 0.0148 0.17 0.3809
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0858 0.0995
Onchocerca volvulus Huntingtin homolog 0.0148 0.17 0.6019
Echinococcus multilocularis tubulin alpha chain 0.024 0.2905 0.2894
Echinococcus granulosus tubulin alpha chain 0.024 0.2905 0.3415
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0255 0.3173
Loa Loa (eye worm) glutaminase 0.033 0.4075 0.9179
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0286 0.0271
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0886 0.1029
Brugia malayi hypothetical protein 0.0023 0.0075 0.0135
Schistosoma mansoni tubulin subunit beta 0.0077 0.0771 0.0893
Loa Loa (eye worm) tubulin alpha chain 0.024 0.2905 0.6544
Schistosoma mansoni smad 0.0024 0.009 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0415 0.0472
Brugia malayi isocitrate dehydrogenase 0.0048 0.0396 0.086
Onchocerca volvulus Peroxidasin homolog 0.0132 0.1489 0.5258
Trichomonas vaginalis tubulin gamma chain, putative 0.0077 0.0771 0.1862
Loa Loa (eye worm) hypothetical protein 0.0034 0.0218 0.0491
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Onchocerca volvulus Peroxidase homolog 0.0132 0.1489 0.5258
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0858 0.2075
Echinococcus multilocularis Tubulin alpha 1 chain 0.024 0.2905 0.2894
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0075 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0111 0.0235
Trypanosoma cruzi epsilon tubulin, putative 0.0177 0.2074 0.5749
Brugia malayi hypothetical protein 0.0032 0.019 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Trichomonas vaginalis tubulin gamma chain, putative 0.0293 0.3596 0.882
Trichomonas vaginalis tubulin alpha chain, putative 0.0177 0.2074 0.507
Trypanosoma brucei beta tubulin 0.0293 0.3596 1
Echinococcus granulosus peroxisome assembly protein 26 0.024 0.2905 0.3415
Echinococcus granulosus tubulin gamma 1 chain 0.0177 0.2074 0.2432
Trypanosoma brucei alpha tubulin, putative 0.01 0.1074 0.2973
Brugia malayi hypothetical protein 0.0118 0.1307 0.292
Brugia malayi tubulin alpha-2 chain 0.024 0.2905 0.6532
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0218 0.0457
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0341 0.0802
Schistosoma mansoni hypothetical protein 0.0334 0.4126 0.4858
Trypanosoma cruzi tubulin delta chain 0.0077 0.0771 0.2111
Plasmodium falciparum tubulin gamma chain 0.0177 0.2074 0.5664
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2336 0.5246
Trichomonas vaginalis set domain proteins, putative 0.0229 0.276 0.6761
Leishmania major beta tubulin 0.0293 0.3596 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0223 0.0511
Leishmania major beta tubulin 0.0293 0.3596 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0022
Schistosoma mansoni ap endonuclease 0.0037 0.0255 0.0283
Trypanosoma brucei unspecified product 0.0019 0.0016 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0286 0.0319
Trichomonas vaginalis tubulin gamma chain, putative 0.0177 0.2074 0.507
Loa Loa (eye worm) glutaminase 2 0.033 0.4075 0.9179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0286 0.0643
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0474 0.1067
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.2905 0.7118
Plasmodium vivax delta tubulin, putative 0.0077 0.0771 0.1954
Brugia malayi Peroxidasin 0.0132 0.1489 0.333
Echinococcus multilocularis tubulin alpha 1C chain 0.024 0.2905 0.2894
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0341 0.0909
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0286 0.0611
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0424 0.0924
Trypanosoma cruzi tubulin gamma chain 0.0177 0.2074 0.5749
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.2905 0.7118
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0226 0.0476
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0286 0.0319
Brugia malayi MH1 domain containing protein 0.0024 0.009 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0708 0.0818
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.2905 0.7118
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0538 0.0618
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0169
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.2808 0.6325
Echinococcus granulosus microtubule associated protein 2 0.0668 0.8476 1
Giardia lamblia Alpha-tubulin 0.024 0.2905 0.8071
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.042 0.0952
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0538 0.0523
Echinococcus granulosus jun protein 0.0081 0.0831 0.0964
Schistosoma mansoni hypothetical protein 0.0072 0.0708 0.0818
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0255 0.067
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0164 0.1906 0.4293
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0255 0.0575
Mycobacterium ulcerans epimerase 0.002 0.0026 0.0027
Brugia malayi hypothetical protein 0.0155 0.1797 0.4027
Echinococcus multilocularis expressed conserved protein 0.0182 0.2148 0.2136
Schistosoma mansoni tubulin subunit gamma 0.0177 0.2074 0.2432
Toxoplasma gondii exonuclease III APE 0.0037 0.0255 0.0484
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.028 0.0313
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Onchocerca volvulus 0.0048 0.0396 0.1329
Loa Loa (eye worm) hypothetical protein 0.0148 0.17 0.383
