Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0032 | 0 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0032 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0032 | 0 | 0.5 |
Chlamydia trachomatis | methylated-DNA protein-cysteine methyltransferase | 0.0402 | 0.311 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0032 | 0 | 0.5 |
Treponema pallidum | methylated-DNA-protein-cysteine S-methyltransferase (dat) | 0.0402 | 0.311 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0032 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0402 | 0.311 | 1 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0402 | 0.311 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0402 | 0.311 | 1 |
Trichomonas vaginalis | methylated-DNA--protein-cysteine methyltransferase, putative | 0.0402 | 0.311 | 1 |
Mycobacterium ulcerans | methylated-DNA--protein-cysteine methyltransferase Ogt | 0.1222 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0164 | 0.1106 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0032 | 0 | 0.5 |
Mycobacterium tuberculosis | Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra | 0.1222 | 1 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex (Not Significant at 5000 nM) | ChEMBL. | 2573731 |
IC50 (binding) | 0 nM | Inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex (Not Significant at 5000 nM) | ChEMBL. | 2573731 |
MED (functional) | 0 mg kg-1 | Minimum effective dose of the compound (ip) tested for its anxiolytic activity in rat using the shock-induced suppression of drinking (SSD) test; NS is No Significant activity at 5 mg/Kg | ChEMBL. | 2573731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.