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0286 0.0319
Brugia malayi Cytochrome P450 family protein 0.0031 0.0181 0.0375
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0226 0.0211
Echinococcus multilocularis Tubulin alpha 1 chain 0.024 0.2905 0.2894
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2336 0.2324
Brugia malayi ecdysteroid receptor 0.0039 0.0286 0.0611
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0339 0.0324
Loa Loa (eye worm) tubulin alpha 2 0.0164 0.1906 0.4293
Brugia malayi bZIP transcription factor family protein 0.0081 0.0831 0.1844
Echinococcus multilocularis tubulin alpha chain 0.024 0.2905 0.2894
Plasmodium falciparum alpha tubulin 1 0.024 0.2905 0.8033
Leishmania major beta tubulin 0.0293 0.3596 1
Echinococcus granulosus expressed conserved protein 0.0182 0.2148 0.2521
Loa Loa (eye worm) hypothetical protein 0.005 0.0424 0.0956
Trypanosoma cruzi zeta tubulin, putative 0.0077 0.0771 0.2111
Onchocerca volvulus 0.0155 0.1797 0.6366
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0022
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.024 0.2905 0.7118
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0164 0.1906 0.4657
Onchocerca volvulus Peroxidasin homolog 0.0132 0.1489 0.5258
Mycobacterium tuberculosis Cell division protein FtsZ 0.0077 0.0771 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0255 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.2302 0.2702
Loa Loa (eye worm) tubulin alpha 2 0.0064 0.0604 0.1359
Trichomonas vaginalis tubulin epsilon chain, putative 0.0293 0.3596 0.882
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0858 0.1932
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0255 0.0591
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0341 0.0802
Trichomonas vaginalis tubulin alpha chain, putative 0.0293 0.3596 0.882
Schistosoma mansoni hypothetical protein 0.0022 0.0063 0.0056
Schistosoma mansoni hypothetical protein 0.0066 0.0633 0.073
Brugia malayi MH2 domain containing protein 0.0024 0.009 0.0169
Loa Loa (eye worm) tubulin beta-2A chain 0.0293 0.3596 0.8099
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.4439 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0149 0.0157
Schistosoma mansoni survival motor neuron protein 0.0047 0.038 0.0431
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0335
Echinococcus multilocularis tubulin subunit TubB 0.024 0.2905 0.2894
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0286 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0169
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.009 0.0088
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0237 0.0222
Echinococcus granulosus alpha tubulin 0.024 0.2905 0.3415
Loa Loa (eye worm) hypothetical protein 0.0164 0.1906 0.4293
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0255 0.0591
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.1074 0.2608
Mycobacterium ulcerans glutaminase 0.033 0.4075 1
Echinococcus multilocularis jun protein 0.0081 0.0831 0.0817
Echinococcus granulosus Tubulin beta 2C chain 0.0293 0.3596 0.4231
Brugia malayi Tubulin beta chain 0.01 0.1074 0.2393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0152 0.0337
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Leishmania major beta tubulin 0.0293 0.3596 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.009 0.0203
Treponema pallidum cell division protein FtsZ 0.0077 0.0771 1
Brugia malayi hypothetical protein 0.0064 0.0604 0.133
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1489 0.3353
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0286 0.0932
Schistosoma mansoni alpha tubulin 0.024 0.2905 0.3415
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1489 0.3353
Brugia malayi tubulin alpha chain - mouse 0.024 0.2905 0.6532
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0339 0.0903
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0415 0.1115
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0085 0.0172
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0181 0.0463
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.0739 0.1635
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.0739 0.9564
Brugia malayi Pre-SET motif family protein 0.0029 0.0149 0.0301
Trichomonas vaginalis tubulin, putative 0.0077 0.0771 0.1862
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.2302 0.5168
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.042 0.1129
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0415 0.1115
Schistosoma mansoni hypothetical protein 0.0047 0.038 0.0431
Brugia malayi alpha-tubulin 0.024 0.2905 0.6532
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0339 0.0903
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0286 0.0319
Echinococcus granulosus Tubulin beta 2C chain 0.0293 0.3596 0.4231
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0149 0.0133
Echinococcus granulosus tubulin epsilon chain 0.0177 0.2074 0.2432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Schistosoma mansoni hypothetical protein 0.008 0.0818 0.0949
Leishmania major beta tubulin 0.0293 0.3596 1
Loa Loa (eye worm) beta-tubulin 0.0293 0.3596 0.8099
Leishmania major beta tubulin 0.0293 0.3596 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0149 0.018
Schistosoma mansoni tubulin subunit alpha 0.024 0.2905 0.3415
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0286 0.0319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0492 0.0477
Echinococcus multilocularis Tubulin beta 2C chain 0.0293 0.3596 0.3586
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.042 0.1129
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0286 0.0643
Entamoeba histolytica hypothetical protein 0.0072 0.0708 0.1934
Leishmania major beta tubulin 0.0293 0.3596 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0085 0.0195
Schistosoma mansoni hypothetical protein 0.0034 0.0218 0.0239
Plasmodium falciparum tubulin delta chain, putative 0.0077 0.0771 0.1954
Echinococcus multilocularis protein patched 0.0083 0.0858 0.0843
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0149 0.0133
Schistosoma mansoni tubulin subunit beta 0.0293 0.3596 0.4231
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0341 0.0802
Schistosoma mansoni hypothetical protein 0.008 0.0818 0.0949
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0197 0.2341 0.2748
Trypanosoma brucei glucosidase, putative 0.0044 0.0341 0.093
Entamoeba histolytica tubulin alpha-1 chain 0.024 0.2905 0.8071
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Onchocerca volvulus 0.01 0.1074 0.3768
Loa Loa (eye worm) hypothetical protein 0.0148 0.17 0.383
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0286 0.0611
Loa Loa (eye worm) hypothetical protein 0.0194 0.2302 0.5185
Echinococcus granulosus tubulin alpha chain 0.024 0.2905 0.3415
Entamoeba histolytica hypothetical protein 0.0024 0.0085 0.0195
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2755 0.2743
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.009 0.0075
Brugia malayi hypothetical protein 0.0072 0.0708 0.1565
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0341 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Schistosoma mansoni tubulin subunit beta 0.0293 0.3596 0.4231
Trypanosoma brucei epsilon tubulin 0.0177 0.2074 0.5758
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0035
Echinococcus multilocularis protein dispatched 1 0.0095 0.1011 0.0997
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0341 0.0909
Trypanosoma brucei tubulin gamma chain 0.0177 0.2074 0.5758
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0181 0.0484
Brugia malayi Blistered cuticle protein 3 0.0132 0.1489 0.333
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.009 0.0203
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0739 0.1862
Schistosoma mansoni alpha tubulin 0.024 0.2905 0.3415
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.1287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0153
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0341 0.0385
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2336 0.2743
Schistosoma mansoni glutaminase 0.033 0.4075 0.4798
Trypanosoma brucei alpha tubulin 0.024 0.2905 0.8075
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.022
Echinococcus granulosus Tubulin beta 2C chain 0.0293 0.3596 0.4231
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0286 0.0611
Schistosoma mansoni jun-related protein 0.0066 0.0633 0.073
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0286 0.0611
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Leishmania major hypothetical protein, conserved 0.005 0.042 0.1129
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.8476 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0286 0.0319
Echinococcus granulosus peroxidasin 0.0132 0.1489 0.1741
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.0739 0.957
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0831 0.0964
Brugia malayi Tubulin alpha-2 chain 0.024 0.2905 0.6532
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0148 0.0299
Brugia malayi Cell division protein ftsZ 0.0077 0.0771 0.1709
Toxoplasma gondii alpha tubulin TUBA1 0.024 0.2905 0.8033
Schistosoma mansoni coup transcription factor 0.0039 0.0286 0.0319
Leishmania major beta tubulin 0.0293 0.3596 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0339 0.0382
Echinococcus multilocularis beta tubulin 0.0293 0.3596 0.3586
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1489 0.333
Entamoeba histolytica tubulin family protein 0.0293 0.3596 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0075 0.0135
Schistosoma mansoni smad1 5 8 and 0.0024 0.009 0.0088
Echinococcus granulosus Tubulin beta 2C chain 0.0293 0.3596 0.4231
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0223 0.0602
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0341 0.0802
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0255 0.2477
Onchocerca volvulus Peroxidase homolog 0.0132 0.1489 0.5258
Brugia malayi hypothetical protein 0.0132 0.1489 0.333
Schistosoma mansoni smad1 5 8 and 0.0024 0.009 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.2397 0.54
Loa Loa (eye worm) hypothetical protein 0.005 0.042 0.0945
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0059
Brugia malayi hypothetical protein 0.0023 0.0075 0.0135
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0396 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0286 0.0643
Onchocerca volvulus 0.0035 0.0226 0.0719
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.2302 0.6386
Mycobacterium ulcerans cell division protein FtsZ 0.0077 0.0771 0.1862
Echinococcus granulosus tubulin subunit beta 0.0293 0.3596 0.4231
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0237 0.0262
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0415 0.1115
Echinococcus multilocularis tubulin alpha 0.0177 0.2074 0.2061
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2336 0.5263
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.8476 0.8474
Brugia malayi MH2 domain containing protein 0.0358 0.4439 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0277 0.3387 0.3377
Trypanosoma cruzi alpha tubulin, putative 0.024 0.2905 0.8071
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0255 0.0591
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0111 0.0095
Echinococcus multilocularis lamin dm0 0.0054 0.0474 0.0459
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.1287
Entamoeba histolytica hypothetical protein 0.0072 0.0708 0.1934
Schistosoma mansoni lamin 0.0054 0.0474 0.0541
Brugia malayi Pre-SET motif family protein 0.0201 0.2397 0.5384
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0286 0.0611
Echinococcus granulosus tubulin alpha 1C chain 0.024 0.2905 0.3415
Onchocerca volvulus 0.0132 0.1489 0.5258
Trichomonas vaginalis tubulin, putative 0.01 0.1074 0.2608
Onchocerca volvulus 0.0047 0.038 0.1273
Schistosoma mansoni alpha glucosidase 0.0044 0.0341 0.0385
Leishmania major beta tubulin 0.0293 0.3596 1
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.1074 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0771 0.1862
Trypanosoma brucei alpha tubulin 0.024 0.2905 0.8075
Loa Loa (eye worm) blistered cuticle protein 3 0.0132 0.1489 0.3353
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0286 0.0611
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0396 0.1083
Echinococcus multilocularis tubulin subunit beta 0.0293 0.3596 0.3586
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0255 0.0542
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0255 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0154
Trypanosoma brucei zeta tubulin 0.0077 0.0771 0.2129
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0169
Brugia malayi CHE-14 protein 0.0083 0.0858 0.1904
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0181 0.0409
Echinococcus multilocularis Tubulin beta 2C chain 0.0293 0.3596 0.3586
Onchocerca volvulus 0.0064 0.0604 0.2076
Echinococcus granulosus Tubulin alpha 1 chain 0.024 0.2905 0.3415
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0237 0.0501
Echinococcus granulosus Tubulin alpha 1 chain 0.024 0.2905 0.3415
Echinococcus multilocularis Smad4 0.0024 0.009 0.0075
Echinococcus multilocularis peroxidasin 0.0132 0.1489 0.1475
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0075 0.007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0286 0.0611
Loa Loa (eye worm) hypothetical protein 0.0155 0.1797 0.4048
Trypanosoma brucei beta tubulin 0.0177 0.2074 0.5758
Onchocerca volvulus 0.0039 0.0286 0.0932
Loa Loa (eye worm) hypothetical protein 0.0158 0.1831 0.4124
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0386 0.0438
Echinococcus multilocularis Tubulin beta 2C chain 0.0293 0.3596 0.3586
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0077 0.0771 0.1862
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0063 0.0047
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0339 0.0924
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.004 0.0091
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0396 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0223 0.0511
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0396 0.0885
Plasmodium falciparum alpha tubulin 2 0.024 0.2905 0.8033
Brugia malayi glutaminase DH11.1 0.033 0.4075 0.9176
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0286 0.0319
Schistosoma mansoni tubulin subunit alpha 0.024 0.2905 0.3415
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0075 0.0135
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0396 0.1063
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0886 0.1029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2723 0.6135
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0708 0.0818
Echinococcus multilocularis Tubulin beta 2C chain 0.0293 0.3596 0.3586
Loa Loa (eye worm) hypothetical protein 0.0054 0.0474 0.1067
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Plasmodium vivax tubulin alpha chain, putative 0.024 0.2905 0.8033
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.2905 0.7118
Chlamydia trachomatis endonuclease IV 0.0074 0.0739 1
Onchocerca volvulus 0.0085 0.0886 0.3091
Entamoeba histolytica hypothetical protein 0.0072 0.0708 0.1934
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.028 0.0313
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0341 0.0909
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0286 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0223 0.0511
Echinococcus granulosus smad 0.0024 0.009 0.0088
Brugia malayi Cytochrome P450 family protein 0.0051 0.0435 0.0948
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0286 0.0319
Trichomonas vaginalis tubulin epsilon chain, putative 0.0293 0.3596 0.882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0286 0.0643
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2723 0.6121
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0341 0.0802
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0207 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0148 0.0333
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0181 0.0408
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0223 0.0581
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0255 0.067
Schistosoma mansoni single-minded 0.0047 0.0386 0.0438
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0207 0.0471
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0255 0.067
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0075 0.0169
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0077 0.0771 0.1954
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0286 0.0319
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.042 0.0952
Loa Loa (eye worm) Smad1 0.0024 0.009 0.0203
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0194 0.0308
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0286 0.0932
Leishmania major beta tubulin 0.0293 0.3596 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0286 0.0611
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0149 0.0157
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0293 0.3596 0.3586
Trichomonas vaginalis tubulin epsilon chain, putative 0.0077 0.0771 0.1862
Plasmodium vivax tubulin beta chain, putative 0.0293 0.3596 1
Leishmania major delta tubulin, putative 0.0077 0.0771 0.2111
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0415 0.1115
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.1074 0.2608
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0286 0.0611
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0286 0.0271
Brugia malayi steroid hormone receptor 0.0039 0.0286 0.0611
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0492 0.1108
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1489 0.333
Loa Loa (eye worm) tubulin alpha-2 chain 0.024 0.2905 0.6544
Loa Loa (eye worm) BEN-1 protein 0.0293 0.3596 0.8099
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0415 0.1115
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0396 0.0885
Echinococcus granulosus tubulin alpha 3 chain 0.024 0.2905 0.3415
Echinococcus multilocularis hypothetical protein 0.024 0.2905 0.2894
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0181 0.0408
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0415 0.0472
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0135 0.0141
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0538 0.1459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0339 0.0797
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0435 0.0979
Trichomonas vaginalis tubulin, putative 0.01 0.1074 0.2608
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0341 0.0768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0255 0.0283
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0739 0.1862
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0415 0.0984
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0474 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0492 0.0563
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.2905 0.7118
Schistosoma mansoni tubulin subunit alpha 0.0077 0.0771 0.0893
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.014 0.1603 0.391
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0341 0.0802
Trypanosoma brucei alpha tubulin 0.024 0.2905 0.8075
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0415 0.0984
Echinococcus multilocularis tubulin alpha 1C chain 0.024 0.2905 0.2894
Onchocerca volvulus 0.0132 0.1489 0.5258
Trichomonas vaginalis tubulin epsilon chain, putative 0.024 0.2905 0.7118
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0339 0.0924
Echinococcus granulosus neuropeptide s receptor 0.0449 0.5625 0.663
Loa Loa (eye worm) hypothetical protein 0.0074 0.0739 0.1664
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0286 0.0319
Giardia lamblia Beta tubulin 0.0293 0.3596 1
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1489 0.3353
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Trypanosoma cruzi tubulin delta chain 0.0077 0.0771 0.2111
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0415 0.1135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0107 0.0226
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0026 0.0024
Echinococcus multilocularis lamin 0.0054 0.0474 0.0459
Plasmodium falciparum tubulin epsilon chain, putative 0.0177 0.2074 0.5664
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0286 0.0319
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0026 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0286 0.0611
Brugia malayi MAP kinase sur-1 0.0049 0.0415 0.0903
Plasmodium vivax tubulin gamma chain, putative 0.0177 0.2074 0.5664
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0339 0.0731
Brugia malayi hypothetical protein 0.0158 0.1831 0.4103
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.009 0.0075
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1489 0.333
Leishmania major beta tubulin 0.0293 0.3596 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0111 0.0112
Echinococcus granulosus Tubulin beta 2C chain 0.0293 0.3596 0.4231
Schistosoma mansoni tubulin subunit beta 0.0293 0.3596 0.4231
Loa Loa (eye worm) hypothetical protein 0.0102 0.1102 0.2482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0339 0.0797
Mycobacterium ulcerans hypothetical protein 0.002 0.0026 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0223 0.0511
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0886 0.0872
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0286 0.0611
Plasmodium vivax tubulin alpha chain, putative 0.024 0.2905 0.8033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0176 0.0396
Echinococcus multilocularis tubulin alpha chain 0.024 0.2905 0.2894
Trypanosoma brucei beta tubulin 0.0293 0.3596 1
Echinococcus multilocularis tubulin alpha chain 0.024 0.2905 0.2894
Leishmania major beta tubulin 0.0293 0.3596 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0415 0.1115
Trypanosoma brucei alpha tubulin 0.024 0.2905 0.8075
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0226 0.0519
Toxoplasma gondii endonuclease IV APN 0.0074 0.0739 0.1862
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.5625 0.663
Echinococcus multilocularis tumor protein p63 0.0327 0.4034 0.4025
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Loa Loa (eye worm) hypothetical protein 0.0048 0.0396 0.0892
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0169
Schistosoma mansoni tubulin subunit beta 0.0293 0.3596 0.4231
Echinococcus granulosus beta tubulin 0.0293 0.3596 0.4231
Loa Loa (eye worm) hypothetical protein 0.0085 0.0886 0.1996
Leishmania major beta tubulin 0.0293 0.3596 1
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1489 0.333
Echinococcus multilocularis tubulin alpha chain 0.024 0.2905 0.2894
Loa Loa (eye worm) alpha-tubulin 0.024 0.2905 0.6544
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0415 0.04
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.009 0.0088
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0286 0.0271
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.1287
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0255 0.0484
Echinococcus multilocularis smad 0.0024 0.009 0.0075
Brugia malayi Tubulin alpha chain 0.024 0.2905 0.6532
Toxoplasma gondii alpha-tubulin I, putative 0.024 0.2905 0.8033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0255 0.067
Giardia lamblia GTOR 0.0043 0.0339 0.0903
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0538 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0154
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0396 0.1063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0286 0.0319
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0415 0.0984
Trichomonas vaginalis tubulin, putative 0.0293 0.3596 0.882
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0255 0.0484
Onchocerca volvulus 0.0054 0.0474 0.1608
Onchocerca volvulus 0.0132 0.1489 0.5258
Schistosoma mansoni tubulin subunit beta 0.0293 0.3596 0.4231
Echinococcus granulosus tubulin delta chain 0.0077 0.0771 0.0893
Toxoplasma gondii beta-tubulin, putative 0.0293 0.3596 1
Schistosoma mansoni patched 1 0.0083 0.0858 0.0995
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0286 0.0271
Schistosoma mansoni hypothetical protein 0.0334 0.4126 0.4858
Loa Loa (eye worm) tubulin beta-1 chain 0.0293 0.3596 0.8099
Echinococcus multilocularis geminin 0.0334 0.4126 0.4117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Echinococcus multilocularis tubulin beta 1 chain 0.0293 0.3596 0.3586
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.042 0.0952
Echinococcus multilocularis tubulin delta chain 0.0077 0.0771 0.0757
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Brugia malayi beta-tubulin, identical 0.0293 0.3596 0.8093
Onchocerca volvulus 0.0054 0.0474 0.1608
Brugia malayi Tubulin alpha chain 0.0077 0.0771 0.1709
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0415 0.1115
Onchocerca volvulus 0.0029 0.0149 0.044
Leishmania major zeta tubulin, putative 0.0077 0.0771 0.2111
Plasmodium falciparum tubulin beta chain 0.0293 0.3596 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0286 0.0932
Loa Loa (eye worm) hypothetical protein 0.0053 0.0461 0.1038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0492 0.0563
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.2905 0.7118
Brugia malayi hypoxia-induced factor 1 0.0146 0.1671 0.3743
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0396 0.1063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Brugia malayi MH1 domain containing protein 0.0024 0.009 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0286 0.0271
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0424 0.0924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0153
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0286 0.0319
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0255 0.0691
Schistosoma mansoni peroxidasin 0.0132 0.1489 0.1741
Onchocerca volvulus 0.0233 0.2808 1
Onchocerca volvulus 0.0114 0.1255 0.4418
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0396 0.086
Echinococcus granulosus tubulin subunit TubB 0.024 0.2905 0.3415
Loa Loa (eye worm) tubulin alpha-3 chain 0.014 0.1603 0.361
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0339 0.0382
Trypanosoma brucei protein kinase, putative 0.0049 0.0415 0.1135
Trypanosoma brucei epsilon tubulin 0.0177 0.2074 0.5758
Schistosoma mansoni tubulin subunit beta 0.0293 0.3596 0.4231
Schistosoma mansoni peroxidasin 0.0132 0.1489 0.1741
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0396 0.0381
Schistosoma mansoni tubulin subunit delta 0.0077 0.0771 0.0893
Leishmania major beta tubulin 0.0293 0.3596 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Onchocerca volvulus Chorion peroxidase homolog 0.0132 0.1489 0.5258
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.5625 0.5618
Onchocerca volvulus Dual oxidase homolog 0.0132 0.1489 0.5258
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0286 0.0319
Trichomonas vaginalis tubulin gamma chain, putative 0.0177 0.2074 0.507
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1489 0.333
Echinococcus multilocularis peroxisome assembly protein 26 0.024 0.2905 0.2894
Echinococcus granulosus Tubulin alpha 1 chain 0.024 0.2905 0.3415
Leishmania major epsilon tubulin, putative 0.0177 0.2074 0.5749
Echinococcus granulosus geminin 0.0334 0.4126 0.4858
Trypanosoma brucei epsilon tubulin 0.0177 0.2074 0.5758
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.022
Loa Loa (eye worm) tubulin beta-4 chain 0.0293 0.3596 0.8099
Echinococcus multilocularis tubulin epsilon chain 0.0177 0.2074 0.2061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0149 0.0157
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0181 0.0463
Loa Loa (eye worm) hypothetical protein 0.0083 0.0858 0.1932
Entamoeba histolytica tubulin alpha chain, putative 0.024 0.2905 0.8071
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Giardia lamblia Delta tubulin 0.0077 0.0771 0.2111
Onchocerca volvulus 0.0229 0.276 0.9828
Mycobacterium leprae cell division protein FtsZ 0.0077 0.0771 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2336 0.2324
Brugia malayi Smad1 0.0024 0.009 0.0169
Loa Loa (eye worm) hypothetical protein 0.014 0.1603 0.361
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0396 0.0381
Echinococcus multilocularis musashi 0.0054 0.0474 0.0459
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Brugia malayi PAS domain containing protein 0.0047 0.0386 0.0837
Schistosoma mansoni hypothetical protein 0.008 0.0818 0.0949
Echinococcus multilocularis tubulin alpha 3 chain 0.024 0.2905 0.2894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0492 0.0477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0492 0.0563
Brugia malayi Pax transcription factor protein 2 0.0233 0.2808 0.6312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0107 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0286 0.0643
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.5625 0.5618
Schistosoma mansoni hypothetical protein 0.005 0.0424 0.0483
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0396 0.045
Trypanosoma brucei beta tubulin 0.0293 0.3596 1
Echinococcus granulosus tubulin beta 1 chain 0.0293 0.3596 0.4231
Leishmania major beta tubulin 0.0293 0.3596 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0858 0.0843
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.042 0.1149
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0237 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0256 0.0593
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0415 0.0984
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0424 0.0956
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0085 0.0217
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0492 0.1077
Entamoeba histolytica tubulin family protein 0.0293 0.3596 1
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0339 0.0903
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0886 0.1968
Schistosoma mansoni hypothetical protein 0.008 0.0818 0.0949
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0149 0.018
Leishmania major cytochrome p450-like protein 0.0031 0.0181 0.0463
Schistosoma mansoni tubulin subunit alpha 0.024 0.2905 0.3415
Trypanosoma cruzi epsilon tubulin, putative 0.0177 0.2074 0.5749
Loa Loa (eye worm) tubulin beta chain 0.0077 0.0771 0.1738
Trypanosoma cruzi zeta tubulin, putative 0.0077 0.0771 0.2111
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0286 0.0319
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0181 0.0408
Brugia malayi MH2 domain containing protein 0.0024 0.009 0.0169
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0341 0.0802
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0415 0.0472
Echinococcus granulosus lamin dm0 0.0054 0.0474 0.0541
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0286 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0149 0.0157
Schistosoma mansoni smad1 5 8 and 0.0024 0.009 0.0088
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0396 0.1083
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0085 0.0172
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.042 0.0952
Brugia malayi Tubulin beta-1 chain 0.0293 0.3596 0.8093
Loa Loa (eye worm) hypothetical protein 0.024 0.2905 0.6544
Schistosoma mansoni intermediate filament proteins 0.0054 0.0474 0.0541
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.1074 0.2608
Loa Loa (eye worm) BEN-1 protein 0.0293 0.3596 0.8099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0492 0.0563
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0396 0.0381
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1489 0.3353
Echinococcus granulosus intermediate filament protein 0.0054 0.0474 0.0541
Brugia malayi hypothetical protein 0.005 0.042 0.0914
Entamoeba histolytica hypothetical protein 0.0072 0.0708 0.1934
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2755 0.3238
Brugia malayi Cytochrome P450 family protein 0.0031 0.0181 0.0375
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0255 0.2477
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0339 0.0903
Brugia malayi Tubulin gamma chain 0.0177 0.2074 0.4652
Loa Loa (eye worm) hypothetical protein 0.0079 0.0802 0.1807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0149 0.0157
Schistosoma mansoni tubulin subunit epsilon 0.0177 0.2074 0.2432
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0286 0.0319
Echinococcus granulosus beta tubulin 0.0293 0.3596 0.4231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0286 0.0643
Loa Loa (eye worm) hypothetical protein 0.0307 0.3773 0.85
Echinococcus granulosus tubulin alpha 0.0177 0.2074 0.2432
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.4439 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0286 0.0319
Onchocerca volvulus Huntingtin homolog 0.0148 0.17 0.6019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0286 0.0611
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0341 0.0728
Schistosoma mansoni lamin 0.0054 0.0474 0.0541
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0341 0.0326
Echinococcus granulosus tubulin alpha chain 0.024 0.2905 0.3415
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0286 0.0271
Echinococcus granulosus tubulin alpha chain 0.024 0.2905 0.3415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0154
Giardia lamblia Beta tubulin 0.0293 0.3596 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0016 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0538 0.6912
Echinococcus multilocularis Tubulin beta 2C chain 0.0293 0.3596 0.3586
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0177 0.2074 0.5664
Trypanosoma cruzi beta tubulin, putative 0.0293 0.3596 1
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0415 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0111 0.0235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0286 0.0271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0831 0.0817
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0415 0.0938
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0396 0.0885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0492 0.0563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0286 0.0643
Leishmania major gamma-tubulin 0.0177 0.2074 0.5749
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.2302 0.229
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0771 0.1862
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0286 0.0319
Leishmania major beta tubulin 0.0293 0.3596 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0111 0.0235
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0538 0.0618
Loa Loa (eye worm) tubulin gamma chain 0.0177 0.2074 0.4671
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0858 0.0995
Echinococcus multilocularis tubulin gamma 1 chain 0.0177 0.2074 0.2061
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0286 0.0271
Schistosoma mansoni alpha-glucosidase 0.0169 0.1979 0.2321
Echinococcus granulosus Niemann Pick C1 protein 0.0277 0.3387 0.3985
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0286 0.0319
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0341 0.0736
Mycobacterium ulcerans endonuclease IV 0.0074 0.0739 0.1782
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0708 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.0154
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0085 0.0793
Loa Loa (eye worm) hypothetical protein 0.0026 0.0111 0.0249
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Echinococcus granulosus tumor protein p63 0.0327 0.4034 0.475
Toxoplasma gondii beta-1 tubulin, putative 0.0293 0.3596 1
Trichomonas vaginalis glutaminase, putative 0.033 0.4075 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.024 0.2905 0.7118
Giardia lamblia Epsilon tubulin 0.0077 0.0771 0.2111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0194 0.0439
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0077 0.0771 1
Loa Loa (eye worm) tubulin alpha 2 0.0164 0.1906 0.4293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.014 0.0307
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0341 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0223 0.0511
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0085 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0286 0.0611
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.009 0.0088
Trypanosoma brucei zeta tubulin, putative 0.0077 0.0771 0.2129
Brugia malayi Tubulin beta chain 0.0077 0.0771 0.1709
Echinococcus granulosus tubulin beta 4A class IVa 0.0293 0.3596 0.4231
Loa Loa (eye worm) hypothetical protein 0.0132 0.1489 0.3353
Brugia malayi nuclear receptor NHR-88 0.0039 0.0286 0.0611
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1671 0.3764
Leishmania major alpha tubulin 0.024 0.2905 0.8071
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0339 0.0903
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0022
Echinococcus granulosus single minded 2 0.0038 0.0269 0.03
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0223 0.0581
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0286 0.0271
Echinococcus multilocularis tubulin alpha 3 chain 0.024 0.2905 0.2894

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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